Hub : Genes

GOLGA5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0710	0.0263	1.9e-03	0.032	0.025	0.014	0.024	0.021	1.2e-05	1.1e-04	3.0e-03	1.5e-04	3.6e-04
2	YFS	Blood	0.0423	0.0106	6.4e-08	0.034	0.022	0.026	0.027	0.030	2.8e-11	9.3e-08	5.3e-09	3.5e-09	2.6e-10
3	TCGA	Liver Hepatocellular Carcinoma	0.2160	0.0780	4.1e-04	0.036	0.084	0.052	NA	0.060	7.9e-03	9.1e-05	1.9e-03	NA	8.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	1.8	-1.4	0.2	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	-1.6	0.3	0.6
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	0.2	0.3	-0.5
Depression (Nagel 2018)	0.1	0.1	0.4	0.6	0.1	-0.0
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.1	-2.2	-0.2	-1.0
Neuroticism (Nagel 2018)	0.2	0.4	1.2	-0.1	-1.1	0.1
Schizophrenia (2018)	0.2	0.4	1.1	-1.1	0.2	0.3
Schizophrenia vs Biploar Disorder	2.4	3.2	5.3	-0.2	2.3	-2.1
Worry (Nagel 2018)	0.4	0.9	2.1	-0.4	-1.5	0.6
Alzheimer’s Disease (in mother)	1.3	1.5	4.1	0.6	2.0	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.4	-0.4	-0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	1.2	1.3	0.3
Crohns Disease (2017)	0.1	0.1	0.4	0.1	-0.6	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.3	-0.0	-0.7
Ulcerative Colitis (UC)	0.2	0.4	0.5	-0.7	0.6	-0.7
Major Depression (MDD)	1.8	2.2	3.3	-1.8	1.5	-1.0
Reaction Time	0.7	1.4	3.2	-0.7	0.7	-1.8
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.9	-1.7	0.4	-1.2
Breast Cancer	2.3	5.6	7.4	-2.3	2.7	-2.0
Ovarian Cancer	0.2	0.3	0.3	0.5	0.5	-0.5
Prostate Cancer	0.8	1.1	1.9	1.1	1.4	0.6
Age at First Birth	0.7	1.0	2.7	-0.4	-0.0	1.6
Bipolar Disorder (2011)	0.9	0.8	2.4	-1.6	0.1	0.2
Body Mass Index (BMI) (2010)	2.4	3.3	4.4	1.9	-2.1	1.4
Coronary Artery Disease (CAD)	0.8	0.9	1.4	-1.2	-0.2	-1.1
Crohns Disease (2012)	0.5	0.8	1.3	0.3	-1.1	1.0
Mean Putamen Volume	0.7	0.7	1.5	-0.4	0.8	1.2
Fasting Glucose	0.9	1.1	3.0	-0.5	0.0	-1.7
HbA1C	0.2	0.2	0.5	-0.1	0.4	-0.7
HDL Cholesterol	0.4	0.6	1.8	-0.1	-0.1	1.3
LDL Cholesterol	0.9	1.4	4.1	0.1	-2.0	-0.1
Lupus	0.3	0.5	1.0	0.4	0.5	-1.0
Neuroticism (2016)	0.3	0.5	0.7	0.8	-0.7	0.5
Primary Biliary Cirrhosis	0.9	1.3	2.0	0.9	-1.4	1.1
Rheumatoid Arthritis	1.3	1.9	3.0	1.7	-1.2	1.0
Schizophrenia (2014)	0.2	0.4	0.8	-0.5	0.1	0.9
Triglycerides	1.4	2.3	6.1	2.5	0.1	-0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	1.3	-0.7	0.2
Ulcerative Colitis	0.2	0.2	0.5	-0.1	0.4	-0.7
Blood Eosinophil Count	0.4	3.4	8.1	2.8	-1.2	-0.8
Blood Platelet Count	0.1	1.2	1.7	-1.1	-0.8	1.3
Blood Red Count	0.1	1.2	2.1	1.4	1.0	0.6
Blood White Count	2.4	17.9	32.2	5.7	-4.3	1.7
Heel T-Score	0.1	1.1	1.7	1.1	-0.5	1.3
BMI	0.4	2.4	6.2	2.5	-0.0	-1.0
Height	0.3	6.6	7.1	-2.6	2.7	-2.4
Waist Hip Ratio (WHR)	0.3	1.4	3.8	0.6	-1.9	-0.2
Systolic Blood Pressure	0.2	0.8	1.2	1.1	-0.1	1.1
Smoking Status	1.0	2.3	6.5	2.6	0.6	-0.4
Allergy or Eczema	1.9	5.1	9.2	-0.2	3.0	-2.5
Cardiovascular Disease	0.2	0.6	1.7	0.4	-0.1	1.3
Hypothyroidism (self reported)	0.4	1.0	1.3	1.0	-0.8	1.1
Respiratory disease	0.2	0.4	0.7	0.6	0.5	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.2	1.1	-1.0	0.4
Lung FEV1/FVC ratio	0.9	4.4	7.5	2.7	-2.0	1.3
Lung FVC	2.4	12.4	34.5	-5.9	1.6	-0.1
Neuroticism	0.1	0.3	0.5	-0.3	-0.4	-0.7
Chronotype (morning person)	0.2	0.4	1.0	-0.1	-0.5	-1.0
Hair Pigment	5.1	145.0	424.4	20.6	3.1	-1.1
Tanning	0.3	4.0	8.6	-2.9	-1.3	1.4
Hand grip strength (left)	1.1	2.9	4.9	0.3	1.9	-2.2
Number of treatments/medications taken	0.0	0.1	0.2	0.1	0.5	-0.0
Average weekly spirits intake	2.1	2.5	4.7	-0.6	1.6	-2.2
Sensitivity / hurt feelings	0.5	0.9	2.1	0.4	-1.5	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.8	0.9	0.8	0.0
Hearing difficulty/problems: Yes	0.5	0.8	1.3	1.1	-0.5	0.9
Relative age of first facial hair	0.3	0.6	1.2	1.1	0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	3.1	1.8	-0.5	-0.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.6	-0.3	0.7	-1.3
Ever had hysterectomy (womb removed)	0.5	0.5	1.1	-0.6	0.2	1.0
Systolic blood pressure, automated reading	0.3	1.0	1.5	1.0	-0.7	1.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.2	2.1	0.5	-0.3
Angina	1.1	1.5	2.4	1.2	-1.6	0.7
Medication for hormone replacement therapy	0.8	0.9	1.1	1.1	0.8	-1.0
Vitamin and mineral supplements	0.2	0.3	0.8	-0.3	-0.9	-0.1
Supplements: Zinc	0.2	0.3	0.8	0.0	0.2	-0.9
Medication: Co-codamol	0.5	0.5	1.2	-0.5	1.1	-0.4
Medication: Metformin	0.4	0.5	0.9	0.8	0.1	1.0
Diabetes (father)	0.3	0.4	0.9	-0.1	0.9	-0.5
Diabetes (mother)	0.1	0.1	0.3	-0.6	0.0	-0.1
Severe depression (siblings)	0.2	0.2	0.4	0.6	0.1	0.4
Pack years adult smoking proportion	1.0	1.5	2.8	1.7	-0.5	1.2
Impedance of leg (right)	0.5	2.3	5.5	1.2	-2.3	0.1
Leg fat-free mass (left)	0.4	2.2	3.8	-0.2	2.0	-1.6
Trunk fat percentage	0.5	1.8	5.3	2.3	-0.2	-0.4
Hand grip strength (right)	0.4	1.2	2.5	0.1	1.0	-1.6
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.8	-0.5	-0.4
Current tobacco smoking	0.3	0.5	1.3	1.1	0.5	-0.0
Average weekly fortified wine intake	1.3	1.5	4.4	-0.3	0.1	-2.1
Maternal smoking around birth	1.5	2.1	6.1	2.5	-0.2	0.5
Fed-up feelings	0.4	0.8	1.6	1.2	0.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	1.3	0.3	-0.9
Relative age voice broke	0.1	0.1	0.2	0.5	-0.1	0.0
Taking other prescription medications	0.1	0.2	0.3	0.3	-0.4	0.6
Age when periods started (menarche)	0.9	2.3	3.9	1.3	-1.0	2.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.1	0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.5	-0.7	1.9	-0.9
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.1	0.0	0.5
Qualifications: CSEs or equivalent	0.6	0.9	2.2	0.3	-1.5	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	1.1	-1.0	0.3	0.2
High blood pressure	0.4	1.1	3.2	0.4	-0.0	1.8
Hayfever, allergic rhinitis or eczema	1.7	3.8	6.6	-0.5	2.1	-2.6
Multivitamins +/- minerals	0.6	0.7	1.5	1.2	0.9	0.0
Stomach or abdominal pain in last month	1.3	1.6	3.3	-0.9	1.8	-0.8
Supplements: Glucosamine	1.9	2.5	6.4	-0.8	0.7	2.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.4	0.9	-0.7
Medication: Atenolol	0.2	0.3	0.8	0.1	-0.3	-0.9
Medication: Levothyroxine sodium	0.5	0.9	1.9	0.1	-1.0	1.4
Sitting height	0.1	0.4	1.1	-0.1	1.1	0.0
Chronic bronchitis/emphysema (father)	1.0	1.1	2.4	-0.1	-1.0	1.5
High blood pressure (mother)	0.1	0.2	0.5	-0.3	-0.7	-0.2
Body mass index (BMI)	0.3	1.1	2.7	1.6	0.4	-0.7
Impedance of leg (left)	0.8	4.0	9.2	1.6	-3.0	0.5
Leg predicted mass (left)	0.4	2.0	3.5	-0.2	1.9	-1.6
Trunk fat mass	0.3	1.5	3.8	1.9	0.1	-0.8
Waist circumference	0.5	1.9	3.6	1.9	-0.3	-1.5
Number of incorrect matches in round	0.3	0.4	0.6	-0.3	-0.8	0.8
Past tobacco smoking	0.6	1.0	2.6	-1.6	-0.6	0.3
Alcohol usually taken with meals	1.2	1.9	4.6	-2.1	0.6	-0.9
Nervous feelings	0.6	1.1	1.8	-0.5	-1.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.4	0.7	-0.5	0.2
Hearing difficulty/problems with background noise	0.6	1.0	2.2	1.5	-0.7	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	0.8	0.7	-0.5
Had menopause	0.9	1.1	1.8	-1.4	1.1	0.5
Had other major operations	0.4	0.5	0.9	0.1	0.7	-0.9
Forced vital capacity (FVC)	1.3	5.1	15.0	-3.9	-0.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.6	-0.6	1.6	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.3	-0.1	1.5	0.2
Qualifications: None of the above	1.2	2.7	4.6	2.1	-0.9	1.6
Financial difficulties in last 2 years	1.3	1.7	4.5	2.1	0.7	0.3
Mouth/teeth dental problems	0.5	0.7	1.5	-0.7	-0.3	-1.2
Heart attack	0.9	1.1	2.1	0.7	0.9	-1.4
Allergy	1.2	2.8	4.5	0.5	-1.9	2.1
Pain all over the body in last month	0.4	0.5	1.0	1.0	0.6	0.1
Diabetes (self-reported)	0.2	0.4	0.5	0.5	0.5	-0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.3	-1.3	-0.0	-1.5
Medication: Ramipril	0.5	0.6	1.9	0.1	1.4	-0.2
Medication: Simvastatin	0.1	0.1	0.1	-0.0	-0.4	-0.4
Fluid intelligence score	0.3	0.6	0.9	-0.7	1.0	-0.7
Illnesses of siblings	0.1	0.1	0.4	-0.0	0.0	-0.6
Neuroticism score	0.1	0.2	0.3	-0.3	-0.6	-0.3
Weight	0.2	1.0	1.4	1.2	0.5	-1.1
Impedance of arm (right)	0.1	0.6	1.2	0.6	-1.1	0.5
Arm fat percentage (right)	0.5	1.9	5.7	2.4	-0.1	-0.0
Trunk fat-free mass	0.3	1.5	1.8	-1.3	1.1	-1.3
Hip circumference	0.5	2.3	3.0	1.7	1.1	-1.7
Time employed in main current job	0.1	0.2	0.4	0.3	-0.1	0.6
Alcohol intake versus 10 years previously	1.8	2.7	7.7	2.8	-0.6	0.2
Father’s age at death	0.4	0.5	1.3	-0.1	1.1	-0.5
Worrier / anxious feelings	0.4	0.7	1.6	-1.2	0.8	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.8	1.4	-0.7	0.8
Falls in the last year	1.5	2.0	5.6	-0.7	-0.1	-2.4
Hair/balding pattern: Pattern 3	1.1	1.6	2.3	1.4	-0.7	1.5
Number of live births	0.3	0.4	0.8	-0.9	-0.1	0.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	9.9	-3.1	-0.8	-0.2
Pulse rate	0.7	1.2	1.7	1.3	0.8	-1.0
Happiness	0.2	0.2	0.4	-0.4	0.2	-0.6
Noisy workplace	1.1	1.4	3.3	0.5	-1.8	0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.7	-1.6	-0.1	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.5	-0.1	-0.4
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	0.3	0.0	-0.1
Asthma	0.1	0.1	0.4	0.1	-0.6	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.9	1.7	-0.9	0.7
Medication: Cholesterol lowering	0.6	0.9	1.6	1.1	-1.3	-0.1
Depression (self-reported)	0.2	0.3	0.5	-0.7	-0.1	-0.6
Medication: Lansoprazole	0.8	0.9	2.4	1.6	-0.5	-0.3
Prospective memory result	0.5	0.6	1.6	-1.3	0.4	-0.3
Lung cancer (father)	0.2	0.2	0.4	0.1	0.4	0.6
Illnesses of mother	0.1	0.1	0.2	0.4	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	8.0	-2.8	-0.2	-0.4
Pulse wave Arterial Stiffness index	1.1	1.3	2.4	-0.6	1.5	-1.0
Impedance of arm (left)	0.1	0.4	0.5	0.7	-0.7	0.5
Arm fat mass (right)	0.3	1.1	3.0	1.7	0.2	-0.4
Trunk predicted mass	0.2	1.4	1.7	-1.3	1.0	-1.2
Standing height	0.1	0.7	1.2	-1.1	0.4	-0.9
Length of working week for main job	0.8	0.9	1.3	-1.2	-1.0	0.6
Exposure to tobacco smoke at home	0.2	0.3	0.6	0.8	0.1	-0.5
Breastfed as a baby	4.7	5.8	10.2	-3.2	1.6	-2.2
Tense / ‘highly strung’	0.5	0.8	1.9	0.0	-1.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.8	0.4	0.6	2.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.7	0.1	-0.2
Birth weight of first child	1.7	3.2	4.5	-2.1	1.9	-1.2
Peak expiratory flow (PEF)	0.3	0.6	1.7	-0.1	-1.3	0.3
Pulse wave reflection index	0.9	1.1	3.2	-1.8	-0.0	0.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	0.9	1.1	0.3
Loud music exposure frequency	0.5	0.6	0.9	0.7	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.3	0.4	-0.9
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	8.9	3.0	-1.3	1.2
Blood clot in the leg (DVT)	0.3	0.4	1.2	-1.1	0.1	0.0
Medication: Paracetamol	0.9	1.5	3.0	1.7	-0.1	1.3
Headache pain in last month	0.3	0.5	1.1	1.1	0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.4	-0.1	-0.5
Glaucoma (self-reported)	0.9	1.1	1.9	0.9	-1.4	0.8
Gout (self-reported)	1.1	1.5	2.9	1.7	1.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	0.1	-0.2	0.5
Medication: Amlodipine	0.4	0.5	0.8	0.1	0.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.5	0.9	-0.1
Birth weight	0.1	0.2	0.3	-0.5	0.2	-0.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.2	1.5	-0.9	1.1
High blood pressure (siblings)	0.8	1.2	2.8	0.8	-0.3	1.7
Forced vital capacity (FVC), Best measure	1.1	4.1	12.0	-3.5	0.3	-0.5
Body fat percentage	0.6	2.2	6.2	2.5	-0.3	-0.6
Leg fat percentage (right)	0.8	2.8	7.8	2.8	-0.3	-0.8
Arm fat-free mass (right)	0.1	0.7	1.4	-0.4	0.8	-1.2
Exposure to tobacco smoke outside home	3.5	4.6	7.1	2.2	-2.7	1.4
Comparative body size at age 10	0.0	0.1	0.3	-0.0	0.6	-0.3
Number of full brothers	1.0	1.3	3.2	1.8	0.0	0.8
Worry too long after embarrassment	0.5	0.9	2.5	-0.4	-1.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	1.4	0.3	-0.1
Wheeze or whistling in the chest in last year	2.2	3.9	11.2	3.4	0.6	0.4
Number of children fathered	1.5	1.7	3.4	-0.9	1.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	2.5	-1.6	-1.0	1.6
Age at first live birth	0.5	1.0	2.6	-1.6	-0.2	-0.5
Pulse wave peak to peak time	1.0	1.2	2.3	0.7	-1.5	0.9
Health satisfaction	1.5	2.0	5.9	2.4	-0.3	-0.1
Shortness of breath walking on level ground	1.1	1.3	3.7	1.9	-0.0	0.4
Qualifications: College or University degree	1.3	4.1	7.6	-2.8	0.9	-2.0
Eye problems/disorders: None of the above	1.6	1.8	4.2	-2.0	-0.7	0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.8	-0.1	0.6
Emphysema/chronic bronchitis	0.3	0.3	0.4	0.6	0.3	-0.6
Medication for pain relief, constipation, heartburn	2.6	4.4	8.5	-2.0	0.9	-2.9
Neck or shoulder pain in last month	0.8	1.2	3.2	0.5	1.8	-0.1
Medication: Blood pressure	0.3	0.5	1.1	-0.4	0.5	1.0
Angina (self-reported)	1.2	1.6	2.9	1.2	-1.7	0.6
Migraine (self-reported)	0.2	0.2	0.6	-0.2	0.8	0.2
Medication: Ibuprofen	1.2	1.4	2.1	1.2	-1.4	0.7
Medication: Allopurinol	0.9	1.1	2.0	1.4	0.5	1.1
Medication: Omeprazole	1.2	1.4	2.4	-0.3	-1.3	1.5
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-0.3	1.1	0.3
Mean time to correctly identify matches	0.2	0.3	0.8	-0.9	0.5	-0.2
Heart disease (mother)	0.3	0.4	1.0	-0.1	0.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.2	0.8	-0.3
Whole body fat mass	0.4	1.8	4.5	2.1	0.1	-1.0
Leg fat mass (right)	0.5	2.0	4.8	2.2	0.1	-1.1
Arm predicted mass (right)	0.2	0.8	1.3	-0.5	1.0	-1.1
Pulse rate, automated reading	0.4	1.4	3.4	1.9	0.9	-0.3
Alcohol intake frequency.	0.6	1.4	2.7	1.7	0.6	-1.1
Comparative height size at age 10	0.4	2.2	3.5	-1.6	0.9	-1.9
Number of full sisters	0.1	0.1	0.2	0.2	0.2	0.5
Suffer from ‘nerves’	0.7	1.1	2.8	0.1	-1.7	0.6
Overall health rating	1.2	2.5	7.5	2.7	-0.2	-0.1
Chest pain or discomfort	0.7	1.1	2.2	1.5	-0.9	0.4
Had major operations	0.6	0.7	1.0	1.0	0.8	0.7
Age at last live birth	1.1	1.5	4.6	-2.1	-0.0	0.2
Family relationship satisfaction	0.5	0.6	1.0	-0.8	-1.0	-0.5
Leg pain on walking	0.5	0.6	1.5	1.2	0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.2	0.3	0.3	0.5
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.0	1.4	-0.7	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	-0.7	-1.3	-0.4
Medication: Aspirin	0.9	1.2	2.1	1.2	-0.5	1.4
Supplements: Vitamin C	0.2	0.3	0.9	-0.9	-0.1	-0.1
Knee pain experienced in last month	0.5	0.7	1.8	0.2	0.6	-1.3
Hypertension (Self-reported)	0.4	1.2	3.5	0.1	0.0	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	7.0	0.4	-1.8	2.6
Illnesses of father: Heart disease	0.8	1.1	2.3	-0.7	-1.5	0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.4	-0.2	0.1	-1.2
Smoking status: Previous	0.6	1.0	2.6	1.6	0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.0	-0.9	1.0	-1.4
Whole body fat-free mass	0.3	1.8	2.2	-0.9	1.5	-1.5
Leg fat-free mass (right)	0.3	1.4	2.5	-0.2	1.6	-1.3
Arm fat percentage (left)	0.5	2.0	5.8	2.4	0.2	-0.1
Average weekly red wine intake	2.9	4.3	8.6	-2.9	2.0	-0.7
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.5	-0.5	1.6	-1.0
Mood swings	0.0	0.1	0.2	0.5	0.1	0.0
Loneliness, isolation	0.6	0.9	2.1	1.5	-0.7	0.2
Long-standing illness, disability or infirmity	1.1	1.7	3.2	1.8	0.8	-1.1
Ever had bowel cancer screening	0.7	0.8	1.1	0.7	1.1	0.9
Diabetes diagnosed by doctor	0.2	0.2	0.5	0.5	0.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	4.2	4.5	6.5	2.6	-1.9	1.9
Friendships satisfaction	0.7	0.9	1.4	1.0	-1.2	0.6
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.4	-0.9	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.4	0.3	-0.7
Eye problems/disorders: Cataract	0.6	0.7	0.9	0.9	1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.7	-1.2	1.9	0.2
Medication for cholesterol	0.5	0.7	1.0	-0.4	-1.0	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.4	0.4	0.3
Back pain experienced in last month	0.5	0.7	1.2	1.1	0.5	0.7
Mineral and other dietary supplements	1.8	2.4	4.6	1.4	0.7	-2.2
Breast cancer (self-reported)	0.2	0.2	0.4	0.4	-0.6	0.1
Asthma (self-reported)	0.0	0.0	0.0	-0.1	-0.2	0.0
Osteoporosis (self-reported)	0.3	0.3	0.5	-0.4	-0.7	0.6
Osteoarthritis (self-reported)	0.6	0.8	1.1	0.9	-0.7	1.0
Medication: Aspirin	0.8	1.0	1.5	0.9	-0.8	1.2
Medication: Gliclazide	0.2	0.2	0.4	-0.0	-0.6	0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	0.1	1.6	-0.9
Smoking status: Current	0.2	0.3	0.8	0.9	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.1	-2.3	-0.3	-0.0
Whole body water mass	0.3	1.5	1.9	-0.9	1.4	-1.3
Leg predicted mass (right)	0.3	1.5	2.8	-0.2	1.7	-1.3
Arm fat mass (left)	0.3	1.0	2.9	1.7	0.4	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.1	-0.7	0.4
Average weekly champagne plus white wine intake	1.4	1.9	2.9	-1.6	1.7	-0.4
Miserableness	0.0	0.0	0.0	-0.2	-0.0	0.2
Guilty feelings	0.2	0.3	0.9	-0.3	0.3	-0.9
Wears glasses or contact lenses	0.8	0.9	1.3	-1.0	-0.8	1.1
Ever taken oral contraceptive pill	0.4	0.4	0.9	1.0	-0.2	0.6
Hearing aid user	0.8	0.9	1.5	1.2	0.0	1.1
Mother’s age at death	1.3	1.7	2.5	-1.5	1.6	-0.5
Financial situation satisfaction	0.6	0.8	1.7	1.3	0.7	0.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.4	1.5	-0.4	-0.4
Commuting to job workplace: Public transport	0.5	0.6	1.0	1.0	-0.7	-0.4
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.3	-1.0	0.6
Medication: Blood pressure	0.6	1.1	1.6	-0.4	1.3	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	1.5	0.8	0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.7	-0.6	-1.0	1.3
High cholesterol (Self-reported)	0.1	0.2	0.5	0.4	-0.7	0.1
Medication: Bendroflumethiazide	0.2	0.3	0.9	-0.2	1.0	-0.2
Medication: Paracetamol	0.3	0.5	0.7	0.9	-0.0	0.8
Medication: Lisinopril	1.9	2.5	5.8	0.1	2.4	1.2
Medication: Atorvastatin	1.2	1.5	4.0	2.0	-0.4	0.4
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.6	-0.8	-0.1
Alcohol drinker status: Never	2.6	3.1	6.5	-0.3	1.7	-2.5
Ever smoked	0.3	0.4	1.0	1.0	0.4	-0.4
Basal metabolic rate	0.2	1.1	1.8	-0.4	1.2	-1.4
Leg fat percentage (left)	0.8	3.0	8.3	2.9	-0.5	-0.7
Arm fat-free mass (left)	0.2	0.8	1.6	-0.5	0.8	-1.3
Number of operations (self-reported)	0.1	0.1	0.2	0.0	-0.3	0.4
Average weekly beer plus cider intake	1.9	2.8	3.9	2.0	-1.7	1.2
Irritability	0.3	0.6	0.9	-0.7	-1.0	0.6
Risk taking	2.2	3.2	4.7	2.2	1.9	1.1
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	-0.1	0.7	0.8
Fractured/broken bones in last 5 years	1.6	2.1	4.7	-0.5	1.2	-2.2
Age started oral contraceptive pill	2.7	3.4	6.5	-2.5	1.5	-1.2
Diastolic blood pressure, automated reading	0.4	1.2	1.3	1.1	-1.1	1.1
Ever depressed for a whole week	0.6	0.7	1.5	0.3	1.2	0.8
Unable to work because of sickness or disability	2.8	3.7	5.8	2.0	-2.4	1.1
Commuting to job workplace: Cycle	0.7	0.9	2.7	-1.6	0.1	0.1
Myopia	0.6	0.8	2.0	-1.4	-0.6	0.3
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.8	-0.9	0.6	-1.9
Cholesterol lowering medication	0.5	0.8	1.4	-0.5	1.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.7	-0.1	-1.3	1.3
Pain experienced in last month	1.1	1.9	4.2	-1.1	-2.1	0.5
Supplements: Calcium	3.2	3.5	6.5	-2.5	1.2	-1.6
Basal cell carcinoma (self-reported)	0.9	1.0	1.6	-1.3	1.2	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.2	1.8	0.6	1.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-1.2	0.1	-0.1
Heart disease (siblings)	0.4	0.4	1.2	-0.3	0.2	-1.1
Alcohol drinker status: Previous	0.4	0.4	1.1	-0.2	1.0	-0.3
Pack years of smoking	1.0	1.5	2.3	1.4	-0.4	1.5
Impedance of whole body	0.3	1.7	3.4	1.2	-1.9	0.6
Leg fat mass (left)	0.5	2.0	4.8	2.2	0.0	-1.0
Arm predicted mass (left)	0.2	1.2	2.1	-0.8	0.9	-1.4