TWAS hub - LIMS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1367	0.0501	1.1e-03	0.006	NA	0.080	NA	0.043	1.1e-01	NA	2.5e-06	NA	5.2e-04
2	GTEx	Whole Blood	0.0560	0.0230	1.2e-03	0.029	NA	0.031	NA	0.032	9.4e-04	NA	7.5e-04	NA	6.2e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.2478	0.0624	1.6e-12	0.142	0.119	0.156	0.149	0.166	7.2e-18	5.0e-15	1.4e-19	1.1e-18	7.5e-21
4	YFS	Blood	0.1101	0.0270	0.0e+00	0.055	0.056	0.095	0.064	0.097	1.8e-17	1.1e-17	2.0e-29	3.7e-20	5.1e-30
5	TCGA	Breast Invasive Carcinoma	0.0281	0.0145	9.5e-04	0.000	0.012	0.004	NA	0.003	3.0e-01	1.4e-03	5.0e-02	NA	6.6e-02
6	TCGA	Thyroid Carcinoma	0.2330	0.0680	2.6e-10	0.019	0.095	0.120	NA	0.106	4.9e-03	1.7e-09	1.1e-11	NA	1.7e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Illnesses of father: Heart disease	4.0	5.5	15.7	-1.4	-2.9	-1.9	-4.0	-0.9	-1.6
Medication for cholesterol	4.0	6.1	10.8	-1.9	-2.7	-3.3	-3.2	-2.0	0.1
Migraine (self-reported)	3.6	4.5	9.1	-1.0	-2.4	-1.8	-3.0	-1.3	-2.5
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	8.4	2.9	2.6	2.7	1.6	0.8	-1.4
Breastfed as a baby	3.3	4.1	9.8	-3.1	-1.2	-2.8	-1.8	-0.7	1.3
Medication for hormone replacement therapy	3.2	3.6	8.0	1.5	1.4	2.0	2.8	2.3	0.2
Exposure to tobacco smoke outside home	2.8	3.7	7.2	1.7	2.5	2.2	2.7	0.9	0.2
Basal cell carcinoma (self-reported)	2.8	3.4	7.6	-2.2	-1.8	-1.2	-1.7	-2.8	-0.4
Ulcerative Colitis	2.7	3.9	6.1	0.5	2.5	1.3	2.2	2.4	2.2
Health satisfaction	2.7	3.5	8.2	0.0	-2.6	-1.3	-2.1	-0.4	-2.9
Severe depression (siblings)	2.6	2.9	8.4	2.9	1.1	1.7	1.4	1.1	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	7.8	-0.3	-1.9	-0.7	-2.0	-2.8	-1.5
Medication: Gliclazide	2.5	2.9	5.7	-2.4	-1.5	-1.1	-1.7	-2.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	14.5	1.4	-2.0	0.2	-1.0	-0.6	-3.8
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	9.7	-1.2	-2.3	-2.5	-3.1	0.2	-0.9
Maternal smoking around birth	2.3	3.4	11.8	1.4	-0.5	2.4	0.4	-0.7	-3.4
Medication: Amlodipine	2.3	3.2	13.1	3.6	0.7	1.6	1.2	1.0	-0.4
Average weekly champagne plus white wine intake	2.3	3.1	8.1	-0.9	-2.9	-1.9	-2.2	-0.3	-0.9
Crohns Disease (2012)	2.2	3.6	11.0	0.5	1.4	0.3	1.8	3.3	2.3
Pain type(s) experienced in last month: Hip pain	2.2	2.7	5.6	-0.8	-2.0	-1.3	-2.0	-0.8	-2.4
Illnesses of father: High blood pressure	2.2	2.7	9.1	3.0	1.3	1.6	1.5	0.5	-0.6
Supplements: Fish oil (including cod liver oil)	2.1	2.7	8.0	1.1	0.9	-0.8	0.6	2.8	2.4
Medication: Atorvastatin	2.0	2.4	4.5	-2.1	-1.0	-0.4	-1.7	-1.9	-1.5
Irritable Bowel Disease (IBD)	1.9	4.6	7.6	0.4	2.4	1.1	2.7	2.8	2.4
Ever had hysterectomy (womb removed)	1.9	2.2	9.5	1.0	-0.8	0.5	-0.4	-1.2	-3.1
High blood pressure (mother)	1.9	2.7	7.8	2.8	1.4	2.1	1.4	0.4	0.2
Happiness	1.9	2.4	4.5	-2.0	-1.2	-1.0	-2.1	-0.9	-1.5
Noisy workplace	1.9	2.3	4.5	0.5	2.0	2.1	1.9	1.0	0.3
Coronary Artery Disease (CAD)	1.8	2.1	4.5	0.2	-1.6	-1.0	-2.1	-1.9	-1.2
Illnesses of siblings	1.8	2.5	5.2	-1.8	0.6	-2.0	-0.0	1.5	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	9.0	3.0	-0.6	0.6	-0.1	0.0	-1.7
Mineral and other dietary supplements	1.8	2.4	7.3	-0.3	-0.5	1.0	-0.6	-2.3	-2.7
Alzheimer’s Disease (in father)	1.7	1.8	5.3	0.8	1.8	0.7	2.3	1.0	0.3
Ever used hormone-replacement therapy (HRT)	1.7	2.2	5.8	1.6	1.3	1.7	2.4	-0.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	7.8	0.8	-2.0	0.8	-0.9	-1.4	-2.8
Medication: Ramipril	1.7	2.2	7.8	1.0	0.1	1.7	-0.0	-1.2	-2.8
Exposure to tobacco smoke at home	1.7	2.0	4.3	1.6	-0.6	0.9	-0.5	-1.9	-2.1
Medication: Omeprazole	1.7	2.0	5.2	-0.1	-1.3	-1.1	-2.3	-1.3	-1.4
Fractured/broken bones in last 5 years	1.7	2.2	6.6	2.6	0.7	1.9	1.5	-0.1	-0.3
LDL Cholesterol	1.6	2.5	5.7	0.1	1.9	0.6	2.4	0.8	2.1
Smoking Status	1.6	3.7	7.6	2.6	1.1	2.8	1.9	1.8	0.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.7	0.0	-2.2	-0.4	-1.4	-1.8	-1.1
Cardiovascular Disease	1.5	4.9	10.6	3.0	2.3	3.3	1.9	0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.6	-1.5	-1.9	-1.5	-1.8	-0.7	0.2
Supplements: Zinc	1.5	1.6	5.0	1.1	0.5	0.6	1.2	2.2	1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.4	1.4	1.1	1.9	1.2	1.2	1.1
Heart disease (mother)	1.5	1.8	6.4	-0.2	-1.1	0.4	-1.6	-0.6	-2.5
Chest pain or discomfort	1.5	2.2	7.5	-1.5	-0.4	0.2	-1.3	-2.7	-1.2
Worry (Nagel 2018)	1.4	3.0	7.0	-0.0	-2.4	-1.7	-2.6	-0.5	-1.5
Ulcerative Colitis (UC)	1.4	2.6	4.3	0.2	1.8	1.2	2.1	1.8	1.9
Qualifications: CSEs or equivalent	1.4	1.9	3.4	0.6	1.5	0.8	1.3	1.8	1.8
High blood pressure (siblings)	1.4	2.0	4.2	1.6	0.4	1.5	-0.1	-1.6	-2.1
Number of children fathered	1.4	1.6	4.4	-2.0	0.9	-0.5	0.2	-0.2	2.1
Friendships satisfaction	1.4	1.7	6.1	-1.0	-1.1	0.1	-1.2	-0.7	-2.5
Unable to work because of sickness or disability	1.4	1.9	6.2	0.4	-1.0	1.4	0.1	-1.3	-2.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.7	1.3	1.3	2.2	1.4	-1.0	-0.2
Heart disease (siblings)	1.4	1.7	4.6	1.0	-0.8	1.5	-0.3	-1.3	-2.1
Body Mass Index (BMI) (2010)	1.3	1.7	4.1	2.0	-0.0	1.5	0.6	0.4	-1.9
Heart attack	1.3	1.7	6.1	0.3	-1.5	-0.5	-0.7	-1.0	-2.5
Falls in the last year	1.3	1.8	3.9	2.0	0.0	1.5	-0.8	0.6	-2.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	8.4	-2.9	0.1	-1.1	-0.2	0.0	1.9
Wheeze or whistling in the chest in last year	1.3	2.2	7.5	-0.5	1.4	1.8	0.7	-2.7	-0.2
Emphysema/chronic bronchitis	1.3	1.5	6.5	2.5	-0.0	1.0	0.8	0.1	-0.9
Medication: Ibuprofen	1.3	1.5	4.2	-0.3	-1.4	-2.0	-1.3	-0.9	-0.3
Suffer from ‘nerves’	1.3	2.0	4.9	-0.6	-1.6	-1.4	-1.5	-2.2	0.2
Supplements: Calcium	1.3	1.4	2.5	1.5	0.6	1.5	1.6	1.1	0.1
Neuroticism (Nagel 2018)	1.2	2.7	6.6	-0.8	-2.4	-0.9	-2.6	-0.9	-1.3
Medication: Cholesterol lowering	1.2	1.9	8.6	1.4	-0.5	0.8	0.2	-0.5	-2.9
Peak expiratory flow (PEF)	1.2	2.8	5.1	0.2	2.3	0.4	2.0	2.1	1.8
Angina (self-reported)	1.2	1.6	3.4	-1.4	-1.9	-0.9	-1.2	-1.1	-0.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.5	0.8	0.6	0.8	1.5	1.6	1.4
Lung FVC	1.1	5.4	12.9	-2.8	1.8	-2.0	-0.1	2.1	3.6
Multivitamins +/- minerals	1.1	1.4	6.7	1.1	-0.1	-0.7	-0.2	2.6	0.2
Stomach or abdominal pain in last month	1.1	1.3	4.4	-1.4	-0.8	-0.5	-0.8	-2.1	-0.1
Glaucoma (self-reported)	1.1	1.3	3.8	0.1	2.0	1.1	1.1	0.7	1.2
Hypertension (Self-reported)	1.1	3.0	6.3	2.5	1.5	2.5	1.4	-0.3	-1.1
Vascular/heart problems diagnosed by doctor	1.1	2.9	6.3	-2.3	-1.3	-2.5	-1.5	0.3	1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.5	6.0	0.4	-1.3	-0.3	-0.5	-0.8	-2.4
Blood White Count	1.0	7.1	31.9	-3.1	-0.5	0.7	-0.1	-5.7	-0.7
Angina	1.0	1.4	2.8	-1.1	-1.7	-0.7	-1.1	-1.2	-1.1
Diabetes (mother)	1.0	1.3	3.6	1.0	-0.4	1.2	0.2	-1.3	-1.9
High blood pressure	1.0	2.6	5.4	2.2	1.1	2.3	1.3	-0.7	-1.5
Medication: Atenolol	1.0	1.2	5.1	1.2	-0.6	0.1	0.1	-0.7	-2.2
Medication: Levothyroxine sodium	1.0	1.7	4.8	0.7	2.2	0.9	1.2	1.5	0.4
Worrier / anxious feelings	1.0	1.9	5.3	0.8	-1.3	-0.1	-1.6	1.1	-2.3
Number of live births	1.0	1.3	3.1	-0.1	-1.2	-0.4	-1.5	-1.1	-1.8
Illnesses of mother	1.0	1.2	3.0	-1.7	-0.4	-1.6	0.1	1.1	0.7
Length of working week for main job	1.0	1.1	2.2	0.6	1.3	0.7	1.0	-1.5	1.1
Blood clot in the leg (DVT)	1.0	1.3	2.8	1.2	1.0	1.7	0.9	-1.3	-0.5
Number of full brothers	1.0	1.2	2.8	0.9	1.1	1.7	1.2	-0.7	0.9
Medication: Allopurinol	1.0	1.3	6.1	-0.2	0.7	-0.4	-0.1	1.2	2.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.4	-1.4	-1.2	-1.8	-0.7	-0.4	0.2
Eye problems/disorders: Cataract	1.0	1.1	2.5	-1.6	-0.9	-1.3	-1.1	-0.5	-0.5
Illnesses of father: None of the above (group 1)	1.0	1.2	3.2	0.5	1.4	0.9	1.8	0.3	1.0
Risk taking	1.0	1.4	3.3	0.9	-1.3	0.3	-0.0	-1.6	-1.8
Alcohol drinker status: Previous	1.0	1.1	2.2	1.5	0.3	1.4	0.7	-0.1	-1.4
Depressed Affect (Nagel 2018)	0.9	1.9	4.6	-1.4	-1.7	-0.6	-2.2	-0.5	-1.0
Crohns Disease (2017)	0.9	2.1	3.9	0.4	1.6	0.4	1.9	2.0	1.5
Breast Cancer	0.9	2.2	5.8	-0.0	-2.2	-0.4	-1.3	-2.4	-0.8
Serious illness, injury or assault to yourself	0.9	1.1	2.3	1.0	0.9	1.5	1.4	0.9	0.2
Hair/balding pattern: Pattern 2	0.9	1.1	2.6	1.1	1.5	0.5	0.6	1.6	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	7.0	-0.2	1.9	0.9	0.8	0.7	2.6
Mouth/teeth dental problems	0.9	1.3	3.3	-1.2	1.8	0.1	0.7	0.0	1.7
Pain all over the body in last month	0.9	0.9	2.4	0.6	0.8	1.5	1.1	0.1	1.1
Medication: Simvastatin	0.9	1.3	2.3	1.4	0.3	1.2	1.5	0.3	-1.3
Alcohol intake versus 10 years previously	0.9	1.3	3.8	0.3	1.2	1.9	0.2	-1.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.6	0.8	0.6	1.6	0.5	-1.1	-0.9
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	-0.9	-1.2	-1.4	-1.1	-1.1	0.2
Tense / ‘highly strung’	0.9	1.5	2.2	-0.9	-1.5	-0.5	-1.5	-1.5	-1.1
Loud music exposure frequency	0.9	1.0	2.5	0.4	1.0	1.1	0.8	0.5	-1.6
Gout (self-reported)	0.9	1.2	4.7	0.4	0.6	-0.6	0.1	1.3	2.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.6	0.2	0.6	1.9	-0.1	0.5	-1.3
Pulse wave peak to peak time	0.9	1.0	2.1	1.0	1.1	1.4	1.0	0.9	-0.6
Loneliness, isolation	0.9	1.3	4.5	0.3	-1.5	0.6	-0.3	-0.6	-2.1
Medication: Blood pressure	0.9	1.6	3.1	1.8	0.9	1.7	1.2	0.0	-1.2
Irritability	0.9	1.5	5.4	0.3	-1.1	1.1	-0.5	-1.0	-2.3
Cholesterol lowering medication	0.9	1.4	3.3	0.3	1.6	1.8	1.5	-0.2	-0.1
Alzheimer’s Disease (in mother)	0.8	0.9	4.0	0.8	-0.6	0.3	-0.1	-0.5	-2.0
Major Depression (MDD)	0.8	1.0	5.0	0.2	-0.9	-0.1	-0.2	-0.1	-2.2
Neuroticism (2016)	0.8	1.1	2.3	1.1	0.3	0.7	0.7	1.4	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.3	0.7	0.6	0.7	1.0	-0.1	1.8
Neuroticism	0.8	1.8	4.6	0.1	-2.1	-0.2	-2.0	0.9	-1.2
Tanning	0.8	9.6	16.3	2.8	3.6	4.0	3.9	2.2	-0.4
Hand grip strength (left)	0.8	2.2	6.1	0.6	1.2	0.0	1.9	2.5	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.0	0.8	2.0	1.1	1.0	1.0	2.0
Number of incorrect matches in round	0.8	1.3	2.5	-0.8	0.5	1.4	1.6	1.2	1.0
Nervous feelings	0.8	1.5	4.6	-0.1	-2.1	-1.7	-1.1	0.3	0.6
Hearing difficulty/problems with background noise	0.8	1.3	3.2	-0.2	-0.1	1.1	0.4	-1.7	-1.8
Forced vital capacity (FVC), Best measure	0.8	2.8	6.0	0.1	2.4	0.2	1.1	2.0	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.5	1.6	-0.9	0.4	1.1	0.5	-1.3
Alcohol intake frequency.	0.8	1.9	7.9	0.3	1.4	2.8	0.9	-0.6	-0.2
Ever had bowel cancer screening	0.8	1.0	3.0	-1.3	1.0	0.1	0.2	0.3	1.7
Mother’s age at death	0.8	1.0	1.7	-1.0	-0.7	-1.3	-1.0	-0.3	1.3
Myopia	0.8	1.2	3.5	0.1	1.9	0.4	1.1	0.3	1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.9	0.6	-1.2	-0.5	-1.7	-0.4	-1.0
Age at First Birth	0.7	1.0	4.7	0.9	0.0	-0.1	-0.2	2.2	-0.8
Mean Putamen Volume	0.7	0.8	3.9	-2.0	0.5	-0.1	-0.2	-0.7	-0.3
Heel T-Score	0.7	5.5	8.8	2.6	3.0	2.8	2.2	1.1	1.9
Hypothyroidism (self reported)	0.7	1.6	2.8	1.2	1.5	1.1	1.1	1.7	-0.6
Hearing difficulty/problems: Yes	0.7	1.1	3.0	0.3	0.9	1.1	1.7	-0.3	-1.1
Medication: Co-codamol	0.7	0.8	1.8	-0.1	-1.1	-0.5	-0.2	1.2	1.3
Hand grip strength (right)	0.7	1.9	5.1	0.1	1.4	-0.2	1.8	2.3	1.1
Alcohol usually taken with meals	0.7	1.2	4.3	-0.2	1.1	0.5	0.9	0.8	2.1
Forced vital capacity (FVC)	0.7	2.7	5.9	-0.2	2.4	0.1	1.2	1.9	2.3
Diabetes (self-reported)	0.7	1.0	4.3	-0.6	0.1	0.7	0.0	-2.1	-0.9
Trunk fat-free mass	0.7	4.2	16.7	1.9	-1.7	-0.5	-1.2	-0.6	-4.1
Time employed in main current job	0.7	0.8	2.9	-0.4	0.7	-1.1	-0.4	-0.1	1.7
Impedance of arm (left)	0.7	3.4	12.3	-0.3	1.6	1.0	2.2	-0.0	3.5
Trunk predicted mass	0.7	3.9	15.4	1.9	-1.6	-0.4	-1.1	-0.5	-3.9
Age at first live birth	0.7	1.2	4.9	-1.0	-0.8	-2.2	-0.3	0.8	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.5	1.1	0.2	0.8	1.6	0.5	0.4
Commuting to job workplace: Walk	0.7	0.8	3.1	0.0	1.8	1.0	0.4	0.2	-0.6
Asthma (self-reported)	0.7	1.4	6.2	0.2	0.6	0.9	-0.1	-2.5	-0.8
Osteoporosis (self-reported)	0.7	0.9	3.1	-0.7	-1.8	-0.4	-0.7	-0.0	-1.1
Medication: Aspirin	0.7	0.9	1.6	1.0	0.8	1.2	1.3	0.7	-0.3
Financial situation satisfaction	0.7	0.8	2.1	0.7	0.3	1.5	0.4	0.3	-1.4
Medication: Bendroflumethiazide	0.7	1.0	2.2	-1.4	-0.7	-1.5	-1.1	0.1	0.6
Age started oral contraceptive pill	0.7	0.9	1.8	-0.9	-0.6	-1.2	-1.3	-0.9	-0.5
Pain experienced in last month	0.7	1.1	3.7	-1.3	0.5	-0.8	0.5	0.1	1.9
Impedance of whole body	0.7	3.3	12.8	-0.6	1.8	0.8	1.7	0.0	3.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	1.3	0.8	0.8	1.4	-0.1	-0.7
Reaction Time	0.6	1.1	4.0	0.2	0.5	2.0	0.1	-0.4	-1.4
Blood Platelet Count	0.6	7.2	18.6	-3.6	-2.5	-1.4	-1.7	-4.3	0.4
Waist Hip Ratio (WHR)	0.6	2.5	4.8	1.9	0.6	2.2	1.5	-1.0	-1.7
Vitamin and mineral supplements	0.6	0.8	2.1	-0.0	0.3	1.1	0.4	-1.5	-1.0
Leg fat-free mass (left)	0.6	3.1	12.9	1.9	-0.8	0.5	-0.4	-1.1	-3.6
Age when periods started (menarche)	0.6	1.5	5.2	-0.8	-2.3	-1.6	-0.6	-0.6	-0.2
Leg predicted mass (left)	0.6	3.0	12.4	1.9	-0.8	0.5	-0.4	-1.0	-3.5
Qualifications: None of the above	0.6	1.3	3.3	0.6	1.5	1.8	0.6	-0.9	-0.5
Allergy	0.6	1.4	4.2	-0.6	-0.6	-0.5	-1.7	2.0	0.3
Impedance of arm (right)	0.6	2.8	6.5	-0.1	1.8	1.6	2.1	0.2	2.5
Asthma	0.6	1.2	5.9	0.1	0.3	0.7	-0.3	-2.4	-0.9
Prospective memory result	0.6	0.7	3.4	0.6	-0.6	0.0	-0.5	0.2	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.0	-0.0	1.6	-0.1	1.1	2.0	2.0
Arm fat-free mass (right)	0.6	2.9	11.4	1.0	-1.4	-0.9	-1.4	-0.8	-3.4
Medication: Blood pressure	0.6	1.1	4.1	2.0	-0.2	0.9	-0.1	-0.4	-1.2
Medication: Seretide 50 evohaler	0.6	0.7	2.5	1.6	-1.1	0.3	-0.6	-0.3	-0.3
Arm predicted mass (right)	0.6	3.1	11.1	1.1	-1.6	-1.0	-1.5	-0.8	-3.3
Family relationship satisfaction	0.6	0.7	1.3	-0.8	-0.9	-0.4	-0.6	-1.1	-1.1
Whole body fat-free mass	0.6	3.6	15.1	1.8	-1.4	-0.2	-1.0	-0.7	-3.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.1	-0.3	-0.7	0.5	0.1	-1.0	-1.5
Osteoarthritis (self-reported)	0.6	0.8	1.5	-0.8	-1.0	-1.2	-0.9	-0.3	-0.6
Whole body water mass	0.6	3.6	14.9	1.9	-1.3	-0.1	-0.9	-0.8	-3.9
Guilty feelings	0.6	0.8	2.7	0.4	0.2	1.6	0.6	-0.5	-1.3
Wears glasses or contact lenses	0.6	0.7	2.4	-0.2	-0.8	-0.6	0.3	-0.8	-1.6
Medication: Lisinopril	0.6	0.8	3.1	0.5	-0.6	-0.6	-1.8	0.7	0.5
Basal metabolic rate	0.6	3.4	14.2	1.9	-1.1	0.2	-0.8	-0.7	-3.8
Arm fat-free mass (left)	0.6	3.2	13.6	1.5	-1.1	-0.2	-1.4	-0.6	-3.7
Arm predicted mass (left)	0.6	3.0	12.5	1.5	-1.1	-0.4	-1.3	-0.6	-3.5
Ovarian Cancer	0.5	0.7	1.4	0.6	0.5	0.8	1.2	1.1	0.4
Fasting Glucose	0.5	0.6	0.9	-0.9	-0.9	-0.5	-0.6	-1.0	0.7
Lupus	0.5	0.7	2.6	-0.4	0.7	0.5	0.8	-1.6	0.5
BMI	0.5	2.7	11.8	0.7	-1.3	0.7	-1.1	-0.8	-3.4
Chronotype (morning person)	0.5	1.2	5.0	0.0	1.2	0.6	0.7	0.2	2.2
Number of treatments/medications taken	0.5	0.9	2.5	1.6	0.4	0.3	0.5	1.4	0.8
Sensitivity / hurt feelings	0.5	0.9	2.7	-1.0	-1.6	-0.2	-0.6	-0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.1	0.6	0.7	1.5	0.5	0.4	0.1
Diabetes (father)	0.5	0.6	3.1	0.3	-0.5	0.4	-0.0	-1.8	-0.2
Current tobacco smoking	0.5	0.8	2.1	1.2	-0.1	1.4	0.8	-0.2	-0.6
Supplements: Glucosamine	0.5	0.6	1.7	-0.0	-1.3	-1.3	-0.4	-0.2	0.4
Waist circumference	0.5	1.9	6.0	1.2	0.1	1.8	-0.1	-0.5	-2.4
Weight	0.5	2.3	9.8	1.4	-0.6	0.9	-0.6	-0.8	-3.1
Father’s age at death	0.5	0.6	1.2	-1.0	-0.0	-1.1	-0.9	0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.4	0.2	1.7	0.3	1.3	1.8	1.6
Medication: Lansoprazole	0.5	0.6	1.1	0.2	-0.7	1.0	0.5	-1.1	-0.8
Lung cancer (father)	0.5	0.5	1.7	-0.4	1.3	0.1	0.3	-0.8	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	1.2	0.7	-0.0	-0.1	1.3	0.4
Shortness of breath walking on level ground	0.5	0.6	1.8	0.6	0.2	0.6	-0.1	-1.0	-1.4
Mean time to correctly identify matches	0.5	0.9	1.8	-1.1	-0.7	0.3	-1.3	-0.5	-1.3
Had major operations	0.5	0.6	1.3	-0.4	-0.7	-1.2	-1.0	-0.3	0.8
Medication: Aspirin	0.5	0.6	1.2	0.4	0.8	1.1	1.0	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.7	1.1	1.0	1.6	0.5	-0.1	-1.1
Leg fat-free mass (right)	0.5	2.6	11.3	1.7	-0.8	0.5	-0.3	-1.0	-3.4
Mood swings	0.5	0.9	4.2	-0.3	-0.9	0.4	-0.4	0.2	-2.0
Long-standing illness, disability or infirmity	0.5	0.7	2.4	0.5	0.4	1.0	0.4	-1.6	-0.6
Diabetes diagnosed by doctor	0.5	0.8	3.0	-0.7	0.0	0.6	-0.4	-1.7	-0.7
Leg predicted mass (right)	0.5	2.6	11.0	1.6	-0.8	0.4	-0.3	-1.1	-3.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	0.4	-0.3	0.4	-0.9	1.2	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	0.7	0.5	1.2	0.9	-0.2	-0.5
High cholesterol (Self-reported)	0.5	0.9	2.5	0.9	0.9	1.6	1.0	0.4	-0.5
Ever depressed for a whole week	0.5	0.6	2.9	-0.7	-0.2	-0.3	-0.5	0.1	-1.7
Bipolar Disorder (2018)	0.4	0.6	2.5	1.6	0.1	0.3	0.2	0.1	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	1.4	-0.9	-0.3	-0.9	-0.7	0.0	1.2
Prostate Cancer	0.4	0.5	1.6	0.5	-0.4	-0.2	-1.0	-0.4	-1.2
HbA1C	0.4	0.5	1.2	-0.9	-0.6	-1.1	-0.4	0.1	0.4
Systolic Blood Pressure	0.4	2.1	6.4	2.5	-0.4	-0.3	0.2	1.9	1.5
Respiratory disease	0.4	1.0	2.1	0.5	0.3	1.4	0.4	-1.4	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	-0.9	1.1	0.7	0.2	-1.2	-0.1
Lung FEV1/FVC ratio	0.4	2.2	5.5	1.2	-2.2	0.4	0.3	-1.0	-2.3
Average weekly spirits intake	0.4	0.5	1.5	-0.8	1.2	0.4	0.3	-0.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	0.7	0.1	1.1	0.6	-0.4	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.0	0.4	-1.0	-0.3	0.0	-0.8	-1.0
Impedance of leg (left)	0.4	2.0	8.5	-1.0	1.3	0.3	0.9	0.0	2.9
Financial difficulties in last 2 years	0.4	0.5	1.2	0.7	-1.1	-0.4	-0.3	-0.1	1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	-0.2	-1.0	-0.0	-0.6	-1.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.8	-0.0	0.6	0.0	0.9	1.7	1.2
Mouth/teeth dental problems: Dentures	0.4	0.6	2.6	-0.0	-1.6	0.4	0.2	-0.9	-0.4
Arm fat mass (right)	0.4	1.7	6.4	1.0	-0.4	1.3	-0.2	-0.8	-2.5
Pulse wave reflection index	0.4	0.5	2.0	-0.0	-0.0	0.3	0.4	-0.7	1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	0.8	-0.8	-0.5	0.4	1.4	-0.7
Medication: Paracetamol	0.4	0.6	1.7	-0.6	1.3	0.2	-0.2	0.3	1.3
Comparative body size at age 10	0.4	1.1	3.6	-1.4	-0.7	-1.9	-0.5	-0.5	0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.3	-1.1	-1.1	-0.8	-0.7	-0.4	-0.7
Overall health rating	0.4	0.8	2.7	0.3	-0.5	1.0	-0.3	-0.8	-1.6
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.1	-0.8	0.8	-0.2	-1.3	-0.2
Average weekly red wine intake	0.4	0.6	2.0	-1.4	0.4	-1.1	-0.2	-0.2	0.6
Back pain experienced in last month	0.4	0.6	1.1	-0.5	-0.7	-1.1	-1.0	0.0	-1.0
Smoking status: Current	0.4	0.6	1.7	1.0	-0.1	1.3	0.7	-0.5	-0.3
Hearing aid user	0.4	0.4	1.0	-1.0	-0.5	-0.6	0.1	0.2	0.9
Commuting to job workplace: Public transport	0.4	0.4	1.5	0.3	-0.1	-0.1	1.0	1.2	-0.2
Diastolic blood pressure, automated reading	0.4	1.1	4.2	2.1	-1.2	0.6	0.2	0.1	-0.8
Pack years of smoking	0.4	0.6	1.8	0.6	-1.1	-0.1	-0.3	-0.6	-1.3
Leg fat mass (left)	0.4	1.4	4.7	0.9	-0.1	1.6	0.1	-0.6	-2.2
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	1.5	-0.2	0.5	0.6	0.5	-1.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	-0.4	-1.5	-0.3	-0.8	-1.4	-0.6
Bipolar Disorder (2011)	0.3	0.3	1.3	1.1	0.2	-0.5	0.2	0.0	0.0
HDL Cholesterol	0.3	0.6	1.7	-0.5	0.4	-0.1	0.3	1.3	1.1
Blood Eosinophil Count	0.3	2.3	5.4	-0.0	1.8	2.3	1.6	-0.2	1.6
Pack years adult smoking proportion	0.3	0.5	1.3	0.5	-0.9	0.1	-0.1	-0.8	-1.1
Impedance of leg (right)	0.3	1.7	7.5	-0.6	1.1	0.1	0.9	0.2	2.7
Townsend deprivation index at recruitment	0.3	0.4	1.8	0.1	0.0	1.4	0.5	-0.6	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.8	-0.5	-0.7	-1.3	0.7	-0.4	0.5
Sitting height	0.3	2.1	5.1	-0.2	-1.8	-2.3	-1.4	-0.6	-1.3
Body mass index (BMI)	0.3	1.5	6.1	0.6	-0.4	1.0	-0.7	-0.7	-2.5
Had menopause	0.3	0.3	1.2	-0.2	-0.8	-0.4	-0.1	-1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.7	-0.8	-0.3	0.1	-0.5	-0.7	-0.6
Neuroticism score	0.3	0.6	1.7	0.1	-1.1	0.5	-0.6	0.3	-1.3
Hip circumference	0.3	1.3	5.2	0.8	-0.8	0.5	-0.9	-0.2	-2.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.3	-0.8	0.9	-0.5	-0.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.1	-0.6	-1.0	-0.7	-0.2	0.5
Hair/balding pattern: Pattern 4	0.3	0.6	2.7	-0.3	-0.0	0.7	0.6	-1.6	0.2
Headache pain in last month	0.3	0.5	1.4	0.4	1.2	0.5	1.2	-0.1	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.0	0.3	1.4	0.6	0.4	1.1	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.1	1.1	0.4	0.4	0.2	-0.0	0.8
Qualifications: College or University degree	0.3	0.8	2.1	-0.1	-1.1	-1.4	-0.4	1.1	-0.7
Neck or shoulder pain in last month	0.3	0.4	0.8	0.8	-0.4	0.7	-0.5	-0.9	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	0.6	0.5	1.0	0.7	-0.4	0.4
Whole body fat mass	0.3	1.4	5.2	0.9	-0.2	1.2	-0.1	-1.0	-2.3
Leg fat mass (right)	0.3	1.2	4.5	0.8	-0.3	1.3	-0.1	-0.5	-2.1
Comparative height size at age 10	0.3	1.5	5.5	2.4	0.7	0.4	1.6	0.5	-0.4
Leg pain on walking	0.3	0.4	0.7	-0.2	-0.8	0.3	-0.3	-0.8	-0.8
Supplements: Vitamin C	0.3	0.4	1.2	0.1	-0.7	-0.2	-0.5	0.5	1.1
Qualifications: nursing, teaching	0.3	0.5	1.7	-0.6	0.2	-1.3	-0.1	0.3	0.9
Arm fat mass (left)	0.3	1.4	4.8	1.0	-0.1	1.4	0.1	-0.8	-2.2
Medication: Paracetamol	0.3	0.5	1.3	-0.6	0.3	-0.9	-0.7	0.2	1.1
Ever smoked	0.3	0.6	1.1	0.4	0.6	1.1	0.8	-1.0	0.4
Schizophrenia (2018)	0.2	0.4	0.9	0.6	-0.3	0.4	0.6	0.5	-0.9
Schizophrenia (2014)	0.2	0.3	0.8	0.7	-0.1	0.7	0.4	-0.1	-0.9
Triglycerides	0.2	0.3	1.0	1.0	0.3	-0.4	0.6	0.2	0.4
Blood Red Count	0.2	2.1	5.1	1.5	1.4	1.0	2.3	0.4	1.5
Allergy or Eczema	0.2	0.4	1.1	-0.3	-1.0	-0.9	0.8	-0.0	-0.2
Hair Pigment	0.2	4.8	7.4	-2.7	-1.5	-2.5	-2.5	-1.6	2.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	0.4	0.2	0.9	0.5	0.0	-0.5
Systolic blood pressure, automated reading	0.2	0.7	2.0	1.4	-1.1	-0.5	-0.5	0.7	0.1
Fed-up feelings	0.2	0.4	1.0	0.4	-0.2	1.0	-0.3	0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	0.5	-0.8	0.5	-0.1	0.0	-0.6
Taking other prescription medications	0.2	0.3	1.2	1.1	-0.1	0.6	-0.5	-0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.7	-0.3	0.0	-0.1	0.2	0.7
Trunk fat mass	0.2	0.9	3.1	0.5	-0.3	1.0	-0.1	-1.0	-1.8
Past tobacco smoking	0.2	0.4	0.9	-0.0	-0.7	-0.9	-0.7	0.1	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.2	0.6	-0.7	0.5	0.5	0.5
Fluid intelligence score	0.2	0.4	2.0	0.1	-0.3	0.1	0.4	-1.4	-0.6
Arm fat percentage (right)	0.2	1.0	2.9	0.7	0.1	1.7	0.4	-0.3	-1.5
Pulse rate	0.2	0.3	1.0	-0.5	-0.2	0.8	-0.4	-1.0	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.8	0.5	0.1	0.2	0.1	-0.5
Birth weight	0.2	0.4	1.3	0.3	-0.1	-0.4	0.8	1.2	-0.2
Leg fat percentage (right)	0.2	0.6	1.8	0.4	-0.1	1.4	0.1	-0.4	-1.2
Worry too long after embarrassment	0.2	0.4	0.8	0.6	-0.6	0.8	0.0	0.3	-0.9
Eye problems/disorders: None of the above	0.2	0.3	0.8	0.9	0.3	-0.5	0.4	-0.0	0.5
Pulse rate, automated reading	0.2	0.8	1.3	1.1	-0.6	1.1	0.7	-1.1	-0.3
Number of full sisters	0.2	0.3	1.5	-0.0	-0.0	1.2	-0.0	-0.2	-0.5
Age at last live birth	0.2	0.2	1.0	-0.4	0.0	-1.0	0.2	0.3	0.4
Smoking status: Previous	0.2	0.4	0.7	0.1	0.8	0.8	0.7	0.5	0.2
Arm fat percentage (left)	0.2	0.6	2.2	0.6	0.2	1.5	0.5	-0.5	-0.9
Breast cancer (self-reported)	0.2	0.2	0.4	0.5	-0.4	0.4	0.6	-0.2	-0.6
Miserableness	0.2	0.4	1.2	-0.2	-0.3	0.3	-0.8	-0.3	-1.1
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	0.4	-0.5	-0.8	-0.1	-0.1
Alcohol drinker status: Never	0.2	0.2	0.4	0.4	-0.6	0.6	0.2	-0.4	-0.4
Leg fat percentage (left)	0.2	0.7	2.5	0.2	0.1	1.6	0.3	-0.6	-1.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	-0.9	-0.4	-0.2	0.1	-0.7	-0.4
Depression (Nagel 2018)	0.1	0.2	0.4	0.3	-0.4	0.6	-0.2	-0.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.7	-0.2	-0.1	-0.1	0.0	-1.3	-0.2
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.6	0.3	0.0	0.2	-0.3	0.6
Height	0.1	2.8	8.0	2.8	-0.5	0.9	0.9	0.0	-2.6
Relative age of first facial hair	0.1	0.2	0.4	-0.3	-0.5	-0.3	-0.6	0.4	0.1
Medication: Metformin	0.1	0.2	0.5	0.3	0.3	0.7	-0.1	-0.3	-0.3
Trunk fat percentage	0.1	0.5	1.2	-0.1	0.2	1.1	0.1	-1.0	-0.8
Average weekly fortified wine intake	0.1	0.2	0.4	-0.2	0.7	0.0	0.6	-0.2	0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.4	-0.1	0.3	0.2	-0.4	-0.2
Had other major operations	0.1	0.2	0.4	0.6	-0.2	0.6	0.1	0.5	-0.0
Depression (self-reported)	0.1	0.2	0.5	0.7	-0.0	0.2	0.2	0.1	-0.6
Standing height	0.1	1.3	3.8	1.9	-0.7	-0.2	0.2	-0.5	-1.7
Birth weight of first child	0.1	0.2	0.8	-0.0	-0.3	-0.6	-0.2	0.2	-0.9
Body fat percentage	0.1	0.6	1.4	0.0	-0.0	1.2	-0.1	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.0	-0.2	-0.2	0.4	0.8	0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.2	-0.1	-0.7	-0.2	-0.3	-0.7
Average weekly beer plus cider intake	0.1	0.1	0.7	0.3	0.2	0.0	0.8	-0.2	0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.1	-0.0	0.4	-0.6	0.1	-0.5
Rheumatoid Arthritis	0.0	0.1	0.1	0.3	0.3	0.2	0.2	0.0	0.3
Relative age voice broke	0.0	0.1	0.2	0.3	-0.1	0.2	0.1	0.3	0.4
Knee pain experienced in last month	0.0	0.1	0.2	0.4	-0.0	0.1	-0.1	-0.0	0.4
Number of operations (self-reported)	0.0	0.1	0.2	0.0	-0.0	-0.3	-0.1	0.5	-0.1

Hub : Genes

LIMS2

Models

Trait associations