Hub : Genes

AZIN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1471	0.0426	3.1e-05	0.086	NA	0.090	NA	0.129	2.9e-07	NA	1.5e-07	NA	2.9e-10
2	GTEx	Cells Transformed fibroblasts	0.1070	0.0360	1.2e-03	0.057	NA	0.026	NA	0.025	4.5e-05	NA	4.5e-03	NA	5.3e-03
3	GTEx	Colon Sigmoid	0.2710	0.0750	2.1e-04	0.146	NA	0.151	NA	0.175	7.9e-06	NA	5.3e-06	NA	8.6e-07
4	GTEx	Esophagus Muscularis	0.1150	0.0450	5.0e-03	0.060	NA	0.030	NA	0.027	1.5e-04	NA	6.2e-03	NA	8.6e-03
5	GTEx	Nerve Tibial	0.2493	0.0602	2.1e-06	0.217	NA	0.211	NA	0.209	2.3e-15	NA	6.3e-15	NA	9.2e-15
6	YFS	Blood	0.0143	0.0074	3.1e-02	0.004	0.001	0.005	0.006	0.005	1.7e-02	0.130	8.7e-03	0.003	6.0e-03
7	TCGA	Lung Adenocarcinoma	0.0764	0.0359	4.0e-03	0.012	0.006	-0.001	NA	0.005	1.4e-02	0.065	4.2e-01	NA	7.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.0	3.1	9.0	-0.8	-1.8	-0.7	-1.2	1.9	-1.7	3.0
Bipolar Disorder or Schizophrenia	1.5	3.6	5.5	-2.3	-2.2	-2.1	-2.2	-0.2	-0.4	2.3
Depressed Affect (Nagel 2018)	0.6	1.2	3.0	-1.7	-0.9	-0.5	-1.2	-0.4	-1.3	-0.8
Depression (Nagel 2018)	1.1	1.7	4.3	-1.4	-1.1	-0.7	-1.0	1.6	-2.1	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.2	1.5	1.0	0.4	0.5	0.1	0.2	0.9
Neuroticism (Nagel 2018)	0.9	2.2	6.7	-2.6	-1.3	-0.8	-1.7	-1.1	-1.4	-0.4
Schizophrenia (2018)	1.3	2.7	5.8	-2.4	-1.4	-2.2	-1.5	-1.7	0.9	0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	1.5	-1.2	-1.0	-0.3	0.3	-0.8	0.6	-1.2
Worry (Nagel 2018)	1.3	2.8	8.7	-2.9	-1.5	-1.2	-2.3	-0.9	-0.9	0.5
Alzheimer’s Disease (in mother)	2.7	3.2	10.4	-1.8	-1.4	-1.8	-3.2	-0.1	-0.6	1.7
Alzheimer’s Disease (in father)	2.1	2.3	6.0	-0.8	0.2	-2.3	-0.7	-2.4	-0.9	1.7
Alzheimer’s Disease (including proxy)	1.9	2.8	6.0	-1.6	-1.1	-2.3	-2.4	-1.1	-0.4	1.8
Crohns Disease (2017)	0.7	1.4	3.1	1.2	0.6	1.8	0.8	0.9	1.5	-1.2
Irritable Bowel Disease (IBD)	1.2	2.9	7.5	2.0	1.5	1.7	1.2	1.0	2.7	-1.1
Ulcerative Colitis (UC)	1.2	2.3	6.6	1.9	1.7	0.7	1.6	-0.0	2.6	-0.6
Major Depression (MDD)	0.8	1.0	4.5	-0.1	0.1	-0.3	-0.2	2.1	1.1	-0.9
Reaction Time	2.0	3.8	9.8	-1.5	-1.4	-1.0	-2.4	-0.2	-2.4	3.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.1	-0.2	0.5	-0.2	0.5	-0.8	0.8
Breast Cancer	0.6	1.5	3.3	1.1	-1.3	-0.9	1.3	0.7	-1.8	1.3
Ovarian Cancer	0.8	1.1	4.2	-1.3	0.6	-0.4	-2.1	-0.3	0.5	-0.9
Prostate Cancer	2.0	2.9	6.5	-2.1	-2.6	-0.5	-2.2	1.8	-0.9	0.2
Age at First Birth	0.5	0.7	2.1	0.0	-0.6	-1.4	-0.2	1.3	0.7	-0.1
Bipolar Disorder (2011)	1.2	1.2	4.0	-1.0	0.2	-0.7	-2.0	-0.1	0.6	1.5
Body Mass Index (BMI) (2010)	0.3	0.5	1.9	0.1	-0.0	-0.4	0.1	-0.2	-1.1	1.4
Coronary Artery Disease (CAD)	0.9	1.1	3.9	0.7	0.2	0.3	-0.6	-1.4	-0.8	2.0
Crohns Disease (2012)	1.2	2.0	3.5	1.9	0.9	1.2	1.2	0.8	1.8	-1.6
Mean Putamen Volume	0.7	0.8	1.7	-1.1	0.3	-1.2	-1.3	-1.1	0.4	0.0
Fasting Glucose	0.6	0.7	2.1	-0.2	-0.1	-0.7	-0.5	-1.1	-1.5	0.9
HbA1C	0.8	0.9	2.1	1.2	-0.1	-0.0	0.8	1.4	0.7	-1.4
HDL Cholesterol	0.6	1.0	3.2	-0.7	-1.4	1.1	-0.4	1.8	-0.4	-0.2
LDL Cholesterol	0.6	1.0	2.5	1.6	0.9	-0.4	1.0	1.1	0.8	-0.8
Lupus	0.5	0.7	1.2	0.9	0.9	-0.6	1.1	0.3	0.7	-1.1
Neuroticism (2016)	0.2	0.4	0.9	-0.8	0.1	-0.2	-1.0	0.5	-0.3	-0.7
Primary Biliary Cirrhosis	0.2	0.3	1.4	-0.6	0.0	-0.4	-0.1	0.3	0.6	-1.2
Rheumatoid Arthritis	0.1	0.2	0.4	-0.4	-0.3	-0.6	0.3	-0.4	-0.1	0.4
Schizophrenia (2014)	2.1	4.6	10.7	-3.3	-2.2	-2.3	-2.6	-1.5	-0.2	1.5
Triglycerides	0.1	0.2	0.6	0.1	0.4	-0.1	-0.2	-0.1	0.7	-0.8
Type 2 Diabetes (T2D) (2012)	1.4	1.6	6.0	-0.1	1.1	-1.7	-0.6	-2.5	0.1	1.0
Ulcerative Colitis	1.3	1.8	6.5	1.4	1.3	0.8	1.4	0.3	2.6	-0.4
Blood Eosinophil Count	0.2	1.7	6.4	2.5	1.6	0.7	1.2	-1.1	-0.3	-0.1
Blood Platelet Count	0.4	5.1	22.3	0.7	-0.8	1.9	0.2	2.9	-0.6	-4.7
Blood Red Count	0.8	7.7	15.2	3.9	3.8	0.2	1.7	-2.6	3.7	0.6
Blood White Count	3.1	23.0	49.0	6.9	7.0	2.3	5.3	-4.0	2.8	-2.7
Heel T-Score	0.2	1.9	4.7	2.2	1.4	-0.7	1.8	-1.6	-0.3	-0.4
BMI	0.2	1.3	2.7	1.5	1.6	-1.0	-0.1	-1.6	-0.8	-0.2
Height	0.1	2.7	16.1	-0.1	1.1	0.4	1.1	0.3	4.0	-0.1
Waist Hip Ratio (WHR)	1.4	6.3	13.9	3.2	3.7	0.6	3.3	-2.0	1.7	-1.3
Systolic Blood Pressure	0.5	2.6	7.5	2.7	1.7	-0.6	1.5	-2.0	0.9	-0.1
Smoking Status	1.2	2.8	12.4	-0.6	-0.3	-1.5	-1.1	-1.5	-3.5	1.1
Allergy or Eczema	0.1	0.4	0.7	-0.4	0.5	0.7	-0.6	0.7	0.5	-0.8
Cardiovascular Disease	1.5	4.9	10.1	3.0	3.0	-0.1	3.2	-1.4	1.8	-1.1
Hypothyroidism (self reported)	1.3	3.1	8.4	-0.6	0.5	-1.7	-0.5	-2.9	-1.0	2.9
Respiratory disease	0.8	1.9	5.9	-1.0	-1.1	1.3	-1.7	2.4	0.7	0.0
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.5	1.6	1.8	-1.0	1.9	-1.3	-0.2	-0.5
Lung FEV1/FVC ratio	0.7	3.3	6.5	-1.7	-0.9	-2.2	-1.8	-0.9	-2.5	2.1
Lung FVC	0.3	1.4	4.8	-0.0	-0.7	-2.2	-0.2	1.0	1.5	-1.1
Neuroticism	1.0	2.5	8.4	-2.9	-1.5	-0.9	-1.9	-0.4	-1.5	-0.0
Chronotype (morning person)	0.6	1.3	4.5	2.1	0.9	1.0	1.5	0.2	0.3	0.5
Hair Pigment	0.1	3.0	5.2	2.1	0.2	2.3	1.3	1.7	1.6	-1.9
Tanning	0.0	0.5	1.0	-0.1	-0.9	1.0	-1.0	0.0	-0.4	0.9
Hand grip strength (left)	0.5	1.3	5.8	0.7	0.4	-2.4	1.4	-0.1	0.8	0.1
Number of treatments/medications taken	1.7	3.0	8.1	0.4	2.6	2.1	-0.3	-0.6	2.8	-1.0
Average weekly spirits intake	1.1	1.3	2.2	1.5	1.4	0.9	1.4	-0.3	1.3	-0.6
Sensitivity / hurt feelings	0.7	1.3	2.8	-1.1	-1.1	-1.1	-0.2	-1.1	-1.7	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.7	-1.0	-1.1	0.1	-0.0	1.3	-1.0	-1.2
Hearing difficulty/problems: Yes	2.3	3.4	6.0	1.9	2.3	2.0	2.5	-0.2	1.7	-1.5
Relative age of first facial hair	1.0	2.1	5.8	-2.4	-2.3	-0.5	-1.8	0.1	-0.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	4.1	-0.5	0.7	2.0	-1.4	0.1	-0.1	0.7
Ever used hormone-replacement therapy (HRT)	1.3	1.6	5.5	-2.3	-0.0	0.1	-2.3	-0.3	0.3	-0.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.4	0.4	0.3	1.2	-0.0	-0.8	1.6	-0.4
Systolic blood pressure, automated reading	0.3	0.9	3.5	1.9	0.7	-0.4	0.7	-1.3	0.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.5	1.1	0.9	0.4	1.2	-0.3	-1.0	-0.6
Angina	0.9	1.2	2.7	-0.4	0.2	-0.3	-1.6	-1.1	-1.4	1.5
Medication for hormone replacement therapy	1.7	1.9	3.2	-1.4	-1.6	-1.8	-0.6	-0.9	-1.1	1.8
Vitamin and mineral supplements	0.7	0.9	2.5	1.2	1.0	-0.3	0.5	-1.6	1.0	0.5
Supplements: Zinc	0.4	0.4	0.7	-0.8	-0.4	0.6	-0.8	0.5	0.2	0.8
Medication: Co-codamol	0.5	0.5	2.9	0.8	0.3	0.1	0.0	1.7	-0.1	0.2
Medication: Metformin	1.0	1.4	3.3	1.6	1.8	0.1	1.0	-1.0	-0.3	-1.4
Diabetes (father)	0.2	0.3	0.7	0.5	-0.0	-0.4	0.9	0.3	-0.6	0.4
Diabetes (mother)	1.7	2.2	6.0	2.3	1.7	0.9	2.5	-0.5	0.4	0.3
Severe depression (siblings)	3.7	4.2	8.1	-2.4	-1.5	-1.2	-2.3	-0.8	-2.4	2.9
Pack years adult smoking proportion	0.2	0.3	0.6	0.2	0.5	0.8	-0.3	0.8	-0.5	-0.0
Impedance of leg (right)	0.5	2.6	5.6	0.8	0.0	2.0	1.6	2.4	1.6	-1.7
Leg fat-free mass (left)	0.1	0.6	1.6	-0.3	1.0	-0.9	-1.2	-0.8	-0.5	0.5
Trunk fat percentage	0.3	1.1	2.9	1.0	0.9	0.1	-0.3	-0.6	-1.6	-1.7
Hand grip strength (right)	0.3	0.9	5.2	0.1	0.1	-2.3	0.8	-0.2	0.6	0.4
Townsend deprivation index at recruitment	1.4	2.0	5.8	-1.2	-2.4	-1.5	-1.1	-0.3	-1.2	1.3
Current tobacco smoking	0.6	1.0	3.8	-0.8	-0.7	-0.7	-0.7	-0.4	-1.9	0.7
Average weekly fortified wine intake	0.7	0.8	3.5	-0.1	0.2	1.4	-0.2	-0.1	1.9	0.2
Maternal smoking around birth	0.5	0.7	1.2	1.1	0.9	-0.4	0.4	-0.9	-0.9	1.0
Fed-up feelings	0.3	0.5	1.3	-1.1	-0.5	-0.4	-1.2	-0.2	-0.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	5.8	-1.3	-1.2	-0.7	-1.2	1.9	-2.4	-0.7
Relative age voice broke	1.6	2.4	7.8	-1.7	-1.8	-0.2	-2.8	0.7	-0.9	1.3
Taking other prescription medications	0.6	1.0	3.9	-0.1	1.4	0.6	-0.4	-0.1	0.7	-2.0
Age when periods started (menarche)	0.2	0.6	1.8	0.3	-0.7	-0.1	-0.4	0.2	1.3	1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.5	-0.0	0.2	0.1	-0.4	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.7	-0.1	-0.7	-2.2	-0.1	-0.8	-1.1	1.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.1	-1.0	0.3	-0.1	-1.8	-1.3	-0.7	0.8
Qualifications: CSEs or equivalent	0.1	0.2	0.6	0.5	-0.6	-0.1	0.8	0.1	-0.2	0.2
Serious illness, injury or assault to yourself	0.6	0.7	3.0	-0.9	0.9	0.2	-0.3	-0.2	0.4	-1.7
High blood pressure	1.2	3.3	8.5	2.5	2.4	-0.6	1.5	-2.9	0.3	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	0.2	0.6	0.5	-0.1	0.6	-0.1	0.1
Multivitamins +/- minerals	0.1	0.2	0.5	0.2	-0.5	-0.6	0.5	0.7	-0.0	-0.3
Stomach or abdominal pain in last month	0.4	0.5	1.4	-0.3	-0.6	0.1	-1.0	1.2	-0.3	0.7
Supplements: Glucosamine	0.6	0.8	3.7	-0.4	-0.6	1.9	0.1	0.9	-0.0	-0.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.9	-1.2	-0.5	1.3	-1.6	1.3	-0.2	-2.0
Medication: Atenolol	1.3	1.7	6.9	-0.4	1.1	-0.1	-0.9	-2.6	0.2	1.6
Medication: Levothyroxine sodium	1.8	3.0	11.1	-0.9	0.5	-2.0	-0.5	-3.3	-0.4	2.0
Sitting height	0.8	5.4	15.9	2.1	3.0	1.1	2.0	0.4	4.0	-1.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.7	-0.4	-0.8	-1.1	-0.5	-0.7	1.1
High blood pressure (mother)	0.6	0.9	2.4	-0.6	0.6	-1.5	-0.2	-1.5	0.7	0.3
Body mass index (BMI)	0.3	1.5	4.0	0.8	1.0	-0.8	-0.4	-1.9	-2.0	-0.4
Impedance of leg (left)	0.4	2.0	3.5	0.9	0.3	1.6	1.9	1.5	1.4	-1.7
Leg predicted mass (left)	0.1	0.7	1.6	-0.4	0.9	-0.9	-1.3	-0.8	-0.7	0.5
Trunk fat mass	0.2	0.9	2.2	1.0	1.2	-0.0	-0.1	-0.6	-1.2	-1.5
Waist circumference	0.4	1.4	4.3	1.2	2.1	0.3	0.5	-1.4	-0.5	-1.3
Number of incorrect matches in round	1.2	2.0	6.9	0.9	2.3	-0.7	0.6	-2.6	0.4	-0.5
Past tobacco smoking	0.3	0.6	1.6	0.4	0.0	0.3	1.3	0.8	1.2	-0.5
Alcohol usually taken with meals	0.5	0.9	2.9	-0.9	-0.1	-1.7	-0.6	-0.1	1.3	-0.4
Nervous feelings	1.2	2.3	4.3	-2.1	-1.3	-1.1	-1.3	-1.1	-1.6	1.8
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	7.7	-2.8	-2.6	-1.2	-2.5	2.6	-1.1	0.0
Hearing difficulty/problems with background noise	0.3	0.4	1.5	-0.9	-0.2	0.1	-1.2	-0.7	0.2	0.4
Hair/balding pattern: Pattern 2	0.5	0.7	2.5	-0.5	-1.3	0.1	-0.3	1.6	0.5	0.2
Had menopause	0.9	1.1	5.0	-2.2	-0.7	0.1	-1.3	-0.4	0.5	0.1
Had other major operations	0.4	0.4	1.4	0.7	0.2	1.2	-0.2	0.3	0.7	-0.6
Forced vital capacity (FVC)	0.5	2.0	6.7	-0.0	-0.0	-1.4	0.5	1.9	2.6	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	4.5	-0.0	-0.4	-2.1	0.3	-0.5	-0.8	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.5	0.2	0.6	-1.6	0.6	-0.4	-0.2	0.8
Qualifications: None of the above	0.3	0.7	1.1	0.9	-0.2	-1.1	0.4	-0.9	-1.1	1.0
Financial difficulties in last 2 years	2.1	2.8	4.7	-1.5	-2.0	-2.2	-1.1	-0.9	-2.0	1.6
Mouth/teeth dental problems	0.3	0.4	1.2	0.2	0.3	-0.1	0.8	-1.0	0.3	-1.1
Heart attack	0.5	0.7	2.0	0.8	0.1	-0.2	0.6	0.3	-1.4	1.2
Allergy	0.1	0.2	0.7	0.0	-0.0	-0.9	0.1	-0.8	0.2	-0.0
Pain all over the body in last month	0.7	0.8	2.2	-0.6	-0.0	-0.8	-0.7	-1.5	-1.0	-0.8
Diabetes (self-reported)	1.3	2.0	6.2	1.6	2.5	-0.4	1.4	-1.3	0.0	-1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.2	-0.2	0.9	0.6	-0.1	-0.5	1.5	-0.0
Medication: Ramipril	1.0	1.3	4.1	0.9	2.0	-0.8	0.9	-1.6	0.3	0.3
Medication: Simvastatin	1.0	1.5	4.2	1.0	2.1	-0.7	0.5	-1.6	0.9	-1.0
Fluid intelligence score	0.1	0.1	0.4	0.2	-0.3	0.3	0.4	0.1	-0.4	0.6
Illnesses of siblings	0.3	0.4	0.9	-1.0	-0.8	-0.1	-0.9	0.6	-0.4	0.5
Neuroticism score	0.9	2.0	6.4	-2.5	-1.9	-0.9	-1.5	-0.0	-0.7	-0.1
Weight	0.1	0.5	1.5	0.5	1.2	-0.2	-0.3	-0.8	-0.7	-0.6
Impedance of arm (right)	0.4	1.8	6.6	-0.6	-1.5	1.4	-0.4	2.6	-0.1	-1.1
Arm fat percentage (right)	0.3	1.3	3.6	1.0	0.6	-0.6	-0.3	-0.7	-1.9	-1.8
Trunk fat-free mass	0.1	0.8	2.3	0.0	1.5	-0.7	-0.1	-1.0	1.2	0.4
Hip circumference	0.2	1.0	2.6	-1.0	0.3	0.1	-1.5	-0.4	-0.8	-1.6
Time employed in main current job	1.8	2.1	8.0	-1.1	-1.6	-2.8	0.1	-1.5	-0.5	0.6
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.7	1.3	0.2	1.0	-0.8	-0.4	0.7
Father’s age at death	1.3	1.7	3.7	-1.4	-1.2	-1.5	-1.9	0.5	-1.4	0.7
Worrier / anxious feelings	0.2	0.4	0.9	-0.4	0.4	-0.1	-0.8	-0.9	0.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	6.5	-1.8	-2.5	-1.2	-2.2	1.5	-1.7	-0.2
Falls in the last year	1.9	2.6	7.4	-0.4	-0.2	2.7	-0.6	2.4	0.3	-2.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.6	0.5	1.6	0.7	-0.4	-0.4	0.1	-0.5
Number of live births	0.6	0.9	2.4	-0.4	-0.9	-1.4	-0.3	-0.6	-0.5	1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.0	-0.5	-0.9	-1.8	-0.1	2.0	1.2	-0.1
Pulse rate	0.2	0.3	1.2	0.4	-0.7	0.0	0.4	1.1	0.4	0.0
Happiness	0.1	0.2	0.3	-0.3	0.6	-0.4	-0.5	-0.0	-0.5	-0.4
Noisy workplace	1.5	1.9	7.6	1.8	2.8	0.6	0.1	-0.8	1.1	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-0.4	0.2	0.1	-1.2	0.1	-0.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	-0.0	0.5	-0.2	0.8	0.6	1.0	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	2.0	0.7	0.4	1.4	-0.0	0.8	0.3	0.0
Asthma	0.7	1.4	3.4	-1.3	-1.2	0.9	-1.2	1.8	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.5	0.1	0.5	1.2	-0.1	0.7	0.6	-0.1
Medication: Cholesterol lowering	1.6	2.4	4.5	2.0	2.1	0.6	1.5	-0.7	1.0	-2.0
Depression (self-reported)	0.5	0.6	1.6	-0.5	-1.3	0.0	-0.4	0.7	-1.0	0.9
Medication: Lansoprazole	0.8	0.9	3.7	0.9	0.3	1.1	0.6	1.9	0.6	-0.1
Prospective memory result	1.1	1.4	4.0	2.0	0.8	-0.8	1.6	0.4	-0.8	-0.9
Lung cancer (father)	0.3	0.4	0.8	-0.8	-0.4	-0.5	-0.4	-0.9	0.0	0.9
Illnesses of mother	2.2	2.7	6.2	-1.5	-2.0	0.7	-1.6	2.5	-1.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.9	0.2	-0.9	-2.2	1.0	1.4	0.9	-0.5
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	1.0	1.4	0.1	0.9	-0.1	0.6	-0.6
Impedance of arm (left)	0.5	2.4	8.1	-0.8	-1.8	1.7	-0.7	2.9	-0.3	-0.9
Arm fat mass (right)	0.2	1.0	2.1	0.7	0.9	-0.8	-0.3	-1.1	-1.4	-1.4
Trunk predicted mass	0.1	0.8	2.4	0.0	1.5	-0.6	-0.1	-1.0	1.2	0.4
Standing height	0.2	1.8	8.0	-0.7	0.5	0.8	-0.0	1.6	2.8	-0.4
Length of working week for main job	0.8	0.9	4.0	0.2	-0.6	-0.8	-0.6	0.8	-2.0	0.3
Exposure to tobacco smoke at home	0.9	1.0	2.1	0.5	1.1	-0.3	1.2	-1.4	0.4	-1.4
Breastfed as a baby	0.9	1.1	2.7	-1.5	-1.6	-1.2	-0.9	0.2	0.3	0.8
Tense / ‘highly strung’	0.6	1.0	3.9	-2.0	-0.8	-0.4	-1.3	-0.5	-0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.8	-0.2	0.1	-0.5	0.9	0.5	-0.5
Hair/balding pattern: Pattern 4	1.1	2.6	10.1	1.5	1.1	1.2	0.8	0.2	3.2	-1.5
Birth weight of first child	0.7	1.3	3.9	-1.1	0.0	-0.6	-1.6	-1.1	-0.1	-2.0
Peak expiratory flow (PEF)	0.3	0.8	3.0	-0.2	-0.6	-0.7	-0.1	1.7	0.3	1.3
Pulse wave reflection index	1.2	1.5	2.7	1.5	1.6	0.5	1.6	-1.0	-0.1	-1.2
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.5	0.0	-0.1	0.8	0.1	2.1	0.1	-1.2
Loud music exposure frequency	1.2	1.3	2.9	-1.1	-0.9	-1.4	-1.7	-0.4	-0.1	1.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.0	-0.7	0.2	0.1	-0.3	-1.4	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	2.5	-0.1	0.6	-0.7	-0.8	-0.0	0.0	1.6
Blood clot in the leg (DVT)	0.6	0.7	2.8	0.5	0.3	-0.7	0.6	-0.6	0.8	1.7
Medication: Paracetamol	0.8	1.3	4.7	0.6	0.4	1.5	0.3	2.2	0.5	-1.2
Headache pain in last month	1.2	2.0	5.2	2.3	1.6	1.2	1.5	1.4	0.0	-0.7
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	8.8	-2.0	-3.0	0.5	-0.9	2.3	-1.0	0.9
Glaucoma (self-reported)	0.8	0.9	2.8	-1.2	0.3	-0.6	-0.9	-1.7	-0.0	0.9
Gout (self-reported)	1.1	1.5	4.1	-0.8	0.7	-2.0	0.0	-2.0	-0.5	-0.9
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	16.2	-0.3	1.1	-2.1	-0.5	-4.0	-0.7	3.2
Medication: Amlodipine	0.8	1.1	2.5	0.9	1.0	-1.3	0.7	-1.6	-1.1	0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.3	0.4	0.2	1.7	-0.0	1.8	0.5	-0.0
Birth weight	0.1	0.1	0.5	0.1	0.0	-0.0	-0.0	0.7	-0.0	-0.7
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.6	1.0	0.4	-0.3	1.0	-1.6	1.9	0.9
High blood pressure (siblings)	0.2	0.3	1.0	0.8	1.0	-0.2	0.3	-0.3	-0.1	0.4
Forced vital capacity (FVC), Best measure	0.5	2.0	4.8	0.5	-0.5	-1.4	1.5	1.4	2.2	-1.5
Body fat percentage	0.3	1.2	3.4	1.2	0.8	-0.1	-0.0	-0.5	-1.9	-1.6
Leg fat percentage (right)	0.3	1.2	2.5	1.6	0.9	0.2	0.5	-0.3	-1.4	-1.6
Arm fat-free mass (right)	0.1	0.7	1.8	0.0	1.3	-1.0	-0.0	-1.3	0.3	0.4
Exposure to tobacco smoke outside home	0.8	1.1	4.6	0.1	-0.4	1.3	-0.2	0.8	-2.1	0.9
Comparative body size at age 10	0.5	1.3	2.6	1.5	1.6	0.6	1.5	-0.1	-0.7	-1.0
Number of full brothers	0.5	0.6	1.8	0.6	-0.8	-0.3	0.1	-0.8	-1.3	0.8
Worry too long after embarrassment	1.0	1.6	5.0	-2.2	-0.1	0.9	-2.0	-0.2	-0.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.9	-1.4	-1.0	-0.6	-1.0	1.4	-1.2	-0.2
Wheeze or whistling in the chest in last year	0.7	1.2	3.4	0.3	0.8	1.8	-0.3	0.5	1.1	-1.6
Number of children fathered	1.1	1.2	3.9	2.0	0.5	0.9	1.5	0.7	-0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.6	0.5	0.5	-0.8	0.4	0.8	1.6	-1.5
Age at first live birth	0.2	0.4	1.2	-0.2	0.6	0.7	-0.3	0.4	0.5	1.1
Pulse wave peak to peak time	0.5	0.6	1.9	-1.0	-1.4	-0.3	-0.8	0.1	-0.3	0.7
Health satisfaction	2.0	2.6	8.7	1.9	3.0	0.2	0.6	-0.3	1.7	-1.5
Shortness of breath walking on level ground	1.5	1.8	4.0	2.0	1.4	0.9	1.8	0.4	1.0	-1.3
Qualifications: College or University degree	0.8	2.4	7.2	-2.4	-0.8	-0.1	-1.9	0.2	-0.5	2.7
Eye problems/disorders: None of the above	0.8	0.9	3.7	0.9	0.4	-0.6	0.5	0.1	-1.0	1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	0.9	0.6	1.4	1.0	-0.4	1.0	-0.6
Emphysema/chronic bronchitis	0.4	0.5	1.2	0.4	-0.8	0.8	-0.0	1.0	-1.1	0.2
Medication for pain relief, constipation, heartburn	0.6	1.0	3.7	-0.1	-0.2	-1.5	0.1	-1.9	-0.8	0.8
Neck or shoulder pain in last month	1.2	1.8	4.3	1.7	2.1	1.2	0.8	-0.9	0.6	-1.4
Medication: Blood pressure	2.7	4.8	13.5	2.7	3.7	-0.5	1.1	-3.2	1.0	-0.1
Angina (self-reported)	0.7	1.0	2.5	-0.1	0.3	-0.0	-1.4	-1.0	-1.1	1.6
Migraine (self-reported)	0.9	1.1	2.7	0.4	-1.0	1.6	0.7	1.2	-0.6	-1.2
Medication: Ibuprofen	0.6	0.8	1.6	0.2	1.3	1.2	-0.5	0.9	1.1	-0.1
Medication: Allopurinol	0.6	0.8	1.9	-0.5	0.7	-1.4	0.3	-1.2	-0.6	-1.0
Medication: Omeprazole	0.2	0.3	0.9	-0.9	-0.2	-0.7	-0.3	0.4	0.2	-0.4
Medication: Seretide 50 evohaler	1.5	1.7	2.9	-0.5	-1.4	1.1	-1.7	1.7	-1.5	0.8
Mean time to correctly identify matches	1.4	2.7	7.2	-1.4	-0.8	-0.6	-2.4	-1.3	-1.1	2.7
Heart disease (mother)	0.8	0.9	4.5	-0.3	0.8	-1.0	-0.2	-0.4	0.2	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.8	-0.2	0.8	-1.0	-1.4	-1.7	-0.5	1.2
Whole body fat mass	0.3	1.0	2.2	1.2	1.2	-0.3	-0.0	-0.7	-1.5	-1.2
Leg fat mass (right)	0.3	1.0	2.0	1.2	1.4	-0.1	0.1	-0.9	-1.3	-1.1
Arm predicted mass (right)	0.1	0.5	1.4	-0.1	1.1	-0.8	-0.2	-1.2	0.3	0.5
Pulse rate, automated reading	0.4	1.1	3.7	1.9	0.7	-1.1	1.3	0.6	-0.1	-0.7
Alcohol intake frequency.	0.7	1.6	2.9	1.6	1.7	-1.0	1.7	-0.8	1.0	0.6
Comparative height size at age 10	0.3	1.5	4.5	-1.1	0.6	0.9	-0.8	2.1	1.7	-0.5
Number of full sisters	1.8	2.2	5.4	-1.9	-0.8	-1.7	-1.3	-2.3	-0.6	0.9
Suffer from ‘nerves’	1.4	2.2	5.5	-2.2	-2.3	0.3	-1.1	1.2	-1.6	-0.2
Overall health rating	0.4	0.9	2.1	0.7	1.1	1.4	-0.2	0.6	-0.5	-1.4
Chest pain or discomfort	2.6	3.7	13.0	-2.3	-1.1	-0.6	-3.6	-0.3	-0.4	2.4
Had major operations	1.1	1.3	5.1	0.4	-0.5	1.0	0.0	2.2	1.1	-1.2
Age at last live birth	0.6	0.8	4.5	-0.3	-0.7	0.1	-0.2	0.6	-0.7	2.1
Family relationship satisfaction	0.5	0.6	1.7	-1.1	0.2	-0.7	-0.7	-0.4	-1.3	-0.2
Leg pain on walking	0.6	0.7	4.2	-0.2	0.0	0.3	0.4	0.5	0.4	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.1	1.2	1.8	0.3	0.9	-1.1	0.3	0.2
Commuting to job workplace: Car/motor vehicle	2.3	2.6	9.0	1.1	0.8	0.8	1.5	1.1	1.9	-3.0
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.3	1.1	1.1	1.8	0.4	0.3	1.5	-0.2
Medication: Aspirin	0.1	0.2	0.8	0.5	0.0	0.2	0.2	0.1	0.9	0.3
Supplements: Vitamin C	3.7	4.4	8.1	-2.8	-2.9	0.5	-2.0	2.3	-1.6	1.5
Knee pain experienced in last month	0.4	0.6	2.7	-0.1	0.4	1.6	-0.6	0.2	-0.2	-0.7
Hypertension (Self-reported)	1.5	4.3	8.7	2.8	2.9	-0.2	2.2	-2.7	0.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.2	-0.1	-0.5	1.8	0.6	1.8	0.9	-1.1
Illnesses of father: Heart disease	1.2	1.7	4.0	1.4	1.0	2.0	1.3	0.5	1.8	-0.0
Illnesses of siblings: Diabetes	0.5	0.6	2.4	0.5	0.4	-0.4	1.6	-0.6	0.1	-0.9
Smoking status: Previous	0.2	0.3	0.6	0.8	0.5	-0.0	-0.6	-0.3	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	0.8	0.1	-0.1	0.8	0.4	-0.2	0.7
Whole body fat-free mass	0.1	0.7	2.0	-0.0	1.4	-0.8	-0.4	-1.1	0.5	0.4
Leg fat-free mass (right)	0.1	0.8	1.4	-0.4	0.9	-1.2	-1.1	-1.1	-0.6	0.5
Arm fat percentage (left)	0.3	1.3	5.2	0.8	0.2	-0.5	-0.6	-0.6	-2.3	-1.5
Average weekly red wine intake	1.5	2.2	6.0	-2.4	-1.4	-2.0	-1.7	-0.3	0.5	0.8
Handedness (chirality/laterality): Left-handed	1.8	2.1	6.2	1.5	2.5	0.5	1.1	-0.5	1.3	-1.6
Mood swings	0.3	0.5	1.4	-0.3	-0.9	-0.3	-0.0	0.3	-1.0	-1.2
Loneliness, isolation	1.5	2.1	5.8	-2.4	-1.6	-0.6	-1.6	0.4	-1.5	0.7
Long-standing illness, disability or infirmity	0.9	1.4	3.8	1.5	1.9	1.5	0.5	-0.6	-0.1	-1.1
Ever had bowel cancer screening	1.0	1.1	1.9	-0.8	-1.1	1.2	-1.0	1.4	-0.2	-1.3
Diabetes diagnosed by doctor	1.0	1.7	5.0	1.4	2.2	-0.8	0.9	-1.6	-0.1	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	0.5	1.3	-0.2	0.3	-1.0	0.3	-0.1
Friendships satisfaction	1.8	2.2	5.0	-1.8	-0.4	-1.7	-1.5	-0.7	-2.2	1.0
Qualifications: nursing, teaching	0.5	0.7	2.6	-0.1	1.1	0.9	-0.6	-0.3	1.6	0.2
Commuting to job workplace: Walk	1.0	1.1	4.1	-0.7	-2.0	-0.9	-0.1	0.9	-0.8	-0.6
Eye problems/disorders: Cataract	1.4	1.6	4.4	-2.1	-1.6	-0.5	-1.8	0.2	-0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.6	-1.2	-0.7	-0.6	-1.0	0.9	0.7	0.1
Medication for cholesterol	1.4	2.1	9.6	-0.5	-1.4	-0.1	-0.7	3.1	-1.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	7.1	-2.7	-0.7	-1.4	-2.1	-0.1	0.2	0.3
Back pain experienced in last month	0.2	0.2	0.7	0.4	0.2	-0.2	0.8	0.8	0.1	-0.4
Mineral and other dietary supplements	1.8	2.5	8.9	0.5	1.0	-2.3	0.0	-3.0	0.6	1.2
Breast cancer (self-reported)	0.8	1.0	2.6	1.6	1.1	0.2	1.6	-0.7	0.1	-0.4
Asthma (self-reported)	0.7	1.4	3.1	-1.4	-1.0	1.2	-1.2	1.8	0.8	-0.7
Osteoporosis (self-reported)	0.6	0.7	1.8	-0.4	0.8	1.3	-1.3	0.2	0.5	-0.4
Osteoarthritis (self-reported)	0.6	0.8	2.6	-0.8	-0.7	1.1	-0.6	0.3	-0.5	1.6
Medication: Aspirin	0.1	0.2	0.5	0.2	-0.0	0.2	-0.3	-0.0	0.7	0.7
Medication: Gliclazide	1.2	1.4	3.7	1.6	1.7	-0.0	0.7	-0.0	-0.0	-1.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.9	-0.6	-0.0	-0.2	-0.7	0.7	0.2	-1.4
Smoking status: Current	1.0	1.6	4.8	-1.3	-1.0	-1.2	-1.0	-0.7	-2.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	11.6	-1.0	-1.9	-3.4	-0.6	0.6	0.1	1.5
Whole body water mass	0.1	0.7	1.8	-0.1	1.4	-0.9	-0.5	-1.1	0.5	0.3
Leg predicted mass (right)	0.1	0.7	1.3	-0.4	0.9	-1.2	-1.1	-1.1	-0.6	0.5
Arm fat mass (left)	0.3	1.1	2.6	0.6	1.0	-0.5	-0.5	-1.1	-1.6	-1.3
Number of self-reported non-cancer illnesses	0.4	0.6	1.5	-0.7	1.2	0.5	-0.1	-1.0	0.9	-0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.8	-0.1	0.3	0.3	-0.7	0.9	0.2	0.4
Miserableness	1.1	1.9	5.2	-2.3	-1.6	-1.2	-1.6	-0.3	-1.0	-0.3
Guilty feelings	0.6	0.9	1.9	-1.4	-1.4	0.1	-0.3	0.8	-0.4	-1.3
Wears glasses or contact lenses	2.7	3.1	7.2	-2.4	-0.6	-2.4	-2.7	-1.1	0.1	-0.7
Ever taken oral contraceptive pill	1.3	1.5	4.8	1.0	2.2	0.6	0.7	-0.8	1.7	0.1
Hearing aid user	0.4	0.4	1.3	-0.1	0.5	0.5	0.8	-1.1	0.0	-0.7
Mother’s age at death	2.0	2.5	7.1	0.7	0.8	2.7	1.0	1.8	1.7	-1.5
Financial situation satisfaction	1.1	1.3	3.0	-1.1	-0.4	-1.7	-1.6	-0.3	-1.4	0.5
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.0	-0.0	1.3	1.0	-0.5	-0.6	0.5	-2.0
Commuting to job workplace: Public transport	1.4	1.7	5.5	-2.4	-1.3	-0.5	-1.5	-0.4	-0.3	1.3
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.7	0.4	-0.1	-0.8	-0.8	0.5	0.4
Medication: Blood pressure	3.6	6.8	13.5	2.6	3.5	1.3	3.0	-3.7	2.0	-0.9
Pain type(s) experienced in last month: Hip pain	1.5	1.9	6.7	0.6	-0.2	2.4	-0.5	2.6	0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.3	-1.0	-1.2	1.0	-0.2	1.5	0.3	-0.7
High cholesterol (Self-reported)	0.6	1.1	4.3	0.3	0.9	0.3	0.4	-0.4	1.5	-2.1
Medication: Bendroflumethiazide	1.8	2.7	5.6	2.3	2.4	0.6	2.0	-1.4	1.1	0.3
Medication: Paracetamol	1.1	1.7	4.5	1.0	0.7	2.0	0.2	2.1	0.8	-1.2
Medication: Lisinopril	1.6	2.0	6.9	1.1	2.3	-0.0	0.4	-2.6	0.3	-0.7
Medication: Atorvastatin	0.3	0.3	1.0	0.6	0.5	0.2	1.0	-0.5	0.6	-0.3
Illnesses of father: High blood pressure	0.9	1.1	2.6	0.4	0.5	-1.6	0.1	-1.3	-1.3	1.2
Alcohol drinker status: Never	2.2	2.6	10.7	0.9	1.4	0.7	1.7	-0.7	3.3	-0.8
Ever smoked	1.2	2.1	5.2	-1.5	-1.2	-0.3	-2.2	-0.2	-2.3	1.0
Basal metabolic rate	0.1	0.6	2.0	0.0	1.4	-0.8	-0.4	-1.1	0.2	0.1
Leg fat percentage (left)	0.4	1.3	2.6	1.6	1.1	-0.2	0.6	-1.0	-1.6	-1.3
Arm fat-free mass (left)	0.2	0.8	2.7	0.2	1.6	-1.0	0.1	-1.4	0.5	0.0
Number of operations (self-reported)	1.8	2.6	5.2	1.6	0.8	2.3	0.6	2.2	2.1	-0.9
Average weekly beer plus cider intake	1.4	2.0	3.6	1.5	-0.9	1.0	1.9	1.9	-0.7	-1.6
Irritability	0.5	0.8	4.3	0.1	0.9	0.4	-0.5	0.2	0.4	-2.1
Risk taking	0.6	0.9	3.4	-0.3	0.1	-1.1	0.0	-1.3	-1.8	-0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.0	-0.2	-0.1	-0.1	0.5	0.8	1.4	-0.6
Fractured/broken bones in last 5 years	0.5	0.6	1.8	-0.6	0.6	1.1	-0.7	0.2	0.3	-1.4
Age started oral contraceptive pill	1.1	1.3	4.5	-1.7	0.1	0.4	-2.1	-1.0	0.4	0.8
Diastolic blood pressure, automated reading	0.5	1.5	4.4	2.1	1.2	-0.7	1.6	-0.7	1.0	-0.5
Ever depressed for a whole week	0.5	0.6	3.2	0.3	0.8	0.3	0.7	-0.4	1.8	0.1
Unable to work because of sickness or disability	0.6	0.7	1.9	1.1	0.7	0.8	1.4	0.7	0.1	-0.6
Commuting to job workplace: Cycle	0.4	0.5	2.3	0.0	-0.4	1.5	-0.0	0.6	0.8	0.2
Myopia	2.0	2.8	4.9	-1.1	-2.0	-2.2	-1.1	-0.3	-1.9	2.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	7.2	-2.0	-2.2	0.5	-0.8	2.7	-0.1	-1.0
Cholesterol lowering medication	0.8	1.2	4.3	-0.4	1.1	-0.8	-0.5	-2.1	1.2	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.5	-0.9	0.1	-1.6	-0.0	-0.0	0.3	-0.3
Pain experienced in last month	0.7	1.2	5.2	-0.7	-1.0	-1.2	-0.1	-0.7	0.2	2.3
Supplements: Calcium	1.6	1.8	5.1	-1.4	-0.6	-0.5	-2.3	0.2	-1.9	1.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.7	-0.1	-0.4	-0.4	0.4	0.0	-0.2	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.9	0.6	0.0	-0.1	0.4	0.4	-1.3	1.4
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	3.3	0.8	0.5	-0.8	0.7	-0.7	0.8	1.8
Heart disease (siblings)	0.2	0.3	1.0	0.6	0.6	0.2	0.2	-1.0	-0.4	-0.3
Alcohol drinker status: Previous	1.0	1.1	2.2	-0.7	-1.0	0.3	-1.0	1.3	-1.5	1.0
Pack years of smoking	0.3	0.4	1.3	0.3	0.6	1.1	-0.3	0.9	-0.3	0.1
Impedance of whole body	0.4	2.0	6.5	-0.1	-1.1	1.8	0.5	2.5	0.5	-1.6
Leg fat mass (left)	0.3	1.2	2.2	1.3	1.4	-0.4	0.2	-1.3	-1.5	-0.9
Arm predicted mass (left)	0.2	1.3	3.5	0.4	1.9	-1.1	0.4	-1.8	0.6	0.1