Best TWAS P=4.19e-15 · Best GWAS P=5.36e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | LIPA | 0.08 | 0.06 | enet | 20 | 0.06 | 6.3e-09 | 7.7 | 7.6 | 3.3e-14 | 0.93 | 0.00 | 1.00 | FALSE |
2 | NTR | Blood | LIPA | 0.30 | 0.22 | lasso | 6 | 0.24 | 1.2e-77 | 7.8 | 7.8 | 8.5e-15 | 0.95 | 0.00 | 1.00 | FALSE |
3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIPA | 0.07 | 0.06 | lasso | 4 | 0.06 | 9.8e-12 | 7.7 | 7.5 | 5.0e-14 | 0.93 | 0.00 | 1.00 | FALSE |
4 | The Cancer Genome Atlas | Glioblastoma Multiforme | LIPA | 0.15 | 0.11 | enet | 8 | 0.05 | 1.5e-02 | 7.4 | 6.3 | 3.3e-10 | 0.88 | 0.01 | 0.94 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIPA | 0.28 | 0.16 | enet | 13 | 0.16 | 1.3e-17 | 7.8 | 7.3 | 2.3e-13 | 0.95 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIPA | 0.11 | 0.05 | lasso | 3 | 0.04 | 1.2e-05 | 7.8 | 7.8 | 4.4e-15 | 0.95 | 0.00 | 1.00 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | LIPA | 0.14 | 0.06 | lasso | 5 | 0.07 | 3.9e-08 | 7.6 | 7.8 | 7.2e-15 | 0.97 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LIPA | 0.14 | 0.11 | lasso | 5 | 0.10 | 1.1e-11 | 7.8 | 7.8 | 4.2e-15 | 1.00 | 0.00 | 1.00 | TRUE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LIPA | 0.16 | 0.11 | lasso | 2 | 0.10 | 3.7e-07 | 7.8 | 7.8 | 8.3e-15 | 1.00 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KIF20B | 0.03 | 0.02 | blup | 75 | 0.01 | 1.0e-02 | 4.4 | -5.3 | 1.3e-07 | -0.14 | 0.03 | 0.74 | TRUE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIPA | 0.11 | 0.03 | lasso | 8 | 0.05 | 7.1e-06 | 7.6 | 6.8 | 9.5e-12 | 0.88 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LIPA | 0.15 | 0.05 | enet | 5 | 0.10 | 1.7e-04 | 7.4 | 6.8 | 7.6e-12 | 0.94 | 0.00 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | LIPA | 0.16 | 0.11 | enet | 11 | 0.12 | 4.1e-12 | 7.8 | 7.4 | 1.8e-13 | 0.97 | 0.00 | 1.00 | FALSE |