TWAS hub - TULP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1710	0.0310	1.4e-12	0.175	0.103	0.171	0.157	0.171	7.6e-21	1.5e-12	2.5e-20	1.0e-18	2.8e-20
2	GTEx	Adrenal Gland	0.2234	0.0738	5.8e-03	0.205	NA	0.123	NA	0.189	6.7e-08	NA	3.5e-05	NA	2.4e-07
3	GTEx	Brain Caudate basal ganglia	0.3280	0.0820	1.1e-04	0.273	NA	0.286	NA	0.192	1.7e-08	NA	7.0e-09	NA	3.5e-06
4	GTEx	Cells Transformed fibroblasts	0.1870	0.0490	3.9e-05	0.077	NA	0.110	NA	0.090	2.0e-06	NA	1.4e-08	NA	3.0e-07
5	GTEx	Esophagus Muscularis	0.1270	0.0470	3.6e-03	0.051	NA	0.034	NA	0.050	4.7e-04	NA	3.8e-03	NA	5.4e-04
6	GTEx	Nerve Tibial	0.1347	0.0456	1.6e-03	0.053	NA	0.047	NA	0.058	1.3e-04	NA	3.0e-04	NA	6.0e-05
7	GTEx	Skin Not Sun Exposed Suprapubic	0.2880	0.0580	5.4e-07	0.207	NA	0.205	NA	0.205	1.4e-11	NA	1.7e-11	NA	1.9e-11
8	GTEx	Skin Sun Exposed Lower leg	0.3630	0.0490	0.0e+00	0.352	NA	0.341	NA	0.352	3.3e-30	NA	3.6e-29	NA	3.5e-30
9	ROSMAP	Brain Pre-frontal Cortex	0.3238	0.0363	0.0e+00	0.384	0.295	0.400	0.391	0.405	1.9e-52	2.5e-38	4.7e-55	1.4e-53	5.0e-56
10	TCGA	Bladder Urothelial Carcinoma	0.0370	0.0210	2.3e-03	0.021	0.021	0.008	NA	0.010	5.9e-03	6.2e-03	6.6e-02	NA	4.4e-02
11	TCGA	Breast Invasive Carcinoma	0.0458	0.0206	1.2e-04	0.017	0.021	0.013	NA	0.024	1.3e-04	3.2e-05	9.5e-04	NA	6.8e-06
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0315	0.0198	9.0e-03	0.011	0.008	0.002	NA	0.006	1.7e-02	3.8e-02	1.7e-01	NA	5.9e-02
13	TCGA	Brain Lower Grade Glioma	0.0825	0.0268	1.2e-11	0.114	0.095	0.097	NA	0.103	7.3e-13	7.0e-11	4.1e-11	NA	1.0e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Chronic bronchitis/emphysema (mother)	7.0	8.1	11.7	3.3	-3.4	2.7	2.6	-2.8	3.0	2.7	3.0	2.8	2.6	1.7	-3.3	2.9
Commuting to job workplace: Walk	6.6	7.1	9.7	2.9	-2.8	2.7	2.0	-2.6	3.0	2.1	2.9	2.9	3.1	1.9	-2.8	2.6
Medication: Cholesterol lowering	6.1	9.4	14.3	3.1	-2.9	2.5	3.8	-2.8	3.2	3.2	3.1	3.4	3.2	3.4	-1.6	3.3
Mouth/teeth dental problems: Mouth ulcers	5.8	9.2	12.4	-3.1	3.1	-2.6	-3.0	3.5	-3.1	-2.7	-3.2	-3.0	-3.2	-2.8	2.8	-3.2
High cholesterol (Self-reported)	5.2	9.3	13.6	3.0	-2.7	2.7	3.1	-2.8	3.1	3.1	3.2	3.4	3.7	3.1	-2.3	3.1
Forced expiratory volume in 1-second (FEV1), predicted	5.1	10.5	16.9	-3.9	4.1	-2.7	-2.1	3.8	-3.7	-3.2	-3.5	-3.2	-2.8	-1.4	3.1	-3.6
Chronic bronchitis/emphysema (father)	4.9	5.7	8.3	2.2	-2.2	2.9	2.8	-2.4	2.3	1.7	2.5	2.3	2.5	2.3	-2.4	2.4
Age at last live birth	4.5	6.6	10.4	-2.5	2.3	-2.5	-2.3	2.8	-2.7	-2.9	-2.8	-3.0	-2.1	-3.2	0.6	-2.7
Medication: Atorvastatin	4.2	5.2	6.9	2.2	-2.1	2.2	2.0	-2.1	2.3	2.4	2.4	2.5	2.5	2.6	-1.8	2.3
Pain type(s) experienced in last month: Hip pain	4.1	5.2	6.9	2.6	-2.6	2.1	2.6	-1.9	2.6	2.0	2.4	2.5	2.3	1.7	-1.2	2.6
Blood White Count	4.0	29.9	35.3	5.8	-5.8	4.7	4.2	-5.8	5.9	4.9	5.7	5.9	5.8	5.1	-5.2	5.9
High blood pressure (mother)	4.0	5.6	7.9	-2.2	2.1	-1.9	-2.6	2.3	-2.3	-2.8	-2.4	-2.5	-2.3	-2.7	2.0	-2.5
Medication: Gliclazide	4.0	4.5	8.0	2.6	-2.8	1.5	2.0	-2.5	2.4	1.3	2.3	2.1	1.4	1.1	-2.5	2.2
Medication: Ramipril	3.7	4.7	9.4	1.8	-1.7	2.0	3.1	-1.9	2.0	2.1	2.1	2.4	2.6	2.8	-0.7	2.3
Age when periods started (menarche)	3.6	8.7	12.6	-3.2	3.1	-3.2	-2.7	2.8	-3.3	-2.7	-3.2	-3.5	-2.9	-2.8	1.4	-3.0
Breastfed as a baby	3.5	4.3	6.7	2.2	-2.4	1.6	2.3	-2.5	2.1	2.6	2.1	1.9	1.7	1.1	-2.1	2.0
Wears glasses or contact lenses	3.5	4.0	6.4	2.1	-2.2	1.5	2.4	-2.3	1.9	2.5	1.9	1.7	1.6	1.4	-2.0	2.1
Eye problems/disorders: None of the above	3.3	3.8	6.0	-2.1	2.2	-1.7	-2.4	2.0	-2.0	-2.4	-1.9	-1.8	-1.6	-1.2	1.3	-2.1
Myopia	3.1	4.5	11.8	-2.0	2.1	-1.6	-3.4	2.4	-2.0	-1.8	-2.0	-1.8	-2.0	-1.9	1.6	-2.3
Heart attack/myocardial infarction (self-reported)	3.1	4.0	5.3	2.0	-1.9	2.1	2.0	-1.9	2.0	2.3	2.1	2.2	1.9	2.2	-0.9	2.2
Medication: Simvastatin	3.0	4.3	6.5	2.1	-1.9	1.9	2.2	-1.5	2.2	2.2	2.1	2.4	2.5	1.9	-1.4	2.3
Irritability	2.9	4.9	6.2	2.4	-2.3	1.8	1.8	-2.4	2.4	1.6	2.4	2.5	2.4	2.2	-2.0	2.5
Number of incorrect matches in round	2.8	4.6	8.2	2.1	-1.9	1.7	2.9	-2.3	2.2	2.1	2.3	2.4	1.9	2.2	-1.0	2.5
Ever had bowel cancer screening	2.7	3.1	5.9	-1.7	1.6	-2.4	-1.2	1.5	-1.8	-1.7	-2.0	-1.8	-2.1	-1.5	1.7	-1.8
Prospective memory result	2.6	3.2	5.2	1.6	-1.6	1.0	2.3	-2.0	1.7	1.8	1.7	1.6	2.0	1.6	-2.1	2.1
Migraine (self-reported)	2.6	3.2	5.4	-1.8	2.0	-1.6	-1.3	1.9	-1.7	-1.4	-1.8	-1.6	-2.1	-1.4	2.3	-2.1
Breast cancer (self-reported)	2.6	3.1	4.0	-1.9	1.9	-2.0	-1.7	1.5	-1.9	-1.6	-2.0	-2.0	-1.8	-1.7	1.1	-1.6
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	5.5	2.1	-2.4	0.7	1.3	-2.0	1.9	1.2	1.7	1.5	1.2	0.4	-2.0	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	4.9	1.6	-1.4	2.2	1.8	-1.4	1.7	1.9	1.9	1.9	2.1	1.0	-0.9	1.8
Osteoarthritis (self-reported)	2.5	3.2	4.4	2.1	-2.1	1.8	1.6	-1.4	2.0	1.9	2.0	1.8	2.0	0.5	-1.4	2.0
Verbal and Numeric Reasoning (VNR)	2.4	5.8	9.1	-2.6	2.5	-1.7	-2.1	2.2	-2.7	-3.0	-2.6	-2.6	-2.3	-2.2	1.9	-2.6
Exposure to tobacco smoke at home	2.4	2.7	4.3	1.8	-1.8	1.6	1.0	-1.6	1.8	1.1	1.8	1.7	1.6	1.5	-1.9	2.1
Angina	2.3	3.0	4.3	1.8	-1.6	1.6	2.1	-1.7	1.8	1.3	1.9	2.1	1.7	1.8	-0.6	1.9
Medication for hormone replacement therapy	2.3	2.6	4.3	2.0	-2.1	1.2	2.0	-1.8	1.9	0.5	1.8	1.7	1.5	0.9	-0.6	1.8
Mouth/teeth dental problems	2.2	3.4	5.2	1.9	-1.8	1.6	1.2	-1.7	2.0	2.2	1.9	2.0	2.3	1.5	-1.6	1.8
Heart attack	2.1	2.6	3.8	1.6	-1.5	1.8	1.6	-1.5	1.6	1.9	1.7	1.8	1.5	2.0	-0.5	1.8
Fluid intelligence score	2.1	4.4	6.8	-2.2	2.0	-1.1	-1.9	1.8	-2.3	-2.6	-2.2	-2.3	-2.0	-2.1	1.9	-2.3
Eye problems/disorders: Glaucoma	2.1	2.4	3.6	1.8	-1.8	1.8	1.3	-1.5	1.6	1.9	1.5	1.6	1.4	0.9	-1.2	1.7
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	5.4	-1.9	1.7	-1.6	-2.0	1.3	-2.0	-2.3	-1.8	-2.2	-1.9	-1.9	0.1	-2.1
Number of full brothers	2.0	2.5	5.1	1.7	-1.6	1.4	0.5	-2.1	1.7	2.3	1.7	1.7	1.3	1.2	-1.0	1.8
Lung FVC	1.9	9.8	13.7	3.3	-3.0	2.6	2.5	-3.4	3.6	3.6	3.2	3.7	2.8	3.3	-1.8	3.2
Qualifications: CSEs or equivalent	1.9	2.5	3.2	-1.4	1.5	-1.6	-1.6	1.7	-1.3	-1.8	-1.5	-1.3	-1.7	-1.4	1.8	-1.8
Happiness	1.8	2.2	4.0	-1.3	1.3	-1.5	-1.4	1.4	-1.4	-1.7	-1.4	-1.4	-1.9	-0.7	2.0	-1.4
Had major operations	1.8	2.1	3.1	-1.4	1.4	-1.2	-1.4	1.4	-1.5	-1.5	-1.3	-1.5	-1.4	-1.8	1.1	-1.6
Guilty feelings	1.8	2.8	4.1	-1.5	1.5	-1.7	-2.0	1.7	-1.5	-1.7	-1.6	-1.5	-1.9	-1.6	1.7	-1.6
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.3	1.3	-1.2	1.8	1.1	-1.6	1.3	1.3	1.3	1.4	1.8	1.3	-0.9	1.5
Had menopause	1.7	2.1	4.9	1.5	-1.6	1.8	1.6	-1.5	1.3	2.2	1.4	1.2	1.3	0.6	-0.7	1.5
Standing height	1.7	17.1	24.5	-4.5	4.7	-3.5	-3.4	4.7	-4.4	-3.7	-4.3	-3.9	-4.3	-2.4	5.0	-4.4
Angina (self-reported)	1.7	2.2	4.2	1.5	-1.3	1.2	2.0	-1.4	1.5	1.1	1.6	1.8	1.5	1.8	-0.4	1.6
Alcohol drinker status: Previous	1.7	1.9	4.3	-1.4	1.6	-1.2	-1.2	1.2	-1.4	-1.2	-1.4	-1.1	-1.5	-0.8	2.1	-1.3
Height	1.6	31.7	40.9	-6.1	6.4	-5.0	-5.6	6.3	-5.9	-4.9	-5.9	-5.3	-5.4	-3.5	6.4	-5.8
Financial difficulties in last 2 years	1.6	2.1	4.0	-1.4	1.4	-1.7	-1.0	1.4	-1.5	-2.0	-1.5	-1.5	-1.2	-0.7	1.7	-1.4
Time employed in main current job	1.6	1.8	2.7	1.4	-1.3	1.6	0.2	-1.4	1.4	1.6	1.6	1.5	1.5	1.2	-0.6	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.4	1.2	-1.1	1.4	1.2	-1.1	1.2	1.1	1.4	1.6	1.7	1.8	-0.8	1.6
Birth weight	1.6	3.5	6.2	-1.9	1.8	-1.8	-1.5	2.1	-1.9	-1.7	-1.9	-1.9	-2.0	-1.6	2.5	-1.6
Worry too long after embarrassment	1.6	2.7	6.3	-1.6	1.6	-1.6	-2.1	1.4	-1.5	-1.0	-1.5	-1.4	-1.9	-0.9	2.5	-1.6
Overall health rating	1.6	3.3	5.1	-2.0	2.0	-2.1	-0.8	2.3	-2.0	-1.4	-2.0	-1.8	-1.7	-1.2	2.0	-2.1
Intelligence (Savage-Jansen 2018)	1.5	4.6	6.1	-2.4	2.3	-1.9	-1.3	2.2	-2.4	-2.4	-2.4	-2.4	-2.3	-1.4	1.5	-2.5
Schizophrenia vs Biploar Disorder	1.5	1.9	4.0	-1.3	1.2	-0.9	-1.3	1.7	-1.3	-0.5	-1.5	-1.6	-1.4	-2.0	1.4	-1.5
Age at first live birth	1.5	2.6	4.5	-1.9	1.9	-1.2	-1.4	2.1	-1.9	-1.4	-1.8	-1.8	-1.2	-1.2	0.7	-1.8
Emphysema/chronic bronchitis	1.5	1.7	2.7	1.6	-1.7	1.1	1.7	-0.8	1.4	1.5	1.3	1.2	1.1	0.9	-1.2	1.3
Medication: Ibuprofen	1.5	1.8	3.8	-1.3	1.3	-1.4	-1.9	1.0	-1.3	-1.7	-1.4	-1.4	-1.4	-0.9	0.7	-1.3
Medication: Bendroflumethiazide	1.5	2.4	8.5	-1.8	2.0	-0.5	-0.4	1.8	-1.6	0.0	-1.4	-1.3	-1.5	-0.6	2.9	-1.5
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.9	1.6	-1.5	1.3	1.7	-1.6	1.5	0.7	1.4	1.5	1.1	1.0	-0.3	1.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	2.4	-1.2	1.1	-1.2	-1.4	1.4	-1.2	-1.2	-1.2	-1.4	-1.6	-1.3	1.4	-1.0
Loneliness, isolation	1.3	1.9	3.1	-1.3	1.3	-1.2	-1.2	1.7	-1.3	-1.7	-1.3	-1.3	-1.1	-1.1	1.5	-1.4
Miserableness	1.3	2.3	3.8	-1.6	1.6	-1.2	-2.0	1.5	-1.7	-1.9	-1.5	-1.5	-1.3	-0.9	1.3	-1.3
Medication: Lisinopril	1.3	1.6	2.8	1.1	-0.8	1.2	1.6	-1.2	1.2	1.1	1.2	1.6	1.5	1.7	-0.5	1.1
Average weekly fortified wine intake	1.2	1.4	2.3	1.5	-1.5	0.8	0.9	-0.9	1.4	1.1	1.3	1.4	1.0	0.6	-0.9	1.5
Supplements: Calcium	1.2	1.4	3.1	1.0	-1.0	1.8	0.8	-1.4	1.0	1.5	1.2	1.0	1.3	0.9	-0.7	1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.2	5.4	1.1	-1.5	0.7	0.7	-1.4	0.8	0.7	0.8	0.8	1.0	0.7	-2.3	0.0
Vitamin and mineral supplements	1.1	1.5	2.9	1.2	-1.1	1.0	1.3	-0.9	1.2	0.9	1.1	1.2	1.7	1.2	-1.6	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-1.1	1.0	-1.2	-1.5	0.8	-1.1	-1.7	-1.3	-1.3	-1.2	-1.1	0.6	-1.2
Comparative body size at age 10	1.1	3.1	6.0	1.7	-1.6	1.3	1.3	-1.9	1.7	1.9	1.6	1.8	1.6	2.5	-1.9	1.9
Triglycerides	1.0	1.7	2.5	-1.6	1.5	-1.4	-0.5	1.4	-1.5	-1.1	-1.4	-1.2	-1.6	-0.3	1.2	-1.3
Medication: Co-codamol	1.0	1.1	1.8	1.0	-0.9	0.7	0.9	-1.1	0.9	1.3	1.0	1.1	1.1	1.2	-1.4	1.0
Impedance of leg (right)	1.0	4.8	6.1	-2.3	2.1	-1.4	-2.4	1.8	-2.4	-2.2	-2.2	-2.5	-2.5	-2.1	2.1	-2.3
Alcohol usually taken with meals	1.0	1.7	3.1	1.4	-1.6	0.9	1.0	-1.5	1.2	1.8	1.2	1.1	0.8	1.1	-1.7	1.3
Diabetes (self-reported)	1.0	1.5	3.2	1.4	-1.5	0.9	1.8	-0.9	1.4	1.3	1.3	1.2	0.9	0.7	-0.6	1.4
Medication: Amlodipine	1.0	1.4	3.4	-1.0	1.1	-1.9	-0.4	1.6	-1.1	-1.3	-1.1	-1.1	-1.2	-1.3	1.0	-1.0
Wheeze or whistling in the chest in last year	1.0	1.7	4.1	1.4	-1.4	1.6	0.7	-1.1	1.5	2.0	1.4	1.4	1.3	1.0	-0.4	1.3
Medication: Aspirin	1.0	1.4	2.2	1.2	-1.1	0.9	1.3	-0.9	1.3	1.1	1.2	1.3	1.5	1.1	-0.8	1.3
Supplements: Vitamin C	1.0	1.2	3.0	-1.0	1.0	-1.0	-1.7	1.2	-0.9	-0.6	-1.1	-1.0	-1.1	-0.9	1.3	-1.0
Impedance of whole body	1.0	5.1	6.5	-2.4	2.2	-1.4	-2.2	2.0	-2.4	-2.5	-2.2	-2.5	-2.3	-2.1	2.3	-2.4
Coronary Artery Disease (CAD)	0.9	1.1	4.9	0.6	-0.3	0.7	1.3	-0.8	0.9	0.4	0.8	0.9	1.5	2.2	-0.2	1.2
Multivitamins +/- minerals	0.9	1.2	2.5	-0.9	0.7	-0.4	-1.2	0.8	-1.0	-1.1	-0.8	-1.0	-1.5	-1.5	1.6	-1.0
Impedance of leg (left)	0.9	4.3	6.1	-2.3	2.1	-1.3	-1.7	1.6	-2.3	-2.5	-2.0	-2.3	-2.2	-1.9	2.1	-2.2
Had other major operations	0.9	1.1	2.9	-0.8	0.6	-1.1	-0.4	0.6	-1.0	-1.7	-1.0	-1.3	-1.2	-1.6	0.2	-0.8
Impedance of arm (right)	0.9	4.2	6.6	-2.0	1.7	-1.4	-2.1	1.9	-2.1	-2.6	-2.0	-2.4	-2.1	-2.5	1.6	-2.2
Medication: Lansoprazole	0.9	1.0	1.8	-1.2	1.3	-0.7	-1.1	1.1	-1.1	-0.3	-1.1	-1.0	-1.1	-0.5	0.5	-1.3
Impedance of arm (left)	0.9	4.0	5.6	-2.1	1.8	-1.2	-2.1	1.8	-2.1	-2.4	-1.9	-2.2	-2.0	-2.1	1.7	-2.2
Average weekly champagne plus white wine intake	0.9	1.3	2.2	1.1	-1.1	0.9	1.4	-1.5	1.1	0.9	1.0	1.0	0.8	1.1	-1.2	1.3
Fasting Glucose	0.8	0.9	2.8	0.6	-0.5	1.3	1.1	-0.6	0.7	1.6	0.5	0.8	0.3	1.0	1.7	0.8
HDL Cholesterol	0.8	1.3	2.0	-1.3	1.3	-1.0	-0.8	1.0	-1.3	-0.7	-1.2	-1.4	-1.1	-1.0	1.1	-1.4
Relative age of first facial hair	0.8	1.7	3.2	-1.4	1.5	-1.1	-1.4	1.3	-1.4	-1.8	-1.2	-1.3	-1.1	-1.1	0.1	-1.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	1.1	-1.0	0.4	0.5	-0.9	1.1	0.2	1.1	1.3	1.0	1.1	-0.9	1.3
Sitting height	0.8	5.4	13.1	-2.6	3.0	-1.8	-1.8	2.8	-2.3	-2.0	-2.3	-1.7	-2.1	-0.4	3.6	-2.4
Heart disease (mother)	0.8	0.9	1.8	0.8	-0.7	0.9	1.1	-1.3	0.9	0.7	1.0	1.2	1.1	1.3	-0.6	0.6
Medication: Paracetamol	0.8	1.3	2.1	1.4	-1.5	1.4	0.3	-1.3	1.3	0.6	1.2	1.1	0.9	0.9	-0.9	1.4
Basal cell carcinoma (self-reported)	0.8	0.9	2.6	-0.5	0.5	-0.6	-1.3	1.0	-0.6	-0.5	-0.9	-0.7	-1.4	-1.1	1.6	-0.8
Bipolar Disorder (2018)	0.7	1.1	2.0	0.9	-0.8	1.1	1.1	-1.2	1.0	0.9	1.1	1.2	0.8	1.4	-0.5	1.2
Current tobacco smoking	0.7	1.1	2.5	0.8	-0.9	1.4	1.1	-0.8	0.9	0.8	1.0	1.1	1.6	1.3	-0.5	1.0
Stomach or abdominal pain in last month	0.7	0.8	1.3	-1.0	1.1	-0.6	-0.6	0.9	-1.0	-1.1	-0.9	-0.9	-1.0	-0.4	1.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.8	-1.0	1.0	-0.9	-1.1	1.3	-1.0	-1.0	-1.0	-1.0	-1.2	-1.1	0.9	-1.3
Number of live births	0.7	1.0	4.7	-0.5	0.3	-1.0	-0.9	0.6	-0.6	-0.4	-0.8	-1.2	-1.0	-2.2	-0.9	-1.0
Length of working week for main job	0.7	0.8	1.3	0.9	-0.9	1.1	-0.1	-0.9	0.9	0.1	1.1	1.1	0.8	1.1	-0.8	0.8
Family relationship satisfaction	0.7	0.8	2.1	-0.7	0.6	-0.8	-1.4	0.6	-0.8	-1.4	-1.0	-0.8	-1.0	-0.5	0.9	-0.7
Medication: Aspirin	0.7	0.9	1.6	0.9	-0.7	0.8	0.9	-0.5	1.0	1.1	0.9	1.2	1.3	1.2	-0.4	1.0
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.8	-0.7	0.8	0.9	-0.3	0.8	1.5	0.9	0.9	1.1	0.9	-0.6	0.7
Age started oral contraceptive pill	0.7	0.8	1.5	0.8	-0.8	1.2	1.0	-0.9	0.7	1.2	0.9	0.7	0.2	0.6	1.1	1.1
Ever depressed for a whole week	0.7	0.8	2.0	-0.9	0.8	-0.2	-1.2	0.7	-0.9	-0.7	-0.8	-0.8	-1.2	-0.8	1.4	-0.9
Pain experienced in last month	0.7	1.2	2.8	-1.6	1.7	-0.9	-1.0	1.1	-1.4	-0.7	-1.1	-1.0	-0.8	0.1	1.0	-1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.9	-0.8	0.8	-0.6	-1.4	0.6	-0.8	-0.4	-0.8	-0.7	-0.9	-0.5	1.1	-0.9
Pulse rate	0.6	1.0	2.6	0.7	-0.7	0.5	1.5	-1.4	0.7	0.7	0.7	0.9	1.2	1.6	-0.9	0.9
Illnesses of mother	0.6	0.7	2.2	0.3	-0.1	0.6	1.0	-0.6	0.4	1.2	0.6	0.7	1.1	1.5	-1.0	0.7
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	-0.9	1.1	-1.1	-0.1	1.1	-0.8	0.1	-0.8	-0.7	-0.8	-0.5	0.8	-1.1
Neck or shoulder pain in last month	0.6	0.8	6.7	0.0	-0.3	-0.1	-1.2	0.8	-0.2	0.3	-0.5	-0.7	-0.8	-2.6	0.2	-0.6
Medication: Blood pressure	0.6	1.0	1.8	1.1	-1.1	0.9	0.9	-0.4	1.2	1.4	1.0	1.2	0.9	0.7	0.6	1.2
Alcohol intake frequency.	0.6	1.4	2.0	-1.2	1.4	-1.2	-1.2	1.2	-1.2	-1.4	-1.3	-1.2	-1.1	-1.0	0.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.1	-0.7	0.8	-0.3	-1.5	1.4	-0.6	0.2	-0.6	-0.3	-0.2	-0.4	1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.7	-1.1	1.4	-1.3	-0.8	1.3	-0.9	-0.2	-1.0	-0.5	-1.1	0.2	1.9	-1.1
Mother’s age at death	0.6	0.8	1.5	-1.2	1.2	-0.2	-0.5	0.7	-1.2	-0.8	-0.9	-1.0	-0.4	-0.8	0.4	-1.0
Lupus	0.5	0.8	1.7	-0.6	0.4	-0.7	-0.9	1.2	-0.7	-0.8	-1.0	-1.0	-1.1	-1.3	0.9	-0.8
Number of treatments/medications taken	0.5	0.9	1.5	1.0	-0.8	1.0	0.7	-0.7	1.0	1.2	1.0	1.1	0.8	1.0	0.5	1.1
Falls in the last year	0.5	0.6	2.9	-0.1	-0.1	-1.2	-0.5	0.5	-0.3	-1.0	-0.4	-0.7	-0.6	-1.7	-0.7	-0.6
Diabetes diagnosed by doctor	0.5	0.9	2.3	1.1	-1.2	0.4	1.5	-0.5	1.0	1.0	1.0	0.9	0.5	0.3	-0.5	1.0
Friendships satisfaction	0.5	0.6	1.7	0.8	-0.7	1.1	0.4	-0.4	0.7	0.5	0.8	0.9	0.6	1.3	0.1	0.7
Qualifications: nursing, teaching	0.5	0.7	3.2	0.7	-0.8	0.7	-0.1	-1.1	0.7	1.0	0.7	0.6	0.9	0.2	-1.8	0.5
Back pain experienced in last month	0.5	0.7	2.0	0.9	-1.1	0.5	1.2	-1.1	0.7	0.1	0.6	0.4	0.8	0.1	-1.4	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	0.9	-0.9	0.7	0.6	-0.9	0.8	0.9	0.8	0.6	0.5	0.3	-0.9	0.7
Leg fat percentage (left)	0.5	1.6	4.2	1.9	-2.0	0.5	1.1	-1.1	1.6	0.7	1.2	1.0	0.6	-0.2	-1.9	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	1.1	-1.2	-0.4	1.3	-0.9	0.9	-0.0	0.6	0.6	-0.1	-0.5	-0.4	1.0
Irritable Bowel Disease (IBD)	0.4	1.1	2.1	1.0	-0.8	0.3	1.0	-0.9	1.0	1.4	0.9	1.4	1.0	1.2	-0.6	1.2
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.6	-0.5	0.1	0.9	-0.8	0.7	1.1	0.7	1.0	1.1	0.7	-1.0	0.9
Allergy or Eczema	0.4	1.2	8.1	0.1	-0.5	-1.1	-1.1	0.5	-0.3	0.1	-0.5	-1.1	-1.4	-2.8	-0.6	-0.6
Diabetes (father)	0.4	0.4	1.4	-0.5	0.4	-1.2	0.3	0.4	-0.5	-0.9	-0.5	-0.6	-0.6	-0.1	-1.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	-0.8	0.6	-0.7	-0.4	0.6	-0.8	-1.2	-0.7	-0.8	-0.6	-0.7	0.5	-0.7
Body mass index (BMI)	0.4	1.9	4.2	1.9	-2.0	0.3	0.9	-1.0	1.7	1.1	1.3	1.2	1.0	-0.0	-2.0	1.5
Hearing difficulty/problems with background noise	0.4	0.6	4.0	-0.4	0.5	-0.7	-0.1	1.1	-0.4	-0.1	-0.5	-0.4	-0.9	-0.5	2.0	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	0.4	-0.2	0.4	1.3	0.2	0.6	1.0	0.7	0.8	0.6	0.8	1.2	0.4
Qualifications: None of the above	0.4	1.0	2.1	1.0	-1.1	0.6	0.7	-1.4	0.9	1.1	1.1	0.7	1.0	0.8	-0.4	1.5
Tense / ‘highly strung’	0.4	0.7	2.2	0.6	-0.3	0.7	0.1	-0.6	0.8	0.3	0.9	1.2	1.5	1.3	0.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.6	-0.8	1.1	-0.7	0.5	0.8	-0.7	-0.4	-0.7	-0.1	-0.6	0.6	1.6	-0.8
Peak expiratory flow (PEF)	0.4	0.8	1.9	1.0	-0.8	0.8	0.4	-0.4	1.2	0.6	1.0	1.4	0.9	1.4	-0.1	0.8
Blood clot in the leg (DVT)	0.4	0.5	1.3	1.0	-1.1	-0.5	1.0	-0.6	0.7	-0.3	0.4	0.4	-0.2	-0.8	-0.3	0.8
Headache pain in last month	0.4	0.6	1.8	-0.8	0.7	-0.7	-0.4	0.7	-0.8	-1.3	-0.9	-0.8	-0.9	-0.6	0.5	-0.9
Gout (self-reported)	0.4	0.6	1.4	-0.9	1.0	-0.2	-1.1	0.6	-0.7	-0.4	-0.7	-0.5	-0.5	0.4	1.2	-0.8
Leg fat percentage (right)	0.4	1.3	3.8	1.7	-2.0	0.2	0.6	-0.9	1.5	0.8	1.0	0.8	0.4	-0.4	-1.8	1.2
Qualifications: College or University degree	0.4	1.3	2.6	-1.2	1.1	-0.4	-1.6	0.8	-1.2	-1.1	-1.2	-1.1	-1.3	-1.1	0.6	-1.4
Smoking status: Current	0.4	0.6	1.4	0.6	-0.7	1.0	0.9	-0.5	0.6	0.4	0.6	0.7	1.2	1.0	-0.5	0.7
Average weekly beer plus cider intake	0.4	0.5	1.8	0.8	-0.9	0.2	0.8	-0.3	0.8	-0.2	0.7	0.6	1.0	-0.1	-1.3	0.7
Risk taking	0.4	0.5	2.6	-0.8	0.7	-0.7	-0.0	0.6	-0.8	-1.6	-0.7	-0.7	-0.2	-0.7	0.1	-0.6
Cholesterol lowering medication	0.4	0.6	2.1	0.6	-0.6	1.2	-0.2	-0.1	0.6	1.4	0.7	0.6	1.1	0.2	-0.7	0.8
Pack years of smoking	0.4	0.5	1.8	-0.4	0.4	-0.9	-0.7	0.4	-0.4	-1.1	-0.6	-0.3	-0.9	-0.5	1.3	-0.6
Depression (Nagel 2018)	0.3	0.5	0.8	0.6	-0.7	0.8	0.5	-0.6	0.6	0.7	0.8	0.7	0.9	0.6	-0.6	0.8
Alzheimer’s Disease (in mother)	0.3	0.3	1.8	-0.3	0.2	-0.1	-0.7	0.5	-0.5	-0.4	-0.5	-0.6	-0.2	-1.4	-0.2	-0.4
Crohns Disease (2012)	0.3	0.5	1.1	0.9	-1.0	0.3	0.8	-0.6	0.8	1.0	0.7	1.1	0.2	0.7	0.3	0.0
HbA1C	0.3	0.4	0.9	0.3	-0.2	0.9	-0.6	-0.6	0.2	0.8	0.5	0.6	0.8	0.7	-0.1	0.6
Ulcerative Colitis	0.3	0.4	0.9	0.7	-0.5	0.1	0.5	-0.4	0.8	0.5	0.7	0.8	1.0	0.8	-0.7	0.7
Blood Red Count	0.3	3.2	9.0	-1.9	2.3	-1.3	-2.1	2.3	-1.6	-0.3	-1.7	-0.9	-1.1	0.4	3.0	-2.0
Chronotype (morning person)	0.3	0.7	1.9	0.7	-0.5	0.4	0.5	-1.2	0.7	0.9	0.8	0.9	0.5	1.4	-0.9	0.8
Townsend deprivation index at recruitment	0.3	0.5	2.0	-0.5	0.5	-1.4	0.2	0.6	-0.4	-1.4	-0.7	-0.2	-0.4	0.4	-0.2	-0.6
Maternal smoking around birth	0.3	0.4	1.0	-0.4	0.4	-0.6	-0.3	0.6	-0.5	-1.0	-0.5	-0.6	-0.4	-1.0	0.9	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.5	3.5	0.4	-0.5	-0.7	-1.2	0.1	0.1	0.6	-0.1	-0.4	-0.9	-1.9	-0.5	-0.2
Medication: Atenolol	0.3	0.4	3.9	-0.3	0.3	0.4	0.2	0.2	-0.2	-0.1	-0.2	-0.0	-0.1	0.6	2.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	0.6	-0.4	0.5	0.4	-0.8	0.7	0.7	0.7	0.9	0.9	1.0	-0.6	0.7
Arm fat percentage (right)	0.3	1.0	3.4	1.5	-1.8	0.0	0.3	-0.5	1.2	0.5	0.8	0.5	0.2	-0.9	-1.9	0.8
Father’s age at death	0.3	0.4	1.0	-0.8	0.9	-0.5	-0.7	0.7	-0.7	-0.4	-0.6	-0.4	-0.5	0.2	1.0	-0.6
Worrier / anxious feelings	0.3	0.7	2.7	0.4	-0.3	0.4	0.2	-0.6	0.5	1.0	0.7	0.8	0.2	1.3	1.6	0.9
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.9	-1.0	0.3	0.2	0.1	0.7	0.6	0.5	0.5	0.4	-0.2	-1.1	0.2
Health satisfaction	0.3	0.4	1.0	-0.5	0.7	-0.3	-0.7	1.0	-0.5	-0.2	-0.6	-0.1	-0.4	0.4	1.0	-0.7
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	-1.0	0.9	-0.6	-0.5	0.6	-1.0	-0.4	-0.7	-0.9	-0.7	-0.7	0.9	-0.8
Medication: Allopurinol	0.3	0.4	1.9	-0.6	0.8	-0.0	-0.9	0.7	-0.5	-0.3	-0.4	-0.3	-0.5	0.3	1.4	-0.7
Medication: Omeprazole	0.3	0.4	0.8	-0.7	0.6	-0.3	-0.6	0.4	-0.7	-0.9	-0.8	-0.6	-0.5	-0.4	0.5	-0.6
Number of full sisters	0.3	0.4	3.0	0.3	-0.3	0.6	0.4	-0.4	0.4	0.2	0.4	0.0	0.6	-0.4	-1.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	0.4	-0.3	0.4	0.6	-0.1	0.5	0.5	0.4	0.6	0.6	0.7	-1.1	0.3
Arm fat percentage (left)	0.3	1.4	4.0	1.7	-1.9	0.2	0.6	-0.7	1.5	0.7	1.0	0.8	0.5	-0.6	-2.0	1.1
Mineral and other dietary supplements	0.3	0.3	2.0	0.4	-0.6	-0.9	-0.0	-0.2	0.3	-0.1	0.1	-0.0	-0.1	-0.9	-1.4	0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.7	-0.6	0.8	0.5	-0.2	0.7	-0.5	0.0	-0.3	-0.1	-0.3	0.7	1.3	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.7	-0.7	0.3	0.7	-0.6	0.6	0.8	0.7	0.6	0.5	0.5	-0.2	0.5
Heart disease (siblings)	0.3	0.4	1.4	0.4	-0.3	0.5	-0.0	-0.8	0.5	0.6	0.6	0.6	0.5	1.2	-0.1	0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	0.5	-0.4	0.9	0.2	-0.5	0.5	0.5	0.6	0.8	0.8	0.9	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.2	0.2	0.6	-0.5	0.5	0.1	-0.8	0.7	-0.6	-0.6	-0.5	-0.5	0.0	-0.3	0.2	-0.5
Reaction Time	0.2	0.3	0.8	0.7	-0.9	-0.1	0.6	-0.4	0.6	0.6	0.4	0.3	0.2	-0.9	-0.4	0.5
Ovarian Cancer	0.2	0.2	0.8	-0.4	0.4	-0.5	-0.4	0.3	-0.6	-0.3	-0.5	-0.7	-0.3	-0.9	-0.4	-0.4
Age at First Birth	0.2	0.3	1.5	-0.0	0.1	0.6	0.6	0.1	0.0	-0.5	0.1	0.4	0.9	1.2	-0.7	0.2
Body Mass Index (BMI) (2010)	0.2	0.2	1.0	0.3	-0.1	0.6	-0.1	-0.3	0.3	1.0	0.5	0.5	0.4	0.8	0.1	0.3
Mean Putamen Volume	0.2	0.2	0.9	0.0	0.1	-0.1	0.8	-0.2	0.1	-0.1	0.0	0.3	-0.2	0.9	0.6	0.4
LDL Cholesterol	0.2	0.3	0.9	0.3	-0.2	0.4	0.9	-0.2	0.4	0.5	0.3	0.9	0.8	0.9	-0.5	0.6
Primary Biliary Cirrhosis	0.2	0.3	1.8	0.2	-0.4	-1.3	0.3	0.0	0.2	0.6	-0.2	-0.0	-0.4	-0.3	-1.0	0.0
BMI	0.2	1.4	4.7	1.6	-1.7	-0.3	0.5	-0.9	1.4	1.3	0.9	0.8	0.6	-0.3	-2.2	1.0
Respiratory disease	0.2	0.3	2.1	0.3	-0.5	0.0	0.4	-0.2	0.3	0.9	0.2	-0.0	0.6	-0.7	-1.4	-0.0
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.6	-0.6	0.4	-0.2	-0.7	0.5	0.1	0.6	0.5	0.4	0.1	-0.2	0.6
Hearing difficulty/problems: Yes	0.2	0.3	1.4	-0.3	0.5	-0.2	-0.2	0.8	-0.2	-0.7	-0.3	0.0	-0.0	0.4	1.2	-0.3
Systolic blood pressure, automated reading	0.2	0.5	2.0	0.7	-0.7	1.0	-0.0	-0.5	0.8	1.4	0.8	0.6	0.9	-0.2	-0.6	0.5
Diabetes (mother)	0.2	0.2	0.9	-0.0	-0.0	-1.0	-0.3	0.5	-0.1	-0.2	-0.4	-0.3	-0.8	-0.7	0.2	-0.4
Severe depression (siblings)	0.2	0.2	0.9	-0.2	0.0	-1.0	0.2	-0.5	-0.1	-0.8	-0.3	-0.3	-0.3	0.0	-0.3	0.2
Leg fat-free mass (left)	0.2	1.2	2.9	-0.8	0.9	-1.7	-1.0	1.7	-0.8	-0.9	-1.1	-0.9	-1.2	-1.0	0.8	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	-0.5	0.4	-0.2	-0.1	0.9	-0.5	0.3	-0.5	-0.5	-0.1	-0.5	0.7	-0.5
Leg predicted mass (left)	0.2	1.1	2.7	-0.7	0.8	-1.7	-0.9	1.6	-0.8	-0.8	-1.1	-0.8	-1.2	-0.9	0.8	-0.9
Allergy	0.2	0.4	3.4	-0.1	0.3	0.1	0.6	-0.4	0.1	-0.7	0.1	0.6	0.3	1.8	0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.9	-0.0	-0.1	0.5	-0.7	-0.1	-0.2	0.3	-0.0	-0.5	0.0	-1.4	-0.8	-0.1
Trunk fat-free mass	0.2	1.3	2.5	-1.1	1.4	-1.5	-0.6	1.6	-1.1	-0.7	-1.3	-0.8	-1.3	-0.2	1.2	-1.0
Hip circumference	0.2	1.0	3.0	-0.4	0.3	-1.3	-0.7	1.5	-0.5	-0.7	-1.0	-1.0	-1.3	-1.7	0.4	-0.9
Alcohol intake versus 10 years previously	0.2	0.2	0.6	-0.5	0.7	-0.8	-0.2	0.4	-0.5	-0.0	-0.6	-0.3	0.4	0.3	-0.7	-0.4
Depression (self-reported)	0.2	0.3	0.9	-0.4	0.5	-0.6	-0.5	0.8	-0.3	-0.3	-0.3	-0.4	-0.4	-0.5	1.0	-0.4
Lung cancer (father)	0.2	0.2	0.7	0.3	-0.3	0.5	0.8	0.1	0.4	0.5	0.4	0.5	-0.2	0.1	0.9	0.0
Trunk predicted mass	0.2	1.2	2.4	-1.1	1.3	-1.5	-0.5	1.5	-1.0	-0.6	-1.2	-0.8	-1.2	-0.3	1.2	-1.0
Pulse wave reflection index	0.2	0.2	1.2	-0.0	-0.0	-0.6	-0.2	0.7	-0.1	-0.2	-0.3	-0.3	-0.8	-1.1	-0.1	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.1	0.0	-0.4	-0.8	0.3	-0.2	-0.9	-0.3	-0.4	-0.6	-0.0	-0.2	-0.1
Loud music exposure frequency	0.2	0.3	1.1	-0.6	0.7	-0.0	-0.6	0.3	-0.6	0.2	-0.5	-0.3	-0.2	0.3	1.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	-0.7	1.0	-0.3	0.2	1.0	-0.7	-0.6	-0.6	-0.1	-0.0	0.3	0.5	-0.9
Medication: Paracetamol	0.2	0.4	0.8	0.9	-0.9	0.7	0.3	-0.5	0.8	-0.0	0.6	0.6	0.4	0.6	-0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.5	-0.6	0.0	0.9	-0.7	0.5	0.3	0.6	0.3	0.8	0.5	-0.7	0.9
Arm fat-free mass (right)	0.2	0.9	2.0	-0.9	1.2	-1.3	-0.5	1.3	-0.9	-0.5	-1.0	-0.6	-1.1	-0.2	1.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.5	-0.3	0.2	-0.8	0.3	0.1	-0.3	-0.4	-0.4	-0.3	-0.1	0.1	-1.2	-0.3
Shortness of breath walking on level ground	0.2	0.3	1.4	0.1	0.1	-0.7	1.2	0.1	0.2	0.4	-0.1	0.4	0.3	1.1	0.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.2	-0.2	0.1	-0.3	-0.3	0.1	-0.3	-1.1	-0.3	-0.5	-0.6	-0.9	0.3	-0.4
Mean time to correctly identify matches	0.2	0.4	1.6	0.7	-0.9	-0.2	0.6	-0.3	0.5	1.0	0.3	0.2	0.0	-1.3	-0.2	0.4
Arm predicted mass (right)	0.2	0.8	1.8	-0.8	1.1	-1.3	-0.5	1.3	-0.8	-0.5	-1.0	-0.6	-1.0	-0.2	1.2	-0.8
Pulse rate, automated reading	0.2	0.5	1.5	0.7	-0.8	0.5	1.0	-1.2	0.6	0.1	0.5	0.5	0.8	0.3	-0.8	0.8
Chest pain or discomfort	0.2	0.3	1.3	-0.4	0.5	0.3	-0.6	0.6	-0.4	-0.6	-0.3	-0.2	0.0	0.1	1.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.3	-0.0	-0.2	-0.9	0.0	0.9	-0.2	-0.0	-0.3	-0.6	-0.5	-1.1	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.1	0.1	-0.2	-0.2	0.2	-0.4	0.1	-0.2	-0.0	-0.2	-1.0	-1.0	0.8	-0.3
Knee pain experienced in last month	0.2	0.3	2.4	0.3	-0.2	0.0	1.5	0.2	0.3	0.3	0.3	0.3	-0.0	0.3	0.8	0.2
Illnesses of siblings: Diabetes	0.2	0.3	1.4	0.5	-0.5	0.6	-0.3	0.0	0.5	1.2	0.6	0.5	0.3	0.2	-0.4	0.2
Whole body fat-free mass	0.2	1.4	2.9	-1.1	1.3	-1.7	-0.7	1.7	-1.1	-0.8	-1.3	-0.9	-1.3	-0.6	1.1	-1.1
Leg fat-free mass (right)	0.2	1.1	2.7	-0.8	1.0	-1.6	-0.7	1.6	-0.8	-1.1	-1.1	-0.8	-1.0	-0.8	0.8	-0.9
Average weekly red wine intake	0.2	0.3	0.8	0.6	-0.7	-0.3	0.3	-0.9	0.5	-0.5	0.5	0.4	-0.2	0.4	-0.5	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.9	-0.2	0.2	-0.5	-0.6	0.4	-0.3	-1.0	-0.3	-0.5	-0.4	-0.7	-0.2	-0.5
Mood swings	0.2	0.4	1.2	-0.4	0.2	-0.3	-1.1	0.5	-0.4	-0.9	-0.4	-0.6	-0.2	-1.0	-0.1	-0.5
Asthma (self-reported)	0.2	0.3	0.7	0.4	-0.5	0.8	0.3	-0.3	0.3	0.9	0.4	-0.0	0.7	-0.8	-0.9	0.1
Whole body water mass	0.2	1.1	2.5	-1.0	1.2	-1.6	-0.6	1.5	-0.9	-0.7	-1.2	-0.8	-1.1	-0.4	1.0	-0.9
Leg predicted mass (right)	0.2	1.0	2.6	-0.8	1.0	-1.6	-0.6	1.5	-0.8	-1.0	-1.1	-0.8	-1.0	-0.7	0.8	-0.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.5	-0.5	0.7	0.4	0.0	0.5	0.6	0.6	0.5	0.9	0.3	0.0	0.6
Hearing aid user	0.2	0.2	0.6	0.3	-0.1	0.8	-0.2	-0.2	0.4	0.7	0.4	0.5	0.4	0.6	0.7	0.1
Financial situation satisfaction	0.2	0.2	0.5	0.1	-0.2	0.1	-0.7	0.2	-0.0	-0.7	-0.1	-0.2	-0.7	-0.5	0.7	-0.3
Medication: Blood pressure	0.2	0.3	0.9	-0.6	0.8	0.4	0.9	0.1	-0.5	0.3	-0.3	-0.2	0.1	0.9	0.9	-0.1
Illnesses of father: High blood pressure	0.2	0.2	0.9	0.4	-0.3	0.1	-0.5	-0.4	0.5	0.1	0.4	0.6	0.7	0.2	-1.0	0.2
Alcohol drinker status: Never	0.2	0.2	0.7	0.5	-0.6	0.8	0.0	-0.5	0.4	-0.2	0.3	0.3	0.0	0.2	-0.7	0.4
Basal metabolic rate	0.2	1.3	2.9	-1.0	1.1	-1.7	-0.8	1.7	-1.0	-0.9	-1.2	-0.9	-1.3	-0.8	1.1	-1.1
Arm fat-free mass (left)	0.2	1.2	2.2	-1.0	1.1	-1.5	-0.7	1.5	-0.9	-0.6	-1.1	-0.9	-1.2	-0.7	1.4	-1.0
Diastolic blood pressure, automated reading	0.2	0.7	1.5	0.7	-0.7	1.2	0.7	-0.5	0.8	0.9	0.8	0.7	1.2	0.3	-1.0	0.5
Unable to work because of sickness or disability	0.2	0.3	0.6	0.6	-0.5	0.6	-0.0	-0.2	0.6	0.4	0.6	0.6	0.7	0.2	-0.2	0.6
Commuting to job workplace: Cycle	0.2	0.3	1.0	0.6	-0.6	0.1	0.2	-0.3	0.5	1.0	0.5	0.3	0.4	-0.5	-0.9	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	-0.8	0.8	-0.9	-0.8	0.7	-0.8	-0.4	-0.7	-0.9	-0.5	-0.9	-0.2	-0.8
Neuroticism (Nagel 2018)	0.1	0.1	0.8	-0.3	0.4	0.1	-0.5	0.2	-0.3	0.2	-0.1	0.1	0.0	0.4	0.9	-0.3
Worry (Nagel 2018)	0.1	0.3	1.1	-0.1	0.2	0.3	-0.1	-0.3	0.1	0.7	0.2	0.6	0.4	1.1	1.0	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.7	0.2	-0.2	0.4	0.1	-0.4	0.2	0.2	0.3	0.3	0.4	0.9	-0.2	0.3
Crohns Disease (2017)	0.1	0.2	0.5	0.4	-0.4	-0.2	0.3	-0.1	0.3	0.7	0.1	0.7	-0.3	0.3	0.6	0.5
Major Depression (MDD)	0.1	0.2	0.6	0.5	-0.8	0.2	0.8	-0.2	0.3	0.0	0.2	0.0	-0.3	-0.4	-0.5	0.3
Rheumatoid Arthritis	0.1	0.1	0.8	-0.1	0.0	0.2	-0.9	-0.3	-0.1	-0.5	-0.1	-0.1	-0.2	0.1	0.5	0.1
Blood Eosinophil Count	0.1	1.0	3.4	1.3	-1.6	0.1	-0.3	-1.1	1.1	0.9	0.7	0.6	0.4	-0.9	-1.8	0.8
Blood Platelet Count	0.1	1.3	2.7	1.2	-1.2	0.7	1.4	-1.1	1.2	0.8	0.9	1.2	1.1	0.8	-1.6	1.0
Waist Hip Ratio (WHR)	0.1	0.4	0.8	0.6	-0.5	-0.1	0.8	-0.9	0.5	0.4	0.4	0.6	0.6	0.8	-0.8	0.7
Systolic Blood Pressure	0.1	0.5	1.4	0.5	-0.3	0.6	0.1	-0.3	0.7	0.9	0.8	0.9	1.2	0.9	-0.4	0.6
Smoking Status	0.1	0.3	1.2	0.5	-0.6	0.4	0.9	-0.4	0.4	0.2	0.3	0.3	0.9	0.2	-1.1	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.8	0.5	-0.5	0.2	0.9	-0.5	0.5	0.4	0.6	0.6	0.2	0.6	-0.1	0.5
Lung FEV1/FVC ratio	0.1	0.5	1.1	-0.3	0.1	-0.6	-0.9	0.9	-0.4	-0.7	-0.5	-0.8	-0.9	-1.0	0.7	-0.5
Neuroticism	0.1	0.2	0.8	-0.5	0.5	-0.6	-0.9	0.5	-0.4	-0.2	-0.5	-0.4	-0.2	-0.3	0.3	-0.4
Hair Pigment	0.1	2.8	3.9	-1.8	1.9	-1.9	-0.1	2.0	-1.7	-1.6	-1.9	-1.7	-1.5	-1.2	1.4	-2.0
Average weekly spirits intake	0.1	0.1	0.3	-0.4	0.4	0.5	-0.5	0.1	-0.5	0.1	-0.3	-0.5	-0.2	-0.5	0.0	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.3	-0.3	-0.0	0.4	0.0	0.3	-0.3	0.2	0.3	0.3	0.0	0.4	0.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.5	-0.0	0.0	0.2	-0.4	-0.4	-0.1	0.1	-0.2	-0.2	0.0	-0.7	-0.4	-0.3
Supplements: Zinc	0.1	0.1	0.5	-0.0	-0.0	0.7	0.1	0.1	0.0	-0.1	0.2	-0.0	0.2	-0.1	0.6	0.2
Medication: Metformin	0.1	0.1	0.6	0.4	-0.5	0.0	0.8	-0.4	0.3	0.1	0.3	0.2	0.0	-0.2	-0.4	0.3
Pack years adult smoking proportion	0.1	0.2	1.0	-0.1	0.1	-0.5	-0.5	-0.0	-0.1	-0.9	-0.3	0.0	-0.4	-0.3	1.0	-0.2
Trunk fat percentage	0.1	0.4	2.3	0.3	-0.5	-0.8	-0.5	0.6	0.1	-0.4	-0.3	-0.5	-0.7	-1.5	-0.3	-0.3
Hand grip strength (right)	0.1	0.2	1.2	-0.1	0.3	-0.3	0.1	0.5	0.1	-0.7	-0.1	0.5	0.4	1.1	0.2	0.2
Relative age voice broke	0.1	0.2	0.5	0.2	-0.2	0.6	0.3	-0.6	0.3	0.0	0.6	0.4	0.6	0.7	-0.7	0.3
Taking other prescription medications	0.1	0.2	1.0	0.4	-0.4	-0.2	0.4	-0.1	0.4	1.0	0.3	0.4	0.4	-0.3	-0.0	0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.7	-0.4	0.5	-0.5	-0.2	0.8	-0.4	0.2	-0.4	-0.1	-0.1	0.2	0.3	-0.4
Supplements: Glucosamine	0.1	0.2	1.6	-0.1	0.3	0.1	-0.3	0.2	-0.0	0.3	0.1	0.1	-0.3	0.2	1.3	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.9	-0.1	0.1	-0.0	0.4	-0.3	-0.2	-0.1	0.0	-0.2	0.6	0.6	-0.9	0.3
Trunk fat mass	0.1	0.3	1.5	0.2	-0.3	-0.9	-0.4	0.8	0.0	-0.4	-0.3	-0.4	-0.8	-1.2	-0.2	-0.3
Waist circumference	0.1	0.2	0.9	0.6	-0.7	-0.5	0.1	0.2	0.4	0.3	0.0	-0.1	-0.2	-0.9	-0.7	0.2
Past tobacco smoking	0.1	0.2	1.6	0.1	0.1	0.0	-0.3	0.1	0.2	-0.0	0.3	0.5	-0.2	0.9	1.3	0.1
Forced vital capacity (FVC)	0.1	0.5	1.6	0.6	-0.3	0.4	0.1	-0.4	0.8	0.9	0.6	1.2	0.7	1.3	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.6	-0.6	0.8	-0.2	-0.1	0.6	0.5	0.6	0.4	0.0	-0.3	-0.4	0.4
Pain all over the body in last month	0.1	0.1	0.4	-0.1	0.2	-0.4	-0.7	0.5	-0.1	-0.0	-0.3	-0.1	0.2	-0.3	-0.5	-0.1
Illnesses of siblings	0.1	0.2	1.0	-0.2	0.0	-0.2	-0.3	0.3	-0.3	-1.0	-0.5	-0.5	-0.2	-0.6	-0.2	-0.4
Neuroticism score	0.1	0.3	1.0	-0.4	0.4	-0.6	-1.0	0.3	-0.4	-0.7	-0.4	-0.4	-0.5	-0.4	0.8	-0.3
Weight	0.1	0.5	1.4	-0.2	0.2	-1.2	-0.6	1.1	-0.3	-0.6	-0.7	-0.5	-0.9	-1.0	0.3	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.3	-0.1	-0.3	-0.4	-0.3	-0.3	0.0	-0.3	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	0.6	-0.2	0.2	-0.1	-0.1	0.8	0.6	0.6	1.1	0.6	1.2	0.4	0.4
Noisy workplace	0.1	0.2	1.1	0.3	-0.4	-0.4	1.1	-0.0	0.3	-0.1	0.0	0.2	0.0	0.5	-0.2	0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	0.2	-0.2	0.5	0.8	-0.3	0.2	0.5	0.3	0.2	0.3	0.3	-0.4	0.3
Asthma	0.1	0.3	0.8	0.2	-0.4	0.8	0.1	-0.0	0.1	0.9	0.3	-0.1	0.6	-0.9	-0.6	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	0.4	-0.1	-0.2	-0.4	0.0	0.6	0.5	0.3	0.8	0.2	0.7	0.6	0.1
Arm fat mass (right)	0.1	0.3	1.1	0.7	-0.8	-0.6	-0.2	0.2	0.5	0.1	0.1	-0.0	-0.4	-1.0	-0.8	0.2
Hair/balding pattern: Pattern 4	0.1	0.4	2.0	-0.2	-0.0	0.2	-0.7	0.0	-0.3	0.3	-0.3	-0.7	-0.3	-1.1	-1.4	-0.5
Glaucoma (self-reported)	0.1	0.1	0.3	-0.2	0.2	-0.0	-0.3	0.3	-0.3	0.2	-0.2	-0.2	-0.4	-0.4	0.6	-0.2
High blood pressure (siblings)	0.1	0.1	0.5	-0.3	0.3	-0.1	0.7	-0.2	-0.1	0.3	0.0	-0.0	-0.0	0.4	0.3	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	1.4	0.2	0.2	0.2	-0.2	-0.2	0.4	0.7	0.2	0.9	0.3	1.2	1.1	0.1
Body fat percentage	0.1	0.4	1.2	0.9	-1.1	-0.3	0.0	0.0	0.6	-0.0	0.3	0.0	-0.3	-1.1	-0.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.3	-0.3	0.5	-0.6	-0.3	0.3	0.4	0.3	0.2	0.1	-0.2	0.3	0.3
Number of children fathered	0.1	0.1	0.4	-0.3	0.1	-0.5	-0.3	0.3	-0.3	-0.3	-0.4	-0.4	-0.6	-0.3	0.6	-0.2
Pulse wave peak to peak time	0.1	0.2	0.5	0.3	-0.5	0.7	-0.4	-0.4	0.2	-0.6	0.3	0.1	0.3	0.0	-0.2	0.5
Medication: Seretide 50 evohaler	0.1	0.2	0.9	0.3	-0.2	-0.6	1.0	0.1	0.4	-0.3	0.1	0.3	-0.2	0.3	0.3	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.1	0.0	0.3	0.0	0.3	-0.1	-0.4	-0.0	-0.3	-0.3	-0.7	0.7	-0.3
Whole body fat mass	0.1	0.3	1.4	0.3	-0.5	-0.8	-0.2	0.6	0.1	-0.2	-0.3	-0.4	-0.7	-1.2	-0.4	-0.2
Leg fat mass (right)	0.1	0.3	1.0	0.8	-1.0	-0.5	-0.2	0.1	0.6	0.1	0.2	0.1	-0.4	-0.9	-0.8	0.3
Comparative height size at age 10	0.1	0.3	1.0	-0.6	0.7	-0.6	0.2	0.9	-0.5	-0.6	-0.5	-0.3	-0.4	0.1	1.0	-0.4
Suffer from ‘nerves’	0.1	0.2	0.8	-0.2	0.1	-0.9	-0.5	0.4	-0.2	-0.3	-0.5	-0.2	-0.4	-0.7	-0.5	-0.5
Leg pain on walking	0.1	0.2	0.6	0.3	-0.2	-0.2	0.8	0.4	0.3	0.5	0.3	0.3	0.4	0.3	0.7	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.0	-0.1	0.2	0.4	0.4	-0.0	-0.5	-0.1	-0.2	0.1	-0.3	-0.3	-0.0
Illnesses of father: Heart disease	0.1	0.2	0.7	0.2	-0.1	0.3	0.5	-0.1	0.3	0.0	0.3	0.5	-0.1	0.9	0.5	0.3
Smoking status: Previous	0.1	0.2	1.0	-0.1	-0.1	-0.4	0.1	-0.1	-0.2	-0.1	-0.3	-0.6	-0.2	-1.0	-1.0	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	1.1	-0.1	-0.0	-0.7	0.6	1.1	-0.1	-0.1	-0.3	-0.2	-0.2	-0.5	0.5	-0.2
Eye problems/disorders: Cataract	0.1	0.1	1.0	0.3	-0.5	-0.1	1.0	-0.2	0.2	0.2	0.2	0.1	-0.1	0.2	-0.3	0.4
Medication for cholesterol	0.1	0.2	1.2	0.0	-0.0	-0.8	-0.4	-0.0	0.1	-0.3	-0.1	-0.0	-0.2	-0.1	-1.1	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	0.2	-0.1	0.1	0.5	-0.3	-0.4	-0.4	-0.3	-0.3	-0.3	0.4	-0.4
Arm fat mass (left)	0.1	0.3	1.0	0.9	-1.0	-0.4	0.1	0.1	0.7	0.4	0.3	0.2	-0.1	-0.8	-0.9	0.4
Commuting to job workplace: Public transport	0.1	0.2	0.6	-0.4	0.6	0.2	0.4	0.1	-0.3	0.4	-0.1	0.2	0.8	0.7	0.2	-0.2
Ever smoked	0.1	0.3	2.3	-0.0	-0.2	0.3	0.1	-0.4	-0.2	-0.1	-0.1	-0.3	0.5	-0.5	-1.5	0.0
Number of operations (self-reported)	0.1	0.2	0.6	-0.2	0.2	0.3	-0.7	0.0	-0.4	-0.4	-0.2	-0.6	-0.1	-0.8	0.4	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.9	-0.4	0.5	0.3	-0.4	-0.1	-0.3	-0.1	-0.2	-0.0	-0.1	0.3	0.9	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.1	0.2	0.4	0.3	-0.3	-0.0	-0.2	-0.0	0.2	0.3	0.6	-0.0	-0.1
Leg fat mass (left)	0.1	0.4	1.4	1.0	-1.2	-0.2	0.1	-0.1	0.8	0.2	0.4	0.3	-0.1	-0.7	-1.0	0.5
Arm predicted mass (left)	0.1	0.6	1.4	-0.6	0.8	-1.2	-0.5	1.2	-0.6	-0.3	-0.8	-0.6	-1.0	-0.4	1.1	-0.7
Depressed Affect (Nagel 2018)	0.0	0.0	0.2	-0.2	0.2	0.1	-0.4	0.2	-0.2	-0.3	-0.0	-0.1	0.2	-0.0	0.1	-0.2
Schizophrenia (2018)	0.0	0.1	0.2	-0.1	0.2	0.2	-0.5	0.3	-0.1	-0.0	-0.1	0.0	0.4	0.0	-0.0	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.1	0.3	0.0	0.0	0.1	-0.5	0.1	0.2	0.6	0.1	0.2	0.1	0.1	0.3	-0.1
Schizophrenia (2014)	0.0	0.1	0.3	0.2	-0.2	0.5	0.6	-0.1	0.3	0.3	0.3	0.2	0.5	-0.1	-0.2	0.1
Heel T-Score	0.0	0.2	1.0	0.2	-0.3	0.7	-0.7	0.3	0.1	0.1	0.2	-0.1	-0.2	-1.0	0.2	-0.2
Cardiovascular Disease	0.0	0.1	0.4	0.3	-0.2	0.2	0.6	-0.1	0.4	0.3	0.3	0.4	0.2	0.7	0.1	0.1
Hypothyroidism (self reported)	0.0	0.1	0.4	0.1	-0.2	-0.4	0.6	-0.0	-0.1	-0.0	0.1	-0.2	0.3	-0.0	-0.7	0.3
Tanning	0.0	0.1	0.4	0.4	-0.5	-0.1	-0.0	-0.5	0.2	-0.5	0.2	-0.0	-0.6	-0.3	0.6	0.4
Hand grip strength (left)	0.0	0.1	0.6	-0.0	0.1	-0.3	0.4	0.3	0.1	-0.5	-0.1	0.2	0.1	0.7	-0.6	0.1
Sensitivity / hurt feelings	0.0	0.0	0.3	-0.1	0.1	0.4	-0.5	-0.2	-0.1	0.2	0.0	-0.0	0.1	0.1	0.2	0.1
Fed-up feelings	0.0	0.1	0.2	-0.0	-0.0	-0.2	0.1	-0.2	-0.0	-0.4	0.1	0.1	0.4	0.5	-0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.7	0.2	-0.2	0.8	-0.3	0.2	0.2	0.3	0.2	0.1	0.1	-0.1	0.3	0.2
High blood pressure	0.0	0.0	0.2	0.2	-0.2	0.4	0.0	-0.0	0.2	0.0	0.1	0.2	-0.3	0.0	0.3	0.1
Nervous feelings	0.0	0.1	0.2	-0.0	0.0	0.1	-0.3	-0.1	0.1	0.5	0.1	0.2	0.2	0.4	0.3	0.3
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.4	-0.1	0.1	-0.4	0.3	-0.1	-0.0	-0.5	-0.2	0.1	-0.7	0.1	0.1	-0.4
Birth weight of first child	0.0	0.1	0.2	0.3	-0.4	0.2	0.5	0.2	0.3	0.3	0.3	0.1	0.2	-0.4	-0.3	0.1
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.2	-0.3	0.4	0.0	0.1	0.0	-0.2	0.3	-0.0	-0.2	0.0	0.1	0.4	-0.2
Hypertension (Self-reported)	0.0	0.0	0.2	0.1	-0.1	0.3	0.2	0.2	0.2	0.1	0.0	0.2	-0.2	0.1	0.4	-0.0
Osteoporosis (self-reported)	0.0	0.1	0.2	0.2	-0.3	-0.2	0.4	-0.3	0.2	-0.2	0.0	0.0	-0.1	-0.3	0.3	0.1

Hub : Genes

TULP3

Models

Trait associations