Hub : Genes

GOLGA5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0710 0.0263 1.9e-03 0.032 0.025 0.014 0.024 0.021 1.2e-05 1.1e-04 3.0e-03 1.5e-04 3.6e-04
2 YFS Blood 0.0423 0.0106 6.4e-08 0.034 0.022 0.026 0.027 0.030 2.8e-11 9.3e-08 5.3e-09 3.5e-09 2.6e-10
3 TCGA Liver Hepatocellular Carcinoma 0.2160 0.0780 4.1e-04 0.036 0.084 0.052 NA 0.060 7.9e-03 9.1e-05 1.9e-03 NA 8.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.8 1.8 -1.4 0.2 0.7
Bipolar Disorder or Schizophrenia 0.4 1.0 2.6 -1.6 0.3 0.6
Depressed Affect (Nagel 2018) 0.1 0.1 0.3 0.2 0.3 -0.5
Depression (Nagel 2018) 0.1 0.1 0.4 0.6 0.1 -0.0
Intelligence (Savage-Jansen 2018) 0.7 2.1 5.1 -2.2 -0.2 -1.0
Neuroticism (Nagel 2018) 0.2 0.4 1.2 -0.1 -1.1 0.1
Schizophrenia (2018) 0.2 0.4 1.1 -1.1 0.2 0.3
Schizophrenia vs Biploar Disorder 2.4 3.2 5.3 -0.2 2.3 -2.1
Worry (Nagel 2018) 0.4 0.9 2.1 -0.4 -1.5 0.6
Alzheimer’s Disease (in mother) 1.3 1.5 4.1 0.6 2.0 -0.4
Alzheimer’s Disease (in father) 0.2 0.2 0.3 0.4 -0.4 -0.6
Alzheimer’s Disease (including proxy) 0.7 1.0 1.7 1.2 1.3 0.3
Crohns Disease (2017) 0.1 0.1 0.4 0.1 -0.6 -0.1
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 -0.3 -0.0 -0.7
Ulcerative Colitis (UC) 0.2 0.4 0.5 -0.7 0.6 -0.7
Major Depression (MDD) 1.8 2.2 3.3 -1.8 1.5 -1.0
Reaction Time 0.7 1.4 3.2 -0.7 0.7 -1.8
Verbal and Numeric Reasoning (VNR) 0.6 1.5 2.9 -1.7 0.4 -1.2
Breast Cancer 2.3 5.6 7.4 -2.3 2.7 -2.0
Ovarian Cancer 0.2 0.3 0.3 0.5 0.5 -0.5
Prostate Cancer 0.8 1.1 1.9 1.1 1.4 0.6
Age at First Birth 0.7 1.0 2.7 -0.4 -0.0 1.6
Bipolar Disorder (2011) 0.9 0.8 2.4 -1.6 0.1 0.2
Body Mass Index (BMI) (2010) 2.4 3.3 4.4 1.9 -2.1 1.4
Coronary Artery Disease (CAD) 0.8 0.9 1.4 -1.2 -0.2 -1.1
Crohns Disease (2012) 0.5 0.8 1.3 0.3 -1.1 1.0
Mean Putamen Volume 0.7 0.7 1.5 -0.4 0.8 1.2
Fasting Glucose 0.9 1.1 3.0 -0.5 0.0 -1.7
HbA1C 0.2 0.2 0.5 -0.1 0.4 -0.7
HDL Cholesterol 0.4 0.6 1.8 -0.1 -0.1 1.3
LDL Cholesterol 0.9 1.4 4.1 0.1 -2.0 -0.1
Lupus 0.3 0.5 1.0 0.4 0.5 -1.0
Neuroticism (2016) 0.3 0.5 0.7 0.8 -0.7 0.5
Primary Biliary Cirrhosis 0.9 1.3 2.0 0.9 -1.4 1.1
Rheumatoid Arthritis 1.3 1.9 3.0 1.7 -1.2 1.0
Schizophrenia (2014) 0.2 0.4 0.8 -0.5 0.1 0.9
Triglycerides 1.4 2.3 6.1 2.5 0.1 -0.8
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.6 1.3 -0.7 0.2
Ulcerative Colitis 0.2 0.2 0.5 -0.1 0.4 -0.7
Blood Eosinophil Count 0.4 3.4 8.1 2.8 -1.2 -0.8
Blood Platelet Count 0.1 1.2 1.7 -1.1 -0.8 1.3
Blood Red Count 0.1 1.2 2.1 1.4 1.0 0.6
Blood White Count 2.4 17.9 32.2 5.7 -4.3 1.7
Heel T-Score 0.1 1.1 1.7 1.1 -0.5 1.3
BMI 0.4 2.4 6.2 2.5 -0.0 -1.0
Height 0.3 6.6 7.1 -2.6 2.7 -2.4
Waist Hip Ratio (WHR) 0.3 1.4 3.8 0.6 -1.9 -0.2
Systolic Blood Pressure 0.2 0.8 1.2 1.1 -0.1 1.1
Smoking Status 1.0 2.3 6.5 2.6 0.6 -0.4
Allergy or Eczema 1.9 5.1 9.2 -0.2 3.0 -2.5
Cardiovascular Disease 0.2 0.6 1.7 0.4 -0.1 1.3
Hypothyroidism (self reported) 0.4 1.0 1.3 1.0 -0.8 1.1
Respiratory disease 0.2 0.4 0.7 0.6 0.5 -0.8
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.2 1.1 -1.0 0.4
Lung FEV1/FVC ratio 0.9 4.4 7.5 2.7 -2.0 1.3
Lung FVC 2.4 12.4 34.5 -5.9 1.6 -0.1
Neuroticism 0.1 0.3 0.5 -0.3 -0.4 -0.7
Chronotype (morning person) 0.2 0.4 1.0 -0.1 -0.5 -1.0
Hair Pigment 5.1 145.0 424.4 20.6 3.1 -1.1
Tanning 0.3 4.0 8.6 -2.9 -1.3 1.4
Hand grip strength (left) 1.1 2.9 4.9 0.3 1.9 -2.2
Number of treatments/medications taken 0.0 0.1 0.2 0.1 0.5 -0.0
Average weekly spirits intake 2.1 2.5 4.7 -0.6 1.6 -2.2
Sensitivity / hurt feelings 0.5 0.9 2.1 0.4 -1.5 0.5
Frequency of depressed mood in last 2 weeks 0.4 0.5 0.8 0.9 0.8 0.0
Hearing difficulty/problems: Yes 0.5 0.8 1.3 1.1 -0.5 0.9
Relative age of first facial hair 0.3 0.6 1.2 1.1 0.5 0.4
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 3.1 1.8 -0.5 -0.1
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.6 -0.3 0.7 -1.3
Ever had hysterectomy (womb removed) 0.5 0.5 1.1 -0.6 0.2 1.0
Systolic blood pressure, automated reading 0.3 1.0 1.5 1.0 -0.7 1.2
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 4.2 2.1 0.5 -0.3
Angina 1.1 1.5 2.4 1.2 -1.6 0.7
Medication for hormone replacement therapy 0.8 0.9 1.1 1.1 0.8 -1.0
Vitamin and mineral supplements 0.2 0.3 0.8 -0.3 -0.9 -0.1
Supplements: Zinc 0.2 0.3 0.8 0.0 0.2 -0.9
Medication: Co-codamol 0.5 0.5 1.2 -0.5 1.1 -0.4
Medication: Metformin 0.4 0.5 0.9 0.8 0.1 1.0
Diabetes (father) 0.3 0.4 0.9 -0.1 0.9 -0.5
Diabetes (mother) 0.1 0.1 0.3 -0.6 0.0 -0.1
Severe depression (siblings) 0.2 0.2 0.4 0.6 0.1 0.4
Pack years adult smoking proportion 1.0 1.5 2.8 1.7 -0.5 1.2
Impedance of leg (right) 0.5 2.3 5.5 1.2 -2.3 0.1
Leg fat-free mass (left) 0.4 2.2 3.8 -0.2 2.0 -1.6
Trunk fat percentage 0.5 1.8 5.3 2.3 -0.2 -0.4
Hand grip strength (right) 0.4 1.2 2.5 0.1 1.0 -1.6
Townsend deprivation index at recruitment 0.2 0.3 0.7 0.8 -0.5 -0.4
Current tobacco smoking 0.3 0.5 1.3 1.1 0.5 -0.0
Average weekly fortified wine intake 1.3 1.5 4.4 -0.3 0.1 -2.1
Maternal smoking around birth 1.5 2.1 6.1 2.5 -0.2 0.5
Fed-up feelings 0.4 0.8 1.6 1.2 0.1 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 1.3 0.3 -0.9
Relative age voice broke 0.1 0.1 0.2 0.5 -0.1 0.0
Taking other prescription medications 0.1 0.2 0.3 0.3 -0.4 0.6
Age when periods started (menarche) 0.9 2.3 3.9 1.3 -1.0 2.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.7 -0.1 0.2 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.5 -0.7 1.9 -0.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.1 0.0 0.5
Qualifications: CSEs or equivalent 0.6 0.9 2.2 0.3 -1.5 -0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -1.0 0.3 0.2
High blood pressure 0.4 1.1 3.2 0.4 -0.0 1.8
Hayfever, allergic rhinitis or eczema 1.7 3.8 6.6 -0.5 2.1 -2.6
Multivitamins +/- minerals 0.6 0.7 1.5 1.2 0.9 0.0
Stomach or abdominal pain in last month 1.3 1.6 3.3 -0.9 1.8 -0.8
Supplements: Glucosamine 1.9 2.5 6.4 -0.8 0.7 2.5
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.8 -0.4 0.9 -0.7
Medication: Atenolol 0.2 0.3 0.8 0.1 -0.3 -0.9
Medication: Levothyroxine sodium 0.5 0.9 1.9 0.1 -1.0 1.4
Sitting height 0.1 0.4 1.1 -0.1 1.1 0.0
Chronic bronchitis/emphysema (father) 1.0 1.1 2.4 -0.1 -1.0 1.5
High blood pressure (mother) 0.1 0.2 0.5 -0.3 -0.7 -0.2
Body mass index (BMI) 0.3 1.1 2.7 1.6 0.4 -0.7
Impedance of leg (left) 0.8 4.0 9.2 1.6 -3.0 0.5
Leg predicted mass (left) 0.4 2.0 3.5 -0.2 1.9 -1.6
Trunk fat mass 0.3 1.5 3.8 1.9 0.1 -0.8
Waist circumference 0.5 1.9 3.6 1.9 -0.3 -1.5
Number of incorrect matches in round 0.3 0.4 0.6 -0.3 -0.8 0.8
Past tobacco smoking 0.6 1.0 2.6 -1.6 -0.6 0.3
Alcohol usually taken with meals 1.2 1.9 4.6 -2.1 0.6 -0.9
Nervous feelings 0.6 1.1 1.8 -0.5 -1.4 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.4 0.7 -0.5 0.2
Hearing difficulty/problems with background noise 0.6 1.0 2.2 1.5 -0.7 0.7
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 0.8 0.7 -0.5
Had menopause 0.9 1.1 1.8 -1.4 1.1 0.5
Had other major operations 0.4 0.5 0.9 0.1 0.7 -0.9
Forced vital capacity (FVC) 1.3 5.1 15.0 -3.9 -0.0 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.6 -0.6 1.6 -0.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.3 -0.1 1.5 0.2
Qualifications: None of the above 1.2 2.7 4.6 2.1 -0.9 1.6
Financial difficulties in last 2 years 1.3 1.7 4.5 2.1 0.7 0.3
Mouth/teeth dental problems 0.5 0.7 1.5 -0.7 -0.3 -1.2
Heart attack 0.9 1.1 2.1 0.7 0.9 -1.4
Allergy 1.2 2.8 4.5 0.5 -1.9 2.1
Pain all over the body in last month 0.4 0.5 1.0 1.0 0.6 0.1
Diabetes (self-reported) 0.2 0.4 0.5 0.5 0.5 -0.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.3 -1.3 -0.0 -1.5
Medication: Ramipril 0.5 0.6 1.9 0.1 1.4 -0.2
Medication: Simvastatin 0.1 0.1 0.1 -0.0 -0.4 -0.4
Fluid intelligence score 0.3 0.6 0.9 -0.7 1.0 -0.7
Illnesses of siblings 0.1 0.1 0.4 -0.0 0.0 -0.6
Neuroticism score 0.1 0.2 0.3 -0.3 -0.6 -0.3
Weight 0.2 1.0 1.4 1.2 0.5 -1.1
Impedance of arm (right) 0.1 0.6 1.2 0.6 -1.1 0.5
Arm fat percentage (right) 0.5 1.9 5.7 2.4 -0.1 -0.0
Trunk fat-free mass 0.3 1.5 1.8 -1.3 1.1 -1.3
Hip circumference 0.5 2.3 3.0 1.7 1.1 -1.7
Time employed in main current job 0.1 0.2 0.4 0.3 -0.1 0.6
Alcohol intake versus 10 years previously 1.8 2.7 7.7 2.8 -0.6 0.2
Father’s age at death 0.4 0.5 1.3 -0.1 1.1 -0.5
Worrier / anxious feelings 0.4 0.7 1.6 -1.2 0.8 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.8 1.4 -0.7 0.8
Falls in the last year 1.5 2.0 5.6 -0.7 -0.1 -2.4
Hair/balding pattern: Pattern 3 1.1 1.6 2.3 1.4 -0.7 1.5
Number of live births 0.3 0.4 0.8 -0.9 -0.1 0.5
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 9.9 -3.1 -0.8 -0.2
Pulse rate 0.7 1.2 1.7 1.3 0.8 -1.0
Happiness 0.2 0.2 0.4 -0.4 0.2 -0.6
Noisy workplace 1.1 1.4 3.3 0.5 -1.8 0.9
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.7 -1.6 -0.1 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 -0.5 -0.1 -0.4
Mouth/teeth dental problems: Dentures 0.0 0.0 0.1 0.3 0.0 -0.1
Asthma 0.1 0.1 0.4 0.1 -0.6 0.1
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.9 1.7 -0.9 0.7
Medication: Cholesterol lowering 0.6 0.9 1.6 1.1 -1.3 -0.1
Depression (self-reported) 0.2 0.3 0.5 -0.7 -0.1 -0.6
Medication: Lansoprazole 0.8 0.9 2.4 1.6 -0.5 -0.3
Prospective memory result 0.5 0.6 1.6 -1.3 0.4 -0.3
Lung cancer (father) 0.2 0.2 0.4 0.1 0.4 0.6
Illnesses of mother 0.1 0.1 0.2 0.4 -0.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.7 8.0 -2.8 -0.2 -0.4
Pulse wave Arterial Stiffness index 1.1 1.3 2.4 -0.6 1.5 -1.0
Impedance of arm (left) 0.1 0.4 0.5 0.7 -0.7 0.5
Arm fat mass (right) 0.3 1.1 3.0 1.7 0.2 -0.4
Trunk predicted mass 0.2 1.4 1.7 -1.3 1.0 -1.2
Standing height 0.1 0.7 1.2 -1.1 0.4 -0.9
Length of working week for main job 0.8 0.9 1.3 -1.2 -1.0 0.6
Exposure to tobacco smoke at home 0.2 0.3 0.6 0.8 0.1 -0.5
Breastfed as a baby 4.7 5.8 10.2 -3.2 1.6 -2.2
Tense / ‘highly strung’ 0.5 0.8 1.9 0.0 -1.4 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.8 0.4 0.6 2.0
Hair/balding pattern: Pattern 4 0.1 0.2 0.5 -0.7 0.1 -0.2
Birth weight of first child 1.7 3.2 4.5 -2.1 1.9 -1.2
Peak expiratory flow (PEF) 0.3 0.6 1.7 -0.1 -1.3 0.3
Pulse wave reflection index 0.9 1.1 3.2 -1.8 -0.0 0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.2 0.9 1.1 0.3
Loud music exposure frequency 0.5 0.6 0.9 0.7 0.9 0.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.7 -0.3 0.4 -0.9
Mouth/teeth dental problems: Bleeding gums 3.1 4.0 8.9 3.0 -1.3 1.2
Blood clot in the leg (DVT) 0.3 0.4 1.2 -1.1 0.1 0.0
Medication: Paracetamol 0.9 1.5 3.0 1.7 -0.1 1.3
Headache pain in last month 0.3 0.5 1.1 1.1 0.1 -0.7
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.3 -0.4 -0.1 -0.5
Glaucoma (self-reported) 0.9 1.1 1.9 0.9 -1.4 0.8
Gout (self-reported) 1.1 1.5 2.9 1.7 1.3 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 0.1 -0.2 0.5
Medication: Amlodipine 0.4 0.5 0.8 0.1 0.9 -0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.5 0.9 -0.1
Birth weight 0.1 0.2 0.3 -0.5 0.2 -0.5
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.2 1.5 -0.9 1.1
High blood pressure (siblings) 0.8 1.2 2.8 0.8 -0.3 1.7
Forced vital capacity (FVC), Best measure 1.1 4.1 12.0 -3.5 0.3 -0.5
Body fat percentage 0.6 2.2 6.2 2.5 -0.3 -0.6
Leg fat percentage (right) 0.8 2.8 7.8 2.8 -0.3 -0.8
Arm fat-free mass (right) 0.1 0.7 1.4 -0.4 0.8 -1.2
Exposure to tobacco smoke outside home 3.5 4.6 7.1 2.2 -2.7 1.4
Comparative body size at age 10 0.0 0.1 0.3 -0.0 0.6 -0.3
Number of full brothers 1.0 1.3 3.2 1.8 0.0 0.8
Worry too long after embarrassment 0.5 0.9 2.5 -0.4 -1.6 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 1.4 0.3 -0.1
Wheeze or whistling in the chest in last year 2.2 3.9 11.2 3.4 0.6 0.4
Number of children fathered 1.5 1.7 3.4 -0.9 1.8 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 2.5 -1.6 -1.0 1.6
Age at first live birth 0.5 1.0 2.6 -1.6 -0.2 -0.5
Pulse wave peak to peak time 1.0 1.2 2.3 0.7 -1.5 0.9
Health satisfaction 1.5 2.0 5.9 2.4 -0.3 -0.1
Shortness of breath walking on level ground 1.1 1.3 3.7 1.9 -0.0 0.4
Qualifications: College or University degree 1.3 4.1 7.6 -2.8 0.9 -2.0
Eye problems/disorders: None of the above 1.6 1.8 4.2 -2.0 -0.7 0.9
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 0.8 -0.1 0.6
Emphysema/chronic bronchitis 0.3 0.3 0.4 0.6 0.3 -0.6
Medication for pain relief, constipation, heartburn 2.6 4.4 8.5 -2.0 0.9 -2.9
Neck or shoulder pain in last month 0.8 1.2 3.2 0.5 1.8 -0.1
Medication: Blood pressure 0.3 0.5 1.1 -0.4 0.5 1.0
Angina (self-reported) 1.2 1.6 2.9 1.2 -1.7 0.6
Migraine (self-reported) 0.2 0.2 0.6 -0.2 0.8 0.2
Medication: Ibuprofen 1.2 1.4 2.1 1.2 -1.4 0.7
Medication: Allopurinol 0.9 1.1 2.0 1.4 0.5 1.1
Medication: Omeprazole 1.2 1.4 2.4 -0.3 -1.3 1.5
Medication: Seretide 50 evohaler 0.4 0.5 1.3 -0.3 1.1 0.3
Mean time to correctly identify matches 0.2 0.3 0.8 -0.9 0.5 -0.2
Heart disease (mother) 0.3 0.4 1.0 -0.1 0.3 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.6 0.2 0.8 -0.3
Whole body fat mass 0.4 1.8 4.5 2.1 0.1 -1.0
Leg fat mass (right) 0.5 2.0 4.8 2.2 0.1 -1.1
Arm predicted mass (right) 0.2 0.8 1.3 -0.5 1.0 -1.1
Pulse rate, automated reading 0.4 1.4 3.4 1.9 0.9 -0.3
Alcohol intake frequency. 0.6 1.4 2.7 1.7 0.6 -1.1
Comparative height size at age 10 0.4 2.2 3.5 -1.6 0.9 -1.9
Number of full sisters 0.1 0.1 0.2 0.2 0.2 0.5
Suffer from ‘nerves’ 0.7 1.1 2.8 0.1 -1.7 0.6
Overall health rating 1.2 2.5 7.5 2.7 -0.2 -0.1
Chest pain or discomfort 0.7 1.1 2.2 1.5 -0.9 0.4
Had major operations 0.6 0.7 1.0 1.0 0.8 0.7
Age at last live birth 1.1 1.5 4.6 -2.1 -0.0 0.2
Family relationship satisfaction 0.5 0.6 1.0 -0.8 -1.0 -0.5
Leg pain on walking 0.5 0.6 1.5 1.2 0.4 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.2 0.3 0.3 0.5
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.0 1.4 -0.7 1.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.6 -0.7 -1.3 -0.4
Medication: Aspirin 0.9 1.2 2.1 1.2 -0.5 1.4
Supplements: Vitamin C 0.2 0.3 0.9 -0.9 -0.1 -0.1
Knee pain experienced in last month 0.5 0.7 1.8 0.2 0.6 -1.3
Hypertension (Self-reported) 0.4 1.2 3.5 0.1 0.0 1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.5 7.0 0.4 -1.8 2.6
Illnesses of father: Heart disease 0.8 1.1 2.3 -0.7 -1.5 0.7
Illnesses of siblings: Diabetes 0.4 0.5 1.4 -0.2 0.1 -1.2
Smoking status: Previous 0.6 1.0 2.6 1.6 0.5 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.0 -0.9 1.0 -1.4
Whole body fat-free mass 0.3 1.8 2.2 -0.9 1.5 -1.5
Leg fat-free mass (right) 0.3 1.4 2.5 -0.2 1.6 -1.3
Arm fat percentage (left) 0.5 2.0 5.8 2.4 0.2 -0.1
Average weekly red wine intake 2.9 4.3 8.6 -2.9 2.0 -0.7
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.5 -0.5 1.6 -1.0
Mood swings 0.0 0.1 0.2 0.5 0.1 0.0
Loneliness, isolation 0.6 0.9 2.1 1.5 -0.7 0.2
Long-standing illness, disability or infirmity 1.1 1.7 3.2 1.8 0.8 -1.1
Ever had bowel cancer screening 0.7 0.8 1.1 0.7 1.1 0.9
Diabetes diagnosed by doctor 0.2 0.2 0.5 0.5 0.7 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 4.2 4.5 6.5 2.6 -1.9 1.9
Friendships satisfaction 0.7 0.9 1.4 1.0 -1.2 0.6
Qualifications: nursing, teaching 0.2 0.3 0.7 -0.4 -0.9 -0.3
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.4 0.3 -0.7
Eye problems/disorders: Cataract 0.6 0.7 0.9 0.9 1.0 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 3.7 -1.2 1.9 0.2
Medication for cholesterol 0.5 0.7 1.0 -0.4 -1.0 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.1 -0.4 0.4 0.3
Back pain experienced in last month 0.5 0.7 1.2 1.1 0.5 0.7
Mineral and other dietary supplements 1.8 2.4 4.6 1.4 0.7 -2.2
Breast cancer (self-reported) 0.2 0.2 0.4 0.4 -0.6 0.1
Asthma (self-reported) 0.0 0.0 0.0 -0.1 -0.2 0.0
Osteoporosis (self-reported) 0.3 0.3 0.5 -0.4 -0.7 0.6
Osteoarthritis (self-reported) 0.6 0.8 1.1 0.9 -0.7 1.0
Medication: Aspirin 0.8 1.0 1.5 0.9 -0.8 1.2
Medication: Gliclazide 0.2 0.2 0.4 -0.0 -0.6 0.5
Illnesses of father: None of the above (group 1) 0.8 1.0 2.4 0.1 1.6 -0.9
Smoking status: Current 0.2 0.3 0.8 0.9 0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 5.1 -2.3 -0.3 -0.0
Whole body water mass 0.3 1.5 1.9 -0.9 1.4 -1.3
Leg predicted mass (right) 0.3 1.5 2.8 -0.2 1.7 -1.3
Arm fat mass (left) 0.3 1.0 2.9 1.7 0.4 -0.4
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 -0.1 -0.7 0.4
Average weekly champagne plus white wine intake 1.4 1.9 2.9 -1.6 1.7 -0.4
Miserableness 0.0 0.0 0.0 -0.2 -0.0 0.2
Guilty feelings 0.2 0.3 0.9 -0.3 0.3 -0.9
Wears glasses or contact lenses 0.8 0.9 1.3 -1.0 -0.8 1.1
Ever taken oral contraceptive pill 0.4 0.4 0.9 1.0 -0.2 0.6
Hearing aid user 0.8 0.9 1.5 1.2 0.0 1.1
Mother’s age at death 1.3 1.7 2.5 -1.5 1.6 -0.5
Financial situation satisfaction 0.6 0.8 1.7 1.3 0.7 0.4
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.4 1.5 -0.4 -0.4
Commuting to job workplace: Public transport 0.5 0.6 1.0 1.0 -0.7 -0.4
Eye problems/disorders: Glaucoma 0.4 0.5 0.9 0.3 -1.0 0.6
Medication: Blood pressure 0.6 1.1 1.6 -0.4 1.3 -1.2
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.1 1.5 0.8 0.3
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.7 -0.6 -1.0 1.3
High cholesterol (Self-reported) 0.1 0.2 0.5 0.4 -0.7 0.1
Medication: Bendroflumethiazide 0.2 0.3 0.9 -0.2 1.0 -0.2
Medication: Paracetamol 0.3 0.5 0.7 0.9 -0.0 0.8
Medication: Lisinopril 1.9 2.5 5.8 0.1 2.4 1.2
Medication: Atorvastatin 1.2 1.5 4.0 2.0 -0.4 0.4
Illnesses of father: High blood pressure 0.3 0.3 0.7 0.6 -0.8 -0.1
Alcohol drinker status: Never 2.6 3.1 6.5 -0.3 1.7 -2.5
Ever smoked 0.3 0.4 1.0 1.0 0.4 -0.4
Basal metabolic rate 0.2 1.1 1.8 -0.4 1.2 -1.4
Leg fat percentage (left) 0.8 3.0 8.3 2.9 -0.5 -0.7
Arm fat-free mass (left) 0.2 0.8 1.6 -0.5 0.8 -1.3
Number of operations (self-reported) 0.1 0.1 0.2 0.0 -0.3 0.4
Average weekly beer plus cider intake 1.9 2.8 3.9 2.0 -1.7 1.2
Irritability 0.3 0.6 0.9 -0.7 -1.0 0.6
Risk taking 2.2 3.2 4.7 2.2 1.9 1.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.7 -0.1 0.7 0.8
Fractured/broken bones in last 5 years 1.6 2.1 4.7 -0.5 1.2 -2.2
Age started oral contraceptive pill 2.7 3.4 6.5 -2.5 1.5 -1.2
Diastolic blood pressure, automated reading 0.4 1.2 1.3 1.1 -1.1 1.1
Ever depressed for a whole week 0.6 0.7 1.5 0.3 1.2 0.8
Unable to work because of sickness or disability 2.8 3.7 5.8 2.0 -2.4 1.1
Commuting to job workplace: Cycle 0.7 0.9 2.7 -1.6 0.1 0.1
Myopia 0.6 0.8 2.0 -1.4 -0.6 0.3
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.8 -0.9 0.6 -1.9
Cholesterol lowering medication 0.5 0.8 1.4 -0.5 1.2 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.7 -0.1 -1.3 1.3
Pain experienced in last month 1.1 1.9 4.2 -1.1 -2.1 0.5
Supplements: Calcium 3.2 3.5 6.5 -2.5 1.2 -1.6
Basal cell carcinoma (self-reported) 0.9 1.0 1.6 -1.3 1.2 0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.2 1.8 0.6 1.2 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.5 -1.2 0.1 -0.1
Heart disease (siblings) 0.4 0.4 1.2 -0.3 0.2 -1.1
Alcohol drinker status: Previous 0.4 0.4 1.1 -0.2 1.0 -0.3
Pack years of smoking 1.0 1.5 2.3 1.4 -0.4 1.5
Impedance of whole body 0.3 1.7 3.4 1.2 -1.9 0.6
Leg fat mass (left) 0.5 2.0 4.8 2.2 0.0 -1.0
Arm predicted mass (left) 0.2 1.2 2.1 -0.8 0.9 -1.4