Best TWAS P=3.06e-09 · Best GWAS P=9.28e-09 conditioned to 0.0119
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KAT2B | 0.05 | 0.02 | bslmm | 462 | 0.02 | 2.7e-03 | -5.7 | -5.9 | 3.1e-09 | 0.64 | 0.01 | 0.98 | TRUE |
| 2 | GTEx | Nerve Tibial | KAT2B | 0.28 | 0.27 | enet | 9 | 0.29 | 1.8e-20 | -5.5 | -5.7 | 1.3e-08 | 0.75 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Thyroid | KAT2B | 0.13 | 0.18 | lasso | 3 | 0.17 | 5.5e-13 | -5.5 | -5.5 | 3.6e-08 | 0.79 | 0.04 | 0.96 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | KAT2B | 0.22 | 0.19 | enet | 21 | 0.29 | 7.0e-38 | -3.7 | -5.6 | 2.3e-08 | 0.69 | 0.99 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KAT2B | 0.06 | 0.04 | blup | 120 | 0.04 | 9.5e-06 | -5.7 | -5.3 | 1.2e-07 | 0.68 | 0.01 | 0.99 | FALSE |