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chr16:52,772,129-54,235,440

Best TWAS P=6.79e-13 · Best GWAS P=2.77e-12 conditioned to 0.278

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	YFS	Blood	AKTIP	0.19	0.27	lasso	13	0.30	3.3e-99	6.9	7.2	6.8e-13	0.91	0.00	1.00	TRUE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RBL2	0.11	0.08	blup	44	0.06	1.5e-03	7.0	-7.2	6.9e-13	-0.92	0.00	0.87	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RBL2	0.22	0.24	enet	15	0.26	1.8e-31	5.8	-6.7	2.0e-11	-0.86	0.74	0.26	FALSE
23	GTEx	Muscle Skeletal	RBL2	0.11	0.00	lasso	5	0.00	2.9e-01	7.0	-6.7	2.9e-11	-0.91	0.01	0.98	FALSE
8	GTEx	Artery Tibial	RBL2	0.16	0.17	enet	11	0.20	2.1e-15	6.0	-6.6	4.0e-11	-0.82	0.53	0.47	FALSE
11	GTEx	Brain Cortex	RBL2	0.51	0.45	enet	12	0.46	3.5e-14	5.5	-6.6	5.7e-11	-0.79	0.16	0.84	FALSE
3	GTEx	Adipose Subcutaneous	RBL2	0.34	0.28	enet	18	0.30	1.0e-24	5.8	-6.3	3.2e-10	-0.75	0.84	0.16	FALSE
15	GTEx	Colon Sigmoid	RBL2	0.38	0.37	lasso	12	0.29	8.4e-11	5.8	-6.3	3.3e-10	-0.79	0.65	0.35	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	RBL2	0.08	0.04	lasso	3	0.03	4.4e-02	6.9	6.2	4.1e-10	0.83	0.01	0.74	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBL2	0.03	0.06	enet	5	0.05	8.2e-07	5.5	-6.2	5.3e-10	-0.81	0.25	0.75	FALSE
22	GTEx	Lung	RBL2	0.29	0.37	enet	16	0.35	9.1e-28	5.8	-6.2	6.3e-10	-0.74	0.84	0.16	FALSE
18	GTEx	Esophagus Mucosa	RBL2	0.36	0.36	enet	37	0.37	2.9e-26	5.8	-6.2	6.8e-10	-0.78	0.85	0.15	FALSE
25	GTEx	Ovary	RBL2	0.41	0.26	enet	29	0.18	3.2e-05	5.8	-6.1	8.9e-10	-0.74	0.07	0.90	FALSE
9	GTEx	Brain Cerebellar Hemisphere	RBL2	0.55	0.55	enet	20	0.46	2.1e-13	5.8	-6.1	1.1e-09	-0.71	0.82	0.18	FALSE
24	GTEx	Nerve Tibial	RBL2	0.46	0.52	enet	19	0.53	1.6e-43	5.8	-6.1	1.4e-09	-0.75	0.84	0.16	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	RBL2	0.35	0.33	enet	16	0.34	2.6e-19	5.8	-6.0	1.7e-09	-0.74	0.86	0.14	FALSE
33	GTEx	Vagina	RBL2	0.41	0.37	enet	13	0.34	1.6e-08	5.8	-6.0	1.9e-09	-0.75	0.28	0.69	FALSE
10	GTEx	Brain Cerebellum	RBL2	0.66	0.72	enet	16	0.70	5.7e-28	5.8	-6.0	2.0e-09	-0.72	0.86	0.14	FALSE
30	GTEx	Skin Sun Exposed Lower leg	RBL2	0.35	0.39	enet	25	0.37	2.9e-32	5.8	-6.0	2.4e-09	-0.73	0.86	0.14	FALSE
16	GTEx	Colon Transverse	RBL2	0.59	0.44	enet	13	0.52	4.4e-28	5.8	-5.9	3.0e-09	-0.75	0.84	0.16	FALSE
34	NTR	Blood	RBL2	0.09	0.11	bslmm	419	0.11	1.1e-33	5.8	-5.9	3.2e-09	-0.69	0.86	0.14	FALSE
26	GTEx	Pancreas	RBL2	0.36	0.36	enet	26	0.36	5.9e-16	5.8	-5.9	3.5e-09	-0.77	0.81	0.19	FALSE
32	GTEx	Thyroid	RBL2	0.34	0.47	lasso	4	0.45	3.6e-38	5.8	-5.9	4.8e-09	-0.71	0.86	0.14	FALSE
6	GTEx	Artery Aorta	RBL2	0.27	0.21	enet	14	0.19	1.5e-10	5.8	-5.8	6.3e-09	-0.71	0.84	0.16	FALSE
4	GTEx	Adipose Visceral Omentum	RBL2	0.30	0.27	lasso	2	0.27	4.3e-14	5.8	-5.8	7.9e-09	-0.70	0.86	0.14	FALSE
13	GTEx	Breast Mammary Tissue (Male)	RBL2	0.40	0.29	lasso	2	0.25	1.4e-06	5.8	-5.8	8.0e-09	-0.69	0.41	0.34	FALSE
19	GTEx	Esophagus Muscularis	RBL2	0.36	0.38	enet	10	0.41	6.8e-27	5.8	-5.8	8.3e-09	-0.69	0.86	0.14	FALSE
14	GTEx	Breast Mammary Tissue (Female)	RBL2	0.47	0.27	lasso	7	0.20	1.1e-06	5.5	-5.7	1.1e-08	-0.69	0.56	0.42	FALSE
12	GTEx	Breast Mammary Tissue	RBL2	0.36	0.35	lasso	3	0.36	3.0e-19	5.8	-5.7	1.3e-08	-0.70	0.84	0.16	FALSE
27	GTEx	Pituitary	RBL2	0.36	0.39	lasso	6	0.40	4.5e-11	5.8	5.6	1.7e-08	0.69	0.67	0.32	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKTIP	0.04	0.03	blup	42	0.05	1.9e-06	5.8	-5.6	1.7e-08	-0.69	0.80	0.20	FALSE
20	GTEx	Heart Atrial Appendage	RBL2	0.28	0.14	enet	25	0.23	8.6e-11	5.8	-5.6	1.8e-08	-0.77	0.10	0.90	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	RBL2	0.38	0.40	enet	17	0.38	1.1e-14	5.8	-5.6	2.3e-08	-0.69	0.86	0.14	FALSE
7	GTEx	Artery Coronary	RBL2	0.36	0.33	enet	14	0.27	1.4e-09	5.8	-5.6	2.5e-08	-0.68	0.83	0.16	FALSE
28	GTEx	Prostate	RBL2	0.55	0.45	lasso	4	0.45	1.0e-12	5.8	-5.4	5.4e-08	-0.70	0.82	0.17	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AKTIP	0.12	0.09	enet	10	0.08	1.9e-10	5.8	-5.4	8.3e-08	-0.64	0.85	0.15	FALSE
21	GTEx	Heart Left Ventricle	RBL2	0.12	0.11	enet	12	0.08	3.3e-05	5.8	-5.3	8.8e-08	-0.59	0.61	0.35	FALSE
5	GTEx	Adrenal Gland	RBL2	0.35	0.27	enet	22	0.25	2.3e-09	5.8	-5.2	2.5e-07	-0.68	0.81	0.19	FALSE
31	GTEx	Stomach	RBL2	0.33	0.26	enet	20	0.26	8.7e-13	5.8	-5.1	2.9e-07	-0.63	0.85	0.15	FALSE