Best TWAS P=1.57e-08 · Best GWAS P=5.37e-07 conditioned to 0.112
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | POLR2D | 0.15 | 0.01 | lasso | 5 | 0.01 | 6.4e-02 | 4.3 | 5.3 | 1.1e-07 | 0.76 | 0.06 | 0.55 | FALSE |
| 2 | GTEx | Artery Aorta | POLR2D | 0.18 | 0.03 | enet | 35 | 0.07 | 7.1e-05 | 4.9 | 5.5 | 3.5e-08 | 0.45 | 0.04 | 0.65 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | AMMECR1L | 0.08 | 0.00 | enet | 17 | 0.00 | 1.6e-01 | 4.6 | 5.2 | 1.9e-07 | 0.32 | 0.04 | 0.35 | FALSE |
| 4 | GTEx | Colon Transverse | AC006011.4 | 0.24 | 0.00 | enet | 21 | 0.02 | 3.6e-02 | 4.3 | 5.5 | 4.3e-08 | 0.57 | 0.05 | 0.35 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | RP5-935K16.1 | 0.30 | 0.36 | lasso | 6 | 0.39 | 4.1e-15 | 4.5 | -5.6 | 1.8e-08 | -0.56 | 0.04 | 0.94 | FALSE |
| 6 | GTEx | Lung | POLR2D | 0.12 | 0.03 | lasso | 4 | 0.05 | 8.4e-05 | 4.5 | 5.2 | 1.7e-07 | 0.45 | 0.03 | 0.88 | FALSE |
| 7 | GTEx | Muscle Skeletal | RP5-935K16.1 | 0.21 | 0.15 | enet | 16 | 0.19 | 9.4e-19 | 4.9 | -5.2 | 2.0e-07 | -0.52 | 0.02 | 0.96 | FALSE |
| 8 | GTEx | Testis | RP5-935K16.1 | 0.45 | 0.34 | enet | 26 | 0.50 | 1.7e-25 | 4.5 | -5.2 | 2.1e-07 | -0.48 | 0.02 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIMS2 | 0.03 | 0.00 | blup | 56 | 0.01 | 1.4e-03 | 4.3 | -5.7 | 1.6e-08 | -0.68 | 0.01 | 0.29 | TRUE |