[Hub]/) : Traits : Type 2 Diabetes (T2D) (2018) :

chr15:89,680,384-91,135,411

Best TWAS P=4.09e-10 · Best GWAS P=3.67e-09 conditioned to 0.696

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adrenal Gland AP3S2 0.37 0.14 lasso 7 0.11 1.1e-04 5.9 6.1 9.6e-10 0.95 0.01 0.99 FALSE
2 GTEx Cells Transformed fibroblasts AP3S2 0.22 0.16 lasso 5 0.18 4.1e-13 5.7 5.8 5.4e-09 0.98 0.01 0.99 FALSE
3 GTEx Esophagus Mucosa AP3S2 0.19 0.16 lasso 1 0.15 4.0e-10 5.7 5.7 1.1e-08 0.94 0.01 0.99 FALSE
4 GTEx Whole Blood AP3S2 0.19 0.06 lasso 2 0.09 2.8e-08 5.7 6.2 4.1e-10 0.92 0.00 1.00 TRUE
5 NTR Blood AP3S2 0.17 0.11 enet 26 0.14 2.7e-43 5.7 5.9 3.9e-09 0.92 0.01 0.99 FALSE
6 The Cancer Genome Atlas Bladder Urothelial Carcinoma AP3S2 0.19 0.27 lasso 4 0.24 2.0e-20 5.9 5.9 4.0e-09 0.97 0.00 1.00 FALSE
7 The Cancer Genome Atlas Breast Invasive Carcinoma AP3S2 0.13 0.19 lasso 5 0.20 5.3e-40 5.7 5.8 6.6e-09 0.98 0.02 0.98 FALSE
8 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma AP3S2 0.23 0.27 lasso 1 0.26 3.8e-13 5.8 5.8 6.8e-09 0.95 0.01 0.99 FALSE
9 The Cancer Genome Atlas Colon Adenocarcinoma AP3S2 0.18 0.18 lasso 4 0.17 5.2e-10 5.8 6.2 4.5e-10 0.94 0.01 0.99 FALSE
10 The Cancer Genome Atlas Esophageal Carcinoma AP3S2 0.22 0.15 lasso 2 0.13 6.2e-05 5.8 5.8 6.8e-09 0.95 0.01 0.98 FALSE
11 The Cancer Genome Atlas Glioblastoma Multiforme AP3S2 0.33 0.30 blup 59 0.25 2.9e-08 5.9 5.6 2.7e-08 0.96 0.01 0.99 FALSE
12 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AP3S2 0.15 0.24 enet 14 0.27 6.3e-30 5.8 5.5 3.2e-08 0.96 0.01 0.99 FALSE
13 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C15orf38 0.02 0.03 lasso 1 0.02 1.9e-03 5.7 -5.7 1.4e-08 -0.96 0.00 0.95 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AP3S2 0.27 0.38 lasso 4 0.39 3.1e-47 5.7 5.8 6.5e-09 0.99 0.01 0.99 FALSE
15 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ANPEP 0.15 0.05 blup 55 0.07 5.6e-05 -5.0 -5.5 3.1e-08 -0.84 0.01 0.93 FALSE
16 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma AP3S2 0.28 0.28 blup 61 0.33 1.5e-19 5.7 5.6 2.4e-08 0.94 0.01 0.99 FALSE
17 The Cancer Genome Atlas Brain Lower Grade Glioma AP3S2 0.23 0.27 lasso 6 0.30 3.2e-34 5.7 6.0 2.6e-09 0.99 0.01 0.99 FALSE
18 The Cancer Genome Atlas Liver Hepatocellular Carcinoma AP3S2 0.27 0.22 lasso 5 0.23 3.0e-11 5.7 5.8 6.7e-09 0.96 0.01 0.99 FALSE
19 The Cancer Genome Atlas Lung Adenocarcinoma AP3S2 0.22 0.38 lasso 4 0.39 2.3e-48 5.9 5.9 3.7e-09 0.99 0.01 0.99 FALSE
20 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AP3S2 0.22 0.26 enet 18 0.30 1.6e-34 5.7 5.9 4.0e-09 0.97 0.01 0.99 FALSE
21 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma AP3S2 0.15 0.14 blup 62 0.15 1.8e-10 5.9 5.8 6.0e-09 0.93 0.01 0.99 FALSE
22 The Cancer Genome Atlas Pancreatic Adenocarcinoma AP3S2 0.44 0.37 lasso 3 0.39 2.2e-17 5.7 5.8 5.3e-09 0.99 0.01 0.99 FALSE
23 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma AP3S2 0.41 0.45 lasso 6 0.44 4.0e-19 5.9 6.0 2.0e-09 1.00 0.00 1.00 FALSE
24 The Cancer Genome Atlas Prostate Adenocarcinoma AP3S2 0.44 0.54 enet 13 0.55 3.3e-68 5.7 5.8 7.8e-09 0.99 0.02 0.98 FALSE
25 The Cancer Genome Atlas Rectum Adenocarcinoma AP3S2 0.18 0.19 lasso 5 0.15 2.1e-04 5.9 5.9 2.9e-09 0.99 0.01 0.92 FALSE
26 The Cancer Genome Atlas Soft Tissue Sarcoma AP3S2 0.14 0.18 enet 5 0.16 1.2e-09 5.7 5.8 5.0e-09 0.98 0.01 0.99 FALSE
27 The Cancer Genome Atlas Skin Cutaneous Melanoma AP3S2 0.19 0.09 lasso 2 0.04 2.7e-02 5.9 5.9 3.7e-09 1.00 0.01 0.90 FALSE
28 The Cancer Genome Atlas Stomach Adenocarcinoma AP3S2 0.13 0.16 lasso 2 0.17 2.6e-12 5.7 5.9 4.2e-09 0.97 0.01 0.99 FALSE
29 The Cancer Genome Atlas Testicular Germ Cell Tumors AP3S2 0.29 0.32 blup 59 0.32 8.2e-12 5.8 5.9 2.9e-09 0.93 0.01 0.99 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma AP3S2 0.30 0.45 lasso 7 0.44 7.0e-47 5.7 6.0 2.5e-09 0.99 0.01 0.99 FALSE
31 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma AP3S2 0.26 0.25 lasso 4 0.25 1.4e-07 5.8 6.0 2.5e-09 0.99 0.01 0.99 FALSE