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chr5:176,067,604-177,426,530

Best TWAS P=2.12e-11 · Best GWAS P=4.48e-09 conditioned to 0.85

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RGS14	0.29	0.16	lasso	7	0.20	2.2e-23	5.8	-6.0	1.9e-09	-0.81	0.01	0.99	FALSE
2	GTEx	Artery Aorta	RGS14	0.35	0.31	lasso	6	0.29	1.5e-16	5.8	-5.7	9.3e-09	-0.73	0.01	0.99	FALSE
3	GTEx	Artery Aorta	LMAN2	0.13	0.10	lasso	6	0.06	1.9e-04	5.9	5.4	7.0e-08	0.99	0.01	0.98	FALSE
4	GTEx	Artery Tibial	RGS14	0.49	0.12	enet	10	0.14	6.2e-11	5.8	-5.5	3.6e-08	-0.74	0.01	0.99	FALSE
5	GTEx	Brain Cerebellum	RGS14	0.25	0.11	enet	10	0.18	4.8e-06	4.8	-5.4	7.6e-08	-0.62	0.04	0.90	FALSE
6	GTEx	Breast Mammary Tissue	RGS14	0.13	0.14	lasso	1	0.11	2.0e-06	5.8	-5.8	6.1e-09	-0.72	0.01	0.98	FALSE
7	GTEx	Breast Mammary Tissue (Female)	RGS14	0.12	0.04	lasso	4	0.09	1.2e-03	5.8	-5.2	2.0e-07	-0.53	0.03	0.34	FALSE
8	GTEx	Cells Transformed fibroblasts	RGS14	0.52	0.39	lasso	6	0.47	4.9e-39	5.8	-5.6	2.0e-08	-0.70	0.01	0.99	FALSE
9	GTEx	Esophagus Muscularis	RGS14	0.13	0.12	enet	3	0.15	3.7e-09	5.8	-5.7	9.4e-09	-0.73	0.02	0.98	FALSE
10	GTEx	Heart Atrial Appendage	RGS14	0.18	0.18	lasso	2	0.20	2.5e-09	5.8	-5.7	1.4e-08	-0.70	0.02	0.98	FALSE
11	GTEx	Heart Left Ventricle	RGS14	0.20	0.11	lasso	2	0.08	3.6e-05	5.8	-5.7	1.2e-08	-0.71	0.01	0.98	FALSE
12	GTEx	Lung	RGS14	0.12	0.11	lasso	1	0.08	5.5e-07	5.8	-5.8	6.1e-09	-0.72	0.01	0.99	FALSE
13	GTEx	Nerve Tibial	RGS14	0.22	0.10	lasso	6	0.08	1.8e-06	4.8	-5.2	2.3e-07	-0.67	0.03	0.96	FALSE
14	GTEx	Pancreas	RGS14	0.25	0.12	lasso	13	0.12	1.5e-05	5.9	-6.3	2.6e-10	-0.93	0.01	0.99	FALSE
15	GTEx	Pituitary	RGS14	0.48	0.34	lasso	6	0.35	1.4e-09	5.8	-5.5	3.4e-08	-0.70	0.02	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	RGS14	0.15	0.16	lasso	3	0.15	9.1e-13	5.8	-5.8	6.1e-09	-0.72	0.01	0.99	FALSE
17	GTEx	Stomach	RGS14	0.11	0.17	enet	6	0.17	1.1e-08	4.8	-5.8	4.8e-09	-0.69	0.07	0.93	FALSE
18	GTEx	Testis	RGS14	0.63	0.47	enet	9	0.47	4.8e-23	5.8	-5.9	3.5e-09	-0.73	0.01	0.99	FALSE
19	GTEx	Thyroid	RGS14	0.15	0.14	enet	9	0.13	2.2e-10	4.8	-5.2	2.5e-07	-0.68	0.11	0.89	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	RGS14	0.32	0.35	enet	12	0.38	1.1e-51	5.4	-6.0	2.3e-09	-0.74	0.13	0.87	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGS14	0.09	0.08	enet	7	0.10	1.2e-08	5.8	-5.2	2.0e-07	-0.80	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS14	0.08	0.10	lasso	2	0.12	1.5e-23	5.4	-5.8	8.9e-09	-0.74	0.14	0.86	FALSE
23	The Cancer Genome Atlas	Glioblastoma Multiforme	RGS14	0.22	0.24	blup	39	0.27	6.9e-09	5.1	-6.7	2.1e-11	-0.86	0.03	0.97	TRUE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS14	0.10	0.07	lasso	2	0.09	3.9e-10	5.1	-5.6	2.3e-08	-0.73	0.06	0.94	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	RGS14	0.03	0.02	blup	39	0.03	8.1e-05	5.4	-5.8	5.6e-09	-0.91	0.02	0.97	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS14	0.14	0.12	lasso	3	0.13	2.1e-14	4.8	-5.2	2.3e-07	-0.63	0.42	0.58	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RGS14	0.13	0.13	lasso	2	0.14	1.1e-09	5.8	-5.6	2.7e-08	-0.69	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS14	0.07	0.11	lasso	3	0.10	8.2e-05	5.5	-5.6	2.7e-08	-0.75	0.03	0.85	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	RGS14	0.03	0.03	lasso	2	0.04	1.3e-03	5.8	-5.8	7.3e-09	-0.71	0.01	0.84	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	RGS14	0.26	0.18	lasso	5	0.19	4.5e-18	5.4	-5.8	6.3e-09	-0.73	0.08	0.92	FALSE