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chr18:50,982,831-52,540,420

Best TWAS P=6.27e-15 · Best GWAS P=1.28e-15 conditioned to 0.87

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POLI	0.23	0.15	lasso	4	0.16	6.0e-11	6.4	-7.8	6.3e-15	-0.86	0.02	0.98	TRUE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	POLI	0.13	0.11	enet	5	0.11	1.8e-08	6.4	-5.5	4.5e-08	-0.67	0.91	0.08	TRUE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	POLI	0.08	0.07	blup	43	0.08	7.1e-10	6.4	-7.4	1.7e-13	-0.78	0.10	0.90	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POLI	0.20	0.17	lasso	4	0.14	1.6e-06	6.4	-7.1	1.7e-12	-0.72	0.06	0.92	FALSE
12	GTEx	Cells Transformed fibroblasts	POLI	0.46	0.36	enet	18	0.36	9.9e-28	6.4	-7.0	2.3e-12	-0.77	0.99	0.01	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	POLI	0.11	0.11	lasso	4	0.11	2.1e-22	6.4	-6.9	3.9e-12	-0.69	0.99	0.01	FALSE
5	GTEx	Brain Cerebellar Hemisphere	POLI	0.48	0.38	lasso	7	0.34	1.3e-09	6.4	-6.9	4.3e-12	-0.68	0.54	0.41	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POLI	0.18	0.16	enet	4	0.16	1.4e-17	6.4	-6.9	4.3e-12	-0.72	0.99	0.01	FALSE
31	YFS	Blood	POLI	0.05	0.05	lasso	3	0.05	1.1e-15	6.4	-6.9	4.9e-12	-0.66	0.97	0.03	FALSE
28	GTEx	Whole Blood	POLI	0.05	0.04	enet	8	0.05	1.6e-05	6.4	-6.8	1.4e-11	-0.59	0.52	0.33	FALSE
6	GTEx	Brain Cerebellum	POLI	0.52	0.32	lasso	5	0.34	8.8e-11	6.4	-6.7	1.8e-11	-0.63	0.68	0.28	FALSE
24	GTEx	Testis	POLI	0.32	0.25	lasso	4	0.23	1.4e-10	6.4	-6.6	2.9e-11	-0.65	0.94	0.06	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	POLI	0.33	0.30	lasso	5	0.34	1.0e-11	6.4	-6.6	3.0e-11	-0.63	0.85	0.12	FALSE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLI	0.14	0.05	lasso	3	0.04	1.1e-02	6.4	-6.6	3.4e-11	-0.65	0.06	0.26	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLI	0.16	0.17	lasso	7	0.17	3.5e-17	6.4	-6.6	3.5e-11	-0.71	0.98	0.02	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLI	0.16	0.13	lasso	3	0.13	2.0e-14	6.4	-6.6	4.6e-11	-0.72	0.91	0.09	FALSE
22	GTEx	Spleen	POLI	0.44	0.26	lasso	3	0.36	3.4e-10	-5.4	-6.5	8.1e-11	-0.57	0.34	0.60	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	POLI	0.11	0.07	blup	43	0.09	4.5e-10	6.4	-6.5	9.7e-11	-0.81	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	POLI	0.10	0.07	lasso	2	0.06	2.7e-04	6.4	-6.4	1.4e-10	-0.68	0.10	0.16	FALSE
10	GTEx	Breast Mammary Tissue (Male)	POLI	0.31	0.35	lasso	3	0.32	4.5e-08	6.4	-6.4	1.9e-10	-0.67	0.11	0.84	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	POLI	0.24	0.28	lasso	2	0.28	7.3e-27	6.4	-6.4	1.9e-10	-0.67	0.99	0.01	FALSE
17	GTEx	Heart Atrial Appendage	POLI	0.29	0.26	enet	12	0.28	3.8e-13	6.4	-6.3	2.2e-10	-0.61	0.97	0.03	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	POLI	0.18	0.12	lasso	3	0.11	8.2e-10	6.4	-6.3	2.3e-10	-0.68	0.96	0.04	FALSE
30	NTR	Blood	POLI	0.09	0.05	enet	19	0.07	9.2e-22	6.4	-6.3	2.5e-10	-0.60	1.00	0.00	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	POLI	0.21	0.19	lasso	4	0.30	2.0e-11	-5.4	-6.3	3.0e-10	-0.57	0.86	0.13	FALSE
19	GTEx	Lung	POLI	0.39	0.31	lasso	5	0.35	2.1e-27	6.4	-6.2	4.2e-10	-0.62	0.99	0.01	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	POLI	0.27	0.16	enet	23	0.16	8.8e-07	6.4	-6.2	4.2e-10	-0.70	0.05	0.92	FALSE
3	GTEx	Artery Aorta	POLI	0.26	0.23	lasso	6	0.23	5.4e-13	6.4	-6.2	6.5e-10	-0.61	0.96	0.04	FALSE
45	The Cancer Genome Atlas	Rectum Adenocarcinoma	POLI	0.20	0.03	blup	43	0.05	3.3e-02	6.4	-6.1	8.3e-10	-0.59	0.01	0.13	FALSE
16	GTEx	Esophagus Muscularis	POLI	0.30	0.20	lasso	7	0.29	4.3e-18	-5.3	-6.1	1.4e-09	-0.58	1.00	0.00	FALSE
4	GTEx	Artery Tibial	POLI	0.50	0.31	lasso	8	0.36	2.5e-29	6.4	-6.0	1.7e-09	-0.63	0.99	0.01	FALSE
7	GTEx	Brain Frontal Cortex BA9	POLI	0.21	0.14	lasso	5	0.16	6.4e-05	-5.3	-6.0	2.0e-09	-0.49	0.24	0.18	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	POLI	0.10	0.04	blup	43	0.05	8.4e-04	6.4	-6.0	2.1e-09	-0.68	0.02	0.87	FALSE
8	GTEx	Brain Putamen basal ganglia	POLI	0.24	0.10	enet	22	0.21	8.9e-06	-5.4	-6.0	2.3e-09	-0.63	0.08	0.45	FALSE
13	GTEx	Colon Transverse	POLI	0.24	0.26	lasso	4	0.25	4.5e-12	6.4	-6.0	2.5e-09	-0.65	0.84	0.16	FALSE
25	GTEx	Thyroid	POLI	0.47	0.37	enet	14	0.44	3.3e-36	6.4	-5.9	4.1e-09	-0.62	0.99	0.01	FALSE
9	GTEx	Breast Mammary Tissue	POLI	0.33	0.28	lasso	7	0.32	6.8e-17	6.4	-5.8	6.3e-09	-0.61	0.98	0.02	FALSE
27	GTEx	Vagina	POLI	0.22	0.11	enet	16	0.17	9.3e-05	7.4	-5.8	6.7e-09	-0.73	0.03	0.69	FALSE
29	METSIM	Adipose	POLI	0.23	0.27	enet	25	0.27	2.8e-40	6.4	-5.8	8.3e-09	-0.64	1.00	0.00	FALSE
15	GTEx	Esophagus Mucosa	POLI	0.42	0.26	lasso	5	0.29	1.2e-19	6.4	-5.7	1.0e-08	-0.64	0.99	0.01	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	POLI	0.13	0.07	blup	43	0.06	3.3e-04	8.0	-5.6	1.6e-08	-0.77	0.00	0.99	FALSE
18	GTEx	Heart Left Ventricle	POLI	0.12	0.09	lasso	10	0.10	6.7e-06	6.4	-5.6	1.8e-08	-0.61	0.64	0.12	FALSE
1	GTEx	Adipose Subcutaneous	POLI	0.55	0.37	lasso	5	0.44	7.6e-40	6.4	-5.6	1.9e-08	-0.64	0.99	0.01	FALSE
23	GTEx	Stomach	POLI	0.21	0.19	enet	13	0.20	5.3e-10	-5.4	-5.6	2.2e-08	-0.52	0.94	0.05	FALSE
2	GTEx	Adipose Visceral Omentum	POLI	0.36	0.34	enet	26	0.34	3.5e-18	6.4	-5.5	4.8e-08	-0.65	0.99	0.01	FALSE
20	GTEx	Nerve Tibial	POLI	0.48	0.32	enet	30	0.39	4.6e-29	6.4	-5.4	7.5e-08	-0.60	0.99	0.01	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	POLI	0.20	0.17	lasso	6	0.18	3.6e-20	6.4	-5.4	8.0e-08	-0.64	0.99	0.01	FALSE
21	GTEx	Prostate	POLI	0.28	0.03	enet	21	0.12	8.0e-04	-5.4	-5.3	1.1e-07	-0.55	0.06	0.25	FALSE
26	GTEx	Thyroid	MBD2	0.08	0.07	enet	11	0.05	7.2e-05	-4.2	5.3	1.1e-07	0.29	0.68	0.02	FALSE