Best TWAS P=1.04e-11 · Best GWAS P=1.71e-12 conditioned to 0.0218
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | ROSMAP | Brain Pre-frontal Cortex | TNKS2 | 0.16 | 0.06 | lasso | 10 | 0.09 | 3.3e-11 | -2.6 | 6.8 | 1.0e-11 | 0.40 | 0.96 | 0.04 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | TNKS2 | 0.22 | 0.11 | lasso | 4 | 0.15 | 5.5e-06 | 5.9 | 6.7 | 1.8e-11 | 0.85 | 0.05 | 0.91 | TRUE |
| 5 | GTEx | Thyroid | TNKS2 | 0.11 | 0.14 | lasso | 2 | 0.13 | 7.4e-10 | 6.7 | 6.6 | 5.0e-11 | 0.81 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Thyroid | FGFBP3 | 0.10 | 0.02 | enet | 12 | 0.02 | 1.2e-02 | 5.9 | 5.9 | 4.1e-09 | 0.76 | 0.01 | 0.91 | FALSE |
| 3 | GTEx | Lung | TNKS2 | 0.12 | 0.10 | lasso | 4 | 0.11 | 1.8e-08 | 6.7 | 5.7 | 1.0e-08 | 0.75 | 0.02 | 0.98 | FALSE |
| 1 | GTEx | Artery Aorta | TNKS2 | 0.25 | 0.07 | enet | 9 | 0.12 | 4.3e-07 | 6.1 | 5.7 | 1.4e-08 | 0.86 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Nerve Tibial | TNKS2 | 0.33 | 0.23 | lasso | 9 | 0.29 | 5.0e-21 | 6.7 | 5.2 | 1.6e-07 | 0.79 | 0.02 | 0.98 | FALSE |