[Hub]/) : Traits : Verbal and Numeric Reasoning (VNR) :

chr16:52,772,129-54,235,440

Best TWAS P=6.79e-13 · Best GWAS P=2.77e-12 conditioned to 0.278

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AKTIP 0.12 0.09 enet 10 0.08 1.9e-10 5.8 -5.4 8.3e-08 -0.64 0.85 0.15 FALSE
2 CommonMind Brain Pre-frontal Cortex RBL2 0.22 0.24 enet 15 0.26 1.8e-31 5.8 -6.7 2.0e-11 -0.86 0.74 0.26 FALSE
3 GTEx Adipose Subcutaneous RBL2 0.34 0.28 enet 18 0.30 1.0e-24 5.8 -6.3 3.2e-10 -0.75 0.84 0.16 FALSE
4 GTEx Adipose Visceral Omentum RBL2 0.30 0.27 lasso 2 0.27 4.3e-14 5.8 -5.8 7.9e-09 -0.70 0.86 0.14 FALSE
5 GTEx Adrenal Gland RBL2 0.35 0.27 enet 22 0.25 2.3e-09 5.8 -5.2 2.5e-07 -0.68 0.81 0.19 FALSE
6 GTEx Artery Aorta RBL2 0.27 0.21 enet 14 0.19 1.5e-10 5.8 -5.8 6.3e-09 -0.71 0.84 0.16 FALSE
7 GTEx Artery Coronary RBL2 0.36 0.33 enet 14 0.27 1.4e-09 5.8 -5.6 2.5e-08 -0.68 0.83 0.16 FALSE
8 GTEx Artery Tibial RBL2 0.16 0.17 enet 11 0.20 2.1e-15 6.0 -6.6 4.0e-11 -0.82 0.53 0.47 FALSE
9 GTEx Brain Cerebellar Hemisphere RBL2 0.55 0.55 enet 20 0.46 2.1e-13 5.8 -6.1 1.1e-09 -0.71 0.82 0.18 FALSE
10 GTEx Brain Cerebellum RBL2 0.66 0.72 enet 16 0.70 5.7e-28 5.8 -6.0 2.0e-09 -0.72 0.86 0.14 FALSE
11 GTEx Brain Cortex RBL2 0.51 0.45 enet 12 0.46 3.5e-14 5.5 -6.6 5.7e-11 -0.79 0.16 0.84 FALSE
12 GTEx Breast Mammary Tissue RBL2 0.36 0.35 lasso 3 0.36 3.0e-19 5.8 -5.7 1.3e-08 -0.70 0.84 0.16 FALSE
13 GTEx Breast Mammary Tissue (Male) RBL2 0.40 0.29 lasso 2 0.25 1.4e-06 5.8 -5.8 8.0e-09 -0.69 0.41 0.34 FALSE
14 GTEx Breast Mammary Tissue (Female) RBL2 0.47 0.27 lasso 7 0.20 1.1e-06 5.5 -5.7 1.1e-08 -0.69 0.56 0.42 FALSE
15 GTEx Colon Sigmoid RBL2 0.38 0.37 lasso 12 0.29 8.4e-11 5.8 -6.3 3.3e-10 -0.79 0.65 0.35 FALSE
16 GTEx Colon Transverse RBL2 0.59 0.44 enet 13 0.52 4.4e-28 5.8 -5.9 3.0e-09 -0.75 0.84 0.16 FALSE
17 GTEx Esophagus Gastroesophageal Junction RBL2 0.38 0.40 enet 17 0.38 1.1e-14 5.8 -5.6 2.3e-08 -0.69 0.86 0.14 FALSE
18 GTEx Esophagus Mucosa RBL2 0.36 0.36 enet 37 0.37 2.9e-26 5.8 -6.2 6.8e-10 -0.78 0.85 0.15 FALSE
19 GTEx Esophagus Muscularis RBL2 0.36 0.38 enet 10 0.41 6.8e-27 5.8 -5.8 8.3e-09 -0.69 0.86 0.14 FALSE
20 GTEx Heart Atrial Appendage RBL2 0.28 0.14 enet 25 0.23 8.6e-11 5.8 -5.6 1.8e-08 -0.77 0.10 0.90 FALSE
21 GTEx Heart Left Ventricle RBL2 0.12 0.11 enet 12 0.08 3.3e-05 5.8 -5.3 8.8e-08 -0.59 0.61 0.35 FALSE
22 GTEx Lung RBL2 0.29 0.37 enet 16 0.35 9.1e-28 5.8 -6.2 6.3e-10 -0.74 0.84 0.16 FALSE
23 GTEx Muscle Skeletal RBL2 0.11 0.00 lasso 5 0.00 2.9e-01 7.0 -6.7 2.9e-11 -0.91 0.01 0.98 FALSE
24 GTEx Nerve Tibial RBL2 0.46 0.52 enet 19 0.53 1.6e-43 5.8 -6.1 1.4e-09 -0.75 0.84 0.16 FALSE
25 GTEx Ovary RBL2 0.41 0.26 enet 29 0.18 3.2e-05 5.8 -6.1 8.9e-10 -0.74 0.07 0.90 FALSE
26 GTEx Pancreas RBL2 0.36 0.36 enet 26 0.36 5.9e-16 5.8 -5.9 3.5e-09 -0.77 0.81 0.19 FALSE
27 GTEx Pituitary RBL2 0.36 0.39 lasso 6 0.40 4.5e-11 5.8 5.6 1.7e-08 0.69 0.67 0.32 FALSE
28 GTEx Prostate RBL2 0.55 0.45 lasso 4 0.45 1.0e-12 5.8 -5.4 5.4e-08 -0.70 0.82 0.17 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic RBL2 0.35 0.33 enet 16 0.34 2.6e-19 5.8 -6.0 1.7e-09 -0.74 0.86 0.14 FALSE
30 GTEx Skin Sun Exposed Lower leg RBL2 0.35 0.39 enet 25 0.37 2.9e-32 5.8 -6.0 2.4e-09 -0.73 0.86 0.14 FALSE
31 GTEx Stomach RBL2 0.33 0.26 enet 20 0.26 8.7e-13 5.8 -5.1 2.9e-07 -0.63 0.85 0.15 FALSE
32 GTEx Thyroid RBL2 0.34 0.47 lasso 4 0.45 3.6e-38 5.8 -5.9 4.8e-09 -0.71 0.86 0.14 FALSE
33 GTEx Vagina RBL2 0.41 0.37 enet 13 0.34 1.6e-08 5.8 -6.0 1.9e-09 -0.75 0.28 0.69 FALSE
34 NTR Blood RBL2 0.09 0.11 bslmm 419 0.11 1.1e-33 5.8 -5.9 3.2e-09 -0.69 0.86 0.14 FALSE
35 YFS Blood AKTIP 0.19 0.27 lasso 13 0.30 3.3e-99 6.9 7.2 6.8e-13 0.91 0.00 1.00 TRUE
36 The Cancer Genome Atlas Esophageal Carcinoma RBL2 0.08 0.04 lasso 3 0.03 4.4e-02 6.9 6.2 4.1e-10 0.83 0.01 0.74 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma AKTIP 0.04 0.03 blup 42 0.05 1.9e-06 5.8 -5.6 1.7e-08 -0.69 0.80 0.20 FALSE
38 The Cancer Genome Atlas Brain Lower Grade Glioma RBL2 0.03 0.06 enet 5 0.05 8.2e-07 5.5 -6.2 5.3e-10 -0.81 0.25 0.75 FALSE
39 The Cancer Genome Atlas Pancreatic Adenocarcinoma RBL2 0.11 0.08 blup 44 0.06 1.5e-03 7.0 -7.2 6.9e-13 -0.92 0.00 0.87 FALSE