Best TWAS P=2.28e-26 · Best GWAS P=1.88e-27 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | -10.62 | 10.6 | 2.3e-26 | -0.98 | 0.00 | 0.99 | TRUE |
| 2 | GTEx | Esophagus Mucosa | BTBD7 | 0.16 | 0.02 | lasso | 5 | 0.05 | 3.5e-04 | -4.23 | 6.2 | 7.7e-10 | -0.06 | 0.22 | 0.04 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | 5.60 | 5.8 | 7.3e-09 | -0.12 | 0.03 | 0.04 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C14orf142 | 0.11 | 0.04 | enet | 7 | 0.05 | 7.2e-07 | 4.15 | -5.7 | 1.5e-08 | 0.00 | 0.01 | 0.81 | TRUE |
| 3 | GTEx | Esophagus Muscularis | RIN3 | 0.17 | 0.05 | lasso | 6 | 0.06 | 1.6e-04 | -8.70 | 8.8 | 1.4e-18 | -0.48 | 0.12 | 0.55 | FALSE |
| 4 | METSIM | Adipose | GOLGA5 | 0.07 | 0.03 | blup | 539 | 0.02 | 1.1e-04 | -0.38 | 5.7 | 1.4e-08 | -0.26 | 0.36 | 0.47 | FALSE |