Hub : Genes

AZIN1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1471 0.0426 3.1e-05 0.086 NA 0.090 NA 0.129 2.9e-07 NA 1.5e-07 NA 2.9e-10
2 GTEx Cells Transformed fibroblasts 0.1070 0.0360 1.2e-03 0.057 NA 0.026 NA 0.025 4.5e-05 NA 4.5e-03 NA 5.3e-03
3 GTEx Colon Sigmoid 0.2710 0.0750 2.1e-04 0.146 NA 0.151 NA 0.175 7.9e-06 NA 5.3e-06 NA 8.6e-07
4 GTEx Esophagus Muscularis 0.1150 0.0450 5.0e-03 0.060 NA 0.030 NA 0.027 1.5e-04 NA 6.2e-03 NA 8.6e-03
5 GTEx Nerve Tibial 0.2493 0.0602 2.1e-06 0.217 NA 0.211 NA 0.209 2.3e-15 NA 6.3e-15 NA 9.2e-15
6 YFS Blood 0.0143 0.0074 3.1e-02 0.004 0.001 0.005 0.006 0.005 1.7e-02 0.130 8.7e-03 0.003 6.0e-03
7 TCGA Lung Adenocarcinoma 0.0764 0.0359 4.0e-03 0.012 0.006 -0.001 NA 0.005 1.4e-02 0.065 4.2e-01 NA 7.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.0 3.1 9.0 -0.8 -1.8 -0.7 -1.2 1.9 -1.7 3.0
Bipolar Disorder or Schizophrenia 1.5 3.6 5.5 -2.3 -2.2 -2.1 -2.2 -0.2 -0.4 2.3
Depressed Affect (Nagel 2018) 0.6 1.2 3.0 -1.7 -0.9 -0.5 -1.2 -0.4 -1.3 -0.8
Depression (Nagel 2018) 1.1 1.7 4.3 -1.4 -1.1 -0.7 -1.0 1.6 -2.1 -0.2
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.2 1.5 1.0 0.4 0.5 0.1 0.2 0.9
Neuroticism (Nagel 2018) 0.9 2.2 6.7 -2.6 -1.3 -0.8 -1.7 -1.1 -1.4 -0.4
Schizophrenia (2018) 1.3 2.7 5.8 -2.4 -1.4 -2.2 -1.5 -1.7 0.9 0.5
Schizophrenia vs Biploar Disorder 0.5 0.7 1.5 -1.2 -1.0 -0.3 0.3 -0.8 0.6 -1.2
Worry (Nagel 2018) 1.3 2.8 8.7 -2.9 -1.5 -1.2 -2.3 -0.9 -0.9 0.5
Alzheimer’s Disease (in mother) 2.7 3.2 10.4 -1.8 -1.4 -1.8 -3.2 -0.1 -0.6 1.7
Alzheimer’s Disease (in father) 2.1 2.3 6.0 -0.8 0.2 -2.3 -0.7 -2.4 -0.9 1.7
Alzheimer’s Disease (including proxy) 1.9 2.8 6.0 -1.6 -1.1 -2.3 -2.4 -1.1 -0.4 1.8
Crohns Disease (2017) 0.7 1.4 3.1 1.2 0.6 1.8 0.8 0.9 1.5 -1.2
Irritable Bowel Disease (IBD) 1.2 2.9 7.5 2.0 1.5 1.7 1.2 1.0 2.7 -1.1
Ulcerative Colitis (UC) 1.2 2.3 6.6 1.9 1.7 0.7 1.6 -0.0 2.6 -0.6
Major Depression (MDD) 0.8 1.0 4.5 -0.1 0.1 -0.3 -0.2 2.1 1.1 -0.9
Reaction Time 2.0 3.8 9.8 -1.5 -1.4 -1.0 -2.4 -0.2 -2.4 3.1
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.6 0.1 -0.2 0.5 -0.2 0.5 -0.8 0.8
Breast Cancer 0.6 1.5 3.3 1.1 -1.3 -0.9 1.3 0.7 -1.8 1.3
Ovarian Cancer 0.8 1.1 4.2 -1.3 0.6 -0.4 -2.1 -0.3 0.5 -0.9
Prostate Cancer 2.0 2.9 6.5 -2.1 -2.6 -0.5 -2.2 1.8 -0.9 0.2
Age at First Birth 0.5 0.7 2.1 0.0 -0.6 -1.4 -0.2 1.3 0.7 -0.1
Bipolar Disorder (2011) 1.2 1.2 4.0 -1.0 0.2 -0.7 -2.0 -0.1 0.6 1.5
Body Mass Index (BMI) (2010) 0.3 0.5 1.9 0.1 -0.0 -0.4 0.1 -0.2 -1.1 1.4
Coronary Artery Disease (CAD) 0.9 1.1 3.9 0.7 0.2 0.3 -0.6 -1.4 -0.8 2.0
Crohns Disease (2012) 1.2 2.0 3.5 1.9 0.9 1.2 1.2 0.8 1.8 -1.6
Mean Putamen Volume 0.7 0.8 1.7 -1.1 0.3 -1.2 -1.3 -1.1 0.4 0.0
Fasting Glucose 0.6 0.7 2.1 -0.2 -0.1 -0.7 -0.5 -1.1 -1.5 0.9
HbA1C 0.8 0.9 2.1 1.2 -0.1 -0.0 0.8 1.4 0.7 -1.4
HDL Cholesterol 0.6 1.0 3.2 -0.7 -1.4 1.1 -0.4 1.8 -0.4 -0.2
LDL Cholesterol 0.6 1.0 2.5 1.6 0.9 -0.4 1.0 1.1 0.8 -0.8
Lupus 0.5 0.7 1.2 0.9 0.9 -0.6 1.1 0.3 0.7 -1.1
Neuroticism (2016) 0.2 0.4 0.9 -0.8 0.1 -0.2 -1.0 0.5 -0.3 -0.7
Primary Biliary Cirrhosis 0.2 0.3 1.4 -0.6 0.0 -0.4 -0.1 0.3 0.6 -1.2
Rheumatoid Arthritis 0.1 0.2 0.4 -0.4 -0.3 -0.6 0.3 -0.4 -0.1 0.4
Schizophrenia (2014) 2.1 4.6 10.7 -3.3 -2.2 -2.3 -2.6 -1.5 -0.2 1.5
Triglycerides 0.1 0.2 0.6 0.1 0.4 -0.1 -0.2 -0.1 0.7 -0.8
Type 2 Diabetes (T2D) (2012) 1.4 1.6 6.0 -0.1 1.1 -1.7 -0.6 -2.5 0.1 1.0
Ulcerative Colitis 1.3 1.8 6.5 1.4 1.3 0.8 1.4 0.3 2.6 -0.4
Blood Eosinophil Count 0.2 1.7 6.4 2.5 1.6 0.7 1.2 -1.1 -0.3 -0.1
Blood Platelet Count 0.4 5.1 22.3 0.7 -0.8 1.9 0.2 2.9 -0.6 -4.7
Blood Red Count 0.8 7.7 15.2 3.9 3.8 0.2 1.7 -2.6 3.7 0.6
Blood White Count 3.1 23.0 49.0 6.9 7.0 2.3 5.3 -4.0 2.8 -2.7
Heel T-Score 0.2 1.9 4.7 2.2 1.4 -0.7 1.8 -1.6 -0.3 -0.4
BMI 0.2 1.3 2.7 1.5 1.6 -1.0 -0.1 -1.6 -0.8 -0.2
Height 0.1 2.7 16.1 -0.1 1.1 0.4 1.1 0.3 4.0 -0.1
Waist Hip Ratio (WHR) 1.4 6.3 13.9 3.2 3.7 0.6 3.3 -2.0 1.7 -1.3
Systolic Blood Pressure 0.5 2.6 7.5 2.7 1.7 -0.6 1.5 -2.0 0.9 -0.1
Smoking Status 1.2 2.8 12.4 -0.6 -0.3 -1.5 -1.1 -1.5 -3.5 1.1
Allergy or Eczema 0.1 0.4 0.7 -0.4 0.5 0.7 -0.6 0.7 0.5 -0.8
Cardiovascular Disease 1.5 4.9 10.1 3.0 3.0 -0.1 3.2 -1.4 1.8 -1.1
Hypothyroidism (self reported) 1.3 3.1 8.4 -0.6 0.5 -1.7 -0.5 -2.9 -1.0 2.9
Respiratory disease 0.8 1.9 5.9 -1.0 -1.1 1.3 -1.7 2.4 0.7 0.0
Type 2 Diabetes (T2D) (2018) 0.9 1.7 3.5 1.6 1.8 -1.0 1.9 -1.3 -0.2 -0.5
Lung FEV1/FVC ratio 0.7 3.3 6.5 -1.7 -0.9 -2.2 -1.8 -0.9 -2.5 2.1
Lung FVC 0.3 1.4 4.8 -0.0 -0.7 -2.2 -0.2 1.0 1.5 -1.1
Neuroticism 1.0 2.5 8.4 -2.9 -1.5 -0.9 -1.9 -0.4 -1.5 -0.0
Chronotype (morning person) 0.6 1.3 4.5 2.1 0.9 1.0 1.5 0.2 0.3 0.5
Hair Pigment 0.1 3.0 5.2 2.1 0.2 2.3 1.3 1.7 1.6 -1.9
Tanning 0.0 0.5 1.0 -0.1 -0.9 1.0 -1.0 0.0 -0.4 0.9
Hand grip strength (left) 0.5 1.3 5.8 0.7 0.4 -2.4 1.4 -0.1 0.8 0.1
Number of treatments/medications taken 1.7 3.0 8.1 0.4 2.6 2.1 -0.3 -0.6 2.8 -1.0
Average weekly spirits intake 1.1 1.3 2.2 1.5 1.4 0.9 1.4 -0.3 1.3 -0.6
Sensitivity / hurt feelings 0.7 1.3 2.8 -1.1 -1.1 -1.1 -0.2 -1.1 -1.7 1.1
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.7 -1.0 -1.1 0.1 -0.0 1.3 -1.0 -1.2
Hearing difficulty/problems: Yes 2.3 3.4 6.0 1.9 2.3 2.0 2.5 -0.2 1.7 -1.5
Relative age of first facial hair 1.0 2.1 5.8 -2.4 -2.3 -0.5 -1.8 0.1 -0.3 0.3
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 4.1 -0.5 0.7 2.0 -1.4 0.1 -0.1 0.7
Ever used hormone-replacement therapy (HRT) 1.3 1.6 5.5 -2.3 -0.0 0.1 -2.3 -0.3 0.3 -0.5
Ever had hysterectomy (womb removed) 0.6 0.7 2.4 0.4 0.3 1.2 -0.0 -0.8 1.6 -0.4
Systolic blood pressure, automated reading 0.3 0.9 3.5 1.9 0.7 -0.4 0.7 -1.3 0.2 0.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.5 1.1 0.9 0.4 1.2 -0.3 -1.0 -0.6
Angina 0.9 1.2 2.7 -0.4 0.2 -0.3 -1.6 -1.1 -1.4 1.5
Medication for hormone replacement therapy 1.7 1.9 3.2 -1.4 -1.6 -1.8 -0.6 -0.9 -1.1 1.8
Vitamin and mineral supplements 0.7 0.9 2.5 1.2 1.0 -0.3 0.5 -1.6 1.0 0.5
Supplements: Zinc 0.4 0.4 0.7 -0.8 -0.4 0.6 -0.8 0.5 0.2 0.8
Medication: Co-codamol 0.5 0.5 2.9 0.8 0.3 0.1 0.0 1.7 -0.1 0.2
Medication: Metformin 1.0 1.4 3.3 1.6 1.8 0.1 1.0 -1.0 -0.3 -1.4
Diabetes (father) 0.2 0.3 0.7 0.5 -0.0 -0.4 0.9 0.3 -0.6 0.4
Diabetes (mother) 1.7 2.2 6.0 2.3 1.7 0.9 2.5 -0.5 0.4 0.3
Severe depression (siblings) 3.7 4.2 8.1 -2.4 -1.5 -1.2 -2.3 -0.8 -2.4 2.9
Pack years adult smoking proportion 0.2 0.3 0.6 0.2 0.5 0.8 -0.3 0.8 -0.5 -0.0
Impedance of leg (right) 0.5 2.6 5.6 0.8 0.0 2.0 1.6 2.4 1.6 -1.7
Leg fat-free mass (left) 0.1 0.6 1.6 -0.3 1.0 -0.9 -1.2 -0.8 -0.5 0.5
Trunk fat percentage 0.3 1.1 2.9 1.0 0.9 0.1 -0.3 -0.6 -1.6 -1.7
Hand grip strength (right) 0.3 0.9 5.2 0.1 0.1 -2.3 0.8 -0.2 0.6 0.4
Townsend deprivation index at recruitment 1.4 2.0 5.8 -1.2 -2.4 -1.5 -1.1 -0.3 -1.2 1.3
Current tobacco smoking 0.6 1.0 3.8 -0.8 -0.7 -0.7 -0.7 -0.4 -1.9 0.7
Average weekly fortified wine intake 0.7 0.8 3.5 -0.1 0.2 1.4 -0.2 -0.1 1.9 0.2
Maternal smoking around birth 0.5 0.7 1.2 1.1 0.9 -0.4 0.4 -0.9 -0.9 1.0
Fed-up feelings 0.3 0.5 1.3 -1.1 -0.5 -0.4 -1.2 -0.2 -0.2 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 5.8 -1.3 -1.2 -0.7 -1.2 1.9 -2.4 -0.7
Relative age voice broke 1.6 2.4 7.8 -1.7 -1.8 -0.2 -2.8 0.7 -0.9 1.3
Taking other prescription medications 0.6 1.0 3.9 -0.1 1.4 0.6 -0.4 -0.1 0.7 -2.0
Age when periods started (menarche) 0.2 0.6 1.8 0.3 -0.7 -0.1 -0.4 0.2 1.3 1.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 -0.5 -0.0 0.2 0.1 -0.4 0.5 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 4.7 -0.1 -0.7 -2.2 -0.1 -0.8 -1.1 1.0
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 3.1 -1.0 0.3 -0.1 -1.8 -1.3 -0.7 0.8
Qualifications: CSEs or equivalent 0.1 0.2 0.6 0.5 -0.6 -0.1 0.8 0.1 -0.2 0.2
Serious illness, injury or assault to yourself 0.6 0.7 3.0 -0.9 0.9 0.2 -0.3 -0.2 0.4 -1.7
High blood pressure 1.2 3.3 8.5 2.5 2.4 -0.6 1.5 -2.9 0.3 0.4
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.4 0.2 0.6 0.5 -0.1 0.6 -0.1 0.1
Multivitamins +/- minerals 0.1 0.2 0.5 0.2 -0.5 -0.6 0.5 0.7 -0.0 -0.3
Stomach or abdominal pain in last month 0.4 0.5 1.4 -0.3 -0.6 0.1 -1.0 1.2 -0.3 0.7
Supplements: Glucosamine 0.6 0.8 3.7 -0.4 -0.6 1.9 0.1 0.9 -0.0 -0.6
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 3.9 -1.2 -0.5 1.3 -1.6 1.3 -0.2 -2.0
Medication: Atenolol 1.3 1.7 6.9 -0.4 1.1 -0.1 -0.9 -2.6 0.2 1.6
Medication: Levothyroxine sodium 1.8 3.0 11.1 -0.9 0.5 -2.0 -0.5 -3.3 -0.4 2.0
Sitting height 0.8 5.4 15.9 2.1 3.0 1.1 2.0 0.4 4.0 -1.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.1 -0.7 -0.4 -0.8 -1.1 -0.5 -0.7 1.1
High blood pressure (mother) 0.6 0.9 2.4 -0.6 0.6 -1.5 -0.2 -1.5 0.7 0.3
Body mass index (BMI) 0.3 1.5 4.0 0.8 1.0 -0.8 -0.4 -1.9 -2.0 -0.4
Impedance of leg (left) 0.4 2.0 3.5 0.9 0.3 1.6 1.9 1.5 1.4 -1.7
Leg predicted mass (left) 0.1 0.7 1.6 -0.4 0.9 -0.9 -1.3 -0.8 -0.7 0.5
Trunk fat mass 0.2 0.9 2.2 1.0 1.2 -0.0 -0.1 -0.6 -1.2 -1.5
Waist circumference 0.4 1.4 4.3 1.2 2.1 0.3 0.5 -1.4 -0.5 -1.3
Number of incorrect matches in round 1.2 2.0 6.9 0.9 2.3 -0.7 0.6 -2.6 0.4 -0.5
Past tobacco smoking 0.3 0.6 1.6 0.4 0.0 0.3 1.3 0.8 1.2 -0.5
Alcohol usually taken with meals 0.5 0.9 2.9 -0.9 -0.1 -1.7 -0.6 -0.1 1.3 -0.4
Nervous feelings 1.2 2.3 4.3 -2.1 -1.3 -1.1 -1.3 -1.1 -1.6 1.8
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.2 7.7 -2.8 -2.6 -1.2 -2.5 2.6 -1.1 0.0
Hearing difficulty/problems with background noise 0.3 0.4 1.5 -0.9 -0.2 0.1 -1.2 -0.7 0.2 0.4
Hair/balding pattern: Pattern 2 0.5 0.7 2.5 -0.5 -1.3 0.1 -0.3 1.6 0.5 0.2
Had menopause 0.9 1.1 5.0 -2.2 -0.7 0.1 -1.3 -0.4 0.5 0.1
Had other major operations 0.4 0.4 1.4 0.7 0.2 1.2 -0.2 0.3 0.7 -0.6
Forced vital capacity (FVC) 0.5 2.0 6.7 -0.0 -0.0 -1.4 0.5 1.9 2.6 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 4.5 -0.0 -0.4 -2.1 0.3 -0.5 -0.8 0.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.5 0.2 0.6 -1.6 0.6 -0.4 -0.2 0.8
Qualifications: None of the above 0.3 0.7 1.1 0.9 -0.2 -1.1 0.4 -0.9 -1.1 1.0
Financial difficulties in last 2 years 2.1 2.8 4.7 -1.5 -2.0 -2.2 -1.1 -0.9 -2.0 1.6
Mouth/teeth dental problems 0.3 0.4 1.2 0.2 0.3 -0.1 0.8 -1.0 0.3 -1.1
Heart attack 0.5 0.7 2.0 0.8 0.1 -0.2 0.6 0.3 -1.4 1.2
Allergy 0.1 0.2 0.7 0.0 -0.0 -0.9 0.1 -0.8 0.2 -0.0
Pain all over the body in last month 0.7 0.8 2.2 -0.6 -0.0 -0.8 -0.7 -1.5 -1.0 -0.8
Diabetes (self-reported) 1.3 2.0 6.2 1.6 2.5 -0.4 1.4 -1.3 0.0 -1.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.2 -0.2 0.9 0.6 -0.1 -0.5 1.5 -0.0
Medication: Ramipril 1.0 1.3 4.1 0.9 2.0 -0.8 0.9 -1.6 0.3 0.3
Medication: Simvastatin 1.0 1.5 4.2 1.0 2.1 -0.7 0.5 -1.6 0.9 -1.0
Fluid intelligence score 0.1 0.1 0.4 0.2 -0.3 0.3 0.4 0.1 -0.4 0.6
Illnesses of siblings 0.3 0.4 0.9 -1.0 -0.8 -0.1 -0.9 0.6 -0.4 0.5
Neuroticism score 0.9 2.0 6.4 -2.5 -1.9 -0.9 -1.5 -0.0 -0.7 -0.1
Weight 0.1 0.5 1.5 0.5 1.2 -0.2 -0.3 -0.8 -0.7 -0.6
Impedance of arm (right) 0.4 1.8 6.6 -0.6 -1.5 1.4 -0.4 2.6 -0.1 -1.1
Arm fat percentage (right) 0.3 1.3 3.6 1.0 0.6 -0.6 -0.3 -0.7 -1.9 -1.8
Trunk fat-free mass 0.1 0.8 2.3 0.0 1.5 -0.7 -0.1 -1.0 1.2 0.4
Hip circumference 0.2 1.0 2.6 -1.0 0.3 0.1 -1.5 -0.4 -0.8 -1.6
Time employed in main current job 1.8 2.1 8.0 -1.1 -1.6 -2.8 0.1 -1.5 -0.5 0.6
Alcohol intake versus 10 years previously 0.4 0.6 1.6 0.7 1.3 0.2 1.0 -0.8 -0.4 0.7
Father’s age at death 1.3 1.7 3.7 -1.4 -1.2 -1.5 -1.9 0.5 -1.4 0.7
Worrier / anxious feelings 0.2 0.4 0.9 -0.4 0.4 -0.1 -0.8 -0.9 0.4 -0.8
Frequency of tiredness / lethargy in last 2 weeks 1.8 3.0 6.5 -1.8 -2.5 -1.2 -2.2 1.5 -1.7 -0.2
Falls in the last year 1.9 2.6 7.4 -0.4 -0.2 2.7 -0.6 2.4 0.3 -2.0
Hair/balding pattern: Pattern 3 0.4 0.6 2.6 0.5 1.6 0.7 -0.4 -0.4 0.1 -0.5
Number of live births 0.6 0.9 2.4 -0.4 -0.9 -1.4 -0.3 -0.6 -0.5 1.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 4.0 -0.5 -0.9 -1.8 -0.1 2.0 1.2 -0.1
Pulse rate 0.2 0.3 1.2 0.4 -0.7 0.0 0.4 1.1 0.4 0.0
Happiness 0.1 0.2 0.3 -0.3 0.6 -0.4 -0.5 -0.0 -0.5 -0.4
Noisy workplace 1.5 1.9 7.6 1.8 2.8 0.6 0.1 -0.8 1.1 0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.3 -0.4 0.2 0.1 -1.2 0.1 -0.9 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.1 -0.0 0.5 -0.2 0.8 0.6 1.0 -0.6
Mouth/teeth dental problems: Dentures 0.3 0.5 2.0 0.7 0.4 1.4 -0.0 0.8 0.3 0.0
Asthma 0.7 1.4 3.4 -1.3 -1.2 0.9 -1.2 1.8 0.7 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.5 0.1 0.5 1.2 -0.1 0.7 0.6 -0.1
Medication: Cholesterol lowering 1.6 2.4 4.5 2.0 2.1 0.6 1.5 -0.7 1.0 -2.0
Depression (self-reported) 0.5 0.6 1.6 -0.5 -1.3 0.0 -0.4 0.7 -1.0 0.9
Medication: Lansoprazole 0.8 0.9 3.7 0.9 0.3 1.1 0.6 1.9 0.6 -0.1
Prospective memory result 1.1 1.4 4.0 2.0 0.8 -0.8 1.6 0.4 -0.8 -0.9
Lung cancer (father) 0.3 0.4 0.8 -0.8 -0.4 -0.5 -0.4 -0.9 0.0 0.9
Illnesses of mother 2.2 2.7 6.2 -1.5 -2.0 0.7 -1.6 2.5 -1.9 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 4.9 0.2 -0.9 -2.2 1.0 1.4 0.9 -0.5
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 1.0 1.4 0.1 0.9 -0.1 0.6 -0.6
Impedance of arm (left) 0.5 2.4 8.1 -0.8 -1.8 1.7 -0.7 2.9 -0.3 -0.9
Arm fat mass (right) 0.2 1.0 2.1 0.7 0.9 -0.8 -0.3 -1.1 -1.4 -1.4
Trunk predicted mass 0.1 0.8 2.4 0.0 1.5 -0.6 -0.1 -1.0 1.2 0.4
Standing height 0.2 1.8 8.0 -0.7 0.5 0.8 -0.0 1.6 2.8 -0.4
Length of working week for main job 0.8 0.9 4.0 0.2 -0.6 -0.8 -0.6 0.8 -2.0 0.3
Exposure to tobacco smoke at home 0.9 1.0 2.1 0.5 1.1 -0.3 1.2 -1.4 0.4 -1.4
Breastfed as a baby 0.9 1.1 2.7 -1.5 -1.6 -1.2 -0.9 0.2 0.3 0.8
Tense / ‘highly strung’ 0.6 1.0 3.9 -2.0 -0.8 -0.4 -1.3 -0.5 -0.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.9 -0.8 -0.2 0.1 -0.5 0.9 0.5 -0.5
Hair/balding pattern: Pattern 4 1.1 2.6 10.1 1.5 1.1 1.2 0.8 0.2 3.2 -1.5
Birth weight of first child 0.7 1.3 3.9 -1.1 0.0 -0.6 -1.6 -1.1 -0.1 -2.0
Peak expiratory flow (PEF) 0.3 0.8 3.0 -0.2 -0.6 -0.7 -0.1 1.7 0.3 1.3
Pulse wave reflection index 1.2 1.5 2.7 1.5 1.6 0.5 1.6 -1.0 -0.1 -1.2
Ever highly irritable/argumentative for 2 days 0.8 0.9 4.5 0.0 -0.1 0.8 0.1 2.1 0.1 -1.2
Loud music exposure frequency 1.2 1.3 2.9 -1.1 -0.9 -1.4 -1.7 -0.4 -0.1 1.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.0 -0.7 0.2 0.1 -0.3 -1.4 0.8 0.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 2.5 -0.1 0.6 -0.7 -0.8 -0.0 0.0 1.6
Blood clot in the leg (DVT) 0.6 0.7 2.8 0.5 0.3 -0.7 0.6 -0.6 0.8 1.7
Medication: Paracetamol 0.8 1.3 4.7 0.6 0.4 1.5 0.3 2.2 0.5 -1.2
Headache pain in last month 1.2 2.0 5.2 2.3 1.6 1.2 1.5 1.4 0.0 -0.7
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 8.8 -2.0 -3.0 0.5 -0.9 2.3 -1.0 0.9
Glaucoma (self-reported) 0.8 0.9 2.8 -1.2 0.3 -0.6 -0.9 -1.7 -0.0 0.9
Gout (self-reported) 1.1 1.5 4.1 -0.8 0.7 -2.0 0.0 -2.0 -0.5 -0.9
Hypothyroidism/myxoedema (self-reported) 2.4 4.7 16.2 -0.3 1.1 -2.1 -0.5 -4.0 -0.7 3.2
Medication: Amlodipine 0.8 1.1 2.5 0.9 1.0 -1.3 0.7 -1.6 -1.1 0.3
Medication: Ventolin 100micrograms inhaler 0.7 0.9 3.3 0.4 0.2 1.7 -0.0 1.8 0.5 -0.0
Birth weight 0.1 0.1 0.5 0.1 0.0 -0.0 -0.0 0.7 -0.0 -0.7
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.6 1.0 0.4 -0.3 1.0 -1.6 1.9 0.9
High blood pressure (siblings) 0.2 0.3 1.0 0.8 1.0 -0.2 0.3 -0.3 -0.1 0.4
Forced vital capacity (FVC), Best measure 0.5 2.0 4.8 0.5 -0.5 -1.4 1.5 1.4 2.2 -1.5
Body fat percentage 0.3 1.2 3.4 1.2 0.8 -0.1 -0.0 -0.5 -1.9 -1.6
Leg fat percentage (right) 0.3 1.2 2.5 1.6 0.9 0.2 0.5 -0.3 -1.4 -1.6
Arm fat-free mass (right) 0.1 0.7 1.8 0.0 1.3 -1.0 -0.0 -1.3 0.3 0.4
Exposure to tobacco smoke outside home 0.8 1.1 4.6 0.1 -0.4 1.3 -0.2 0.8 -2.1 0.9
Comparative body size at age 10 0.5 1.3 2.6 1.5 1.6 0.6 1.5 -0.1 -0.7 -1.0
Number of full brothers 0.5 0.6 1.8 0.6 -0.8 -0.3 0.1 -0.8 -1.3 0.8
Worry too long after embarrassment 1.0 1.6 5.0 -2.2 -0.1 0.9 -2.0 -0.2 -0.1 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 1.9 -1.4 -1.0 -0.6 -1.0 1.4 -1.2 -0.2
Wheeze or whistling in the chest in last year 0.7 1.2 3.4 0.3 0.8 1.8 -0.3 0.5 1.1 -1.6
Number of children fathered 1.1 1.2 3.9 2.0 0.5 0.9 1.5 0.7 -0.7 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 2.6 0.5 0.5 -0.8 0.4 0.8 1.6 -1.5
Age at first live birth 0.2 0.4 1.2 -0.2 0.6 0.7 -0.3 0.4 0.5 1.1
Pulse wave peak to peak time 0.5 0.6 1.9 -1.0 -1.4 -0.3 -0.8 0.1 -0.3 0.7
Health satisfaction 2.0 2.6 8.7 1.9 3.0 0.2 0.6 -0.3 1.7 -1.5
Shortness of breath walking on level ground 1.5 1.8 4.0 2.0 1.4 0.9 1.8 0.4 1.0 -1.3
Qualifications: College or University degree 0.8 2.4 7.2 -2.4 -0.8 -0.1 -1.9 0.2 -0.5 2.7
Eye problems/disorders: None of the above 0.8 0.9 3.7 0.9 0.4 -0.6 0.5 0.1 -1.0 1.9
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.1 0.9 0.6 1.4 1.0 -0.4 1.0 -0.6
Emphysema/chronic bronchitis 0.4 0.5 1.2 0.4 -0.8 0.8 -0.0 1.0 -1.1 0.2
Medication for pain relief, constipation, heartburn 0.6 1.0 3.7 -0.1 -0.2 -1.5 0.1 -1.9 -0.8 0.8
Neck or shoulder pain in last month 1.2 1.8 4.3 1.7 2.1 1.2 0.8 -0.9 0.6 -1.4
Medication: Blood pressure 2.7 4.8 13.5 2.7 3.7 -0.5 1.1 -3.2 1.0 -0.1
Angina (self-reported) 0.7 1.0 2.5 -0.1 0.3 -0.0 -1.4 -1.0 -1.1 1.6
Migraine (self-reported) 0.9 1.1 2.7 0.4 -1.0 1.6 0.7 1.2 -0.6 -1.2
Medication: Ibuprofen 0.6 0.8 1.6 0.2 1.3 1.2 -0.5 0.9 1.1 -0.1
Medication: Allopurinol 0.6 0.8 1.9 -0.5 0.7 -1.4 0.3 -1.2 -0.6 -1.0
Medication: Omeprazole 0.2 0.3 0.9 -0.9 -0.2 -0.7 -0.3 0.4 0.2 -0.4
Medication: Seretide 50 evohaler 1.5 1.7 2.9 -0.5 -1.4 1.1 -1.7 1.7 -1.5 0.8
Mean time to correctly identify matches 1.4 2.7 7.2 -1.4 -0.8 -0.6 -2.4 -1.3 -1.1 2.7
Heart disease (mother) 0.8 0.9 4.5 -0.3 0.8 -1.0 -0.2 -0.4 0.2 -2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 2.8 -0.2 0.8 -1.0 -1.4 -1.7 -0.5 1.2
Whole body fat mass 0.3 1.0 2.2 1.2 1.2 -0.3 -0.0 -0.7 -1.5 -1.2
Leg fat mass (right) 0.3 1.0 2.0 1.2 1.4 -0.1 0.1 -0.9 -1.3 -1.1
Arm predicted mass (right) 0.1 0.5 1.4 -0.1 1.1 -0.8 -0.2 -1.2 0.3 0.5
Pulse rate, automated reading 0.4 1.1 3.7 1.9 0.7 -1.1 1.3 0.6 -0.1 -0.7
Alcohol intake frequency. 0.7 1.6 2.9 1.6 1.7 -1.0 1.7 -0.8 1.0 0.6
Comparative height size at age 10 0.3 1.5 4.5 -1.1 0.6 0.9 -0.8 2.1 1.7 -0.5
Number of full sisters 1.8 2.2 5.4 -1.9 -0.8 -1.7 -1.3 -2.3 -0.6 0.9
Suffer from ‘nerves’ 1.4 2.2 5.5 -2.2 -2.3 0.3 -1.1 1.2 -1.6 -0.2
Overall health rating 0.4 0.9 2.1 0.7 1.1 1.4 -0.2 0.6 -0.5 -1.4
Chest pain or discomfort 2.6 3.7 13.0 -2.3 -1.1 -0.6 -3.6 -0.3 -0.4 2.4
Had major operations 1.1 1.3 5.1 0.4 -0.5 1.0 0.0 2.2 1.1 -1.2
Age at last live birth 0.6 0.8 4.5 -0.3 -0.7 0.1 -0.2 0.6 -0.7 2.1
Family relationship satisfaction 0.5 0.6 1.7 -1.1 0.2 -0.7 -0.7 -0.4 -1.3 -0.2
Leg pain on walking 0.6 0.7 4.2 -0.2 0.0 0.3 0.4 0.5 0.4 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.1 1.2 1.8 0.3 0.9 -1.1 0.3 0.2
Commuting to job workplace: Car/motor vehicle 2.3 2.6 9.0 1.1 0.8 0.8 1.5 1.1 1.9 -3.0
Illness, injury, bereavement, stress in last 2 years 0.9 1.2 3.3 1.1 1.1 1.8 0.4 0.3 1.5 -0.2
Medication: Aspirin 0.1 0.2 0.8 0.5 0.0 0.2 0.2 0.1 0.9 0.3
Supplements: Vitamin C 3.7 4.4 8.1 -2.8 -2.9 0.5 -2.0 2.3 -1.6 1.5
Knee pain experienced in last month 0.4 0.6 2.7 -0.1 0.4 1.6 -0.6 0.2 -0.2 -0.7
Hypertension (Self-reported) 1.5 4.3 8.7 2.8 2.9 -0.2 2.2 -2.7 0.9 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 3.2 -0.1 -0.5 1.8 0.6 1.8 0.9 -1.1
Illnesses of father: Heart disease 1.2 1.7 4.0 1.4 1.0 2.0 1.3 0.5 1.8 -0.0
Illnesses of siblings: Diabetes 0.5 0.6 2.4 0.5 0.4 -0.4 1.6 -0.6 0.1 -0.9
Smoking status: Previous 0.2 0.3 0.6 0.8 0.5 -0.0 -0.6 -0.3 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.6 0.8 0.1 -0.1 0.8 0.4 -0.2 0.7
Whole body fat-free mass 0.1 0.7 2.0 -0.0 1.4 -0.8 -0.4 -1.1 0.5 0.4
Leg fat-free mass (right) 0.1 0.8 1.4 -0.4 0.9 -1.2 -1.1 -1.1 -0.6 0.5
Arm fat percentage (left) 0.3 1.3 5.2 0.8 0.2 -0.5 -0.6 -0.6 -2.3 -1.5
Average weekly red wine intake 1.5 2.2 6.0 -2.4 -1.4 -2.0 -1.7 -0.3 0.5 0.8
Handedness (chirality/laterality): Left-handed 1.8 2.1 6.2 1.5 2.5 0.5 1.1 -0.5 1.3 -1.6
Mood swings 0.3 0.5 1.4 -0.3 -0.9 -0.3 -0.0 0.3 -1.0 -1.2
Loneliness, isolation 1.5 2.1 5.8 -2.4 -1.6 -0.6 -1.6 0.4 -1.5 0.7
Long-standing illness, disability or infirmity 0.9 1.4 3.8 1.5 1.9 1.5 0.5 -0.6 -0.1 -1.1
Ever had bowel cancer screening 1.0 1.1 1.9 -0.8 -1.1 1.2 -1.0 1.4 -0.2 -1.3
Diabetes diagnosed by doctor 1.0 1.7 5.0 1.4 2.2 -0.8 0.9 -1.6 -0.1 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 0.5 1.3 -0.2 0.3 -1.0 0.3 -0.1
Friendships satisfaction 1.8 2.2 5.0 -1.8 -0.4 -1.7 -1.5 -0.7 -2.2 1.0
Qualifications: nursing, teaching 0.5 0.7 2.6 -0.1 1.1 0.9 -0.6 -0.3 1.6 0.2
Commuting to job workplace: Walk 1.0 1.1 4.1 -0.7 -2.0 -0.9 -0.1 0.9 -0.8 -0.6
Eye problems/disorders: Cataract 1.4 1.6 4.4 -2.1 -1.6 -0.5 -1.8 0.2 -0.6 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.6 -1.2 -0.7 -0.6 -1.0 0.9 0.7 0.1
Medication for cholesterol 1.4 2.1 9.6 -0.5 -1.4 -0.1 -0.7 3.1 -1.5 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 7.1 -2.7 -0.7 -1.4 -2.1 -0.1 0.2 0.3
Back pain experienced in last month 0.2 0.2 0.7 0.4 0.2 -0.2 0.8 0.8 0.1 -0.4
Mineral and other dietary supplements 1.8 2.5 8.9 0.5 1.0 -2.3 0.0 -3.0 0.6 1.2
Breast cancer (self-reported) 0.8 1.0 2.6 1.6 1.1 0.2 1.6 -0.7 0.1 -0.4
Asthma (self-reported) 0.7 1.4 3.1 -1.4 -1.0 1.2 -1.2 1.8 0.8 -0.7
Osteoporosis (self-reported) 0.6 0.7 1.8 -0.4 0.8 1.3 -1.3 0.2 0.5 -0.4
Osteoarthritis (self-reported) 0.6 0.8 2.6 -0.8 -0.7 1.1 -0.6 0.3 -0.5 1.6
Medication: Aspirin 0.1 0.2 0.5 0.2 -0.0 0.2 -0.3 -0.0 0.7 0.7
Medication: Gliclazide 1.2 1.4 3.7 1.6 1.7 -0.0 0.7 -0.0 -0.0 -1.9
Illnesses of father: None of the above (group 1) 0.4 0.5 1.9 -0.6 -0.0 -0.2 -0.7 0.7 0.2 -1.4
Smoking status: Current 1.0 1.6 4.8 -1.3 -1.0 -1.2 -1.0 -0.7 -2.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 11.6 -1.0 -1.9 -3.4 -0.6 0.6 0.1 1.5
Whole body water mass 0.1 0.7 1.8 -0.1 1.4 -0.9 -0.5 -1.1 0.5 0.3
Leg predicted mass (right) 0.1 0.7 1.3 -0.4 0.9 -1.2 -1.1 -1.1 -0.6 0.5
Arm fat mass (left) 0.3 1.1 2.6 0.6 1.0 -0.5 -0.5 -1.1 -1.6 -1.3
Number of self-reported non-cancer illnesses 0.4 0.6 1.5 -0.7 1.2 0.5 -0.1 -1.0 0.9 -0.6
Average weekly champagne plus white wine intake 0.2 0.2 0.8 -0.1 0.3 0.3 -0.7 0.9 0.2 0.4
Miserableness 1.1 1.9 5.2 -2.3 -1.6 -1.2 -1.6 -0.3 -1.0 -0.3
Guilty feelings 0.6 0.9 1.9 -1.4 -1.4 0.1 -0.3 0.8 -0.4 -1.3
Wears glasses or contact lenses 2.7 3.1 7.2 -2.4 -0.6 -2.4 -2.7 -1.1 0.1 -0.7
Ever taken oral contraceptive pill 1.3 1.5 4.8 1.0 2.2 0.6 0.7 -0.8 1.7 0.1
Hearing aid user 0.4 0.4 1.3 -0.1 0.5 0.5 0.8 -1.1 0.0 -0.7
Mother’s age at death 2.0 2.5 7.1 0.7 0.8 2.7 1.0 1.8 1.7 -1.5
Financial situation satisfaction 1.1 1.3 3.0 -1.1 -0.4 -1.7 -1.6 -0.3 -1.4 0.5
Tinnitus: Yes, now most or all of the time 0.9 1.1 4.0 -0.0 1.3 1.0 -0.5 -0.6 0.5 -2.0
Commuting to job workplace: Public transport 1.4 1.7 5.5 -2.4 -1.3 -0.5 -1.5 -0.4 -0.3 1.3
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 -0.7 0.4 -0.1 -0.8 -0.8 0.5 0.4
Medication: Blood pressure 3.6 6.8 13.5 2.6 3.5 1.3 3.0 -3.7 2.0 -0.9
Pain type(s) experienced in last month: Hip pain 1.5 1.9 6.7 0.6 -0.2 2.4 -0.5 2.6 0.4 0.6
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.3 -1.0 -1.2 1.0 -0.2 1.5 0.3 -0.7
High cholesterol (Self-reported) 0.6 1.1 4.3 0.3 0.9 0.3 0.4 -0.4 1.5 -2.1
Medication: Bendroflumethiazide 1.8 2.7 5.6 2.3 2.4 0.6 2.0 -1.4 1.1 0.3
Medication: Paracetamol 1.1 1.7 4.5 1.0 0.7 2.0 0.2 2.1 0.8 -1.2
Medication: Lisinopril 1.6 2.0 6.9 1.1 2.3 -0.0 0.4 -2.6 0.3 -0.7
Medication: Atorvastatin 0.3 0.3 1.0 0.6 0.5 0.2 1.0 -0.5 0.6 -0.3
Illnesses of father: High blood pressure 0.9 1.1 2.6 0.4 0.5 -1.6 0.1 -1.3 -1.3 1.2
Alcohol drinker status: Never 2.2 2.6 10.7 0.9 1.4 0.7 1.7 -0.7 3.3 -0.8
Ever smoked 1.2 2.1 5.2 -1.5 -1.2 -0.3 -2.2 -0.2 -2.3 1.0
Basal metabolic rate 0.1 0.6 2.0 0.0 1.4 -0.8 -0.4 -1.1 0.2 0.1
Leg fat percentage (left) 0.4 1.3 2.6 1.6 1.1 -0.2 0.6 -1.0 -1.6 -1.3
Arm fat-free mass (left) 0.2 0.8 2.7 0.2 1.6 -1.0 0.1 -1.4 0.5 0.0
Number of operations (self-reported) 1.8 2.6 5.2 1.6 0.8 2.3 0.6 2.2 2.1 -0.9
Average weekly beer plus cider intake 1.4 2.0 3.6 1.5 -0.9 1.0 1.9 1.9 -0.7 -1.6
Irritability 0.5 0.8 4.3 0.1 0.9 0.4 -0.5 0.2 0.4 -2.1
Risk taking 0.6 0.9 3.4 -0.3 0.1 -1.1 0.0 -1.3 -1.8 -0.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.0 -0.2 -0.1 -0.1 0.5 0.8 1.4 -0.6
Fractured/broken bones in last 5 years 0.5 0.6 1.8 -0.6 0.6 1.1 -0.7 0.2 0.3 -1.4
Age started oral contraceptive pill 1.1 1.3 4.5 -1.7 0.1 0.4 -2.1 -1.0 0.4 0.8
Diastolic blood pressure, automated reading 0.5 1.5 4.4 2.1 1.2 -0.7 1.6 -0.7 1.0 -0.5
Ever depressed for a whole week 0.5 0.6 3.2 0.3 0.8 0.3 0.7 -0.4 1.8 0.1
Unable to work because of sickness or disability 0.6 0.7 1.9 1.1 0.7 0.8 1.4 0.7 0.1 -0.6
Commuting to job workplace: Cycle 0.4 0.5 2.3 0.0 -0.4 1.5 -0.0 0.6 0.8 0.2
Myopia 2.0 2.8 4.9 -1.1 -2.0 -2.2 -1.1 -0.3 -1.9 2.2
Vascular/heart problems diagnosed by doctor 0.9 2.5 7.2 -2.0 -2.2 0.5 -0.8 2.7 -0.1 -1.0
Cholesterol lowering medication 0.8 1.2 4.3 -0.4 1.1 -0.8 -0.5 -2.1 1.2 0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.5 -0.9 0.1 -1.6 -0.0 -0.0 0.3 -0.3
Pain experienced in last month 0.7 1.2 5.2 -0.7 -1.0 -1.2 -0.1 -0.7 0.2 2.3
Supplements: Calcium 1.6 1.8 5.1 -1.4 -0.6 -0.5 -2.3 0.2 -1.9 1.3
Basal cell carcinoma (self-reported) 0.1 0.2 0.7 -0.1 -0.4 -0.4 0.4 0.0 -0.2 0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.9 0.6 0.0 -0.1 0.4 0.4 -1.3 1.4
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 3.3 0.8 0.5 -0.8 0.7 -0.7 0.8 1.8
Heart disease (siblings) 0.2 0.3 1.0 0.6 0.6 0.2 0.2 -1.0 -0.4 -0.3
Alcohol drinker status: Previous 1.0 1.1 2.2 -0.7 -1.0 0.3 -1.0 1.3 -1.5 1.0
Pack years of smoking 0.3 0.4 1.3 0.3 0.6 1.1 -0.3 0.9 -0.3 0.1
Impedance of whole body 0.4 2.0 6.5 -0.1 -1.1 1.8 0.5 2.5 0.5 -1.6
Leg fat mass (left) 0.3 1.2 2.2 1.3 1.4 -0.4 0.2 -1.3 -1.5 -0.9
Arm predicted mass (left) 0.2 1.3 3.5 0.4 1.9 -1.1 0.4 -1.8 0.6 0.1