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chr11:107,277,331-109,054,930

Best TWAS P=1.87e-12 · Best GWAS P=4.76e-18 conditioned to 2.5e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Pituitary	ACAT1	0.16	0.09	lasso	10	0.08	5.3e-03	6.3	7.0	1.9e-12	0.87	0.03	0.87	TRUE
11	GTEx	Nerve Tibial	ACAT1	0.05	0.02	lasso	5	0.00	9.0e-01	-6.0	-6.7	2.1e-11	-0.82	0.08	0.86	FALSE
3	GTEx	Artery Tibial	ACAT1	0.12	0.08	lasso	7	0.11	3.9e-09	5.5	-6.5	6.3e-11	-0.84	0.03	0.97	FALSE
7	GTEx	Esophagus Mucosa	ACAT1	0.10	0.12	lasso	5	0.13	4.9e-09	5.5	-6.4	1.3e-10	-0.83	0.36	0.64	FALSE
16	YFS	Blood	ACAT1	0.20	0.21	enet	32	0.34	1.3e-114	-5.7	-6.2	4.5e-10	-0.78	1.00	0.00	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	ACAT1	0.11	0.12	lasso	5	0.08	2.6e-05	5.5	-6.1	1.3e-09	-0.78	0.07	0.92	FALSE
10	GTEx	Heart Left Ventricle	KDELC2	0.07	0.05	lasso	4	0.06	3.8e-04	3.0	-6.0	1.9e-09	-0.65	0.04	0.85	FALSE
8	GTEx	Esophagus Muscularis	ATM	0.07	0.07	lasso	4	0.04	1.6e-03	-5.8	-6.0	2.2e-09	-0.74	0.39	0.31	FALSE
6	GTEx	Cells Transformed fibroblasts	ATM	0.07	0.06	lasso	2	0.05	2.2e-04	-5.7	-5.9	3.3e-09	-0.74	0.53	0.37	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ATM	0.05	0.10	lasso	4	0.10	6.6e-12	-5.7	-5.9	3.8e-09	-0.74	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Stomach Adenocarcinoma	ATM	0.04	0.03	lasso	2	0.03	5.7e-03	-5.9	-5.8	5.0e-09	-0.74	0.09	0.10	FALSE
9	GTEx	Esophagus Muscularis	RP11-144G7.2	0.06	0.04	lasso	2	0.03	3.5e-03	5.5	-5.8	6.4e-09	-0.75	0.05	0.80	FALSE
4	GTEx	Artery Tibial	NPAT	0.06	0.06	lasso	4	0.05	5.6e-05	-5.7	5.8	8.1e-09	0.73	0.78	0.07	FALSE
2	GTEx	Adipose Visceral Omentum	KDELC2	0.14	0.11	lasso	3	0.08	4.5e-05	3.0	-5.6	1.9e-08	-0.64	0.10	0.87	FALSE
5	GTEx	Cells Transformed fibroblasts	ACAT1	0.18	0.15	lasso	8	0.21	1.7e-15	-4.5	-5.4	5.3e-08	-0.67	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATM	0.05	0.03	blup	72	0.03	2.9e-04	-5.9	-5.4	5.7e-08	-0.67	0.78	0.12	FALSE
14	GTEx	Skin Sun Exposed Lower leg	ACAT1	0.13	0.15	lasso	2	0.14	1.0e-11	5.5	-5.4	7.2e-08	-0.74	1.00	0.00	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	ATM	0.05	0.05	blup	370	0.05	5.8e-07	-5.8	-5.2	1.8e-07	-0.72	0.71	0.29	FALSE