Best TWAS P=3.97e-08 · Best GWAS P=3.97e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CCDC53 | 0.14 | 0.16 | lasso | 13 | 0.15 | 1.5e-12 | -5.4 | 5.3 | 1.4e-07 | -0.99 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CCDC53 | 0.10 | 0.18 | lasso | 1 | 0.17 | 1.5e-12 | -5.5 | 5.5 | 4.0e-08 | -1.00 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Heart Left Ventricle | CCDC53 | 0.14 | 0.20 | lasso | 4 | 0.18 | 9.6e-10 | -5.5 | 5.3 | 9.6e-08 | -1.00 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | CCDC53 | 0.24 | 0.20 | lasso | 7 | 0.20 | 4.9e-16 | -5.0 | 5.2 | 2.0e-07 | -0.96 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Spleen | CCDC53 | 0.25 | 0.19 | lasso | 11 | 0.16 | 5.8e-05 | -5.5 | 5.3 | 1.0e-07 | -1.00 | 0.02 | 0.95 | FALSE |
| 6 | YFS | Blood | CCDC53 | 0.17 | 0.34 | lasso | 9 | 0.36 | 2.0e-124 | -4.9 | 5.2 | 2.6e-07 | -0.99 | 0.13 | 0.86 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PMCH | 0.02 | 0.00 | blup | 36 | 0.01 | 1.0e-02 | -4.9 | -5.3 | 9.3e-08 | 0.88 | 0.01 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC53 | 0.07 | 0.07 | blup | 55 | 0.06 | 1.3e-04 | -4.6 | 5.2 | 2.5e-07 | -0.94 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC53 | 0.06 | 0.10 | lasso | 3 | 0.10 | 7.3e-11 | -5.5 | 5.2 | 2.1e-07 | -1.00 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC53 | 0.08 | 0.09 | lasso | 3 | 0.09 | 4.9e-10 | -5.5 | 5.4 | 5.7e-08 | -1.00 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C12orf48 | 0.05 | 0.05 | blup | 62 | 0.04 | 7.0e-04 | -5.3 | -5.2 | 2.6e-07 | 0.96 | 0.02 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC53 | 0.06 | 0.07 | lasso | 4 | 0.06 | 3.0e-03 | -4.9 | 5.2 | 2.0e-07 | -0.99 | 0.01 | 0.89 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC53 | 0.10 | 0.18 | lasso | 4 | 0.18 | 1.6e-18 | -5.5 | 5.2 | 1.5e-07 | -0.99 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC53 | 0.04 | 0.07 | lasso | 4 | 0.06 | 2.1e-05 | -5.5 | 5.4 | 5.2e-08 | -1.00 | 0.00 | 0.99 | FALSE |