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chr5:178,343,081-180,033,292

Best TWAS P=2.62e-19 · Best GWAS P=1.57e-17 conditioned to 0.00618

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LTC4S	0.04	0.00	blup	39	0.02	2.6e-03	1.1	-9.0	2.6e-19	0.75	0.01	0.65	TRUE
7	GTEx	Nerve Tibial	CANX	0.18	0.08	lasso	7	0.07	5.7e-06	7.7	8.8	1.3e-18	-0.83	0.01	0.99	FALSE
3	GTEx	Cells Transformed fibroblasts	CANX	0.11	0.08	enet	5	0.01	3.4e-02	8.4	8.3	1.3e-16	-0.89	0.01	0.99	FALSE
20	YFS	Blood	CANX	0.07	0.08	enet	21	0.08	1.0e-25	8.4	8.0	1.5e-15	-0.88	0.00	1.00	FALSE
6	GTEx	Esophagus Muscularis	CANX	0.11	0.05	enet	3	0.04	1.6e-03	-8.5	8.0	1.9e-15	-0.95	0.00	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CANX	0.14	0.17	lasso	4	0.17	1.0e-20	8.4	7.8	6.0e-15	-0.90	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	CANX	0.03	0.02	blup	41	0.03	2.0e-04	8.2	7.5	4.5e-14	-0.82	0.01	0.94	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	CANX	0.10	0.02	lasso	4	0.04	1.4e-03	-7.2	7.5	7.1e-14	-0.68	0.01	0.67	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	HMGB3P22	0.08	0.04	lasso	5	0.04	2.4e-06	7.7	7.0	1.8e-12	-0.85	0.02	0.98	FALSE
15	GTEx	Thyroid	C5orf45	0.09	0.05	lasso	3	0.05	2.1e-04	-6.1	-6.8	9.7e-12	0.30	0.36	0.08	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C5orf45	0.14	0.18	bslmm	447	0.17	1.1e-20	-6.2	-6.7	1.7e-11	0.25	1.00	0.00	FALSE
17	NTR	Blood	SQSTM1	0.01	0.00	enet	10	0.00	2.2e-02	5.6	-6.3	3.0e-10	0.27	0.52	0.09	FALSE
14	GTEx	Thyroid	CANX	0.08	0.02	enet	11	0.01	2.8e-02	-8.5	6.2	4.2e-10	-0.90	0.00	0.98	FALSE
21	YFS	Blood	SQSTM1	0.07	0.05	bslmm	447	0.09	2.3e-29	6.0	-6.2	6.0e-10	0.38	1.00	0.00	FALSE
10	GTEx	Nerve Tibial	CTC-241N9.1	0.13	0.10	lasso	5	0.10	1.4e-07	5.8	-6.1	9.4e-10	0.11	0.99	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	SQSTM1	0.09	0.09	lasso	7	0.09	2.9e-11	-5.6	-6.1	1.3e-09	0.23	1.00	0.00	FALSE
4	GTEx	Cells Transformed fibroblasts	TBC1D9B	0.13	0.06	lasso	5	0.09	4.2e-07	4.4	-6.1	1.4e-09	0.30	0.69	0.26	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C5orf45	0.06	0.02	enet	7	0.06	1.3e-04	2.8	-5.8	7.7e-09	0.13	0.20	0.03	FALSE
11	GTEx	Skin Sun Exposed Lower leg	CTC-241N9.1	0.13	0.08	lasso	1	0.05	4.1e-05	5.8	-5.8	8.1e-09	0.06	0.86	0.00	FALSE
5	GTEx	Cells Transformed fibroblasts	CTC-241N9.1	0.19	0.03	enet	16	0.04	4.4e-04	5.8	-5.7	1.1e-08	0.14	0.95	0.00	FALSE
13	GTEx	Testis	CTC-241N9.1	0.14	0.10	enet	8	0.12	8.7e-06	6.1	-5.5	4.7e-08	0.01	0.85	0.01	FALSE
8	GTEx	Nerve Tibial	HNRNPH1	0.11	0.01	enet	15	0.02	8.2e-03	-3.7	5.3	1.1e-07	-0.45	0.07	0.37	FALSE
12	GTEx	Stomach	TBC1D9B	0.30	0.00	enet	28	0.07	2.8e-04	4.4	-5.2	2.0e-07	0.31	0.14	0.19	FALSE
16	METSIM	Adipose	CANX	0.07	0.06	enet	17	0.06	9.3e-10	7.2	5.2	2.0e-07	-0.74	0.04	0.96	FALSE
9	GTEx	Nerve Tibial	TBC1D9B	0.22	0.08	enet	20	0.25	1.0e-17	4.4	-5.2	2.6e-07	0.30	0.98	0.01	FALSE