Best TWAS P=6.18e-26 · Best GWAS P=8.63e-22 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HELLS | 0.04 | 0.04 | enet | 12 | 0.04 | 5.1e-06 | -9.4 | -10.5 | 9.2e-26 | 0.41 | 0.03 | 0.97 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | HELLS | 0.08 | 0.06 | enet | 30 | 0.04 | 7.0e-04 | -9.3 | -6.7 | 2.6e-11 | 0.35 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Artery Aorta | CYP2C8 | 0.21 | 0.00 | lasso | 8 | 0.00 | 2.2e-01 | -8.3 | -7.4 | 1.0e-13 | 0.09 | 0.18 | 0.04 | FALSE |
| 4 | GTEx | Brain Cerebellum | HELLS | 0.26 | 0.20 | lasso | 9 | 0.19 | 2.8e-06 | -8.1 | -8.2 | 2.7e-16 | 0.36 | 0.06 | 0.94 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | HELLS | 0.16 | 0.09 | enet | 20 | 0.15 | 1.0e-04 | -8.2 | -6.6 | 4.7e-11 | 0.43 | 0.07 | 0.88 | FALSE |
| 6 | GTEx | Nerve Tibial | HELLS | 0.12 | 0.12 | enet | 17 | 0.10 | 1.6e-07 | -9.3 | -9.1 | 9.5e-20 | 0.38 | 0.03 | 0.97 | TRUE |
| 7 | GTEx | Ovary | HELLS | 0.15 | 0.04 | lasso | 5 | 0.09 | 3.1e-03 | -9.4 | -8.9 | 5.4e-19 | 0.34 | 0.04 | 0.81 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | HELLS | 0.05 | 0.02 | lasso | 3 | 0.00 | 1.2e-01 | -8.2 | -6.7 | 2.0e-11 | 0.25 | 0.14 | 0.67 | TRUE |
| 9 | GTEx | Testis | HELLS | 0.08 | 0.00 | enet | 27 | 0.00 | 3.1e-01 | -8.2 | -7.0 | 3.2e-12 | 0.14 | 0.06 | 0.62 | FALSE |
| 10 | GTEx | Testis | PIPSL | 0.14 | 0.00 | enet | 21 | 0.00 | 3.0e-01 | -1.3 | 6.7 | 3.0e-11 | -0.38 | 0.03 | 0.52 | TRUE |
| 11 | GTEx | Thyroid | HELLS | 0.07 | 0.00 | enet | 8 | 0.00 | 2.7e-01 | -9.4 | -9.3 | 1.1e-20 | 0.38 | 0.04 | 0.66 | FALSE |
| 12 | METSIM | Adipose | HELLS | 0.03 | 0.04 | lasso | 3 | 0.03 | 9.3e-05 | -9.3 | -9.3 | 9.2e-21 | 0.39 | 0.03 | 0.97 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | HELLS | 0.02 | 0.01 | blup | 372 | 0.00 | 6.9e-02 | -8.1 | -7.5 | 6.0e-14 | 0.18 | 0.05 | 0.91 | TRUE |
| 14 | YFS | Blood | PDLIM1 | 0.12 | 0.07 | lasso | 11 | 0.07 | 2.3e-22 | -5.9 | 6.0 | 1.7e-09 | 0.07 | 0.97 | 0.03 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -9.3 | -8.5 | 1.8e-17 | 0.35 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TBC1D12 | 0.04 | 0.01 | blup | 63 | 0.03 | 8.3e-03 | -8.2 | 9.6 | 6.4e-22 | -0.43 | 0.02 | 0.74 | FALSE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HELLS | 0.03 | 0.03 | blup | 47 | 0.03 | 1.7e-04 | -8.2 | -9.1 | 1.2e-19 | 0.38 | 0.04 | 0.96 | TRUE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NOC3L | 0.03 | 0.01 | blup | 47 | 0.02 | 2.6e-03 | 1.6 | -5.2 | 2.0e-07 | 0.15 | 0.02 | 0.05 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HELLS | 0.03 | 0.03 | lasso | 3 | 0.02 | 5.7e-03 | -8.2 | -7.5 | 8.0e-14 | 0.32 | 0.04 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HELLS | 0.03 | 0.02 | blup | 47 | 0.03 | 2.1e-04 | -8.2 | -9.0 | 2.9e-19 | 0.33 | 0.03 | 0.94 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -9.4 | -10.5 | 6.2e-26 | 0.49 | 0.01 | 0.97 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -8.2 | -9.7 | 4.9e-22 | 0.40 | 0.06 | 0.85 | FALSE |