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chr10:90,278,380-91,869,909

Best TWAS P=4.19e-15 · Best GWAS P=5.36e-15 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LIPA	0.14	0.11	lasso	5	0.10	1.1e-11	7.8	7.8	4.2e-15	1.00	0.00	1.00	TRUE
10	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIF20B	0.03	0.02	blup	75	0.01	1.0e-02	4.4	-5.3	1.3e-07	-0.14	0.03	0.74	TRUE
6	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIPA	0.11	0.05	lasso	3	0.04	1.2e-05	7.8	7.8	4.4e-15	0.95	0.00	1.00	FALSE
7	The Cancer Genome Atlas	Lung Adenocarcinoma	LIPA	0.14	0.06	lasso	5	0.07	3.9e-08	7.6	7.8	7.2e-15	0.97	0.00	1.00	FALSE
9	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LIPA	0.16	0.11	lasso	2	0.10	3.7e-07	7.8	7.8	8.3e-15	1.00	0.00	1.00	FALSE
2	NTR	Blood	LIPA	0.30	0.22	lasso	6	0.24	1.2e-77	7.8	7.8	8.5e-15	0.95	0.00	1.00	FALSE
1	METSIM	Adipose	LIPA	0.08	0.06	enet	20	0.06	6.3e-09	7.7	7.6	3.3e-14	0.93	0.00	1.00	FALSE
3	The Cancer Genome Atlas	Breast Invasive Carcinoma	LIPA	0.07	0.06	lasso	4	0.06	9.8e-12	7.7	7.5	5.0e-14	0.93	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Thyroid Carcinoma	LIPA	0.16	0.11	enet	11	0.12	4.1e-12	7.8	7.4	1.8e-13	0.97	0.00	1.00	FALSE
5	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIPA	0.28	0.16	enet	13	0.16	1.3e-17	7.8	7.3	2.3e-13	0.95	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LIPA	0.15	0.05	enet	5	0.10	1.7e-04	7.4	6.8	7.6e-12	0.94	0.00	0.99	FALSE
11	The Cancer Genome Atlas	Prostate Adenocarcinoma	LIPA	0.11	0.03	lasso	8	0.05	7.1e-06	7.6	6.8	9.5e-12	0.88	0.01	0.99	FALSE
4	The Cancer Genome Atlas	Glioblastoma Multiforme	LIPA	0.15	0.11	enet	8	0.05	1.5e-02	7.4	6.3	3.3e-10	0.88	0.01	0.94	FALSE