Best TWAS P=2.84e-09 · Best GWAS P=2.76e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TULP3 | 0.17 | 0.18 | enet | 13 | 0.17 | 2.5e-20 | -5.8 | 5.8 | 5.2e-09 | -1.00 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adrenal Gland | TULP3 | 0.22 | 0.20 | lasso | 3 | 0.19 | 2.4e-07 | -5.9 | -5.8 | 9.1e-09 | 0.98 | 0.01 | 0.98 | FALSE |
3 | GTEx | Breast Mammary Tissue | RHNO1 | 0.13 | 0.10 | lasso | 3 | 0.09 | 3.6e-05 | -5.8 | 5.8 | 7.1e-09 | -0.98 | 0.01 | 0.99 | FALSE |
4 | GTEx | Esophagus Muscularis | TULP3 | 0.13 | 0.05 | lasso | 4 | 0.05 | 5.4e-04 | -5.9 | -5.8 | 6.4e-09 | 0.94 | 0.02 | 0.98 | FALSE |
5 | GTEx | Nerve Tibial | TULP3 | 0.13 | 0.05 | lasso | 2 | 0.06 | 6.0e-05 | -5.9 | 5.9 | 3.8e-09 | -1.00 | 0.01 | 0.99 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | TULP3 | 0.36 | 0.35 | lasso | 7 | 0.35 | 3.5e-30 | -5.9 | 5.7 | 1.3e-08 | -0.99 | 0.01 | 0.99 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | TULP3 | 0.32 | 0.38 | lasso | 6 | 0.40 | 5.0e-56 | -5.8 | 5.9 | 4.0e-09 | -0.98 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TULP3 | 0.04 | 0.02 | blup | 70 | 0.02 | 6.2e-03 | -4.4 | 5.8 | 4.8e-09 | -0.91 | 0.01 | 0.94 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TULP3 | 0.03 | 0.01 | blup | 70 | 0.01 | 3.8e-02 | -5.8 | -5.2 | 2.4e-07 | 0.80 | 0.01 | 0.61 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TULP3 | 0.08 | 0.11 | lasso | 5 | 0.10 | 1.0e-11 | -5.9 | 5.9 | 2.8e-09 | -0.98 | 0.01 | 0.99 | TRUE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C12orf32 | 0.03 | 0.00 | blup | 47 | 0.02 | 2.6e-02 | -5.0 | 5.3 | 1.1e-07 | -0.91 | 0.02 | 0.73 | FALSE |