Best TWAS P=1.48e-21 · Best GWAS P=7.79e-14 conditioned to 0.161
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PPP2R3C | 0.21 | 0.12 | lasso | 10 | 0.14 | 2.6e-11 | 6.7 | -5.6 | 2.5e-08 | 0.00 | 0.52 | 0.48 | FALSE |
2 | GTEx | Adipose Subcutaneous | FAM177A1 | 0.19 | 0.06 | lasso | 8 | 0.11 | 3.6e-09 | -4.4 | -6.6 | 3.5e-11 | -0.13 | 0.90 | 0.08 | FALSE |
3 | GTEx | Adrenal Gland | FAM177A1 | 0.17 | 0.07 | enet | 7 | 0.04 | 1.2e-02 | -4.8 | -5.4 | 6.5e-08 | -0.23 | 0.17 | 0.18 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | FAM177A1 | 0.19 | 0.04 | lasso | 10 | 0.10 | 1.7e-08 | 3.3 | -6.6 | 3.7e-11 | -0.08 | 0.69 | 0.19 | FALSE |
5 | NTR | Blood | KIAA0391 | 0.05 | 0.05 | lasso | 10 | 0.05 | 2.4e-15 | 6.7 | 5.2 | 2.0e-07 | -0.06 | 0.32 | 0.68 | FALSE |
6 | NTR | Blood | NFKBIA | 0.26 | 0.09 | lasso | 10 | 0.12 | 3.4e-36 | 7.4 | 9.5 | 1.5e-21 | 0.91 | 0.00 | 1.00 | TRUE |
7 | NTR | Blood | PPP2R3C | 0.06 | 0.04 | lasso | 5 | 0.04 | 4.2e-14 | -4.7 | 6.5 | 8.3e-11 | 0.22 | 1.00 | 0.00 | FALSE |
8 | YFS | Blood | KIAA0391 | 0.29 | 0.36 | lasso | 7 | 0.38 | 5.8e-132 | 6.7 | 6.3 | 3.0e-10 | 0.01 | 0.30 | 0.70 | FALSE |
9 | YFS | Blood | NFKBIA | 0.24 | 0.11 | enet | 33 | 0.17 | 3.5e-53 | 7.5 | 8.7 | 3.1e-18 | 0.73 | 0.00 | 1.00 | FALSE |
10 | YFS | Blood | PPP2R3C | 0.53 | 0.46 | bslmm | 383 | 0.60 | 2.4e-254 | -4.7 | 7.0 | 2.4e-12 | 0.16 | 1.00 | 0.00 | TRUE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | KIAA0391 | 0.20 | 0.00 | blup | 110 | 0.01 | 1.5e-01 | 6.1 | -7.3 | 2.6e-13 | -0.22 | 0.02 | 0.40 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA0391 | 0.07 | 0.04 | blup | 110 | 0.04 | 1.9e-05 | 3.5 | -6.0 | 2.4e-09 | -0.01 | 0.04 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPP2R3C | 0.08 | 0.04 | blup | 51 | 0.07 | 7.8e-09 | 4.7 | -5.5 | 4.8e-08 | -0.04 | 0.01 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA0391 | 0.12 | 0.11 | enet | 14 | 0.14 | 2.0e-13 | 3.3 | -5.9 | 3.6e-09 | -0.04 | 0.69 | 0.31 | FALSE |