Best TWAS P=9.33e-28 · Best GWAS P=3.76e-59 conditioned to 3.91e-25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STXBP6 | 0.21 | 0.04 | lasso | 10 | 0.16 | 1.2e-19 | 10.9 | -10.9 | 9.3e-28 | -0.59 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Heart Left Ventricle | STXBP6 | 0.26 | 0.08 | lasso | 8 | 0.12 | 3.5e-07 | 6.9 | -8.6 | 7.7e-18 | -0.53 | 0.17 | 0.41 | TRUE |
| 6 | GTEx | Stomach | STXBP6 | 0.18 | 0.05 | enet | 6 | 0.04 | 4.1e-03 | 10.6 | -9.0 | 2.3e-19 | -0.65 | 0.12 | 0.41 | FALSE |
| 3 | GTEx | Esophagus Muscularis | STXBP6 | 0.31 | 0.15 | lasso | 12 | 0.15 | 2.6e-09 | 9.1 | -8.9 | 8.4e-19 | -0.65 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | STXBP6 | 0.12 | 0.08 | lasso | 3 | 0.06 | 4.7e-06 | -9.7 | -7.1 | 9.0e-13 | -0.61 | 0.41 | 0.48 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | STXBP6 | 0.33 | 0.28 | lasso | 8 | 0.29 | 3.9e-22 | 5.8 | -5.4 | 7.3e-08 | -0.51 | 1.00 | 0.00 | FALSE |