Best TWAS P=5.53e-25 · Best GWAS P=1.02e-29 conditioned to 3.22e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TNFRSF10A | 0.27 | 0.09 | lasso | 7 | 0.08 | 2.8e-07 | 4.9 | 5.4 | 6.2e-08 | 0.09 | 0.96 | 0.00 | TRUE |
| 2 | GTEx | Adrenal Gland | TNFRSF10C | 0.37 | 0.37 | lasso | 4 | 0.36 | 7.8e-14 | -5.5 | -6.4 | 1.7e-10 | -0.26 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Artery Aorta | TNFRSF10B | 0.26 | 0.23 | lasso | 2 | 0.22 | 2.1e-12 | 6.7 | -6.4 | 1.2e-10 | -0.47 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TNFRSF10A | 0.41 | 0.22 | lasso | 7 | 0.33 | 3.4e-25 | 4.9 | 5.6 | 2.0e-08 | 0.12 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-1149O23.3 | 0.19 | 0.10 | lasso | 4 | 0.14 | 1.7e-10 | 4.9 | 5.6 | 2.2e-08 | 0.10 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Whole Blood | TNFRSF10B | 0.12 | 0.07 | lasso | 6 | 0.07 | 8.7e-07 | 10.0 | 10.3 | 5.5e-25 | 0.65 | 0.03 | 0.96 | TRUE |
| 7 | NTR | Blood | TNFRSF10B | 0.15 | 0.11 | enet | 36 | 0.12 | 1.1e-35 | 10.0 | 9.7 | 3.3e-22 | 0.67 | 1.00 | 0.00 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | TNFRSF10C | 0.26 | 0.23 | lasso | 9 | 0.21 | 5.8e-27 | -5.5 | -6.2 | 5.6e-10 | -0.25 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TNFRSF10C | 0.13 | 0.09 | blup | 53 | 0.09 | 6.6e-10 | 10.0 | -10.0 | 1.5e-23 | -0.71 | 0.25 | 0.75 | FALSE |