TWAS hub - GBF1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.075	0.039	0.0098	0.001	NA	0.005	NA	-0.003	0.240	NA	0.14000	NA	0.6700
2	TCGA	Bladder Urothelial Carcinoma	0.031	0.020	0.0051	0.006	0.023	0.041	NA	0.023	0.084	0.0046	0.00021	NA	0.0043

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Systolic Blood Pressure	10.0	50.3	94.9	-9.7	2.4
Intelligence (Savage-Jansen 2018)	8.5	26.0	51.4	0.8	-7.2
Friendships satisfaction	7.3	9.1	18.1	0.3	-4.2
Schizophrenia (2018)	7.1	14.8	29.5	-5.4	-0.2
Illnesses of father: None of the above (group 1)	7.1	8.7	10.0	3.2	-2.7
Systolic blood pressure, automated reading	6.9	19.9	37.0	-6.1	1.7
Bipolar Disorder or Schizophrenia	6.6	16.1	32.0	-5.7	-0.4
Verbal and Numeric Reasoning (VNR)	6.1	14.7	29.0	0.6	-5.4
Schizophrenia (2014)	6.1	13.5	26.9	-5.2	0.2
Hand grip strength (left)	6.1	16.1	18.4	3.7	4.3
Hand grip strength (right)	5.9	16.0	19.4	3.6	4.4
Cardiovascular Disease	5.4	17.8	35.5	-6.0	0.1
Coronary Artery Disease (CAD)	5.1	6.1	12.1	-3.5	-0.0
Illnesses of father: High blood pressure	5.1	6.3	6.4	-2.5	2.5
Bipolar Disorder (2011)	5.0	4.9	8.1	-2.8	-1.3
High blood pressure	5.0	13.8	27.5	-5.2	-0.4
Migraine (self-reported)	5.0	6.2	12.5	3.5	-0.2
Family relationship satisfaction	5.0	6.1	10.2	-1.4	-3.2
Impedance of leg (right)	4.9	23.6	45.4	-6.7	-1.3
Vascular/heart problems diagnosed by doctor	4.9	13.3	26.6	5.2	0.0
Impedance of leg (left)	4.8	23.3	43.8	-6.6	-1.7
Hypertension (Self-reported)	4.7	13.0	25.7	-5.1	-0.6
Impedance of whole body	4.7	23.8	36.0	-6.0	-3.4
Worry (Nagel 2018)	4.4	9.4	15.4	-3.9	1.8
Qualifications: A levels/AS levels or equivalent	4.3	9.6	18.6	-0.7	-4.3
Suffer from ‘nerves’	4.2	6.6	12.1	-3.5	1.1
Major Depression (MDD)	4.1	5.0	9.9	-3.1	-0.2
Primary Biliary Cirrhosis	4.1	5.8	11.7	-0.0	3.4
Number of incorrect matches in round	4.0	6.7	12.5	-0.9	3.5
Fluid intelligence score	4.0	8.4	14.1	1.6	-3.8
Impedance of arm (left)	4.0	18.3	20.8	-4.6	-4.0
Alcohol usually taken with meals	3.9	6.3	12.2	-0.6	-3.5
Qualifications: College or University degree	3.9	12.2	20.5	-2.0	-4.5
Age at First Birth	3.8	5.5	8.1	1.7	-2.9
Qualifications: None of the above	3.8	8.2	16.5	0.0	4.1
Alzheimer’s Disease (in mother)	3.6	4.2	6.3	2.5	-1.5
Severe depression (siblings)	3.6	4.1	5.6	-2.4	-1.6
Qualifications: NVQ or HND or HNC or equivalent	3.6	4.3	7.3	-1.2	2.7
High blood pressure (mother)	3.5	5.0	9.6	-3.1	0.6
Hair/balding pattern: Pattern 2	3.5	4.4	7.0	2.6	1.3
Impedance of arm (right)	3.4	16.0	16.5	-4.1	-3.9
Neck or shoulder pain in last month	3.4	4.9	8.2	-2.9	1.2
Average weekly champagne plus white wine intake	3.4	4.6	6.7	1.6	-2.6
Medication: Paracetamol	3.3	5.5	8.1	-1.7	2.9
BMI	3.1	17.9	34.2	5.8	-1.2
Body Mass Index (BMI) (2010)	3.0	4.1	7.1	2.7	-1.0
Medication: Metformin	3.0	4.3	4.7	1.9	2.2
Medication: Atenolol	3.0	3.8	6.3	-2.5	1.1
Tense / ‘highly strung’	3.0	5.0	6.9	-2.6	1.8
Medication: Paracetamol	3.0	4.6	7.0	-1.5	2.6
Diastolic blood pressure, automated reading	3.0	9.2	18.4	-4.3	0.2
Leg fat-free mass (left)	2.9	15.1	30.3	5.5	0.1
Maternal smoking around birth	2.9	4.1	5.8	1.6	2.4
Leg fat-free mass (right)	2.9	15.4	30.7	5.5	-0.2
Leg predicted mass (right)	2.9	15.3	30.5	5.5	-0.1
Nervous feelings	2.8	5.3	9.1	-3.0	1.2
Ever highly irritable/argumentative for 2 days	2.8	3.3	4.3	-2.1	1.5
Leg predicted mass (left)	2.7	14.3	28.5	5.3	0.1
Pain all over the body in last month	2.7	2.9	4.3	-1.2	2.1
Commuting to job workplace: Car/motor vehicle	2.7	3.1	3.4	1.7	1.9
Heart disease (siblings)	2.7	3.3	4.5	-2.1	1.5
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	5.3	-2.3	-0.9
Heart attack	2.6	3.3	5.2	-2.3	1.2
Worrier / anxious feelings	2.6	4.9	9.2	-3.0	0.8
Ever taken oral contraceptive pill	2.6	2.9	5.5	2.4	0.5
Medication: Blood pressure	2.6	4.9	9.0	-3.0	0.9
Heart attack/myocardial infarction (self-reported)	2.6	3.4	4.7	-2.2	1.4
Hair/balding pattern: Pattern 3	2.4	3.6	6.1	-2.5	-1.0
Schizophrenia vs Biploar Disorder	2.3	3.0	5.5	-2.3	0.8
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	5.0	-0.0	2.2
Pulse wave reflection index	2.3	2.9	5.1	2.3	-0.8
Loud music exposure frequency	2.3	2.5	4.9	0.3	2.2
Whole body fat-free mass	2.3	13.2	25.8	5.1	0.8
Whole body water mass	2.3	13.1	25.5	5.0	0.9
Commuting to job workplace: Public transport	2.3	2.8	4.7	-0.9	-2.2
Alzheimer’s Disease (including proxy)	2.2	3.2	3.6	1.9	-1.7
Neuroticism	2.2	5.2	8.2	-2.9	1.5
Supplements: Zinc	2.2	2.4	3.4	1.2	1.9
Past tobacco smoking	2.2	4.1	7.5	0.8	-2.7
Age at first live birth	2.2	4.0	5.7	1.5	-2.4
Mouth/teeth dental problems: Loose teeth	2.2	2.6	2.8	1.6	1.7
Commuting to job workplace: Walk	2.2	2.4	4.6	-2.1	0.3
Neuroticism (Nagel 2018)	2.1	4.8	5.7	-2.4	2.0
Birth weight	2.1	4.6	9.0	3.0	-0.4
Medication: Blood pressure	2.1	3.7	7.2	-2.7	-0.5
Angina (self-reported)	2.1	2.8	4.3	-2.1	1.1
Tinnitus: Yes, now most or all of the time	2.1	2.5	4.1	0.9	2.0
Basal metabolic rate	2.1	11.5	22.9	4.8	0.4
Commuting to job workplace: Cycle	2.1	2.6	4.5	-0.8	-2.1
Arm predicted mass (left)	2.1	10.8	20.9	4.6	0.8
Stomach or abdominal pain in last month	2.0	2.5	3.5	1.3	1.9
Medication: Lansoprazole	2.0	2.3	3.6	-1.0	1.9
Wheeze or whistling in the chest in last year	2.0	3.7	4.9	1.6	2.2
Medication: Aspirin	2.0	2.6	4.7	-2.2	-0.7
Medication: Bendroflumethiazide	2.0	3.0	5.9	-2.4	0.3
Arm fat-free mass (left)	2.0	10.3	19.4	4.4	1.1
Medication: Co-codamol	1.9	2.2	2.5	-1.6	1.4
Medication: Ramipril	1.9	2.4	4.8	-2.2	0.2
Birth weight of first child	1.9	3.5	5.9	2.4	-1.0
Mineral and other dietary supplements	1.9	2.6	4.6	-2.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	3.2	-1.8	-1.5
Asthma	1.8	3.6	6.3	1.0	2.5
Trunk predicted mass	1.8	10.3	18.8	4.3	1.3
Glaucoma (self-reported)	1.8	2.2	3.4	-0.9	-1.9
Arm fat-free mass (right)	1.8	9.4	16.8	4.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	4.6	-2.1	-0.1
Medication: Aspirin	1.8	2.4	3.8	-2.0	-1.0
Qualifications: nursing, teaching	1.8	2.8	5.7	0.1	-2.4
Bipolar Disorder (2018)	1.7	2.7	5.1	-2.3	-0.6
Mean Putamen Volume	1.7	1.9	3.8	2.0	-0.2
Allergy or Eczema	1.7	4.5	7.1	2.7	-1.4
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.1	0.7	-1.8
Medication: Levothyroxine sodium	1.7	2.9	3.2	-1.8	1.6
Diabetes (self-reported)	1.7	2.6	5.1	2.2	0.4
Trunk fat-free mass	1.7	10.0	18.1	4.2	1.4
Medication: Allopurinol	1.7	2.3	4.4	-0.5	-2.1
Arm predicted mass (right)	1.7	8.9	16.4	4.0	1.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	3.8	0.7	-1.9
Illnesses of father: Heart disease	1.7	2.3	3.4	-1.9	1.1
Number of operations (self-reported)	1.7	2.6	4.5	0.8	-2.1
Blood White Count	1.6	12.1	21.7	-4.7	1.6
Average weekly spirits intake	1.6	2.0	3.8	0.5	1.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.1	-2.0	0.3
Body mass index (BMI)	1.6	6.8	13.6	3.7	0.1
Weight	1.6	7.6	14.6	3.8	-0.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	5.0	-0.1	-2.2
Asthma (self-reported)	1.6	3.2	5.9	0.7	2.4
Fractured/broken bones in last 5 years	1.6	2.0	3.5	-1.9	-0.7
Reaction Time	1.5	2.9	5.7	-2.4	0.3
Diabetes (father)	1.5	1.9	3.4	0.6	1.8
Taking other prescription medications	1.5	2.3	4.5	-2.1	-0.1
Trunk fat mass	1.5	6.5	8.1	2.9	-2.2
Hip circumference	1.5	6.5	11.9	3.5	-1.1
Mean time to correctly identify matches	1.5	2.9	5.8	-2.4	0.1
Smoking status: Previous	1.5	2.3	2.7	-1.4	1.6
Mood swings	1.5	2.6	4.7	-0.7	2.2
Heel T-Score	1.4	11.4	13.8	3.7	-3.0
Type 2 Diabetes (T2D) (2018)	1.4	2.5	3.8	1.9	-1.1
Lung FEV1/FVC ratio	1.4	7.3	14.0	0.8	3.7
Angina	1.4	1.8	2.5	-1.6	1.1
Trunk fat percentage	1.4	5.6	8.6	1.6	-2.9
Arm fat mass (right)	1.4	5.6	9.6	3.1	-1.3
Breastfed as a baby	1.4	1.7	3.5	-1.9	-0.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	4.2	-2.0	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.1	-1.1	1.4
Medication: Atorvastatin	1.4	1.8	2.5	-1.6	1.0
Ever smoked	1.4	2.4	3.6	-1.1	1.9
Myopia	1.4	2.1	3.3	0.9	-1.8
Alcohol drinker status: Previous	1.4	1.6	2.4	-0.9	-1.6
Triglycerides	1.3	2.1	2.9	-1.7	1.2
Smoking Status	1.3	3.0	5.6	0.6	2.4
Number of treatments/medications taken	1.3	2.4	4.1	-2.0	0.8
Fed-up feelings	1.3	2.4	4.4	0.6	2.1
Had other major operations	1.3	1.6	3.1	-0.2	-1.8
Noisy workplace	1.3	1.6	3.1	0.1	1.8
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.1	0.5	1.8
Number of full brothers	1.3	1.7	2.7	-1.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.6	-1.6	0.7
Supplements: Vitamin C	1.3	1.5	1.7	1.2	1.3
Long-standing illness, disability or infirmity	1.3	2.0	3.6	-1.9	-0.6
Eye problems/disorders: Cataract	1.3	1.5	2.7	0.6	1.6
Fasting Glucose	1.2	1.4	2.9	-0.1	1.7
Lupus	1.2	1.9	3.1	1.8	-0.8
Blood Red Count	1.2	11.4	20.2	-4.5	-1.6
Neuroticism score	1.2	2.4	3.2	-1.8	1.3
Exposure to tobacco smoke at home	1.2	1.3	2.4	-0.5	1.5
Medication: Amlodipine	1.2	1.7	3.3	-1.8	-0.4
Whole body fat mass	1.2	5.1	7.0	2.6	-1.8
Illnesses of siblings: Diabetes	1.2	1.5	2.8	1.7	0.4
Diabetes diagnosed by doctor	1.2	1.9	3.7	1.9	0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	2.8	1.1	1.7
Medication for cholesterol	1.2	1.8	3.6	1.9	-0.2
Arm fat mass (left)	1.2	5.1	9.2	3.0	-1.0
Eye problems/disorders: Glaucoma	1.2	1.4	2.8	-0.3	-1.7
Depression (Nagel 2018)	1.1	1.6	2.2	-1.5	-1.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.6	-1.0	-1.3
Hypothyroidism (self reported)	1.1	2.5	4.5	-0.6	2.1
Respiratory disease	1.1	2.3	3.0	1.3	1.7
Lung FVC	1.1	5.6	6.7	-2.1	2.6
Illnesses of mother	1.1	1.4	2.2	0.8	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.5	-1.6	0.9
Emphysema/chronic bronchitis	1.1	1.2	1.7	0.8	1.3
Leg fat mass (left)	1.1	4.2	7.4	2.7	-1.0
Waist circumference	1.0	3.6	6.3	2.5	-0.9
Medication: Simvastatin	1.0	1.5	2.8	1.7	-0.4
Arm fat percentage (right)	1.0	4.0	5.0	2.2	-1.7
Mouth/teeth dental problems: Dentures	1.0	1.6	2.8	1.7	0.7
Body fat percentage	1.0	3.8	6.1	1.3	-2.5
Eye problems/disorders: None of the above	1.0	1.2	1.2	1.1	-1.1
Medication for pain relief, constipation, heartburn	1.0	1.7	1.9	1.2	-1.4
Medication: Omeprazole	1.0	1.2	2.2	-0.4	1.5
Leg fat mass (right)	1.0	3.9	7.3	2.7	-0.7
Knee pain experienced in last month	1.0	1.5	1.8	1.1	1.3
Smoking status: Current	1.0	1.6	2.9	0.5	1.7
Pack years of smoking	1.0	1.5	1.7	-1.1	1.3
Neuroticism (2016)	0.9	1.2	1.6	-1.2	-1.0
Pack years adult smoking proportion	0.9	1.4	1.5	-1.2	1.2
Supplements: Glucosamine	0.9	1.1	1.3	1.1	-1.0
Number of live births	0.9	1.2	1.9	-1.4	-0.7
Gout (self-reported)	0.9	1.3	1.8	-0.8	-1.4
Medication: Ibuprofen	0.9	1.1	1.2	1.1	1.0
Overall health rating	0.9	1.9	3.0	-0.8	1.7
Hearing aid user	0.9	1.0	2.1	-0.0	1.4
Serious illness, injury or assault to yourself	0.8	1.0	1.3	-0.9	-1.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.7	1.3	-0.6
Father’s age at death	0.8	1.0	1.4	0.8	-1.2
Arm fat percentage (left)	0.8	3.2	3.6	1.9	-1.6
Medication: Lisinopril	0.8	1.0	1.9	-1.4	0.4
Unable to work because of sickness or disability	0.8	1.1	1.1	-1.0	1.0
Blood Eosinophil Count	0.7	5.4	10.8	-3.3	0.2
Chronotype (morning person)	0.7	1.6	2.8	0.6	-1.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.8	-1.4	-0.3
Townsend deprivation index at recruitment	0.7	1.0	1.7	0.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.7	0.7	-1.6
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	-0.1	1.3
Had menopause	0.7	0.9	0.9	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.2	1.1	-1.5
Allergy	0.7	1.5	3.1	-1.7	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	1.2	0.5
Length of working week for main job	0.7	0.7	1.4	-0.3	1.2
Peak expiratory flow (PEF)	0.7	1.5	2.0	1.4	1.0
Pulse wave peak to peak time	0.7	0.9	1.7	1.3	0.0
Medication: Seretide 50 evohaler	0.7	0.8	1.1	0.8	1.0
Heart disease (mother)	0.7	0.9	1.7	-1.3	0.3
Number of full sisters	0.7	0.9	1.8	1.3	0.1
Age at last live birth	0.7	1.0	1.2	1.1	-0.9
Back pain experienced in last month	0.7	1.1	1.7	-1.3	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.7	0.2	1.3
Vitamin and mineral supplements	0.6	0.8	1.0	-1.0	-0.7
Current tobacco smoking	0.6	1.0	2.0	0.2	1.4
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.1	1.5	-0.7
Happiness	0.6	0.8	0.9	0.8	-1.0
Lung cancer (father)	0.6	0.7	1.4	1.2	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-0.1	1.2
High blood pressure (siblings)	0.6	0.8	1.7	-1.3	0.1
Leg pain on walking	0.6	0.7	1.0	-1.0	0.6
Average weekly red wine intake	0.6	0.9	1.5	-1.2	-0.5
Medication: Gliclazide	0.6	0.7	1.3	0.4	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.0	-1.4	-0.3
Leg fat percentage (left)	0.6	2.3	3.0	1.3	-1.7
Age started oral contraceptive pill	0.6	0.8	1.5	0.0	-1.2
Depressed Affect (Nagel 2018)	0.5	1.0	2.0	-0.2	1.4
Ulcerative Colitis (UC)	0.5	0.9	1.8	0.4	-1.3
Rheumatoid Arthritis	0.5	0.7	1.3	-0.1	1.2
Sensitivity / hurt feelings	0.5	0.9	1.1	-0.9	1.0
Relative age voice broke	0.5	0.8	1.4	-1.2	0.4
Time employed in main current job	0.5	0.6	1.0	1.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.7	-0.3	1.3
Falls in the last year	0.5	0.7	0.9	-1.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.8	-0.8	1.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.2	-1.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.7	1.3	-0.3
Pulse rate, automated reading	0.5	1.7	3.4	-1.8	-0.2
Comparative height size at age 10	0.5	2.7	4.0	2.0	1.2
Breast cancer (self-reported)	0.5	0.6	0.9	-0.6	-1.0
Wears glasses or contact lenses	0.5	0.6	0.8	-0.6	-0.9
High cholesterol (Self-reported)	0.5	1.0	1.3	1.1	0.8
Pain experienced in last month	0.5	0.9	1.6	1.2	-0.5
HbA1C	0.4	0.5	0.7	-0.8	-0.5
Tanning	0.4	5.1	9.2	1.0	-3.0
Relative age of first facial hair	0.4	0.8	0.9	-0.9	0.9
Average weekly fortified wine intake	0.4	0.4	0.9	0.9	0.0
Qualifications: CSEs or equivalent	0.4	0.6	0.8	0.9	0.6
Hearing difficulty/problems with background noise	0.4	0.7	0.9	-0.9	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.5	-0.7	-0.6
Mouth/teeth dental problems	0.4	0.6	0.7	-0.8	-0.7
Pulse rate	0.4	0.6	1.0	-1.0	0.6
Leg fat percentage (right)	0.4	1.5	1.8	1.1	-1.3
Exposure to tobacco smoke outside home	0.4	0.5	0.8	0.9	0.4
Shortness of breath walking on level ground	0.4	0.5	0.7	0.5	0.8
Mother’s age at death	0.4	0.5	1.0	0.1	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.3	1.0
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.1	1.0
LDL Cholesterol	0.3	0.5	0.7	0.8	0.5
Height	0.3	5.5	9.3	3.0	-1.3
Diabetes (mother)	0.3	0.3	0.6	0.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	-0.4	-0.7
Age when periods started (menarche)	0.3	0.8	1.1	1.0	0.7
Multivitamins +/- minerals	0.3	0.4	0.5	0.7	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.3	-0.7
Illnesses of siblings	0.3	0.4	0.6	0.7	-0.4
Medication: Cholesterol lowering	0.3	0.4	0.8	0.2	0.9
Depression (self-reported)	0.3	0.4	0.6	-0.8	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.4	-0.7	1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	0.0	-0.9
Comparative body size at age 10	0.3	0.8	1.6	1.3	0.2
Worry too long after embarrassment	0.3	0.6	1.1	-1.1	0.3
Number of children fathered	0.3	0.3	0.7	-0.0	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.8	-0.1
Miserableness	0.3	0.6	1.1	0.3	1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.8	0.4
Alcohol drinker status: Never	0.3	0.3	0.5	-0.7	-0.5
Irritability	0.3	0.6	1.1	0.2	1.1
Ulcerative Colitis	0.2	0.3	0.6	-0.8	0.2
Blood Platelet Count	0.2	1.9	3.1	-0.8	-1.8
Hair Pigment	0.2	5.1	5.2	-2.2	2.3
Hearing difficulty/problems: Yes	0.2	0.2	0.4	0.6	-0.3
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.6	-0.2
Sitting height	0.2	1.2	2.4	-1.5	-0.1
Forced vital capacity (FVC)	0.2	0.7	1.0	-1.0	0.7
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.2	-0.8
Prospective memory result	0.2	0.3	0.6	0.2	0.7
Standing height	0.2	2.3	3.4	1.1	-1.8
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.9	0.4
Headache pain in last month	0.2	0.3	0.6	0.7	-0.3
Had major operations	0.2	0.2	0.2	0.5	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.7	-0.1
Loneliness, isolation	0.2	0.2	0.4	-0.3	-0.6
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.3	0.7
Average weekly beer plus cider intake	0.2	0.3	0.4	0.7	0.5
Supplements: Calcium	0.2	0.2	0.2	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	-0.3	0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.0	-0.8
Prostate Cancer	0.1	0.2	0.4	0.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.4	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.4	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.1	0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.5	-0.7	0.4
Chest pain or discomfort	0.1	0.2	0.3	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	0.7	-0.0
Ever had bowel cancer screening	0.1	0.1	0.1	-0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.0	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.1	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	-0.8	-0.0
Financial situation satisfaction	0.1	0.1	0.2	0.5	0.0
Risk taking	0.1	0.1	0.2	-0.4	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	0.4	0.4
Ever depressed for a whole week	0.1	0.1	0.1	-0.3	-0.3
Cholesterol lowering medication	0.1	0.2	0.2	-0.4	-0.4
Crohns Disease (2017)	0.0	0.0	0.1	-0.2	-0.2
Breast Cancer	0.0	0.1	0.1	-0.4	-0.1
Ovarian Cancer	0.0	0.0	0.0	0.2	-0.1
Crohns Disease (2012)	0.0	0.1	0.1	0.3	-0.1
HDL Cholesterol	0.0	0.1	0.1	-0.0	0.4
Waist Hip Ratio (WHR)	0.0	0.2	0.3	-0.5	-0.2
Financial difficulties in last 2 years	0.0	0.1	0.1	0.2	-0.3
Health satisfaction	0.0	0.0	0.0	0.2	-0.1
Alcohol intake frequency.	0.0	0.0	0.0	0.1	-0.1
Guilty feelings	0.0	0.1	0.1	0.3	-0.2

Hub : Genes

GBF1

Models

Trait associations