Best TWAS P=1.09e-12 · Best GWAS P=6.47e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 4 | 0.03 | 0.00028 | -5.7 | 5.7 | 1.2e-08 | -0.77 | 0.39 | 0.55 | FALSE |
| 2 | GTEx | Artery Aorta | PEF1 | 0.15 | 0.05 | lasso | 5 | 0.04 | 0.00222 | -6.8 | 7.1 | 1.1e-12 | -0.97 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Colon Sigmoid | PEF1 | 0.16 | 0.09 | lasso | 3 | 0.09 | 0.00043 | -5.9 | 6.7 | 2.6e-11 | -0.93 | 0.01 | 0.94 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PEF1 | 0.05 | 0.03 | enet | 9 | 0.02 | 0.00462 | -6.8 | 6.2 | 7.7e-10 | -0.88 | 0.01 | 0.99 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 0.00042 | -5.7 | 5.4 | 6.9e-08 | -0.75 | 0.34 | 0.59 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | TINAGL1 | 0.05 | 0.03 | enet | 5 | 0.03 | 0.00120 | -4.9 | -5.2 | 1.7e-07 | 0.36 | 0.01 | 0.21 | FALSE |