Best TWAS P=2.53e-14 · Best GWAS P=1.18e-15 conditioned to 0.0124
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | C18orf25 | 0.15 | 0.08 | enet | 11 | 0.06 | 2.7e-04 | 7.7 | 7.5 | 8.5e-14 | 0.97 | 0.02 | 0.96 | FALSE |
| 2 | GTEx | Whole Blood | ATP5A1 | 0.12 | 0.05 | enet | 34 | 0.02 | 9.1e-03 | -5.6 | 5.8 | 7.5e-09 | 0.35 | 0.86 | 0.02 | FALSE |
| 3 | METSIM | Adipose | ATP5A1 | 0.03 | 0.04 | lasso | 12 | 0.03 | 4.4e-05 | -5.6 | 5.6 | 2.6e-08 | 0.44 | 0.95 | 0.01 | FALSE |
| 4 | NTR | Blood | C18orf25 | 0.06 | 0.06 | enet | 23 | 0.06 | 1.6e-19 | 8.0 | -7.6 | 2.5e-14 | -0.93 | 0.02 | 0.98 | TRUE |
| 5 | YFS | Blood | ATP5A1 | 0.14 | 0.16 | lasso | 18 | 0.17 | 2.3e-54 | -5.6 | 5.1 | 2.7e-07 | 0.38 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATP5A1 | 0.02 | 0.02 | lasso | 1 | 0.02 | 1.2e-04 | -5.6 | 5.6 | 2.8e-08 | 0.45 | 0.06 | 0.90 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C18orf25 | 0.03 | 0.03 | lasso | 3 | 0.02 | 2.5e-03 | 4.1 | 5.6 | 2.3e-08 | 0.78 | 0.06 | 0.72 | FALSE |