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chr10:95,019,584-97,748,040

Best TWAS P=6.18e-26 · Best GWAS P=8.63e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HELLS	0.04	0.04	enet	12	0.04	5.1e-06	-9.4	-10.5	9.2e-26	0.41	0.03	0.97	TRUE
6	GTEx	Nerve Tibial	HELLS	0.12	0.12	enet	17	0.10	1.6e-07	-9.3	-9.1	9.5e-20	0.38	0.03	0.97	TRUE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HELLS	0.03	0.03	blup	47	0.03	1.7e-04	-8.2	-9.1	1.2e-19	0.38	0.04	0.96	TRUE
13	ROSMAP	Brain Pre-frontal Cortex	HELLS	0.02	0.01	blup	372	0.00	6.9e-02	-8.1	-7.5	6.0e-14	0.18	0.05	0.91	TRUE
8	GTEx	Skin Sun Exposed Lower leg	HELLS	0.05	0.02	lasso	3	0.00	1.2e-01	-8.2	-6.7	2.0e-11	0.25	0.14	0.67	TRUE
10	GTEx	Testis	PIPSL	0.14	0.00	enet	21	0.00	3.0e-01	-1.3	6.7	3.0e-11	-0.38	0.03	0.52	TRUE
14	YFS	Blood	PDLIM1	0.12	0.07	lasso	11	0.07	2.3e-22	-5.9	6.0	1.7e-09	0.07	0.97	0.03	TRUE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	TBC1D12	0.04	0.04	blup	63	0.03	3.9e-04	-9.4	-10.5	6.2e-26	0.49	0.01	0.97	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	HELLS	0.05	0.02	blup	47	0.03	9.6e-04	-8.2	-9.7	4.9e-22	0.40	0.06	0.85	FALSE
16	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TBC1D12	0.04	0.01	blup	63	0.03	8.3e-03	-8.2	9.6	6.4e-22	-0.43	0.02	0.74	FALSE
12	METSIM	Adipose	HELLS	0.03	0.04	lasso	3	0.03	9.3e-05	-9.3	-9.3	9.2e-21	0.39	0.03	0.97	FALSE
11	GTEx	Thyroid	HELLS	0.07	0.00	enet	8	0.00	2.7e-01	-9.4	-9.3	1.1e-20	0.38	0.04	0.66	FALSE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	HELLS	0.03	0.02	blup	47	0.03	2.1e-04	-8.2	-9.0	2.9e-19	0.33	0.03	0.94	FALSE
7	GTEx	Ovary	HELLS	0.15	0.04	lasso	5	0.09	3.1e-03	-9.4	-8.9	5.4e-19	0.34	0.04	0.81	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	HELLS	0.04	0.01	blup	47	0.03	1.3e-06	-9.3	-8.5	1.8e-17	0.35	0.02	0.98	FALSE
4	GTEx	Brain Cerebellum	HELLS	0.26	0.20	lasso	9	0.19	2.8e-06	-8.1	-8.2	2.7e-16	0.36	0.06	0.94	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	HELLS	0.03	0.03	lasso	3	0.02	5.7e-03	-8.2	-7.5	8.0e-14	0.32	0.04	0.93	FALSE
3	GTEx	Artery Aorta	CYP2C8	0.21	0.00	lasso	8	0.00	2.2e-01	-8.3	-7.4	1.0e-13	0.09	0.18	0.04	FALSE
9	GTEx	Testis	HELLS	0.08	0.00	enet	27	0.00	3.1e-01	-8.2	-7.0	3.2e-12	0.14	0.06	0.62	FALSE
2	GTEx	Adipose Subcutaneous	HELLS	0.08	0.06	enet	30	0.04	7.0e-04	-9.3	-6.7	2.6e-11	0.35	0.03	0.97	FALSE
5	GTEx	Brain Frontal Cortex BA9	HELLS	0.16	0.09	enet	20	0.15	1.0e-04	-8.2	-6.6	4.7e-11	0.43	0.07	0.88	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NOC3L	0.03	0.01	blup	47	0.02	2.6e-03	1.6	-5.2	2.0e-07	0.15	0.02	0.05	FALSE