Best TWAS P=3.98e-18 · Best GWAS P=6.16e-18 conditioned to 0.119
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | GTEx | Testis | KB-1507C5.2 | 0.28 | 0.17 | lasso | 6 | 0.17 | 4.7e-08 | -8.02 | 8.7 | 4.0e-18 | -0.93 | 0.03 | 0.97 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | KB-1507C5.2 | 0.07 | 0.03 | lasso | 3 | 0.04 | 1.8e-05 | -5.99 | 7.8 | 4.5e-15 | -0.76 | 0.74 | 0.21 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | AZIN1 | 0.11 | 0.06 | enet | 12 | 0.03 | 4.5e-03 | -7.68 | 7.0 | 2.6e-12 | -0.55 | 0.62 | 0.23 | FALSE |
| 2 | GTEx | Artery Tibial | AZIN1 | 0.15 | 0.09 | lasso | 2 | 0.13 | 2.9e-10 | 4.74 | 6.9 | 6.3e-12 | -0.61 | 0.74 | 0.25 | FALSE |
| 1 | GTEx | Artery Aorta | KB-1507C5.2 | 0.20 | 0.17 | lasso | 9 | 0.16 | 2.8e-09 | -6.13 | 6.3 | 3.3e-10 | -0.59 | 0.93 | 0.07 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | KB-1732A1.1 | 0.09 | 0.04 | blup | 475 | 0.04 | 2.4e-06 | -8.54 | 5.5 | 3.3e-08 | -0.69 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | AZIN1 | 0.12 | 0.06 | enet | 23 | 0.03 | 6.2e-03 | -6.14 | 5.3 | 9.9e-08 | -0.65 | 0.12 | 0.77 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | KLF10 | 0.09 | 0.00 | bslmm | 494 | 0.02 | 1.9e-03 | 0.38 | 5.1 | 2.8e-07 | -0.66 | 0.01 | 0.95 | FALSE |