TWAS hub - LMAN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1310	0.0530	0.00078	0.098	NA	0.044	NA	0.065	4.7e-06	NA	0.0019	NA	0.00019
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0442	0.0255	0.00540	-0.002	0.002	-0.002	NA	-0.002	9.3e-01	0.16	0.8500	NA	0.82000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Allergy or Eczema	9.8	25.8	39.9	6.3	3.4
Number of self-reported non-cancer illnesses	9.8	17.0	23.8	4.9	3.2
Height	8.9	171.4	224.9	-10.9	-15.0
Standing height	8.2	81.2	104.0	-7.6	-10.2
Allergy	7.6	17.6	30.1	-5.5	-2.2
Hayfever, allergic rhinitis or eczema	7.4	16.1	25.9	5.1	2.5
Heart disease (siblings)	7.2	8.9	13.0	3.6	2.2
Blood Eosinophil Count	6.5	50.0	71.7	8.5	5.3
Blood Red Count	6.5	62.4	104.0	10.2	4.6
Sitting height	5.9	41.9	53.1	-5.5	-7.3
Heart disease (mother)	5.7	7.0	10.4	3.2	1.9
Trunk fat-free mass	5.6	32.1	44.3	-4.5	-6.7
Trunk predicted mass	5.6	32.0	44.1	-4.5	-6.6
Pulse wave peak to peak time	5.6	6.6	7.6	-2.4	-2.7
Cardiovascular Disease	5.5	18.1	22.1	3.8	4.7
Medication: Blood pressure	5.3	10.1	12.3	3.5	2.8
Other serious medical condition/disability diagnosed by doctor	4.9	6.4	11.3	3.4	1.2
Comparative height size at age 10	4.9	27.2	37.5	-4.1	-6.1
High blood pressure (mother)	4.5	6.3	8.7	2.0	2.9
Hypertension (Self-reported)	4.5	12.6	14.3	3.8	3.3
Gout (self-reported)	4.4	6.1	7.1	2.7	2.3
Ulcerative Colitis (UC)	4.2	7.9	14.0	3.7	1.4
Illnesses of siblings	4.2	5.9	6.4	-2.5	-2.3
Arm fat-free mass (right)	4.2	21.5	32.3	-3.3	-5.7
Whole body fat-free mass	4.2	24.1	34.9	-3.6	-5.9
Forced vital capacity (FVC)	4.1	15.9	20.2	-3.4	-4.5
Arm predicted mass (right)	4.1	20.8	31.7	-3.2	-5.6
Rheumatoid Arthritis	3.9	5.4	7.1	2.7	1.9
Whole body water mass	3.9	22.5	32.9	-3.5	-5.7
Hearing aid user	3.9	4.4	5.6	-2.4	-1.8
Loneliness, isolation	3.8	5.3	6.7	2.0	2.6
Arm predicted mass (left)	3.8	19.5	27.7	-3.4	-5.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.8	13.0	-3.6	-3.2
Forced vital capacity (FVC), Best measure	3.7	13.4	16.7	-3.2	-4.1
Arm fat-free mass (left)	3.7	18.9	28.0	-3.1	-5.3
High blood pressure	3.6	9.9	13.0	3.6	2.6
Pulse wave Arterial Stiffness index	3.5	4.1	4.6	1.9	2.1
Irritable Bowel Disease (IBD)	3.4	8.1	15.8	4.0	0.6
High blood pressure (siblings)	3.4	4.8	6.4	1.8	2.5
Wheeze or whistling in the chest in last year	3.4	6.1	11.7	3.4	0.7
Qualifications: nursing, teaching	3.4	5.3	8.6	-1.4	-2.9
Basal metabolic rate	3.4	18.7	28.2	-3.0	-5.3
Diastolic blood pressure, automated reading	3.4	10.6	10.8	3.3	3.2
Hayfever/allergic rhinitis (self-reported)	3.3	4.3	7.6	2.7	1.1
Average weekly red wine intake	3.1	4.6	5.5	-1.9	-2.3
Alzheimer’s Disease (including proxy)	3.0	4.3	6.2	-2.5	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.1	8.6	-1.9	-2.9
Ever had hysterectomy (womb removed)	2.9	3.2	5.5	1.0	2.3
Forced expiratory volume in 1-second (FEV1)	2.9	9.8	10.2	-3.2	-3.1
Headache pain in last month	2.9	4.9	6.5	2.5	1.8
Medication: Ventolin 100micrograms inhaler	2.9	3.7	6.8	2.6	0.8
Migraine (self-reported)	2.9	3.6	4.6	1.6	2.1
Alzheimer’s Disease (in mother)	2.8	3.3	3.4	-1.8	-1.8
Ulcerative Colitis	2.8	4.1	7.6	2.8	0.8
Supplements: Calcium	2.8	3.1	3.2	1.7	1.8
Respiratory disease	2.7	6.0	11.9	3.5	0.1
Vitamin and mineral supplements	2.7	3.7	5.7	-1.3	-2.4
Number of incorrect matches in round	2.6	4.3	4.6	-2.0	-2.2
Mood swings	2.6	4.8	6.9	1.6	2.6
Number of treatments/medications taken	2.5	4.5	7.3	2.7	1.3
Hair/balding pattern: Pattern 3	2.5	3.8	3.9	-2.0	-1.9
Birth weight	2.5	5.5	5.7	-2.4	-2.3
Illnesses of father: Heart disease	2.5	3.5	3.9	2.0	1.8
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	5.0	-1.0	-2.2
Systolic Blood Pressure	2.4	12.0	13.8	3.2	3.7
Depression (self-reported)	2.4	2.9	4.9	-0.9	-2.2
Illnesses of mother	2.4	2.9	3.8	-1.9	-1.4
Knee pain experienced in last month	2.4	3.7	6.3	2.5	1.0
Leg fat-free mass (right)	2.4	12.6	20.1	-2.3	-4.5
Leg predicted mass (right)	2.4	12.8	20.3	-2.3	-4.5
Hearing difficulty/problems with background noise	2.3	3.6	6.6	-0.8	-2.6
Hair/balding pattern: Pattern 2	2.3	2.9	4.0	1.3	2.0
Asthma	2.3	4.5	8.9	3.0	0.3
Medication: Omeprazole	2.3	2.7	5.0	-0.6	-2.2
Supplements: Vitamin C	2.3	2.7	4.5	0.9	2.1
Mineral and other dietary supplements	2.3	3.1	3.9	-2.0	-1.5
Vascular/heart problems diagnosed by doctor	2.3	6.4	8.8	-3.0	-2.0
Taking other prescription medications	2.2	3.4	6.6	2.6	-0.4
Exposure to tobacco smoke at home	2.2	2.5	3.5	1.9	1.2
Medication for cholesterol	2.2	3.3	4.4	-2.1	-1.5
Asthma (self-reported)	2.2	4.4	8.9	3.0	0.1
Cholesterol lowering medication	2.2	3.2	4.8	2.2	1.3
Blood White Count	2.1	15.5	29.1	5.4	1.4
Leg predicted mass (left)	2.1	11.2	17.8	-2.1	-4.2
Chronic bronchitis/emphysema (mother)	2.1	2.5	3.2	1.8	1.4
Leg fat-free mass (left)	2.0	10.8	17.4	-2.0	-4.2
Medication: Seretide 50 evohaler	2.0	2.3	3.3	1.1	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.9	1.0	2.0
Mother’s age at death	2.0	2.5	4.8	-2.2	-0.4
Financial situation satisfaction	2.0	2.5	4.4	-2.1	-0.8
Coronary Artery Disease (CAD)	1.9	2.2	3.7	1.9	0.9
Mouth/teeth dental problems: Loose teeth	1.9	2.2	3.3	1.8	1.1
Medication: Allopurinol	1.9	2.5	3.4	1.3	1.8
Systolic blood pressure, automated reading	1.8	5.3	5.8	2.2	2.4
Pulse rate, automated reading	1.8	5.7	8.0	2.8	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	2.7	1.6	1.3
Friendships satisfaction	1.8	2.2	2.3	1.5	1.5
Weight	1.7	8.5	13.7	-1.8	-3.7
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.1	-1.8	-0.8
Age at last live birth	1.6	2.4	3.1	-1.3	-1.8
Mean time to correctly identify matches	1.5	2.9	5.5	-0.6	-2.3
Had major operations	1.5	1.8	3.5	0.3	1.9
High cholesterol (Self-reported)	1.5	2.7	3.0	1.6	1.7
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.2	-1.8	-0.9
Lung FEV1/FVC ratio	1.4	7.3	14.1	-3.8	-0.6
Medication: Levothyroxine sodium	1.4	2.3	2.5	1.6	1.5
Time employed in main current job	1.4	1.6	2.5	-0.9	-1.6
Falls in the last year	1.4	1.9	3.2	0.8	1.8
Length of working week for main job	1.4	1.6	2.4	-0.9	-1.6
Pulse wave reflection index	1.4	1.8	2.4	1.0	1.6
Loud music exposure frequency	1.4	1.5	2.1	1.4	1.0
Comparative body size at age 10	1.4	3.9	6.8	1.0	2.6
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.3	-2.1	0.0
Illnesses of father: None of the above (group 1)	1.4	1.7	1.8	-1.3	-1.3
Depressed Affect (Nagel 2018)	1.3	2.6	3.3	1.4	1.8
Chronotype (morning person)	1.3	2.9	3.7	1.5	1.9
Chronic bronchitis/emphysema (father)	1.3	1.5	2.5	-0.7	-1.6
Happiness	1.3	1.5	2.7	-0.6	-1.6
Medication: Bendroflumethiazide	1.3	2.0	3.7	0.4	1.9
Basal cell carcinoma (self-reported)	1.3	1.6	1.9	-1.4	-1.1
Qualifications: CSEs or equivalent	1.2	1.6	2.7	0.7	1.6
Heart attack	1.2	1.6	2.6	-1.6	-0.7
Ever had bowel cancer screening	1.2	1.4	2.7	1.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.6	-1.0	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	3.3	-1.8	-1.4
Alcohol drinker status: Previous	1.2	1.3	1.5	-1.2	-1.1
Smoking Status	1.1	2.6	3.3	-1.8	-1.4
Tanning	1.1	13.6	19.5	2.8	4.4
Diabetes (father)	1.1	1.3	2.0	1.4	0.8
Hand grip strength (right)	1.1	3.0	4.3	-1.3	-2.1
Mouth/teeth dental problems: Dentures	1.1	1.9	2.0	1.4	1.3
Hair/balding pattern: Pattern 4	1.1	2.8	5.2	-0.6	-2.3
Alcohol intake frequency.	1.1	2.5	3.8	2.0	1.0
Eye problems/disorders: Cataract	1.1	1.2	1.4	-1.0	-1.2
Medication: Aspirin	1.1	1.5	3.0	1.7	-0.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.6	-1.6	0.0
Crohns Disease (2017)	1.0	2.2	3.8	2.0	-0.8
HDL Cholesterol	1.0	1.7	2.0	-1.4	-1.1
Primary Biliary Cirrhosis	1.0	1.4	2.6	1.6	0.4
Schizophrenia (2014)	1.0	2.1	3.7	-1.9	-0.8
Medication: Co-codamol	1.0	1.1	1.7	-1.3	-0.7
Nervous feelings	1.0	1.9	2.5	-1.6	-1.1
Prospective memory result	1.0	1.2	1.5	-1.2	-1.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.5	1.6	1.1
Medication: Ibuprofen	1.0	1.2	2.2	-0.5	1.5
Miserableness	1.0	1.8	2.0	1.4	1.2
Medication: Lisinopril	1.0	1.3	2.2	1.5	0.6
Alzheimer’s Disease (in father)	0.9	1.0	2.0	-1.4	0.1
Age at First Birth	0.9	1.3	2.3	-0.6	-1.5
Hypothyroidism (self reported)	0.9	2.1	2.4	1.4	1.6
Type 2 Diabetes (T2D) (2018)	0.9	1.6	2.7	1.7	0.7
Angina	0.9	1.1	1.9	-0.6	-1.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.1	-0.3	-1.5
Age at first live birth	0.9	1.5	1.7	-1.1	-1.3
Eye problems/disorders: None of the above	0.9	1.0	1.1	1.1	0.9
Angina (self-reported)	0.9	1.2	1.9	-0.8	-1.4
Breast cancer (self-reported)	0.9	1.1	1.2	1.0	1.1
Supplements: Fish oil (including cod liver oil)	0.9	1.1	1.2	1.0	1.1
Alcohol drinker status: Never	0.9	1.1	2.2	1.5	0.1
Body Mass Index (BMI) (2010)	0.8	1.0	1.5	-1.2	-0.7
Mean Putamen Volume	0.8	0.9	1.8	0.1	1.3
Blood Platelet Count	0.8	9.0	17.9	-0.3	4.2
Fed-up feelings	0.8	1.4	1.7	1.0	1.3
Had other major operations	0.8	0.9	1.1	-0.8	-1.1
Financial difficulties in last 2 years	0.8	1.0	1.5	-1.2	0.8
Pain all over the body in last month	0.8	0.9	1.5	-1.2	-0.5
Medication: Simvastatin	0.8	1.2	1.5	1.2	0.9
Arm fat percentage (right)	0.8	3.1	3.3	1.7	1.8
Worrier / anxious feelings	0.8	1.5	1.8	-1.3	-1.1
Arm fat percentage (left)	0.8	3.3	3.8	1.9	1.7
Long-standing illness, disability or infirmity	0.8	1.2	1.8	1.4	0.7
Smoking status: Current	0.8	1.3	2.6	-1.6	-0.2
Major Depression (MDD)	0.7	0.9	1.0	0.8	1.0
Pack years adult smoking proportion	0.7	1.0	1.4	1.2	0.7
Medication: Blood pressure	0.7	1.3	2.0	1.4	0.7
Family relationship satisfaction	0.7	0.9	0.9	1.0	0.9
Medication: Aspirin	0.7	0.9	1.6	1.3	-0.4
Myopia	0.7	1.0	1.5	0.6	1.2
Neuroticism (2016)	0.6	0.8	0.8	-0.9	-0.9
Relative age of first facial hair	0.6	1.3	2.4	-1.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	-0.7	-1.4
Fluid intelligence score	0.6	1.2	2.4	0.3	-1.6
Hip circumference	0.6	2.4	4.8	-0.1	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	0.9	-0.7	1.0
Medication: Lansoprazole	0.6	0.7	1.3	-0.2	-1.2
Leg fat percentage (right)	0.6	2.1	2.4	1.6	1.3
Triglycerides	0.5	0.8	1.5	1.2	0.0
BMI	0.5	2.9	3.5	1.9	1.5
Hand grip strength (left)	0.5	1.3	1.5	-1.1	-1.2
Medication: Metformin	0.5	0.8	1.5	1.2	-0.1
Severe depression (siblings)	0.5	0.5	1.0	0.2	1.0
Current tobacco smoking	0.5	0.8	1.6	-1.2	0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.6	-0.7	-0.8
Supplements: Glucosamine	0.5	0.6	1.0	0.5	1.0
Medication: Ramipril	0.5	0.6	1.2	1.1	0.3
Birth weight of first child	0.5	0.9	1.0	-0.9	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.2	-1.1	-0.7
Number of full sisters	0.5	0.6	1.0	0.5	1.0
Leg pain on walking	0.5	0.6	1.2	0.1	-1.1
Eye problems/disorders: Glaucoma	0.5	0.6	0.8	0.7	0.9
Medication: Atorvastatin	0.5	0.6	1.2	1.1	0.3
Ever smoked	0.5	0.8	1.0	-1.0	-0.7
Leg fat percentage (left)	0.5	1.7	1.8	1.4	1.2
Risk taking	0.5	0.7	1.0	0.7	1.0
Bipolar Disorder (2018)	0.4	0.7	1.3	1.1	0.2
Schizophrenia (2018)	0.4	0.8	1.1	-1.1	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.1	0.9	-1.1
Lung FVC	0.4	2.2	2.5	-1.6	-1.4
Hearing difficulty/problems: Yes	0.4	0.5	1.1	0.1	1.0
Medication for hormone replacement therapy	0.4	0.5	0.6	-0.8	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-0.0	1.1
Impedance of arm (right)	0.4	2.1	4.2	0.1	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.6	0.8	0.6
Tense / ‘highly strung’	0.4	0.7	0.8	-0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.2	-0.1	1.1
Medication: Amlodipine	0.4	0.6	1.2	1.1	0.0
Number of children fathered	0.4	0.5	0.7	-0.5	-0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	-0.5	-1.0
Commuting to job workplace: Walk	0.4	0.4	0.4	0.6	0.7
Commuting to job workplace: Public transport	0.4	0.4	0.7	0.8	0.4
Average weekly beer plus cider intake	0.4	0.5	1.0	-1.0	-0.1
Age started oral contraceptive pill	0.4	0.6	0.6	0.8	0.7
Unable to work because of sickness or disability	0.4	0.6	1.0	-1.0	-0.3
Pack years of smoking	0.4	0.6	1.1	1.0	0.3
Breast Cancer	0.3	0.8	1.2	-1.1	-0.7
Heel T-Score	0.3	2.0	4.0	2.0	-0.1
Waist Hip Ratio (WHR)	0.3	1.2	1.2	1.1	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.3	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.7	0.4
Supplements: Zinc	0.3	0.3	0.3	0.6	0.5
Serious illness, injury or assault to yourself	0.3	0.3	0.5	0.7	0.3
Multivitamins +/- minerals	0.3	0.4	0.6	-0.5	0.8
Body mass index (BMI)	0.3	1.4	2.3	1.5	0.7
Trunk fat mass	0.3	1.1	2.1	-0.3	-1.4
Past tobacco smoking	0.3	0.5	0.5	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	1.0	-0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	0.0	-0.8
Diabetes (self-reported)	0.3	0.4	0.4	0.6	-0.6
Father’s age at death	0.3	0.4	0.7	0.8	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.1	-0.5	-1.0
Glaucoma (self-reported)	0.3	0.3	0.5	0.4	0.7
Body fat percentage	0.3	1.1	1.5	1.2	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	0.2
Number of full brothers	0.3	0.4	0.7	-0.8	0.4
Shortness of breath walking on level ground	0.3	0.4	0.7	0.9	0.3
Emphysema/chronic bronchitis	0.3	0.4	0.8	0.9	-0.1
Overall health rating	0.3	0.6	1.2	1.1	-0.1
Chest pain or discomfort	0.3	0.4	0.4	-0.7	-0.7
Back pain experienced in last month	0.3	0.5	0.7	-0.8	0.5
Osteoporosis (self-reported)	0.3	0.4	0.4	-0.6	0.6
Medication: Gliclazide	0.3	0.3	0.5	0.2	-0.7
Illnesses of father: High blood pressure	0.3	0.4	0.5	0.6	0.7
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.9	-0.3
Ever depressed for a whole week	0.3	0.3	0.4	-0.6	-0.5
Pain experienced in last month	0.3	0.5	1.0	-0.3	-1.0
Worry (Nagel 2018)	0.2	0.4	0.5	-0.7	-0.5
Ovarian Cancer	0.2	0.2	0.4	-0.7	-0.0
Crohns Disease (2012)	0.2	0.4	0.6	0.4	-0.8
LDL Cholesterol	0.2	0.3	0.5	-0.3	-0.7
Average weekly spirits intake	0.2	0.2	0.4	-0.6	0.0
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.0	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	-0.4	-0.6
Mouth/teeth dental problems	0.2	0.3	0.6	0.2	0.8
Number of live births	0.2	0.3	0.4	0.4	-0.6
Impedance of arm (left)	0.2	1.0	2.0	0.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.1	-0.7
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.8	-0.4
Medication: Paracetamol	0.2	0.3	0.6	0.0	0.8
Health satisfaction	0.2	0.3	0.3	-0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	-0.7	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	0.1	-0.8
Illnesses of siblings: Diabetes	0.2	0.3	0.3	0.4	0.6
Smoking status: Previous	0.2	0.3	0.5	-0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.7	-0.2
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.7	-0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.4	0.7	0.5
Guilty feelings	0.2	0.3	0.5	0.7	-0.1
Ever taken oral contraceptive pill	0.2	0.3	0.4	0.6	0.4
Number of operations (self-reported)	0.2	0.3	0.5	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.1	-0.6
Impedance of whole body	0.2	0.8	1.3	-0.5	1.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.1	0.6
Depression (Nagel 2018)	0.1	0.2	0.3	-0.1	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.6	0.4
Reaction Time	0.1	0.2	0.4	-0.0	-0.7
Prostate Cancer	0.1	0.1	0.2	-0.1	0.5
Fasting Glucose	0.1	0.1	0.2	-0.4	-0.1
Neuroticism	0.1	0.4	0.6	-0.3	-0.8
Hair Pigment	0.1	1.5	2.0	0.9	1.4
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	0.5	0.0
Diabetes (mother)	0.1	0.1	0.2	0.4	-0.1
Impedance of leg (right)	0.1	0.6	0.6	-0.7	0.8
Trunk fat percentage	0.1	0.4	0.6	0.8	0.3
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.5	0.2
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	0.4
Maternal smoking around birth	0.1	0.1	0.2	-0.4	0.3
Relative age voice broke	0.1	0.1	0.2	-0.4	0.2
Age when periods started (menarche)	0.1	0.2	0.3	0.5	-0.2
Medication: Atenolol	0.1	0.1	0.2	0.2	0.4
Impedance of leg (left)	0.1	0.7	1.1	-1.1	0.5
Waist circumference	0.1	0.4	0.5	0.7	-0.6
Alcohol usually taken with meals	0.1	0.2	0.4	0.6	-0.3
Had menopause	0.1	0.1	0.2	-0.1	-0.5
Qualifications: None of the above	0.1	0.2	0.3	0.4	-0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.4	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.5	0.3
Pulse rate	0.1	0.2	0.3	0.6	-0.1
Lung cancer (father)	0.1	0.1	0.1	-0.4	0.0
Breastfed as a baby	0.1	0.2	0.3	-0.2	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.3	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.3	-0.4
Worry too long after embarrassment	0.1	0.2	0.2	0.5	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	-0.1
Qualifications: College or University degree	0.1	0.2	0.3	-0.2	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.2	0.1	-0.4
Whole body fat mass	0.1	0.5	1.0	0.1	-1.0
Leg fat mass (right)	0.1	0.2	0.5	0.2	-0.7
Suffer from ‘nerves’	0.1	0.2	0.2	0.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.0	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.4	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.5	-0.0
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.1	-0.6
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.3	0.2
Leg fat mass (left)	0.1	0.3	0.5	0.2	-0.7
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	-0.1	0.0
Lupus	0.0	0.1	0.1	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.1	0.0	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	-0.1
Neuroticism score	0.0	0.0	0.0	-0.0	-0.2
Noisy workplace	0.0	0.0	0.1	-0.2	0.0
Medication: Cholesterol lowering	0.0	0.1	0.1	0.3	0.0
Arm fat mass (right)	0.0	0.2	0.3	0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.0	0.2
Arm fat mass (left)	0.0	0.2	0.3	0.5	-0.3
Wears glasses or contact lenses	0.0	0.0	0.0	0.1	-0.2
Medication: Paracetamol	0.0	0.1	0.1	-0.3	0.2
Irritability	0.0	0.1	0.1	0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

LMAN2

Models

Trait associations