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chr7:148,071,652-149,691,341

Best TWAS P=1.04e-15 · Best GWAS P=6.83e-12 conditioned to 0.766

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adrenal Gland	ZNF786	0.36	0.20	lasso	12	0.26	5.2e-10	6.4	-8.0	1.0e-15	-0.87	0.02	0.98	TRUE
29	GTEx	Skin Not Sun Exposed Suprapubic	ZNF786	0.17	0.04	enet	34	0.07	1.9e-04	6.2	-7.2	4.2e-13	-0.72	0.07	0.90	FALSE
32	GTEx	Stomach	ZNF786	0.20	0.12	enet	16	0.09	6.8e-05	6.2	-7.0	2.4e-12	-0.72	0.11	0.86	FALSE
30	GTEx	Small Intestine Terminal Ileum	ZNF786	0.31	0.20	lasso	7	0.20	3.6e-05	6.9	-6.9	4.5e-12	-0.97	0.02	0.96	FALSE
34	GTEx	Testis	ZNF786	0.17	0.02	lasso	3	0.03	1.6e-02	5.5	-6.8	9.1e-12	-0.70	0.06	0.48	FALSE
12	GTEx	Brain Hypothalamus	ZNF783	0.25	0.14	lasso	5	0.05	3.1e-02	6.1	6.4	1.6e-10	0.83	0.06	0.61	FALSE
6	GTEx	Artery Tibial	ZNF786	0.12	0.10	lasso	2	0.11	1.2e-08	6.1	-6.3	3.5e-10	-0.92	0.08	0.92	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF398	0.02	0.00	blup	65	0.01	4.3e-03	6.4	6.3	3.5e-10	0.87	0.02	0.80	FALSE
36	GTEx	Whole Blood	ZNF282	0.19	0.13	lasso	8	0.12	4.2e-11	6.1	-6.2	4.3e-10	-0.89	0.06	0.94	FALSE
21	GTEx	Heart Left Ventricle	ZNF786	0.18	0.11	lasso	7	0.08	3.7e-05	6.0	-6.2	4.5e-10	-0.88	0.05	0.95	FALSE
38	METSIM	Adipose	ZNF786	0.09	0.13	enet	32	0.13	7.7e-19	6.2	-6.2	4.6e-10	-0.88	0.10	0.90	FALSE
17	GTEx	Colon Transverse	ZNF786	0.15	0.10	enet	8	0.11	7.9e-06	6.0	-6.2	5.6e-10	-0.93	0.02	0.98	FALSE
11	GTEx	Brain Hypothalamus	ZNF786	0.30	0.25	lasso	5	0.23	3.7e-06	6.0	-6.2	6.0e-10	-0.92	0.02	0.96	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF786	0.03	0.05	lasso	1	0.04	1.1e-05	6.2	-6.2	6.2e-10	-0.87	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZNF786	0.11	0.19	lasso	1	0.17	5.2e-10	6.2	-6.2	6.3e-10	-0.88	0.01	0.99	FALSE
25	GTEx	Nerve Tibial	ZNF786	0.11	0.09	lasso	2	0.07	1.2e-05	6.1	-6.2	6.7e-10	-0.87	0.15	0.85	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ZNF786	0.11	0.15	lasso	6	0.14	4.3e-17	6.1	-6.1	8.5e-10	-0.88	0.19	0.81	FALSE
2	GTEx	Adipose Subcutaneous	ZNF786	0.13	0.09	lasso	3	0.08	3.5e-07	6.1	-6.1	8.6e-10	-0.90	0.12	0.88	FALSE
20	GTEx	Esophagus Muscularis	ZNF786	0.07	0.05	lasso	4	0.04	9.9e-04	6.1	-6.1	8.9e-10	-0.88	0.13	0.77	FALSE
27	GTEx	Pituitary	ZNF786	0.48	0.29	lasso	4	0.35	1.4e-09	6.2	-6.1	9.3e-10	-0.87	0.12	0.88	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	ZNF786	0.31	0.50	enet	15	0.50	2.4e-73	6.1	-6.1	9.9e-10	-0.88	0.21	0.79	FALSE
9	GTEx	Brain Cortex	ZNF786	0.43	0.27	lasso	11	0.28	1.9e-08	6.2	-6.1	1.4e-09	-0.89	0.06	0.94	FALSE
14	GTEx	Breast Mammary Tissue	ZNF786	0.12	0.10	enet	6	0.08	5.3e-05	6.0	-6.0	1.4e-09	-0.86	0.08	0.92	FALSE
31	GTEx	Spleen	ZNF786	0.41	0.30	lasso	6	0.36	4.2e-10	6.0	-6.0	1.4e-09	-0.87	0.15	0.84	FALSE
35	GTEx	Thyroid	ZNF786	0.21	0.21	lasso	5	0.22	3.7e-17	6.1	-6.0	1.4e-09	-0.87	0.20	0.80	FALSE
45	The Cancer Genome Atlas	Esophageal Carcinoma	ZNF786	0.21	0.29	lasso	4	0.26	7.2e-09	6.1	-6.0	1.6e-09	-0.87	0.01	0.99	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	ZNF786	0.18	0.24	lasso	3	0.16	3.7e-05	6.0	-6.0	1.7e-09	-0.86	0.06	0.89	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF425	0.04	0.06	lasso	3	0.06	4.0e-04	6.1	-6.0	1.7e-09	-0.88	0.01	0.92	FALSE
5	GTEx	Artery Aorta	ZNF786	0.16	0.04	lasso	2	0.07	1.2e-04	6.2	-6.0	1.8e-09	-0.88	0.06	0.93	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF786	0.17	0.25	lasso	4	0.24	2.6e-24	6.1	-6.0	1.8e-09	-0.86	0.01	0.99	FALSE
15	GTEx	Breast Mammary Tissue (Female)	ZNF786	0.10	0.17	lasso	1	0.10	8.8e-04	6.0	-6.0	2.0e-09	-0.85	0.08	0.69	FALSE
22	GTEx	Liver	ZNF786	0.27	0.16	lasso	3	0.12	2.6e-04	6.1	-6.0	2.0e-09	-0.85	0.03	0.86	FALSE
23	GTEx	Lung	ZNF786	0.15	0.16	lasso	6	0.14	4.5e-11	6.0	-6.0	2.2e-09	-0.87	0.22	0.78	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	ZNF786	0.12	0.20	blup	29	0.19	3.0e-11	6.2	-6.0	2.2e-09	-0.84	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF786	0.12	0.19	lasso	3	0.16	2.7e-07	6.1	-6.0	2.2e-09	-0.88	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF786	0.08	0.11	lasso	5	0.10	2.9e-11	6.2	-6.0	2.4e-09	-0.85	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF786	0.06	0.05	lasso	2	0.04	1.4e-05	6.0	-6.0	2.6e-09	-0.86	0.02	0.96	FALSE
53	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZNF786	0.08	0.09	lasso	2	0.09	9.4e-07	6.0	-6.0	2.6e-09	-0.86	0.02	0.98	FALSE
7	GTEx	Brain Cerebellar Hemisphere	ZNF786	0.37	0.25	enet	19	0.22	2.7e-06	6.0	-6.0	2.7e-09	-0.88	0.04	0.96	FALSE
8	GTEx	Brain Cerebellum	ZNF786	0.43	0.23	lasso	9	0.28	6.7e-09	6.0	-6.0	2.7e-09	-0.89	0.05	0.95	FALSE
26	GTEx	Pancreas	ZNF786	0.33	0.28	enet	34	0.29	9.2e-13	6.1	-5.9	3.7e-09	-0.80	0.17	0.83	FALSE
57	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF786	0.06	0.08	blup	29	0.07	9.8e-05	6.1	-5.9	3.7e-09	-0.82	0.01	0.97	FALSE
16	GTEx	Cells Transformed fibroblasts	ZNF786	0.17	0.14	lasso	4	0.14	2.2e-10	6.2	-5.9	3.9e-09	-0.83	0.16	0.84	FALSE
24	GTEx	Muscle Skeletal	ZNF786	0.06	0.00	enet	13	0.00	2.8e-01	6.0	-5.9	4.7e-09	-0.61	0.07	0.37	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZNF786	0.13	0.13	blup	29	0.12	2.1e-05	5.7	-5.8	4.9e-09	-0.84	0.01	0.98	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF786	0.10	0.10	blup	29	0.10	9.5e-08	6.2	-5.8	6.1e-09	-0.84	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF786	0.10	0.14	lasso	6	0.15	1.0e-14	6.0	-5.8	6.1e-09	-0.83	0.02	0.98	FALSE
19	GTEx	Esophagus Mucosa	ZNF425	0.07	0.01	enet	11	0.02	2.3e-02	6.0	-5.8	6.4e-09	-0.69	0.08	0.38	FALSE
28	GTEx	Prostate	ZNF786	0.22	0.12	lasso	4	0.11	1.1e-03	6.0	-5.8	7.7e-09	-0.86	0.06	0.82	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF786	0.06	0.08	lasso	3	0.08	7.8e-10	5.7	-5.8	8.2e-09	-0.86	0.02	0.98	FALSE
33	GTEx	Stomach	ZNF425	0.11	0.01	lasso	3	0.02	4.8e-02	6.1	-5.7	1.4e-08	-0.84	0.06	0.75	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF786	0.05	0.09	lasso	2	0.09	9.2e-18	5.7	-5.7	1.4e-08	-0.85	0.02	0.98	FALSE
18	GTEx	Esophagus Mucosa	ZNF786	0.25	0.20	lasso	4	0.21	4.7e-14	6.0	-5.7	1.6e-08	-0.85	0.21	0.79	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF786	0.16	0.10	blup	29	0.12	1.9e-10	6.1	-5.6	2.1e-08	-0.79	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	ZNF786	0.14	0.12	lasso	5	0.11	2.8e-06	6.0	-5.6	2.2e-08	-0.85	0.19	0.79	FALSE
37	GTEx	Whole Blood	ZNF786	0.06	0.01	enet	6	0.03	1.4e-03	6.1	-5.6	2.4e-08	-0.84	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF786	0.15	0.15	blup	29	0.16	5.7e-08	6.0	-5.6	2.4e-08	-0.84	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZNF786	0.11	0.01	enet	6	0.05	7.0e-03	6.0	-5.5	3.2e-08	-0.78	0.01	0.75	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF786	0.02	0.03	enet	4	0.02	2.1e-03	6.2	-5.5	4.2e-08	-0.82	0.01	0.97	FALSE
10	GTEx	Brain Frontal Cortex BA9	ZNF786	0.40	0.28	lasso	6	0.32	3.7e-09	6.1	-5.3	9.9e-08	-0.80	0.06	0.94	FALSE