Hub : Genes

TULP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1710	0.0310	1.4e-12	0.175	0.103	0.171	0.157	0.171	7.6e-21	1.5e-12	2.5e-20	1.0e-18	2.8e-20
2	GTEx	Adrenal Gland	0.2234	0.0738	5.8e-03	0.205	NA	0.123	NA	0.189	6.7e-08	NA	3.5e-05	NA	2.4e-07
3	GTEx	Brain Caudate basal ganglia	0.3280	0.0820	1.1e-04	0.273	NA	0.286	NA	0.192	1.7e-08	NA	7.0e-09	NA	3.5e-06
4	GTEx	Cells Transformed fibroblasts	0.1870	0.0490	3.9e-05	0.077	NA	0.110	NA	0.090	2.0e-06	NA	1.4e-08	NA	3.0e-07
5	GTEx	Esophagus Muscularis	0.1270	0.0470	3.6e-03	0.051	NA	0.034	NA	0.050	4.7e-04	NA	3.8e-03	NA	5.4e-04
6	GTEx	Nerve Tibial	0.1347	0.0456	1.6e-03	0.053	NA	0.047	NA	0.058	1.3e-04	NA	3.0e-04	NA	6.0e-05
7	GTEx	Skin Not Sun Exposed Suprapubic	0.2880	0.0580	5.4e-07	0.207	NA	0.205	NA	0.205	1.4e-11	NA	1.7e-11	NA	1.9e-11
8	GTEx	Skin Sun Exposed Lower leg	0.3630	0.0490	0.0e+00	0.352	NA	0.341	NA	0.352	3.3e-30	NA	3.6e-29	NA	3.5e-30
9	ROSMAP	Brain Pre-frontal Cortex	0.3238	0.0363	0.0e+00	0.384	0.295	0.400	0.391	0.405	1.9e-52	2.5e-38	4.7e-55	1.4e-53	5.0e-56
10	TCGA	Bladder Urothelial Carcinoma	0.0370	0.0210	2.3e-03	0.021	0.021	0.008	NA	0.010	5.9e-03	6.2e-03	6.6e-02	NA	4.4e-02
11	TCGA	Breast Invasive Carcinoma	0.0458	0.0206	1.2e-04	0.017	0.021	0.013	NA	0.024	1.3e-04	3.2e-05	9.5e-04	NA	6.8e-06
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0315	0.0198	9.0e-03	0.011	0.008	0.002	NA	0.006	1.7e-02	3.8e-02	1.7e-01	NA	5.9e-02
13	TCGA	Brain Lower Grade Glioma	0.0825	0.0268	1.2e-11	0.114	0.095	0.097	NA	0.103	7.3e-13	7.0e-11	4.1e-11	NA	1.0e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.7	1.1	2.0	0.9	-0.8	1.1	1.1	-1.2	1.0	0.9	1.1	1.2	0.8	1.4	-0.5	1.2
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	0.5	-0.4	0.9	0.2	-0.5	0.5	0.5	0.6	0.8	0.8	0.9	-0.3	0.6
Depressed Affect (Nagel 2018)	0.0	0.0	0.2	-0.2	0.2	0.1	-0.4	0.2	-0.2	-0.3	-0.0	-0.1	0.2	-0.0	0.1	-0.2
Depression (Nagel 2018)	0.3	0.5	0.8	0.6	-0.7	0.8	0.5	-0.6	0.6	0.7	0.8	0.7	0.9	0.6	-0.6	0.8
Intelligence (Savage-Jansen 2018)	1.5	4.6	6.1	-2.4	2.3	-1.9	-1.3	2.2	-2.4	-2.4	-2.4	-2.4	-2.3	-1.4	1.5	-2.5
Neuroticism (Nagel 2018)	0.1	0.1	0.8	-0.3	0.4	0.1	-0.5	0.2	-0.3	0.2	-0.1	0.1	0.0	0.4	0.9	-0.3
Schizophrenia (2018)	0.0	0.1	0.2	-0.1	0.2	0.2	-0.5	0.3	-0.1	-0.0	-0.1	0.0	0.4	0.0	-0.0	-0.1
Schizophrenia vs Biploar Disorder	1.5	1.9	4.0	-1.3	1.2	-0.9	-1.3	1.7	-1.3	-0.5	-1.5	-1.6	-1.4	-2.0	1.4	-1.5
Worry (Nagel 2018)	0.1	0.3	1.1	-0.1	0.2	0.3	-0.1	-0.3	0.1	0.7	0.2	0.6	0.4	1.1	1.0	0.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.8	-0.3	0.2	-0.1	-0.7	0.5	-0.5	-0.4	-0.5	-0.6	-0.2	-1.4	-0.2	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.7	0.2	-0.2	0.4	0.1	-0.4	0.2	0.2	0.3	0.3	0.4	0.9	-0.2	0.3
Alzheimer’s Disease (including proxy)	0.2	0.2	0.6	-0.5	0.5	0.1	-0.8	0.7	-0.6	-0.6	-0.5	-0.5	0.0	-0.3	0.2	-0.5
Crohns Disease (2017)	0.1	0.2	0.5	0.4	-0.4	-0.2	0.3	-0.1	0.3	0.7	0.1	0.7	-0.3	0.3	0.6	0.5
Irritable Bowel Disease (IBD)	0.4	1.1	2.1	1.0	-0.8	0.3	1.0	-0.9	1.0	1.4	0.9	1.4	1.0	1.2	-0.6	1.2
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.6	-0.5	0.1	0.9	-0.8	0.7	1.1	0.7	1.0	1.1	0.7	-1.0	0.9
Major Depression (MDD)	0.1	0.2	0.6	0.5	-0.8	0.2	0.8	-0.2	0.3	0.0	0.2	0.0	-0.3	-0.4	-0.5	0.3
Reaction Time	0.2	0.3	0.8	0.7	-0.9	-0.1	0.6	-0.4	0.6	0.6	0.4	0.3	0.2	-0.9	-0.4	0.5
Verbal and Numeric Reasoning (VNR)	2.4	5.8	9.1	-2.6	2.5	-1.7	-2.1	2.2	-2.7	-3.0	-2.6	-2.6	-2.3	-2.2	1.9	-2.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.2	0.2	0.8	-0.4	0.4	-0.5	-0.4	0.3	-0.6	-0.3	-0.5	-0.7	-0.3	-0.9	-0.4	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.5	-0.0	0.1	0.6	0.6	0.1	0.0	-0.5	0.1	0.4	0.9	1.2	-0.7	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	1.0	0.3	-0.1	0.6	-0.1	-0.3	0.3	1.0	0.5	0.5	0.4	0.8	0.1	0.3
Coronary Artery Disease (CAD)	0.9	1.1	4.9	0.6	-0.3	0.7	1.3	-0.8	0.9	0.4	0.8	0.9	1.5	2.2	-0.2	1.2
Crohns Disease (2012)	0.3	0.5	1.1	0.9	-1.0	0.3	0.8	-0.6	0.8	1.0	0.7	1.1	0.2	0.7	0.3	0.0
Mean Putamen Volume	0.2	0.2	0.9	0.0	0.1	-0.1	0.8	-0.2	0.1	-0.1	0.0	0.3	-0.2	0.9	0.6	0.4
Fasting Glucose	0.8	0.9	2.8	0.6	-0.5	1.3	1.1	-0.6	0.7	1.6	0.5	0.8	0.3	1.0	1.7	0.8
HbA1C	0.3	0.4	0.9	0.3	-0.2	0.9	-0.6	-0.6	0.2	0.8	0.5	0.6	0.8	0.7	-0.1	0.6
HDL Cholesterol	0.8	1.3	2.0	-1.3	1.3	-1.0	-0.8	1.0	-1.3	-0.7	-1.2	-1.4	-1.1	-1.0	1.1	-1.4
LDL Cholesterol	0.2	0.3	0.9	0.3	-0.2	0.4	0.9	-0.2	0.4	0.5	0.3	0.9	0.8	0.9	-0.5	0.6
Lupus	0.5	0.8	1.7	-0.6	0.4	-0.7	-0.9	1.2	-0.7	-0.8	-1.0	-1.0	-1.1	-1.3	0.9	-0.8
Neuroticism (2016)	0.0	0.1	0.3	0.0	0.0	0.1	-0.5	0.1	0.2	0.6	0.1	0.2	0.1	0.1	0.3	-0.1
Primary Biliary Cirrhosis	0.2	0.3	1.8	0.2	-0.4	-1.3	0.3	0.0	0.2	0.6	-0.2	-0.0	-0.4	-0.3	-1.0	0.0
Rheumatoid Arthritis	0.1	0.1	0.8	-0.1	0.0	0.2	-0.9	-0.3	-0.1	-0.5	-0.1	-0.1	-0.2	0.1	0.5	0.1
Schizophrenia (2014)	0.0	0.1	0.3	0.2	-0.2	0.5	0.6	-0.1	0.3	0.3	0.3	0.2	0.5	-0.1	-0.2	0.1
Triglycerides	1.0	1.7	2.5	-1.6	1.5	-1.4	-0.5	1.4	-1.5	-1.1	-1.4	-1.2	-1.6	-0.3	1.2	-1.3
Type 2 Diabetes (T2D) (2012)	1.1	1.2	5.4	1.1	-1.5	0.7	0.7	-1.4	0.8	0.7	0.8	0.8	1.0	0.7	-2.3	0.0
Ulcerative Colitis	0.3	0.4	0.9	0.7	-0.5	0.1	0.5	-0.4	0.8	0.5	0.7	0.8	1.0	0.8	-0.7	0.7
Blood Eosinophil Count	0.1	1.0	3.4	1.3	-1.6	0.1	-0.3	-1.1	1.1	0.9	0.7	0.6	0.4	-0.9	-1.8	0.8
Blood Platelet Count	0.1	1.3	2.7	1.2	-1.2	0.7	1.4	-1.1	1.2	0.8	0.9	1.2	1.1	0.8	-1.6	1.0
Blood Red Count	0.3	3.2	9.0	-1.9	2.3	-1.3	-2.1	2.3	-1.6	-0.3	-1.7	-0.9	-1.1	0.4	3.0	-2.0
Blood White Count	4.0	29.9	35.3	5.8	-5.8	4.7	4.2	-5.8	5.9	4.9	5.7	5.9	5.8	5.1	-5.2	5.9
Heel T-Score	0.0	0.2	1.0	0.2	-0.3	0.7	-0.7	0.3	0.1	0.1	0.2	-0.1	-0.2	-1.0	0.2	-0.2
BMI	0.2	1.4	4.7	1.6	-1.7	-0.3	0.5	-0.9	1.4	1.3	0.9	0.8	0.6	-0.3	-2.2	1.0
Height	1.6	31.7	40.9	-6.1	6.4	-5.0	-5.6	6.3	-5.9	-4.9	-5.9	-5.3	-5.4	-3.5	6.4	-5.8
Waist Hip Ratio (WHR)	0.1	0.4	0.8	0.6	-0.5	-0.1	0.8	-0.9	0.5	0.4	0.4	0.6	0.6	0.8	-0.8	0.7
Systolic Blood Pressure	0.1	0.5	1.4	0.5	-0.3	0.6	0.1	-0.3	0.7	0.9	0.8	0.9	1.2	0.9	-0.4	0.6
Smoking Status	0.1	0.3	1.2	0.5	-0.6	0.4	0.9	-0.4	0.4	0.2	0.3	0.3	0.9	0.2	-1.1	0.4
Allergy or Eczema	0.4	1.2	8.1	0.1	-0.5	-1.1	-1.1	0.5	-0.3	0.1	-0.5	-1.1	-1.4	-2.8	-0.6	-0.6
Cardiovascular Disease	0.0	0.1	0.4	0.3	-0.2	0.2	0.6	-0.1	0.4	0.3	0.3	0.4	0.2	0.7	0.1	0.1
Hypothyroidism (self reported)	0.0	0.1	0.4	0.1	-0.2	-0.4	0.6	-0.0	-0.1	-0.0	0.1	-0.2	0.3	-0.0	-0.7	0.3
Respiratory disease	0.2	0.3	2.1	0.3	-0.5	0.0	0.4	-0.2	0.3	0.9	0.2	-0.0	0.6	-0.7	-1.4	-0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.8	0.5	-0.5	0.2	0.9	-0.5	0.5	0.4	0.6	0.6	0.2	0.6	-0.1	0.5
Lung FEV1/FVC ratio	0.1	0.5	1.1	-0.3	0.1	-0.6	-0.9	0.9	-0.4	-0.7	-0.5	-0.8	-0.9	-1.0	0.7	-0.5
Lung FVC	1.9	9.8	13.7	3.3	-3.0	2.6	2.5	-3.4	3.6	3.6	3.2	3.7	2.8	3.3	-1.8	3.2
Neuroticism	0.1	0.2	0.8	-0.5	0.5	-0.6	-0.9	0.5	-0.4	-0.2	-0.5	-0.4	-0.2	-0.3	0.3	-0.4
Chronotype (morning person)	0.3	0.7	1.9	0.7	-0.5	0.4	0.5	-1.2	0.7	0.9	0.8	0.9	0.5	1.4	-0.9	0.8
Hair Pigment	0.1	2.8	3.9	-1.8	1.9	-1.9	-0.1	2.0	-1.7	-1.6	-1.9	-1.7	-1.5	-1.2	1.4	-2.0
Tanning	0.0	0.1	0.4	0.4	-0.5	-0.1	-0.0	-0.5	0.2	-0.5	0.2	-0.0	-0.6	-0.3	0.6	0.4
Hand grip strength (left)	0.0	0.1	0.6	-0.0	0.1	-0.3	0.4	0.3	0.1	-0.5	-0.1	0.2	0.1	0.7	-0.6	0.1
Number of treatments/medications taken	0.5	0.9	1.5	1.0	-0.8	1.0	0.7	-0.7	1.0	1.2	1.0	1.1	0.8	1.0	0.5	1.1
Average weekly spirits intake	0.1	0.1	0.3	-0.4	0.4	0.5	-0.5	0.1	-0.5	0.1	-0.3	-0.5	-0.2	-0.5	0.0	-0.4
Sensitivity / hurt feelings	0.0	0.0	0.3	-0.1	0.1	0.4	-0.5	-0.2	-0.1	0.2	0.0	-0.0	0.1	0.1	0.2	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.6	-0.6	0.4	-0.2	-0.7	0.5	0.1	0.6	0.5	0.4	0.1	-0.2	0.6
Hearing difficulty/problems: Yes	0.2	0.3	1.4	-0.3	0.5	-0.2	-0.2	0.8	-0.2	-0.7	-0.3	0.0	-0.0	0.4	1.2	-0.3
Relative age of first facial hair	0.8	1.7	3.2	-1.4	1.5	-1.1	-1.4	1.3	-1.4	-1.8	-1.2	-1.3	-1.1	-1.1	0.1	-1.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.3	-0.3	-0.0	0.4	0.0	0.3	-0.3	0.2	0.3	0.3	0.0	0.4	0.3
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.9	1.6	-1.5	1.3	1.7	-1.6	1.5	0.7	1.4	1.5	1.1	1.0	-0.3	1.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.5	-0.0	0.0	0.2	-0.4	-0.4	-0.1	0.1	-0.2	-0.2	0.0	-0.7	-0.4	-0.3
Systolic blood pressure, automated reading	0.2	0.5	2.0	0.7	-0.7	1.0	-0.0	-0.5	0.8	1.4	0.8	0.6	0.9	-0.2	-0.6	0.5
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	5.5	2.1	-2.4	0.7	1.3	-2.0	1.9	1.2	1.7	1.5	1.2	0.4	-2.0	1.9
Angina	2.3	3.0	4.3	1.8	-1.6	1.6	2.1	-1.7	1.8	1.3	1.9	2.1	1.7	1.8	-0.6	1.9
Medication for hormone replacement therapy	2.3	2.6	4.3	2.0	-2.1	1.2	2.0	-1.8	1.9	0.5	1.8	1.7	1.5	0.9	-0.6	1.8
Vitamin and mineral supplements	1.1	1.5	2.9	1.2	-1.1	1.0	1.3	-0.9	1.2	0.9	1.1	1.2	1.7	1.2	-1.6	1.3
Supplements: Zinc	0.1	0.1	0.5	-0.0	-0.0	0.7	0.1	0.1	0.0	-0.1	0.2	-0.0	0.2	-0.1	0.6	0.2
Medication: Co-codamol	1.0	1.1	1.8	1.0	-0.9	0.7	0.9	-1.1	0.9	1.3	1.0	1.1	1.1	1.2	-1.4	1.0
Medication: Metformin	0.1	0.1	0.6	0.4	-0.5	0.0	0.8	-0.4	0.3	0.1	0.3	0.2	0.0	-0.2	-0.4	0.3
Diabetes (father)	0.4	0.4	1.4	-0.5	0.4	-1.2	0.3	0.4	-0.5	-0.9	-0.5	-0.6	-0.6	-0.1	-1.0	-0.7
Diabetes (mother)	0.2	0.2	0.9	-0.0	-0.0	-1.0	-0.3	0.5	-0.1	-0.2	-0.4	-0.3	-0.8	-0.7	0.2	-0.4
Severe depression (siblings)	0.2	0.2	0.9	-0.2	0.0	-1.0	0.2	-0.5	-0.1	-0.8	-0.3	-0.3	-0.3	0.0	-0.3	0.2
Pack years adult smoking proportion	0.1	0.2	1.0	-0.1	0.1	-0.5	-0.5	-0.0	-0.1	-0.9	-0.3	0.0	-0.4	-0.3	1.0	-0.2
Impedance of leg (right)	1.0	4.8	6.1	-2.3	2.1	-1.4	-2.4	1.8	-2.4	-2.2	-2.2	-2.5	-2.5	-2.1	2.1	-2.3
Leg fat-free mass (left)	0.2	1.2	2.9	-0.8	0.9	-1.7	-1.0	1.7	-0.8	-0.9	-1.1	-0.9	-1.2	-1.0	0.8	-1.0
Trunk fat percentage	0.1	0.4	2.3	0.3	-0.5	-0.8	-0.5	0.6	0.1	-0.4	-0.3	-0.5	-0.7	-1.5	-0.3	-0.3
Hand grip strength (right)	0.1	0.2	1.2	-0.1	0.3	-0.3	0.1	0.5	0.1	-0.7	-0.1	0.5	0.4	1.1	0.2	0.2
Townsend deprivation index at recruitment	0.3	0.5	2.0	-0.5	0.5	-1.4	0.2	0.6	-0.4	-1.4	-0.7	-0.2	-0.4	0.4	-0.2	-0.6
Current tobacco smoking	0.7	1.1	2.5	0.8	-0.9	1.4	1.1	-0.8	0.9	0.8	1.0	1.1	1.6	1.3	-0.5	1.0
Average weekly fortified wine intake	1.2	1.4	2.3	1.5	-1.5	0.8	0.9	-0.9	1.4	1.1	1.3	1.4	1.0	0.6	-0.9	1.5
Maternal smoking around birth	0.3	0.4	1.0	-0.4	0.4	-0.6	-0.3	0.6	-0.5	-1.0	-0.5	-0.6	-0.4	-1.0	0.9	-0.4
Fed-up feelings	0.0	0.1	0.2	-0.0	-0.0	-0.2	0.1	-0.2	-0.0	-0.4	0.1	0.1	0.4	0.5	-0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	-0.8	0.6	-0.7	-0.4	0.6	-0.8	-1.2	-0.7	-0.8	-0.6	-0.7	0.5	-0.7
Relative age voice broke	0.1	0.2	0.5	0.2	-0.2	0.6	0.3	-0.6	0.3	0.0	0.6	0.4	0.6	0.7	-0.7	0.3
Taking other prescription medications	0.1	0.2	1.0	0.4	-0.4	-0.2	0.4	-0.1	0.4	1.0	0.3	0.4	0.4	-0.3	-0.0	0.3
Age when periods started (menarche)	3.6	8.7	12.6	-3.2	3.1	-3.2	-2.7	2.8	-3.3	-2.7	-3.2	-3.5	-2.9	-2.8	1.4	-3.0
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.3	1.3	-1.2	1.8	1.1	-1.6	1.3	1.3	1.3	1.4	1.8	1.3	-0.9	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.7	0.2	-0.2	0.8	-0.3	0.2	0.2	0.3	0.2	0.1	0.1	-0.1	0.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	-0.5	0.4	-0.2	-0.1	0.9	-0.5	0.3	-0.5	-0.5	-0.1	-0.5	0.7	-0.5
Qualifications: CSEs or equivalent	1.9	2.5	3.2	-1.4	1.5	-1.6	-1.6	1.7	-1.3	-1.8	-1.5	-1.3	-1.7	-1.4	1.8	-1.8
Serious illness, injury or assault to yourself	0.1	0.2	0.7	-0.4	0.5	-0.5	-0.2	0.8	-0.4	0.2	-0.4	-0.1	-0.1	0.2	0.3	-0.4
High blood pressure	0.0	0.0	0.2	0.2	-0.2	0.4	0.0	-0.0	0.2	0.0	0.1	0.2	-0.3	0.0	0.3	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.5	3.5	0.4	-0.5	-0.7	-1.2	0.1	0.1	0.6	-0.1	-0.4	-0.9	-1.9	-0.5	-0.2
Multivitamins +/- minerals	0.9	1.2	2.5	-0.9	0.7	-0.4	-1.2	0.8	-1.0	-1.1	-0.8	-1.0	-1.5	-1.5	1.6	-1.0
Stomach or abdominal pain in last month	0.7	0.8	1.3	-1.0	1.1	-0.6	-0.6	0.9	-1.0	-1.1	-0.9	-0.9	-1.0	-0.4	1.1	-0.9
Supplements: Glucosamine	0.1	0.2	1.6	-0.1	0.3	0.1	-0.3	0.2	-0.0	0.3	0.1	0.1	-0.3	0.2	1.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	1.1	-1.0	0.4	0.5	-0.9	1.1	0.2	1.1	1.3	1.0	1.1	-0.9	1.3
Medication: Atenolol	0.3	0.4	3.9	-0.3	0.3	0.4	0.2	0.2	-0.2	-0.1	-0.2	-0.0	-0.1	0.6	2.0	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.9	-0.1	0.1	-0.0	0.4	-0.3	-0.2	-0.1	0.0	-0.2	0.6	0.6	-0.9	0.3
Sitting height	0.8	5.4	13.1	-2.6	3.0	-1.8	-1.8	2.8	-2.3	-2.0	-2.3	-1.7	-2.1	-0.4	3.6	-2.4
Chronic bronchitis/emphysema (father)	4.9	5.7	8.3	2.2	-2.2	2.9	2.8	-2.4	2.3	1.7	2.5	2.3	2.5	2.3	-2.4	2.4
High blood pressure (mother)	4.0	5.6	7.9	-2.2	2.1	-1.9	-2.6	2.3	-2.3	-2.8	-2.4	-2.5	-2.3	-2.7	2.0	-2.5
Body mass index (BMI)	0.4	1.9	4.2	1.9	-2.0	0.3	0.9	-1.0	1.7	1.1	1.3	1.2	1.0	-0.0	-2.0	1.5
Impedance of leg (left)	0.9	4.3	6.1	-2.3	2.1	-1.3	-1.7	1.6	-2.3	-2.5	-2.0	-2.3	-2.2	-1.9	2.1	-2.2
Leg predicted mass (left)	0.2	1.1	2.7	-0.7	0.8	-1.7	-0.9	1.6	-0.8	-0.8	-1.1	-0.8	-1.2	-0.9	0.8	-0.9
Trunk fat mass	0.1	0.3	1.5	0.2	-0.3	-0.9	-0.4	0.8	0.0	-0.4	-0.3	-0.4	-0.8	-1.2	-0.2	-0.3
Waist circumference	0.1	0.2	0.9	0.6	-0.7	-0.5	0.1	0.2	0.4	0.3	0.0	-0.1	-0.2	-0.9	-0.7	0.2
Number of incorrect matches in round	2.8	4.6	8.2	2.1	-1.9	1.7	2.9	-2.3	2.2	2.1	2.3	2.4	1.9	2.2	-1.0	2.5
Past tobacco smoking	0.1	0.2	1.6	0.1	0.1	0.0	-0.3	0.1	0.2	-0.0	0.3	0.5	-0.2	0.9	1.3	0.1
Alcohol usually taken with meals	1.0	1.7	3.1	1.4	-1.6	0.9	1.0	-1.5	1.2	1.8	1.2	1.1	0.8	1.1	-1.7	1.3
Nervous feelings	0.0	0.1	0.2	-0.0	0.0	0.1	-0.3	-0.1	0.1	0.5	0.1	0.2	0.2	0.4	0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	0.6	-0.4	0.5	0.4	-0.8	0.7	0.7	0.7	0.9	0.9	1.0	-0.6	0.7
Hearing difficulty/problems with background noise	0.4	0.6	4.0	-0.4	0.5	-0.7	-0.1	1.1	-0.4	-0.1	-0.5	-0.4	-0.9	-0.5	2.0	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.6	0.4	-0.2	0.4	1.3	0.2	0.6	1.0	0.7	0.8	0.6	0.8	1.2	0.4
Had menopause	1.7	2.1	4.9	1.5	-1.6	1.8	1.6	-1.5	1.3	2.2	1.4	1.2	1.3	0.6	-0.7	1.5
Had other major operations	0.9	1.1	2.9	-0.8	0.6	-1.1	-0.4	0.6	-1.0	-1.7	-1.0	-1.3	-1.2	-1.6	0.2	-0.8
Forced vital capacity (FVC)	0.1	0.5	1.6	0.6	-0.3	0.4	0.1	-0.4	0.8	0.9	0.6	1.2	0.7	1.3	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.6	-0.6	0.8	-0.2	-0.1	0.6	0.5	0.6	0.4	0.0	-0.3	-0.4	0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.9	-0.8	0.8	-0.6	-1.4	0.6	-0.8	-0.4	-0.8	-0.7	-0.9	-0.5	1.1	-0.9
Qualifications: None of the above	0.4	1.0	2.1	1.0	-1.1	0.6	0.7	-1.4	0.9	1.1	1.1	0.7	1.0	0.8	-0.4	1.5
Financial difficulties in last 2 years	1.6	2.1	4.0	-1.4	1.4	-1.7	-1.0	1.4	-1.5	-2.0	-1.5	-1.5	-1.2	-0.7	1.7	-1.4
Mouth/teeth dental problems	2.2	3.4	5.2	1.9	-1.8	1.6	1.2	-1.7	2.0	2.2	1.9	2.0	2.3	1.5	-1.6	1.8
Heart attack	2.1	2.6	3.8	1.6	-1.5	1.8	1.6	-1.5	1.6	1.9	1.7	1.8	1.5	2.0	-0.5	1.8
Allergy	0.2	0.4	3.4	-0.1	0.3	0.1	0.6	-0.4	0.1	-0.7	0.1	0.6	0.3	1.8	0.3	0.3
Pain all over the body in last month	0.1	0.1	0.4	-0.1	0.2	-0.4	-0.7	0.5	-0.1	-0.0	-0.3	-0.1	0.2	-0.3	-0.5	-0.1
Diabetes (self-reported)	1.0	1.5	3.2	1.4	-1.5	0.9	1.8	-0.9	1.4	1.3	1.3	1.2	0.9	0.7	-0.6	1.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.9	-0.0	-0.1	0.5	-0.7	-0.1	-0.2	0.3	-0.0	-0.5	0.0	-1.4	-0.8	-0.1
Medication: Ramipril	3.7	4.7	9.4	1.8	-1.7	2.0	3.1	-1.9	2.0	2.1	2.1	2.4	2.6	2.8	-0.7	2.3
Medication: Simvastatin	3.0	4.3	6.5	2.1	-1.9	1.9	2.2	-1.5	2.2	2.2	2.1	2.4	2.5	1.9	-1.4	2.3
Fluid intelligence score	2.1	4.4	6.8	-2.2	2.0	-1.1	-1.9	1.8	-2.3	-2.6	-2.2	-2.3	-2.0	-2.1	1.9	-2.3
Illnesses of siblings	0.1	0.2	1.0	-0.2	0.0	-0.2	-0.3	0.3	-0.3	-1.0	-0.5	-0.5	-0.2	-0.6	-0.2	-0.4
Neuroticism score	0.1	0.3	1.0	-0.4	0.4	-0.6	-1.0	0.3	-0.4	-0.7	-0.4	-0.4	-0.5	-0.4	0.8	-0.3
Weight	0.1	0.5	1.4	-0.2	0.2	-1.2	-0.6	1.1	-0.3	-0.6	-0.7	-0.5	-0.9	-1.0	0.3	-0.5
Impedance of arm (right)	0.9	4.2	6.6	-2.0	1.7	-1.4	-2.1	1.9	-2.1	-2.6	-2.0	-2.4	-2.1	-2.5	1.6	-2.2
Arm fat percentage (right)	0.3	1.0	3.4	1.5	-1.8	0.0	0.3	-0.5	1.2	0.5	0.8	0.5	0.2	-0.9	-1.9	0.8
Trunk fat-free mass	0.2	1.3	2.5	-1.1	1.4	-1.5	-0.6	1.6	-1.1	-0.7	-1.3	-0.8	-1.3	-0.2	1.2	-1.0
Hip circumference	0.2	1.0	3.0	-0.4	0.3	-1.3	-0.7	1.5	-0.5	-0.7	-1.0	-1.0	-1.3	-1.7	0.4	-0.9
Time employed in main current job	1.6	1.8	2.7	1.4	-1.3	1.6	0.2	-1.4	1.4	1.6	1.6	1.5	1.5	1.2	-0.6	1.3
Alcohol intake versus 10 years previously	0.2	0.2	0.6	-0.5	0.7	-0.8	-0.2	0.4	-0.5	-0.0	-0.6	-0.3	0.4	0.3	-0.7	-0.4
Father’s age at death	0.3	0.4	1.0	-0.8	0.9	-0.5	-0.7	0.7	-0.7	-0.4	-0.6	-0.4	-0.5	0.2	1.0	-0.6
Worrier / anxious feelings	0.3	0.7	2.7	0.4	-0.3	0.4	0.2	-0.6	0.5	1.0	0.7	0.8	0.2	1.3	1.6	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.8	-1.0	1.0	-0.9	-1.1	1.3	-1.0	-1.0	-1.0	-1.0	-1.2	-1.1	0.9	-1.3
Falls in the last year	0.5	0.6	2.9	-0.1	-0.1	-1.2	-0.5	0.5	-0.3	-1.0	-0.4	-0.7	-0.6	-1.7	-0.7	-0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.3	-0.1	-0.3	-0.4	-0.3	-0.3	0.0	-0.3	-0.4	-0.1
Number of live births	0.7	1.0	4.7	-0.5	0.3	-1.0	-0.9	0.6	-0.6	-0.4	-0.8	-1.2	-1.0	-2.2	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.3	0.6	-0.2	0.2	-0.1	-0.1	0.8	0.6	0.6	1.1	0.6	1.2	0.4	0.4
Pulse rate	0.6	1.0	2.6	0.7	-0.7	0.5	1.5	-1.4	0.7	0.7	0.7	0.9	1.2	1.6	-0.9	0.9
Happiness	1.8	2.2	4.0	-1.3	1.3	-1.5	-1.4	1.4	-1.4	-1.7	-1.4	-1.4	-1.9	-0.7	2.0	-1.4
Noisy workplace	0.1	0.2	1.1	0.3	-0.4	-0.4	1.1	-0.0	0.3	-0.1	0.0	0.2	0.0	0.5	-0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.4	-0.1	0.1	-0.4	0.3	-0.1	-0.0	-0.5	-0.2	0.1	-0.7	0.1	0.1	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.4	1.2	-1.1	1.4	1.2	-1.1	1.2	1.1	1.4	1.6	1.7	1.8	-0.8	1.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	0.2	-0.2	0.5	0.8	-0.3	0.2	0.5	0.3	0.2	0.3	0.3	-0.4	0.3
Asthma	0.1	0.3	0.8	0.2	-0.4	0.8	0.1	-0.0	0.1	0.9	0.3	-0.1	0.6	-0.9	-0.6	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.8	-1.1	1.0	-1.2	-1.5	0.8	-1.1	-1.7	-1.3	-1.3	-1.2	-1.1	0.6	-1.2
Medication: Cholesterol lowering	6.1	9.4	14.3	3.1	-2.9	2.5	3.8	-2.8	3.2	3.2	3.1	3.4	3.2	3.4	-1.6	3.3
Depression (self-reported)	0.2	0.3	0.9	-0.4	0.5	-0.6	-0.5	0.8	-0.3	-0.3	-0.3	-0.4	-0.4	-0.5	1.0	-0.4
Medication: Lansoprazole	0.9	1.0	1.8	-1.2	1.3	-0.7	-1.1	1.1	-1.1	-0.3	-1.1	-1.0	-1.1	-0.5	0.5	-1.3
Prospective memory result	2.6	3.2	5.2	1.6	-1.6	1.0	2.3	-2.0	1.7	1.8	1.7	1.6	2.0	1.6	-2.1	2.1
Lung cancer (father)	0.2	0.2	0.7	0.3	-0.3	0.5	0.8	0.1	0.4	0.5	0.4	0.5	-0.2	0.1	0.9	0.0
Illnesses of mother	0.6	0.7	2.2	0.3	-0.1	0.6	1.0	-0.6	0.4	1.2	0.6	0.7	1.1	1.5	-1.0	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	0.4	-0.1	-0.2	-0.4	0.0	0.6	0.5	0.3	0.8	0.2	0.7	0.6	0.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	-0.9	1.1	-1.1	-0.1	1.1	-0.8	0.1	-0.8	-0.7	-0.8	-0.5	0.8	-1.1
Impedance of arm (left)	0.9	4.0	5.6	-2.1	1.8	-1.2	-2.1	1.8	-2.1	-2.4	-1.9	-2.2	-2.0	-2.1	1.7	-2.2
Arm fat mass (right)	0.1	0.3	1.1	0.7	-0.8	-0.6	-0.2	0.2	0.5	0.1	0.1	-0.0	-0.4	-1.0	-0.8	0.2
Trunk predicted mass	0.2	1.2	2.4	-1.1	1.3	-1.5	-0.5	1.5	-1.0	-0.6	-1.2	-0.8	-1.2	-0.3	1.2	-1.0
Standing height	1.7	17.1	24.5	-4.5	4.7	-3.5	-3.4	4.7	-4.4	-3.7	-4.3	-3.9	-4.3	-2.4	5.0	-4.4
Length of working week for main job	0.7	0.8	1.3	0.9	-0.9	1.1	-0.1	-0.9	0.9	0.1	1.1	1.1	0.8	1.1	-0.8	0.8
Exposure to tobacco smoke at home	2.4	2.7	4.3	1.8	-1.8	1.6	1.0	-1.6	1.8	1.1	1.8	1.7	1.6	1.5	-1.9	2.1
Breastfed as a baby	3.5	4.3	6.7	2.2	-2.4	1.6	2.3	-2.5	2.1	2.6	2.1	1.9	1.7	1.1	-2.1	2.0
Tense / ‘highly strung’	0.4	0.7	2.2	0.6	-0.3	0.7	0.1	-0.6	0.8	0.3	0.9	1.2	1.5	1.3	0.1	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.6	-0.8	1.1	-0.7	0.5	0.8	-0.7	-0.4	-0.7	-0.1	-0.6	0.6	1.6	-0.8
Hair/balding pattern: Pattern 4	0.1	0.4	2.0	-0.2	-0.0	0.2	-0.7	0.0	-0.3	0.3	-0.3	-0.7	-0.3	-1.1	-1.4	-0.5
Birth weight of first child	0.0	0.1	0.2	0.3	-0.4	0.2	0.5	0.2	0.3	0.3	0.3	0.1	0.2	-0.4	-0.3	0.1
Peak expiratory flow (PEF)	0.4	0.8	1.9	1.0	-0.8	0.8	0.4	-0.4	1.2	0.6	1.0	1.4	0.9	1.4	-0.1	0.8
Pulse wave reflection index	0.2	0.2	1.2	-0.0	-0.0	-0.6	-0.2	0.7	-0.1	-0.2	-0.3	-0.3	-0.8	-1.1	-0.1	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.1	0.0	-0.4	-0.8	0.3	-0.2	-0.9	-0.3	-0.4	-0.6	-0.0	-0.2	-0.1
Loud music exposure frequency	0.2	0.3	1.1	-0.6	0.7	-0.0	-0.6	0.3	-0.6	0.2	-0.5	-0.3	-0.2	0.3	1.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.0	-0.7	1.0	-0.3	0.2	1.0	-0.7	-0.6	-0.6	-0.1	-0.0	0.3	0.5	-0.9
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	2.4	-1.2	1.1	-1.2	-1.4	1.4	-1.2	-1.2	-1.2	-1.4	-1.6	-1.3	1.4	-1.0
Blood clot in the leg (DVT)	0.4	0.5	1.3	1.0	-1.1	-0.5	1.0	-0.6	0.7	-0.3	0.4	0.4	-0.2	-0.8	-0.3	0.8
Medication: Paracetamol	0.2	0.4	0.8	0.9	-0.9	0.7	0.3	-0.5	0.8	-0.0	0.6	0.6	0.4	0.6	-0.6	0.8
Headache pain in last month	0.4	0.6	1.8	-0.8	0.7	-0.7	-0.4	0.7	-0.8	-1.3	-0.9	-0.8	-0.9	-0.6	0.5	-0.9
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	5.4	-1.9	1.7	-1.6	-2.0	1.3	-2.0	-2.3	-1.8	-2.2	-1.9	-1.9	0.1	-2.1
Glaucoma (self-reported)	0.1	0.1	0.3	-0.2	0.2	-0.0	-0.3	0.3	-0.3	0.2	-0.2	-0.2	-0.4	-0.4	0.6	-0.2
Gout (self-reported)	0.4	0.6	1.4	-0.9	1.0	-0.2	-1.1	0.6	-0.7	-0.4	-0.7	-0.5	-0.5	0.4	1.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.5	-0.6	0.0	0.9	-0.7	0.5	0.3	0.6	0.3	0.8	0.5	-0.7	0.9
Medication: Amlodipine	1.0	1.4	3.4	-1.0	1.1	-1.9	-0.4	1.6	-1.1	-1.3	-1.1	-1.1	-1.2	-1.3	1.0	-1.0
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.2	-0.3	0.4	0.0	0.1	0.0	-0.2	0.3	-0.0	-0.2	0.0	0.1	0.4	-0.2
Birth weight	1.6	3.5	6.2	-1.9	1.8	-1.8	-1.5	2.1	-1.9	-1.7	-1.9	-1.9	-2.0	-1.6	2.5	-1.6
Chronic bronchitis/emphysema (mother)	7.0	8.1	11.7	3.3	-3.4	2.7	2.6	-2.8	3.0	2.7	3.0	2.8	2.6	1.7	-3.3	2.9
High blood pressure (siblings)	0.1	0.1	0.5	-0.3	0.3	-0.1	0.7	-0.2	-0.1	0.3	0.0	-0.0	-0.0	0.4	0.3	0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	1.4	0.2	0.2	0.2	-0.2	-0.2	0.4	0.7	0.2	0.9	0.3	1.2	1.1	0.1
Body fat percentage	0.1	0.4	1.2	0.9	-1.1	-0.3	0.0	0.0	0.6	-0.0	0.3	0.0	-0.3	-1.1	-0.9	0.3
Leg fat percentage (right)	0.4	1.3	3.8	1.7	-2.0	0.2	0.6	-0.9	1.5	0.8	1.0	0.8	0.4	-0.4	-1.8	1.2
Arm fat-free mass (right)	0.2	0.9	2.0	-0.9	1.2	-1.3	-0.5	1.3	-0.9	-0.5	-1.0	-0.6	-1.1	-0.2	1.4	-0.8
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.9	-1.0	0.3	0.2	0.1	0.7	0.6	0.5	0.5	0.4	-0.2	-1.1	0.2
Comparative body size at age 10	1.1	3.1	6.0	1.7	-1.6	1.3	1.3	-1.9	1.7	1.9	1.6	1.8	1.6	2.5	-1.9	1.9
Number of full brothers	2.0	2.5	5.1	1.7	-1.6	1.4	0.5	-2.1	1.7	2.3	1.7	1.7	1.3	1.2	-1.0	1.8
Worry too long after embarrassment	1.6	2.7	6.3	-1.6	1.6	-1.6	-2.1	1.4	-1.5	-1.0	-1.5	-1.4	-1.9	-0.9	2.5	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.3	-0.3	0.5	-0.6	-0.3	0.3	0.4	0.3	0.2	0.1	-0.2	0.3	0.3
Wheeze or whistling in the chest in last year	1.0	1.7	4.1	1.4	-1.4	1.6	0.7	-1.1	1.5	2.0	1.4	1.4	1.3	1.0	-0.4	1.3
Number of children fathered	0.1	0.1	0.4	-0.3	0.1	-0.5	-0.3	0.3	-0.3	-0.3	-0.4	-0.4	-0.6	-0.3	0.6	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.5	-0.3	0.2	-0.8	0.3	0.1	-0.3	-0.4	-0.4	-0.3	-0.1	0.1	-1.2	-0.3
Age at first live birth	1.5	2.6	4.5	-1.9	1.9	-1.2	-1.4	2.1	-1.9	-1.4	-1.8	-1.8	-1.2	-1.2	0.7	-1.8
Pulse wave peak to peak time	0.1	0.2	0.5	0.3	-0.5	0.7	-0.4	-0.4	0.2	-0.6	0.3	0.1	0.3	0.0	-0.2	0.5
Health satisfaction	0.3	0.4	1.0	-0.5	0.7	-0.3	-0.7	1.0	-0.5	-0.2	-0.6	-0.1	-0.4	0.4	1.0	-0.7
Shortness of breath walking on level ground	0.2	0.3	1.4	0.1	0.1	-0.7	1.2	0.1	0.2	0.4	-0.1	0.4	0.3	1.1	0.2	-0.1
Qualifications: College or University degree	0.4	1.3	2.6	-1.2	1.1	-0.4	-1.6	0.8	-1.2	-1.1	-1.2	-1.1	-1.3	-1.1	0.6	-1.4
Eye problems/disorders: None of the above	3.3	3.8	6.0	-2.1	2.2	-1.7	-2.4	2.0	-2.0	-2.4	-1.9	-1.8	-1.6	-1.2	1.3	-2.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.2	-0.2	0.1	-0.3	-0.3	0.1	-0.3	-1.1	-0.3	-0.5	-0.6	-0.9	0.3	-0.4
Emphysema/chronic bronchitis	1.5	1.7	2.7	1.6	-1.7	1.1	1.7	-0.8	1.4	1.5	1.3	1.2	1.1	0.9	-1.2	1.3
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	-1.0	0.9	-0.6	-0.5	0.6	-1.0	-0.4	-0.7	-0.9	-0.7	-0.7	0.9	-0.8
Neck or shoulder pain in last month	0.6	0.8	6.7	0.0	-0.3	-0.1	-1.2	0.8	-0.2	0.3	-0.5	-0.7	-0.8	-2.6	0.2	-0.6
Medication: Blood pressure	0.6	1.0	1.8	1.1	-1.1	0.9	0.9	-0.4	1.2	1.4	1.0	1.2	0.9	0.7	0.6	1.2
Angina (self-reported)	1.7	2.2	4.2	1.5	-1.3	1.2	2.0	-1.4	1.5	1.1	1.6	1.8	1.5	1.8	-0.4	1.6
Migraine (self-reported)	2.6	3.2	5.4	-1.8	2.0	-1.6	-1.3	1.9	-1.7	-1.4	-1.8	-1.6	-2.1	-1.4	2.3	-2.1
Medication: Ibuprofen	1.5	1.8	3.8	-1.3	1.3	-1.4	-1.9	1.0	-1.3	-1.7	-1.4	-1.4	-1.4	-0.9	0.7	-1.3
Medication: Allopurinol	0.3	0.4	1.9	-0.6	0.8	-0.0	-0.9	0.7	-0.5	-0.3	-0.4	-0.3	-0.5	0.3	1.4	-0.7
Medication: Omeprazole	0.3	0.4	0.8	-0.7	0.6	-0.3	-0.6	0.4	-0.7	-0.9	-0.8	-0.6	-0.5	-0.4	0.5	-0.6
Medication: Seretide 50 evohaler	0.1	0.2	0.9	0.3	-0.2	-0.6	1.0	0.1	0.4	-0.3	0.1	0.3	-0.2	0.3	0.3	-0.0
Mean time to correctly identify matches	0.2	0.4	1.6	0.7	-0.9	-0.2	0.6	-0.3	0.5	1.0	0.3	0.2	0.0	-1.3	-0.2	0.4
Heart disease (mother)	0.8	0.9	1.8	0.8	-0.7	0.9	1.1	-1.3	0.9	0.7	1.0	1.2	1.1	1.3	-0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.1	0.0	0.3	0.0	0.3	-0.1	-0.4	-0.0	-0.3	-0.3	-0.7	0.7	-0.3
Whole body fat mass	0.1	0.3	1.4	0.3	-0.5	-0.8	-0.2	0.6	0.1	-0.2	-0.3	-0.4	-0.7	-1.2	-0.4	-0.2
Leg fat mass (right)	0.1	0.3	1.0	0.8	-1.0	-0.5	-0.2	0.1	0.6	0.1	0.2	0.1	-0.4	-0.9	-0.8	0.3
Arm predicted mass (right)	0.2	0.8	1.8	-0.8	1.1	-1.3	-0.5	1.3	-0.8	-0.5	-1.0	-0.6	-1.0	-0.2	1.2	-0.8
Pulse rate, automated reading	0.2	0.5	1.5	0.7	-0.8	0.5	1.0	-1.2	0.6	0.1	0.5	0.5	0.8	0.3	-0.8	0.8
Alcohol intake frequency.	0.6	1.4	2.0	-1.2	1.4	-1.2	-1.2	1.2	-1.2	-1.4	-1.3	-1.2	-1.1	-1.0	0.8	-1.2
Comparative height size at age 10	0.1	0.3	1.0	-0.6	0.7	-0.6	0.2	0.9	-0.5	-0.6	-0.5	-0.3	-0.4	0.1	1.0	-0.4
Number of full sisters	0.3	0.4	3.0	0.3	-0.3	0.6	0.4	-0.4	0.4	0.2	0.4	0.0	0.6	-0.4	-1.7	0.1
Suffer from ‘nerves’	0.1	0.2	0.8	-0.2	0.1	-0.9	-0.5	0.4	-0.2	-0.3	-0.5	-0.2	-0.4	-0.7	-0.5	-0.5
Overall health rating	1.6	3.3	5.1	-2.0	2.0	-2.1	-0.8	2.3	-2.0	-1.4	-2.0	-1.8	-1.7	-1.2	2.0	-2.1
Chest pain or discomfort	0.2	0.3	1.3	-0.4	0.5	0.3	-0.6	0.6	-0.4	-0.6	-0.3	-0.2	0.0	0.1	1.1	-0.5
Had major operations	1.8	2.1	3.1	-1.4	1.4	-1.2	-1.4	1.4	-1.5	-1.5	-1.3	-1.5	-1.4	-1.8	1.1	-1.6
Age at last live birth	4.5	6.6	10.4	-2.5	2.3	-2.5	-2.3	2.8	-2.7	-2.9	-2.8	-3.0	-2.1	-3.2	0.6	-2.7
Family relationship satisfaction	0.7	0.8	2.1	-0.7	0.6	-0.8	-1.4	0.6	-0.8	-1.4	-1.0	-0.8	-1.0	-0.5	0.9	-0.7
Leg pain on walking	0.1	0.2	0.6	0.3	-0.2	-0.2	0.8	0.4	0.3	0.5	0.3	0.3	0.4	0.3	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.3	-0.0	-0.2	-0.9	0.0	0.9	-0.2	-0.0	-0.3	-0.6	-0.5	-1.1	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.0	-0.1	0.2	0.4	0.4	-0.0	-0.5	-0.1	-0.2	0.1	-0.3	-0.3	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.1	0.1	-0.2	-0.2	0.2	-0.4	0.1	-0.2	-0.0	-0.2	-1.0	-1.0	0.8	-0.3
Medication: Aspirin	1.0	1.4	2.2	1.2	-1.1	0.9	1.3	-0.9	1.3	1.1	1.2	1.3	1.5	1.1	-0.8	1.3
Supplements: Vitamin C	1.0	1.2	3.0	-1.0	1.0	-1.0	-1.7	1.2	-0.9	-0.6	-1.1	-1.0	-1.1	-0.9	1.3	-1.0
Knee pain experienced in last month	0.2	0.3	2.4	0.3	-0.2	0.0	1.5	0.2	0.3	0.3	0.3	0.3	-0.0	0.3	0.8	0.2
Hypertension (Self-reported)	0.0	0.0	0.2	0.1	-0.1	0.3	0.2	0.2	0.2	0.1	0.0	0.2	-0.2	0.1	0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	0.4	-0.3	0.4	0.6	-0.1	0.5	0.5	0.4	0.6	0.6	0.7	-1.1	0.3
Illnesses of father: Heart disease	0.1	0.2	0.7	0.2	-0.1	0.3	0.5	-0.1	0.3	0.0	0.3	0.5	-0.1	0.9	0.5	0.3
Illnesses of siblings: Diabetes	0.2	0.3	1.4	0.5	-0.5	0.6	-0.3	0.0	0.5	1.2	0.6	0.5	0.3	0.2	-0.4	0.2
Smoking status: Previous	0.1	0.2	1.0	-0.1	-0.1	-0.4	0.1	-0.1	-0.2	-0.1	-0.3	-0.6	-0.2	-1.0	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	5.1	10.5	16.9	-3.9	4.1	-2.7	-2.1	3.8	-3.7	-3.2	-3.5	-3.2	-2.8	-1.4	3.1	-3.6
Whole body fat-free mass	0.2	1.4	2.9	-1.1	1.3	-1.7	-0.7	1.7	-1.1	-0.8	-1.3	-0.9	-1.3	-0.6	1.1	-1.1
Leg fat-free mass (right)	0.2	1.1	2.7	-0.8	1.0	-1.6	-0.7	1.6	-0.8	-1.1	-1.1	-0.8	-1.0	-0.8	0.8	-0.9
Arm fat percentage (left)	0.3	1.4	4.0	1.7	-1.9	0.2	0.6	-0.7	1.5	0.7	1.0	0.8	0.5	-0.6	-2.0	1.1
Average weekly red wine intake	0.2	0.3	0.8	0.6	-0.7	-0.3	0.3	-0.9	0.5	-0.5	0.5	0.4	-0.2	0.4	-0.5	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.9	-0.2	0.2	-0.5	-0.6	0.4	-0.3	-1.0	-0.3	-0.5	-0.4	-0.7	-0.2	-0.5
Mood swings	0.2	0.4	1.2	-0.4	0.2	-0.3	-1.1	0.5	-0.4	-0.9	-0.4	-0.6	-0.2	-1.0	-0.1	-0.5
Loneliness, isolation	1.3	1.9	3.1	-1.3	1.3	-1.2	-1.2	1.7	-1.3	-1.7	-1.3	-1.3	-1.1	-1.1	1.5	-1.4
Long-standing illness, disability or infirmity	0.1	0.2	1.1	-0.1	-0.0	-0.7	0.6	1.1	-0.1	-0.1	-0.3	-0.2	-0.2	-0.5	0.5	-0.2
Ever had bowel cancer screening	2.7	3.1	5.9	-1.7	1.6	-2.4	-1.2	1.5	-1.8	-1.7	-2.0	-1.8	-2.1	-1.5	1.7	-1.8
Diabetes diagnosed by doctor	0.5	0.9	2.3	1.1	-1.2	0.4	1.5	-0.5	1.0	1.0	1.0	0.9	0.5	0.3	-0.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.1	-0.7	0.8	-0.3	-1.5	1.4	-0.6	0.2	-0.6	-0.3	-0.2	-0.4	1.3	-0.8
Friendships satisfaction	0.5	0.6	1.7	0.8	-0.7	1.1	0.4	-0.4	0.7	0.5	0.8	0.9	0.6	1.3	0.1	0.7
Qualifications: nursing, teaching	0.5	0.7	3.2	0.7	-0.8	0.7	-0.1	-1.1	0.7	1.0	0.7	0.6	0.9	0.2	-1.8	0.5
Commuting to job workplace: Walk	6.6	7.1	9.7	2.9	-2.8	2.7	2.0	-2.6	3.0	2.1	2.9	2.9	3.1	1.9	-2.8	2.6
Eye problems/disorders: Cataract	0.1	0.1	1.0	0.3	-0.5	-0.1	1.0	-0.2	0.2	0.2	0.2	0.1	-0.1	0.2	-0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	5.8	9.2	12.4	-3.1	3.1	-2.6	-3.0	3.5	-3.1	-2.7	-3.2	-3.0	-3.2	-2.8	2.8	-3.2
Medication for cholesterol	0.1	0.2	1.2	0.0	-0.0	-0.8	-0.4	-0.0	0.1	-0.3	-0.1	-0.0	-0.2	-0.1	-1.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	4.9	1.6	-1.4	2.2	1.8	-1.4	1.7	1.9	1.9	1.9	2.1	1.0	-0.9	1.8
Back pain experienced in last month	0.5	0.7	2.0	0.9	-1.1	0.5	1.2	-1.1	0.7	0.1	0.6	0.4	0.8	0.1	-1.4	0.8
Mineral and other dietary supplements	0.3	0.3	2.0	0.4	-0.6	-0.9	-0.0	-0.2	0.3	-0.1	0.1	-0.0	-0.1	-0.9	-1.4	0.2
Breast cancer (self-reported)	2.6	3.1	4.0	-1.9	1.9	-2.0	-1.7	1.5	-1.9	-1.6	-2.0	-2.0	-1.8	-1.7	1.1	-1.6
Asthma (self-reported)	0.2	0.3	0.7	0.4	-0.5	0.8	0.3	-0.3	0.3	0.9	0.4	-0.0	0.7	-0.8	-0.9	0.1
Osteoporosis (self-reported)	0.0	0.1	0.2	0.2	-0.3	-0.2	0.4	-0.3	0.2	-0.2	0.0	0.0	-0.1	-0.3	0.3	0.1
Osteoarthritis (self-reported)	2.5	3.2	4.4	2.1	-2.1	1.8	1.6	-1.4	2.0	1.9	2.0	1.8	2.0	0.5	-1.4	2.0
Medication: Aspirin	0.7	0.9	1.6	0.9	-0.7	0.8	0.9	-0.5	1.0	1.1	0.9	1.2	1.3	1.2	-0.4	1.0
Medication: Gliclazide	4.0	4.5	8.0	2.6	-2.8	1.5	2.0	-2.5	2.4	1.3	2.3	2.1	1.4	1.1	-2.5	2.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	0.2	-0.1	0.1	0.5	-0.3	-0.4	-0.4	-0.3	-0.3	-0.3	0.4	-0.4
Smoking status: Current	0.4	0.6	1.4	0.6	-0.7	1.0	0.9	-0.5	0.6	0.4	0.6	0.7	1.2	1.0	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.7	-1.1	1.4	-1.3	-0.8	1.3	-0.9	-0.2	-1.0	-0.5	-1.1	0.2	1.9	-1.1
Whole body water mass	0.2	1.1	2.5	-1.0	1.2	-1.6	-0.6	1.5	-0.9	-0.7	-1.2	-0.8	-1.1	-0.4	1.0	-0.9
Leg predicted mass (right)	0.2	1.0	2.6	-0.8	1.0	-1.6	-0.6	1.5	-0.8	-1.0	-1.1	-0.8	-1.0	-0.7	0.8	-0.9
Arm fat mass (left)	0.1	0.3	1.0	0.9	-1.0	-0.4	0.1	0.1	0.7	0.4	0.3	0.2	-0.1	-0.8	-0.9	0.4
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	0.5	-0.5	0.7	0.4	0.0	0.5	0.6	0.6	0.5	0.9	0.3	0.0	0.6
Average weekly champagne plus white wine intake	0.9	1.3	2.2	1.1	-1.1	0.9	1.4	-1.5	1.1	0.9	1.0	1.0	0.8	1.1	-1.2	1.3
Miserableness	1.3	2.3	3.8	-1.6	1.6	-1.2	-2.0	1.5	-1.7	-1.9	-1.5	-1.5	-1.3	-0.9	1.3	-1.3
Guilty feelings	1.8	2.8	4.1	-1.5	1.5	-1.7	-2.0	1.7	-1.5	-1.7	-1.6	-1.5	-1.9	-1.6	1.7	-1.6
Wears glasses or contact lenses	3.5	4.0	6.4	2.1	-2.2	1.5	2.4	-2.3	1.9	2.5	1.9	1.7	1.6	1.4	-2.0	2.1
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.8	-0.7	0.8	0.9	-0.3	0.8	1.5	0.9	0.9	1.1	0.9	-0.6	0.7
Hearing aid user	0.2	0.2	0.6	0.3	-0.1	0.8	-0.2	-0.2	0.4	0.7	0.4	0.5	0.4	0.6	0.7	0.1
Mother’s age at death	0.6	0.8	1.5	-1.2	1.2	-0.2	-0.5	0.7	-1.2	-0.8	-0.9	-1.0	-0.4	-0.8	0.4	-1.0
Financial situation satisfaction	0.2	0.2	0.5	0.1	-0.2	0.1	-0.7	0.2	-0.0	-0.7	-0.1	-0.2	-0.7	-0.5	0.7	-0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	0.9	-0.9	0.7	0.6	-0.9	0.8	0.9	0.8	0.6	0.5	0.3	-0.9	0.7
Commuting to job workplace: Public transport	0.1	0.2	0.6	-0.4	0.6	0.2	0.4	0.1	-0.3	0.4	-0.1	0.2	0.8	0.7	0.2	-0.2
Eye problems/disorders: Glaucoma	2.1	2.4	3.6	1.8	-1.8	1.8	1.3	-1.5	1.6	1.9	1.5	1.6	1.4	0.9	-1.2	1.7
Medication: Blood pressure	0.2	0.3	0.9	-0.6	0.8	0.4	0.9	0.1	-0.5	0.3	-0.3	-0.2	0.1	0.9	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	4.1	5.2	6.9	2.6	-2.6	2.1	2.6	-1.9	2.6	2.0	2.4	2.5	2.3	1.7	-1.2	2.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.7	-0.6	0.8	0.5	-0.2	0.7	-0.5	0.0	-0.3	-0.1	-0.3	0.7	1.3	-0.6
High cholesterol (Self-reported)	5.2	9.3	13.6	3.0	-2.7	2.7	3.1	-2.8	3.1	3.1	3.2	3.4	3.7	3.1	-2.3	3.1
Medication: Bendroflumethiazide	1.5	2.4	8.5	-1.8	2.0	-0.5	-0.4	1.8	-1.6	0.0	-1.4	-1.3	-1.5	-0.6	2.9	-1.5
Medication: Paracetamol	0.8	1.3	2.1	1.4	-1.5	1.4	0.3	-1.3	1.3	0.6	1.2	1.1	0.9	0.9	-0.9	1.4
Medication: Lisinopril	1.3	1.6	2.8	1.1	-0.8	1.2	1.6	-1.2	1.2	1.1	1.2	1.6	1.5	1.7	-0.5	1.1
Medication: Atorvastatin	4.2	5.2	6.9	2.2	-2.1	2.2	2.0	-2.1	2.3	2.4	2.4	2.5	2.5	2.6	-1.8	2.3
Illnesses of father: High blood pressure	0.2	0.2	0.9	0.4	-0.3	0.1	-0.5	-0.4	0.5	0.1	0.4	0.6	0.7	0.2	-1.0	0.2
Alcohol drinker status: Never	0.2	0.2	0.7	0.5	-0.6	0.8	0.0	-0.5	0.4	-0.2	0.3	0.3	0.0	0.2	-0.7	0.4
Ever smoked	0.1	0.3	2.3	-0.0	-0.2	0.3	0.1	-0.4	-0.2	-0.1	-0.1	-0.3	0.5	-0.5	-1.5	0.0
Basal metabolic rate	0.2	1.3	2.9	-1.0	1.1	-1.7	-0.8	1.7	-1.0	-0.9	-1.2	-0.9	-1.3	-0.8	1.1	-1.1
Leg fat percentage (left)	0.5	1.6	4.2	1.9	-2.0	0.5	1.1	-1.1	1.6	0.7	1.2	1.0	0.6	-0.2	-1.9	1.3
Arm fat-free mass (left)	0.2	1.2	2.2	-1.0	1.1	-1.5	-0.7	1.5	-0.9	-0.6	-1.1	-0.9	-1.2	-0.7	1.4	-1.0
Number of operations (self-reported)	0.1	0.2	0.6	-0.2	0.2	0.3	-0.7	0.0	-0.4	-0.4	-0.2	-0.6	-0.1	-0.8	0.4	-0.1
Average weekly beer plus cider intake	0.4	0.5	1.8	0.8	-0.9	0.2	0.8	-0.3	0.8	-0.2	0.7	0.6	1.0	-0.1	-1.3	0.7
Irritability	2.9	4.9	6.2	2.4	-2.3	1.8	1.8	-2.4	2.4	1.6	2.4	2.5	2.4	2.2	-2.0	2.5
Risk taking	0.4	0.5	2.6	-0.8	0.7	-0.7	-0.0	0.6	-0.8	-1.6	-0.7	-0.7	-0.2	-0.7	0.1	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.9	-0.4	0.5	0.3	-0.4	-0.1	-0.3	-0.1	-0.2	-0.0	-0.1	0.3	0.9	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.7	-0.7	0.3	0.7	-0.6	0.6	0.8	0.7	0.6	0.5	0.5	-0.2	0.5
Age started oral contraceptive pill	0.7	0.8	1.5	0.8	-0.8	1.2	1.0	-0.9	0.7	1.2	0.9	0.7	0.2	0.6	1.1	1.1
Diastolic blood pressure, automated reading	0.2	0.7	1.5	0.7	-0.7	1.2	0.7	-0.5	0.8	0.9	0.8	0.7	1.2	0.3	-1.0	0.5
Ever depressed for a whole week	0.7	0.8	2.0	-0.9	0.8	-0.2	-1.2	0.7	-0.9	-0.7	-0.8	-0.8	-1.2	-0.8	1.4	-0.9
Unable to work because of sickness or disability	0.2	0.3	0.6	0.6	-0.5	0.6	-0.0	-0.2	0.6	0.4	0.6	0.6	0.7	0.2	-0.2	0.6
Commuting to job workplace: Cycle	0.2	0.3	1.0	0.6	-0.6	0.1	0.2	-0.3	0.5	1.0	0.5	0.3	0.4	-0.5	-0.9	0.3
Myopia	3.1	4.5	11.8	-2.0	2.1	-1.6	-3.4	2.4	-2.0	-1.8	-2.0	-1.8	-2.0	-1.9	1.6	-2.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	-0.8	0.8	-0.9	-0.8	0.7	-0.8	-0.4	-0.7	-0.9	-0.5	-0.9	-0.2	-0.8
Cholesterol lowering medication	0.4	0.6	2.1	0.6	-0.6	1.2	-0.2	-0.1	0.6	1.4	0.7	0.6	1.1	0.2	-0.7	0.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.1	0.2	0.4	0.3	-0.3	-0.0	-0.2	-0.0	0.2	0.3	0.6	-0.0	-0.1
Pain experienced in last month	0.7	1.2	2.8	-1.6	1.7	-0.9	-1.0	1.1	-1.4	-0.7	-1.1	-1.0	-0.8	0.1	1.0	-1.3
Supplements: Calcium	1.2	1.4	3.1	1.0	-1.0	1.8	0.8	-1.4	1.0	1.5	1.2	1.0	1.3	0.9	-0.7	1.2
Basal cell carcinoma (self-reported)	0.8	0.9	2.6	-0.5	0.5	-0.6	-1.3	1.0	-0.6	-0.5	-0.9	-0.7	-1.4	-1.1	1.6	-0.8
Heart attack/myocardial infarction (self-reported)	3.1	4.0	5.3	2.0	-1.9	2.1	2.0	-1.9	2.0	2.3	2.1	2.2	1.9	2.2	-0.9	2.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	1.1	-1.2	-0.4	1.3	-0.9	0.9	-0.0	0.6	0.6	-0.1	-0.5	-0.4	1.0
Heart disease (siblings)	0.3	0.4	1.4	0.4	-0.3	0.5	-0.0	-0.8	0.5	0.6	0.6	0.6	0.5	1.2	-0.1	0.7
Alcohol drinker status: Previous	1.7	1.9	4.3	-1.4	1.6	-1.2	-1.2	1.2	-1.4	-1.2	-1.4	-1.1	-1.5	-0.8	2.1	-1.3
Pack years of smoking	0.4	0.5	1.8	-0.4	0.4	-0.9	-0.7	0.4	-0.4	-1.1	-0.6	-0.3	-0.9	-0.5	1.3	-0.6
Impedance of whole body	1.0	5.1	6.5	-2.4	2.2	-1.4	-2.2	2.0	-2.4	-2.5	-2.2	-2.5	-2.3	-2.1	2.3	-2.4
Leg fat mass (left)	0.1	0.4	1.4	1.0	-1.2	-0.2	0.1	-0.1	0.8	0.2	0.4	0.3	-0.1	-0.7	-1.0	0.5
Arm predicted mass (left)	0.1	0.6	1.4	-0.6	0.8	-1.2	-0.5	1.2	-0.6	-0.3	-0.8	-0.6	-1.0	-0.4	1.1	-0.7