Best TWAS P=1.35e-11 · Best GWAS P=1.85e-12 conditioned to 0.00107
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NPM3 | 0.03 | 0.01 | lasso | 2 | 0.03 | 1.2e-04 | 6.4 | -5.5 | 3.7e-08 | 0.55 | 0.12 | 0.60 | FALSE |
| 2 | GTEx | Pancreas | NPM3 | 0.20 | 0.15 | lasso | 4 | 0.07 | 5.4e-04 | 6.3 | -5.8 | 7.0e-09 | 0.49 | 0.19 | 0.62 | FALSE |
| 3 | GTEx | Testis | NPM3 | 0.13 | 0.15 | lasso | 3 | 0.13 | 2.5e-06 | 6.3 | -6.4 | 1.6e-10 | 0.56 | 0.16 | 0.77 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | NPM3 | 0.05 | 0.01 | blup | 257 | 0.04 | 1.5e-05 | 6.2 | -5.3 | 9.0e-08 | 0.68 | 0.04 | 0.91 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GBF1 | 0.03 | 0.01 | enet | 8 | 0.04 | 2.1e-04 | 4.8 | -5.4 | 7.4e-08 | 0.33 | 0.03 | 0.76 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NPM3 | 0.02 | 0.03 | lasso | 3 | 0.02 | 9.2e-04 | 6.3 | -6.8 | 1.4e-11 | 0.65 | 0.01 | 0.79 | TRUE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C10orf76 | 0.19 | 0.20 | lasso | 1 | 0.18 | 4.6e-07 | 6.3 | 6.3 | 2.2e-10 | -0.55 | 0.16 | 0.80 | FALSE |