Best TWAS P=2.62e-19 · Best GWAS P=1.57e-17 conditioned to 0.00618
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C5orf45 | 0.14 | 0.18 | bslmm | 447 | 0.17 | 1.1e-20 | -6.2 | -6.7 | 1.7e-11 | 0.25 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CANX | 0.14 | 0.17 | lasso | 4 | 0.17 | 1.0e-20 | 8.4 | 7.8 | 6.0e-15 | -0.90 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CANX | 0.11 | 0.08 | enet | 5 | 0.01 | 3.4e-02 | 8.4 | 8.3 | 1.3e-16 | -0.89 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TBC1D9B | 0.13 | 0.06 | lasso | 5 | 0.09 | 4.2e-07 | 4.4 | -6.1 | 1.4e-09 | 0.30 | 0.69 | 0.26 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | CTC-241N9.1 | 0.19 | 0.03 | enet | 16 | 0.04 | 4.4e-04 | 5.8 | -5.7 | 1.1e-08 | 0.14 | 0.95 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Muscularis | CANX | 0.11 | 0.05 | enet | 3 | 0.04 | 1.6e-03 | -8.5 | 8.0 | 1.9e-15 | -0.95 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Nerve Tibial | CANX | 0.18 | 0.08 | lasso | 7 | 0.07 | 5.7e-06 | 7.7 | 8.8 | 1.3e-18 | -0.83 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Nerve Tibial | HNRNPH1 | 0.11 | 0.01 | enet | 15 | 0.02 | 8.2e-03 | -3.7 | 5.3 | 1.1e-07 | -0.45 | 0.07 | 0.37 | FALSE |
| 9 | GTEx | Nerve Tibial | TBC1D9B | 0.22 | 0.08 | enet | 20 | 0.25 | 1.0e-17 | 4.4 | -5.2 | 2.6e-07 | 0.30 | 0.98 | 0.01 | FALSE |
| 10 | GTEx | Nerve Tibial | CTC-241N9.1 | 0.13 | 0.10 | lasso | 5 | 0.10 | 1.4e-07 | 5.8 | -6.1 | 9.4e-10 | 0.11 | 0.99 | 0.00 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | CTC-241N9.1 | 0.13 | 0.08 | lasso | 1 | 0.05 | 4.1e-05 | 5.8 | -5.8 | 8.1e-09 | 0.06 | 0.86 | 0.00 | FALSE |
| 12 | GTEx | Stomach | TBC1D9B | 0.30 | 0.00 | enet | 28 | 0.07 | 2.8e-04 | 4.4 | -5.2 | 2.0e-07 | 0.31 | 0.14 | 0.19 | FALSE |
| 13 | GTEx | Testis | CTC-241N9.1 | 0.14 | 0.10 | enet | 8 | 0.12 | 8.7e-06 | 6.1 | -5.5 | 4.7e-08 | 0.01 | 0.85 | 0.01 | FALSE |
| 14 | GTEx | Thyroid | CANX | 0.08 | 0.02 | enet | 11 | 0.01 | 2.8e-02 | -8.5 | 6.2 | 4.2e-10 | -0.90 | 0.00 | 0.98 | FALSE |
| 15 | GTEx | Thyroid | C5orf45 | 0.09 | 0.05 | lasso | 3 | 0.05 | 2.1e-04 | -6.1 | -6.8 | 9.7e-12 | 0.30 | 0.36 | 0.08 | FALSE |
| 16 | METSIM | Adipose | CANX | 0.07 | 0.06 | enet | 17 | 0.06 | 9.3e-10 | 7.2 | 5.2 | 2.0e-07 | -0.74 | 0.04 | 0.96 | FALSE |
| 17 | NTR | Blood | SQSTM1 | 0.01 | 0.00 | enet | 10 | 0.00 | 2.2e-02 | 5.6 | -6.3 | 3.0e-10 | 0.27 | 0.52 | 0.09 | FALSE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | SQSTM1 | 0.09 | 0.09 | lasso | 7 | 0.09 | 2.9e-11 | -5.6 | -6.1 | 1.3e-09 | 0.23 | 1.00 | 0.00 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | HMGB3P22 | 0.08 | 0.04 | lasso | 5 | 0.04 | 2.4e-06 | 7.7 | 7.0 | 1.8e-12 | -0.85 | 0.02 | 0.98 | FALSE |
| 20 | YFS | Blood | CANX | 0.07 | 0.08 | enet | 21 | 0.08 | 1.0e-25 | 8.4 | 8.0 | 1.5e-15 | -0.88 | 0.00 | 1.00 | FALSE |
| 21 | YFS | Blood | SQSTM1 | 0.07 | 0.05 | bslmm | 447 | 0.09 | 2.3e-29 | 6.0 | -6.2 | 6.0e-10 | 0.38 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Colon Adenocarcinoma | CANX | 0.10 | 0.02 | lasso | 4 | 0.04 | 1.4e-03 | -7.2 | 7.5 | 7.1e-14 | -0.68 | 0.01 | 0.67 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LTC4S | 0.04 | 0.00 | blup | 39 | 0.02 | 2.6e-03 | 1.1 | -9.0 | 2.6e-19 | 0.75 | 0.01 | 0.65 | TRUE |
| 24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CANX | 0.03 | 0.02 | blup | 41 | 0.03 | 2.0e-04 | 8.2 | 7.5 | 4.5e-14 | -0.82 | 0.01 | 0.94 | FALSE |
| 25 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C5orf45 | 0.06 | 0.02 | enet | 7 | 0.06 | 1.3e-04 | 2.8 | -5.8 | 7.7e-09 | 0.13 | 0.20 | 0.03 | FALSE |