Best TWAS P=1.75e-09 · Best GWAS P=1.91e-11 conditioned to 0.00131
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HMG20A | 0.06 | 0.03 | enet | 10 | 0.06 | 9.8e-08 | 3.8 | 6.0 | 2.5e-09 | -0.78 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MAN2C1 | 0.13 | 0.17 | lasso | 5 | 0.18 | 2.5e-21 | -4.5 | -5.2 | 2.2e-07 | 0.04 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | SNUPN | 0.14 | 0.12 | enet | 7 | 0.11 | 2.0e-06 | 4.0 | -5.4 | 6.5e-08 | 0.03 | 0.25 | 0.65 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | MAN2C1 | 0.23 | 0.15 | lasso | 5 | 0.15 | 1.2e-04 | -4.4 | -5.4 | 6.8e-08 | 0.04 | 0.04 | 0.76 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | CTD-2323K18.1 | 0.36 | 0.24 | lasso | 5 | 0.19 | 3.4e-05 | 4.5 | -5.2 | 2.1e-07 | 0.02 | 0.06 | 0.59 | FALSE |
| 6 | GTEx | Colon Transverse | RCN2 | 0.20 | 0.04 | enet | 21 | 0.08 | 1.8e-04 | -5.0 | 5.7 | 1.5e-08 | -0.67 | 0.04 | 0.80 | FALSE |
| 7 | GTEx | Colon Transverse | CTD-2323K18.1 | 0.13 | 0.04 | lasso | 11 | 0.05 | 1.8e-03 | -4.9 | -5.6 | 2.3e-08 | 0.03 | 0.04 | 0.85 | FALSE |
| 8 | GTEx | Lung | SNUPN | 0.14 | 0.06 | lasso | 2 | 0.07 | 2.7e-06 | -5.0 | -5.6 | 2.4e-08 | 0.04 | 0.02 | 0.97 | FALSE |
| 9 | GTEx | Muscle Skeletal | HMG20A | 0.04 | 0.00 | lasso | 4 | 0.01 | 7.2e-02 | -6.6 | 5.7 | 1.5e-08 | -0.81 | 0.02 | 0.81 | FALSE |
| 10 | GTEx | Muscle Skeletal | MAN2C1 | 0.05 | 0.01 | enet | 6 | 0.03 | 5.6e-04 | -5.0 | -5.5 | 4.3e-08 | 0.06 | 0.02 | 0.96 | FALSE |
| 11 | GTEx | Ovary | RP11-797A18.6 | 0.21 | 0.04 | enet | 15 | 0.13 | 3.7e-04 | -3.1 | 5.2 | 1.9e-07 | -0.76 | 0.03 | 0.71 | FALSE |
| 12 | GTEx | Pituitary | HMG20A | 0.12 | 0.12 | enet | 15 | 0.15 | 1.1e-04 | 4.5 | 5.8 | 8.2e-09 | -0.74 | 0.04 | 0.80 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | SNUPN | 0.13 | 0.00 | enet | 9 | 0.06 | 2.6e-04 | 4.2 | -5.5 | 3.9e-08 | -0.04 | 0.05 | 0.56 | FALSE |
| 14 | GTEx | Thyroid | HMG20A | 0.06 | 0.01 | enet | 9 | 0.05 | 6.9e-05 | 3.8 | 5.2 | 2.2e-07 | -0.46 | 0.53 | 0.07 | FALSE |
| 15 | GTEx | Thyroid | SNUPN | 0.15 | 0.10 | lasso | 7 | 0.16 | 6.2e-12 | 4.5 | -5.8 | 7.2e-09 | 0.03 | 0.10 | 0.88 | FALSE |
| 16 | YFS | Blood | IMP3 | 0.02 | 0.01 | enet | 9 | 0.02 | 5.9e-06 | -4.0 | 5.3 | 1.4e-07 | -0.02 | 0.01 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNUPN | 0.04 | 0.02 | lasso | 3 | 0.03 | 3.3e-06 | 4.1 | -5.2 | 1.9e-07 | 0.01 | 0.05 | 0.88 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SNUPN | 0.11 | 0.06 | blup | 38 | 0.06 | 3.9e-04 | -4.8 | -5.4 | 7.1e-08 | 0.03 | 0.01 | 0.92 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MAN2C1 | 0.08 | 0.06 | blup | 14 | 0.09 | 2.0e-10 | -4.8 | -5.2 | 2.5e-07 | 0.03 | 0.00 | 0.98 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAN2C1 | 0.07 | 0.04 | blup | 15 | 0.05 | 6.6e-06 | 4.0 | -5.4 | 7.3e-08 | 0.02 | 0.02 | 0.46 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNUPN | 0.13 | 0.09 | blup | 38 | 0.12 | 6.0e-13 | 4.1 | -6.0 | 1.7e-09 | 0.01 | 0.21 | 0.70 | TRUE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | MAN2C1 | 0.09 | 0.05 | blup | 13 | 0.06 | 3.1e-06 | 4.0 | -5.5 | 5.1e-08 | 0.02 | 0.02 | 0.55 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | SNUPN | 0.19 | 0.12 | enet | 11 | 0.20 | 1.1e-19 | 4.1 | -5.7 | 9.3e-09 | 0.02 | 0.04 | 0.93 | FALSE |