TWAS hub - KAT2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0480	0.0220	1.5e-03	0.019	0.015	0.015	0.018	0.017	2.0e-03	4.9e-03	5.5e-03	2.8e-03	2.8e-03
2	GTEx	Artery Aorta	0.1850	0.0630	1.7e-03	-0.003	NA	-0.005	NA	-0.002	4.9e-01	NA	7.7e-01	NA	4.4e-01
3	GTEx	Nerve Tibial	0.2826	0.0603	3.3e-11	0.269	NA	0.286	NA	0.285	3.5e-19	NA	1.8e-20	NA	2.2e-20
4	GTEx	Thyroid	0.1270	0.0370	2.6e-06	0.176	NA	0.169	NA	0.170	1.9e-13	NA	6.4e-13	NA	5.5e-13
5	NTR	Blood	0.0431	0.0137	3.6e-06	0.020	0.019	0.019	0.028	0.027	3.0e-07	5.4e-07	7.0e-07	1.5e-09	3.7e-09
6	ROSMAP	Brain Pre-frontal Cortex	0.2235	0.0358	0.0e+00	0.189	0.264	0.292	0.265	0.283	1.0e-23	8.5e-34	7.0e-38	5.2e-34	1.2e-36
7	YFS	Blood	0.0989	0.0253	5.9e-10	0.028	0.033	0.035	0.045	0.038	1.2e-09	3.8e-11	1.3e-11	2.0e-14	1.3e-12
8	TCGA	Brain Lower Grade Glioma	0.0640	0.0254	9.5e-06	0.036	0.044	0.033	NA	0.040	5.3e-05	9.5e-06	9.8e-05	NA	2.0e-05
9	TCGA	Pheochromocytoma and Paraganglioma	0.1410	0.0750	6.5e-03	0.012	0.055	0.064	NA	0.051	1.0e-01	3.1e-03	1.5e-03	NA	4.5e-03
10	TCGA	Thyroid Carcinoma	0.1230	0.0610	1.8e-04	0.013	0.041	0.030	NA	0.017	1.7e-02	7.0e-05	5.7e-04	NA	7.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Medication: Blood pressure	5.8	10.2	19.4	-4.4	2.1	-4.0	-3.3	1.7	-4.1	2.1	-4.1	-1.5	-2.9
High blood pressure	5.7	15.8	30.4	-4.2	5.2	-5.5	-5.1	1.7	-3.6	2.1	-3.7	-2.0	-4.3
Hair/balding pattern: Pattern 4	5.3	12.7	23.9	4.9	-4.7	4.9	4.7	0.1	3.8	-0.3	4.0	-0.8	2.1
Hypertension (Self-reported)	5.1	14.2	26.0	-3.8	4.7	-5.1	-4.8	2.4	-3.0	2.2	-3.3	-2.3	-4.6
Medication for cholesterol, blood pressure or diabetes	4.7	7.8	13.4	3.2	-2.1	3.7	3.3	-2.1	2.7	-2.0	2.8	2.3	3.2
Vascular/heart problems diagnosed by doctor	4.5	12.2	23.2	3.6	-4.5	4.8	4.3	-1.7	3.5	-2.0	3.3	2.0	3.6
Medication: Lansoprazole	3.4	3.8	5.6	-1.5	2.1	-2.4	-2.2	2.0	-1.6	1.8	-1.4	-2.0	-2.3
Medication: Amlodipine	3.4	4.7	9.9	-3.1	2.0	-3.0	-2.5	1.0	-2.6	1.3	-2.7	-0.9	-0.6
Cardiovascular Disease	3.3	11.0	21.1	-2.7	4.6	-4.2	-4.1	3.1	-1.6	3.0	-2.6	-2.4	-3.7
Medication: Ramipril	3.3	4.3	8.3	-2.8	1.7	-2.9	-2.7	0.5	-2.4	1.5	-2.5	-0.5	-1.3
Mouth/teeth dental problems: Loose teeth	3.3	3.9	6.6	-1.3	1.8	-2.5	-2.6	1.3	-2.4	2.3	-1.4	-2.4	-0.6
Medication: Allopurinol	3.3	4.3	8.4	2.1	-2.0	2.4	1.7	-2.6	1.8	-2.9	2.7	0.6	-0.2
Average weekly spirits intake	3.2	4.0	11.8	-3.4	1.0	-2.3	-2.1	-1.3	-2.5	-0.3	-2.3	1.3	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.5	17.2	3.0	-2.2	3.6	4.2	-1.1	2.0	-2.3	2.1	1.3	2.0
Eye problems/disorders: Cataract	2.8	3.2	6.9	-2.2	2.0	-2.3	-2.1	-0.4	-1.2	-0.9	-1.4	-1.6	-2.6
Blood White Count	2.7	20.3	35.2	-5.9	5.1	-5.7	-5.5	-0.6	-5.6	0.0	-5.3	1.8	-4.0
Age at last live birth	2.7	3.9	8.0	2.5	-2.4	2.3	2.2	-1.3	2.2	-1.2	2.8	1.0	0.9
Medication: Gliclazide	2.7	3.0	6.7	2.6	-1.4	1.5	1.7	2.4	0.6	1.5	1.2	-1.9	1.6
Body mass index (BMI)	2.6	11.1	30.8	-5.5	2.0	-3.1	-2.8	-0.6	-4.9	-0.9	-4.8	2.6	-2.1
Medication: Simvastatin	2.4	3.5	7.5	-0.3	1.2	-1.7	-2.2	2.2	-1.0	2.5	-0.4	-2.7	-2.3
Medication: Bendroflumethiazide	2.4	3.6	7.7	-2.8	2.1	-2.2	-2.3	1.2	-1.8	0.7	-2.1	-0.2	-1.8
Supplements: Zinc	2.3	2.5	10.0	1.8	0.2	0.6	-0.2	-0.2	3.2	-0.3	2.8	-1.4	-1.1
Qualifications: None of the above	2.3	5.0	8.7	-2.9	3.0	-2.6	-2.5	1.2	-2.5	1.0	-2.4	-0.3	-2.3
Medication: Atenolol	2.1	2.7	4.9	-1.8	1.6	-2.1	-2.2	0.3	-1.6	1.1	-1.5	0.5	-2.2
Guilty feelings	2.1	3.1	11.5	-2.3	3.4	-2.3	-2.0	-0.1	-0.8	-0.4	-1.9	0.7	-0.6
Primary Biliary Cirrhosis	2.0	2.9	6.8	-2.6	1.6	-1.9	-1.9	0.5	-2.0	-0.3	-2.5	-0.6	-1.1
Impedance of leg (right)	2.0	9.7	28.3	5.3	-2.8	2.9	2.5	1.6	3.5	2.5	4.3	-2.0	1.4
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	5.1	1.9	-1.7	2.2	2.3	-1.4	2.0	-1.6	2.1	0.6	1.1
Commuting to job workplace: Walk	2.0	2.2	4.4	2.0	-1.0	1.9	1.2	-0.6	1.8	-1.8	2.1	-0.9	0.2
Medication: Blood pressure	2.0	3.8	10.0	-1.8	3.2	-2.7	-2.6	0.5	-1.7	0.6	-1.5	-0.9	-2.1
Supplements: Calcium	2.0	2.2	6.0	-0.6	2.5	-1.8	-2.1	1.2	0.3	1.9	-0.7	-1.3	-0.5
Impedance of whole body	2.0	10.2	32.3	5.7	-1.9	2.7	2.2	2.0	3.6	3.0	4.4	-2.7	0.8
Impedance of leg (left)	1.9	9.3	27.8	5.3	-3.0	2.9	2.5	1.7	3.4	2.6	4.0	-1.8	1.2
Arm fat mass (right)	1.9	7.7	20.1	-4.5	1.6	-2.4	-2.1	-0.2	-4.3	-0.4	-4.0	2.3	-1.8
Arm fat percentage (left)	1.9	7.4	19.9	-4.3	1.8	-2.6	-2.4	0.1	-4.5	0.1	-3.9	1.4	-1.8
Irritability	1.9	3.2	7.3	-1.5	2.7	-2.7	-2.3	0.6	-1.0	1.1	-1.2	-2.3	0.4
BMI	1.8	10.7	30.6	-5.5	2.1	-3.0	-2.7	-0.1	-5.0	-0.6	-4.8	2.1	-1.6
Taking other prescription medications	1.8	2.8	5.6	-1.3	1.3	-2.0	-1.7	1.4	-2.4	0.6	-1.9	-2.0	-1.4
Waist circumference	1.8	6.6	18.3	-4.3	1.2	-2.4	-2.2	-0.6	-3.8	-0.9	-3.5	2.1	-1.7
Impedance of arm (right)	1.8	8.3	24.3	4.9	-1.3	2.3	1.8	1.8	3.1	3.2	4.0	-2.9	0.9
Arm fat mass (left)	1.8	7.6	19.8	-4.5	1.6	-2.3	-2.0	-0.2	-4.3	-0.7	-4.1	2.3	-1.8
Angina	1.7	2.2	4.6	-1.7	1.9	-2.0	-1.4	0.4	-2.1	0.9	-1.7	-0.9	0.1
Arm fat percentage (right)	1.7	6.8	18.6	-4.1	1.6	-2.4	-2.3	0.1	-4.3	0.5	-3.7	1.5	-1.7
Comparative body size at age 10	1.7	4.8	9.7	-2.9	2.1	-2.7	-2.3	0.1	-3.1	-0.2	-3.0	0.1	-1.9
Wheeze or whistling in the chest in last year	1.7	3.0	7.9	-2.5	0.8	-1.0	-0.7	-2.8	-1.6	-2.8	-0.8	1.7	-0.5
Age at first live birth	1.7	3.1	8.3	2.7	-1.3	1.8	1.4	-0.8	2.4	-1.1	2.9	0.4	-0.0
Overall health rating	1.7	3.7	7.1	-2.6	1.8	-2.7	-2.3	0.7	-2.4	0.5	-2.2	-0.4	-1.7
Illnesses of father: None of the above (group 1)	1.7	2.1	8.5	1.7	-0.5	1.0	1.5	-0.9	1.1	-0.9	1.5	-0.8	2.9
Fasting Glucose	1.6	1.9	11.7	-1.1	-0.7	0.4	0.8	-1.6	-0.1	-1.0	-0.4	3.4	1.0
Hearing difficulty/problems: Yes	1.6	2.4	4.5	-1.6	2.1	-2.0	-1.9	1.1	-1.5	1.4	-1.3	1.2	-0.8
Mouth/teeth dental problems	1.6	2.4	4.7	1.6	-1.9	2.2	1.9	-0.7	1.8	-1.1	1.4	1.5	0.7
Commuting to job workplace: Public transport	1.6	1.9	4.5	-1.2	1.8	-1.0	-1.3	1.5	-0.0	0.3	-1.3	-1.7	-2.1
High cholesterol (Self-reported)	1.6	2.9	7.1	-1.4	2.2	-2.3	-2.7	0.7	-1.0	1.6	-1.2	-0.8	-1.8
Age started oral contraceptive pill	1.6	2.0	16.0	0.3	0.9	-1.2	-0.8	0.6	-0.6	0.7	-0.1	-4.0	-0.2
Mean Putamen Volume	1.5	1.7	3.0	-1.5	0.8	-1.6	-1.7	1.1	-0.7	1.1	-1.4	-1.0	-1.4
Systolic Blood Pressure	1.5	7.7	22.4	-2.9	3.1	-4.7	-4.3	1.4	-0.8	1.6	-2.0	-1.4	-2.6
Systolic blood pressure, automated reading	1.5	4.4	11.3	-2.4	2.0	-3.4	-3.0	0.9	-1.1	0.9	-1.6	-1.6	-2.4
Hair/balding pattern: Pattern 2	1.5	1.9	3.9	1.6	-0.8	1.7	1.4	-0.0	2.0	-0.5	1.9	-0.1	1.6
Hip circumference	1.5	6.4	16.6	-4.1	0.5	-1.4	-1.0	-1.7	-4.0	-1.9	-3.6	2.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	11.6	2.2	-1.6	3.3	3.4	-0.7	1.9	-1.3	1.6	2.2	1.9
Impedance of arm (left)	1.5	7.0	22.9	4.8	-1.1	2.1	1.7	1.8	2.7	2.6	3.5	-2.9	0.6
Exposure to tobacco smoke outside home	1.5	2.1	7.6	-1.7	0.9	-1.3	-0.8	-0.4	-2.8	-0.4	-2.2	-0.9	-1.0
Leg fat percentage (left)	1.5	5.4	15.3	-3.8	0.8	-2.3	-1.9	0.1	-3.9	0.1	-3.4	1.2	-1.2
Leg fat mass (left)	1.5	5.8	16.3	-4.0	0.8	-2.0	-1.6	-0.1	-3.9	-0.3	-3.6	2.1	-1.1
Crohns Disease (2017)	1.4	3.1	9.2	-1.1	-0.7	0.4	1.1	-3.0	-1.0	-2.0	-0.3	3.0	2.2
Irritable Bowel Disease (IBD)	1.4	3.4	13.2	-0.3	-0.7	0.5	1.1	-3.6	-0.2	-2.8	0.2	2.6	1.9
Major Depression (MDD)	1.4	1.7	3.3	-1.8	1.2	-1.7	-1.6	0.6	-1.4	0.8	-1.8	-0.1	-0.7
Multivitamins +/- minerals	1.4	1.7	4.3	1.5	-0.4	1.0	0.7	-1.6	1.7	-2.1	1.8	-0.5	-0.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.3	-1.1	1.6	-1.6	-1.6	1.2	-1.6	1.8	-1.1	-0.4	-0.6
Angina (self-reported)	1.4	1.8	4.6	-1.5	1.6	-1.8	-1.2	0.4	-2.1	1.0	-1.6	-0.6	0.0
Leg fat mass (right)	1.4	5.6	16.2	-4.0	0.9	-1.9	-1.6	-0.2	-3.9	-0.4	-3.5	2.0	-1.0
Friendships satisfaction	1.4	1.7	9.1	1.2	0.3	-0.2	-0.4	1.1	0.9	1.8	1.1	-3.0	0.2
Number of self-reported non-cancer illnesses	1.4	2.4	4.7	-1.1	1.2	-2.0	-1.9	1.7	-1.1	1.1	-0.7	-1.9	-2.2
Ever depressed for a whole week	1.4	1.7	8.9	-1.1	0.5	-0.9	-1.2	-0.4	-0.5	-1.4	-0.7	1.0	-3.0
Alzheimer’s Disease (in mother)	1.3	1.5	6.7	-0.8	2.0	-0.7	-0.1	-2.6	0.3	-1.3	0.2	-0.1	1.1
Coronary Artery Disease (CAD)	1.3	1.5	3.6	-1.4	0.5	-1.3	-0.8	0.8	-1.4	1.1	-1.9	1.0	1.7
Average weekly fortified wine intake	1.3	1.5	3.1	-1.6	1.4	-1.8	-1.4	-1.2	-1.4	-0.1	-1.3	-0.3	0.2
Number of incorrect matches in round	1.3	2.2	11.6	0.8	1.4	-1.0	-1.5	0.5	0.7	-0.2	0.7	-3.4	-1.8
Pain all over the body in last month	1.3	1.4	3.2	-1.6	0.7	-1.3	-0.5	0.8	-1.7	0.7	-1.8	-0.4	1.0
Medication: Cholesterol lowering	1.3	2.0	4.5	-1.4	1.2	-2.1	-2.0	0.5	-1.3	0.8	-0.9	-2.1	-0.7
Medication: Ventolin 100micrograms inhaler	1.3	1.7	8.6	-2.0	-0.4	0.1	-0.5	-0.4	-0.5	-1.3	-1.2	2.9	-0.2
Forced vital capacity (FVC), Best measure	1.3	4.7	10.5	2.5	-1.7	3.2	3.2	-0.1	2.7	-1.0	2.1	1.8	1.3
Leg fat percentage (right)	1.3	4.8	14.4	-3.6	0.9	-2.2	-1.9	-0.1	-3.8	0.0	-3.1	1.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	3.5	-1.2	1.9	-1.4	-1.4	1.0	-0.5	1.7	-0.9	1.3	-0.6
Had major operations	1.3	1.5	2.6	1.3	-1.6	1.1	1.5	-1.1	0.6	-1.5	1.5	-1.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.1	-1.5	0.8	-1.3	-1.3	0.6	-1.2	0.3	-1.8	1.0	-1.6
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.3	1.4	0.1	1.2	1.2	-0.2	1.2	0.2	1.8	-1.3	1.8
Myopia	1.3	1.9	8.2	-0.9	1.9	-1.2	-1.4	0.4	-0.3	-0.3	-1.2	1.1	-2.9
Qualifications: CSEs or equivalent	1.2	1.6	5.9	-1.7	1.1	-0.7	-0.7	1.4	-1.4	0.8	-2.4	0.5	0.5
Hayfever, allergic rhinitis or eczema	1.2	2.6	8.9	1.6	-0.9	1.8	1.3	-2.0	0.9	-3.0	1.8	0.4	-0.8
Emphysema/chronic bronchitis	1.2	1.3	2.9	-1.0	1.2	-1.5	-1.7	0.6	0.1	-0.5	-0.7	-1.5	-1.6
Whole body fat mass	1.2	5.0	14.6	-3.6	0.8	-1.9	-1.5	-0.3	-3.8	-0.5	-3.3	1.8	-1.3
Ever had bowel cancer screening	1.2	1.4	3.8	-1.5	2.0	-1.7	-1.6	0.9	-0.4	0.7	-0.9	-0.5	-0.4
Diastolic blood pressure, automated reading	1.2	3.8	9.6	-3.1	1.7	-2.5	-2.2	1.5	-1.7	0.0	-2.6	-1.0	-1.3
Basal cell carcinoma (self-reported)	1.2	1.4	3.5	-1.3	1.3	-1.4	-1.5	0.9	-0.9	0.2	-0.9	-1.9	-0.7
Body Mass Index (BMI) (2010)	1.1	1.5	3.1	-1.8	0.9	-1.2	-1.2	-1.0	-1.8	-0.9	-1.6	-0.2	0.7
Crohns Disease (2012)	1.1	1.7	6.7	0.0	-1.5	1.1	1.3	-1.5	0.6	-0.8	0.6	2.6	1.3
Weight	1.1	5.4	15.1	-3.9	0.5	-1.2	-1.0	-0.8	-3.3	-1.5	-3.2	3.2	-1.0
Exposure to tobacco smoke at home	1.1	1.2	3.3	-1.2	0.7	-0.1	0.4	-1.8	-1.8	-1.0	-0.9	0.7	1.0
Birth weight of first child	1.1	2.0	5.8	0.7	-0.9	1.4	1.6	-1.3	1.8	-2.4	1.7	0.0	0.8
Body fat percentage	1.1	4.3	14.1	-3.1	0.8	-1.9	-1.6	0.1	-3.8	0.4	-2.9	1.0	-1.5
Neck or shoulder pain in last month	1.1	1.6	14.3	-0.0	0.3	-0.9	-0.4	0.7	-0.3	0.2	-0.3	-3.8	0.3
Commuting to job workplace: Car/motor vehicle	1.1	1.2	7.2	0.0	-0.7	0.3	0.8	-1.3	-1.5	0.4	-0.2	2.7	-0.0
Mood swings	1.1	2.0	4.9	-2.0	2.2	-1.7	-1.7	0.2	-1.4	0.5	-1.7	0.5	-0.5
Diabetes diagnosed by doctor	1.1	1.8	7.0	-0.9	0.7	-1.4	-0.5	0.3	-2.6	0.4	-1.5	-2.2	-0.4
Qualifications: nursing, teaching	1.1	1.7	5.0	0.5	-0.8	1.4	1.5	-2.2	0.4	-2.0	0.7	0.9	1.4
Osteoporosis (self-reported)	1.1	1.3	3.4	-1.5	1.8	-1.5	-1.6	-0.9	-0.7	-0.4	-1.1	0.3	-0.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.6	2.1	-1.1	1.0	0.8	0.5	1.6	0.5	1.6	-0.8	0.6
Medication: Lisinopril	1.1	1.4	3.5	-1.4	0.7	-0.8	-0.8	-1.2	-0.2	-1.4	-0.4	1.8	-1.9
Bipolar Disorder (2018)	1.0	1.6	7.0	-0.7	-0.2	-0.4	-0.6	-2.6	-1.0	-1.5	-0.7	1.9	-0.6
HbA1C	1.0	1.1	4.8	0.5	-1.0	1.2	1.6	-0.1	-0.5	-0.5	0.3	0.1	2.2
Medication: Metformin	1.0	1.5	7.1	-0.7	0.4	-1.2	-0.5	-0.2	-2.7	0.6	-1.2	-1.8	0.0
Relative age voice broke	1.0	1.6	3.4	1.8	-0.9	1.9	1.6	-0.8	1.0	-0.5	1.6	-0.6	0.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.7	0.9	-1.5	1.1	0.2	-0.7	1.4	-0.3	1.9	-0.3	0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.2	-0.5	1.2	-1.4	-1.2	0.5	-1.1	1.2	-0.7	-1.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.9	1.7	-0.0	0.5	0.7	0.4	2.2	0.3	2.0	-1.3	0.9
Mouth/teeth dental problems: Dentures	1.0	1.6	4.8	-2.2	1.6	-1.7	-1.5	0.2	-1.2	0.8	-1.3	-0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.7	1.3	1.0	-0.1	-0.3	-0.4	1.2	-0.5	1.3	-2.2	0.8
Family relationship satisfaction	1.0	1.2	3.7	-0.4	1.0	-1.3	-0.9	1.2	-0.7	1.5	-0.7	-1.9	-0.2
Ulcerative Colitis (UC)	0.9	1.7	7.6	0.3	-0.7	0.2	0.6	-2.7	0.3	-2.5	0.6	1.2	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.8	2.2	-2.1	1.8	1.6	-0.3	0.9	-0.3	2.0	0.3	0.6
Allergy or Eczema	0.9	2.3	8.5	1.5	-0.2	1.5	1.3	-2.3	0.4	-2.9	1.5	0.2	0.0
Number of treatments/medications taken	0.9	1.7	3.6	-1.2	0.5	-1.5	-1.2	1.0	-1.9	0.5	-1.5	-1.1	-1.7
Severe depression (siblings)	0.9	1.0	3.7	0.6	0.3	0.5	-0.1	-0.6	1.9	-0.9	1.4	-0.0	-1.4
Trunk fat mass	0.9	3.9	11.8	-3.1	0.5	-1.5	-1.2	-0.0	-3.4	-0.1	-2.9	1.8	-1.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.3	-0.6	0.1	-0.2	-0.5	-1.7	0.3	-1.7	0.4	1.0	-1.8
Lung cancer (father)	0.9	1.1	2.8	1.5	-1.7	1.3	1.4	0.1	1.2	-0.3	1.0	-0.0	-0.0
Gout (self-reported)	0.9	1.3	4.7	0.3	-0.8	0.9	0.9	-2.2	0.8	-2.0	1.1	0.1	-0.2
Worry too long after embarrassment	0.9	1.6	7.6	1.4	0.6	0.8	0.9	-0.4	2.8	-0.7	1.7	0.1	1.1
Number of children fathered	0.9	1.0	4.2	-1.1	0.8	-1.0	-0.7	-0.7	-0.8	-2.0	-0.8	0.1	-0.7
Medication: Omeprazole	0.9	1.0	4.5	0.9	-1.6	0.7	0.5	-0.4	-0.1	-1.1	0.6	0.1	-2.1
Chest pain or discomfort	0.9	1.3	3.9	-1.0	1.4	-1.5	-1.3	0.2	1.1	-0.3	0.2	-2.0	-0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.6	0.7	-0.7	0.5	0.1	-1.0	1.9	-0.8	1.3	1.0	-1.2
Illnesses of siblings: Diabetes	0.9	1.1	2.2	-1.2	1.4	-1.2	-1.2	0.8	-0.9	0.6	-1.5	0.7	-0.4
Illnesses of father: High blood pressure	0.9	1.1	3.1	1.0	-1.8	1.5	0.9	-0.2	0.9	-0.6	1.5	-0.5	0.1
Pack years of smoking	0.9	1.3	3.2	1.6	-1.3	1.3	1.2	0.2	1.0	-0.7	1.3	-1.8	-0.0
Depressed Affect (Nagel 2018)	0.8	1.7	3.9	-1.9	2.0	-1.8	-1.6	-1.1	-0.5	-0.6	-1.2	0.3	-0.4
Alzheimer’s Disease (including proxy)	0.8	1.2	5.4	0.0	0.3	0.4	1.0	-2.3	0.6	-1.3	0.5	1.2	1.4
Bipolar Disorder (2011)	0.8	0.7	3.1	-0.1	-0.8	0.0	0.2	-1.8	0.7	-0.9	0.4	1.2	1.0
Blood Red Count	0.8	7.3	38.8	-1.3	-0.9	-0.1	0.4	-6.2	-1.2	-5.2	0.2	1.6	0.1
Hand grip strength (left)	0.8	2.1	6.1	1.4	-1.5	2.0	2.5	0.3	-0.0	-1.0	0.1	1.6	1.8
Diabetes (mother)	0.8	1.0	2.8	-1.2	0.8	-1.3	-0.9	0.5	-1.3	-0.2	-1.7	0.2	-0.9
Trunk fat percentage	0.8	3.3	11.0	-2.6	0.6	-1.6	-1.4	0.3	-3.3	0.5	-2.5	1.0	-1.6
Townsend deprivation index at recruitment	0.8	1.1	3.8	-1.0	1.2	-1.1	-0.8	1.3	-0.4	0.1	-0.8	-1.9	-0.6
Maternal smoking around birth	0.8	1.2	2.6	1.6	-1.5	1.6	1.2	-0.2	0.7	0.3	1.5	-0.5	0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	-0.4	1.1	-1.5	-1.1	0.1	0.6	0.7	0.2	-1.1	1.6
Serious illness, injury or assault to yourself	0.8	1.0	4.7	-1.1	-0.5	-0.4	-0.2	0.1	-2.2	1.1	-1.1	0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	7.3	1.5	-1.1	2.4	2.7	-0.3	1.2	-0.6	0.9	2.0	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.9	-1.3	0.2	-1.1	-1.7	1.2	-0.3	0.0	-1.1	-0.5	-1.1
Standing height	0.8	7.5	13.8	3.3	-3.0	3.7	3.7	-0.5	3.1	-1.3	3.0	1.6	2.0
Peak expiratory flow (PEF)	0.8	1.8	6.8	0.4	-1.4	1.8	1.8	-1.2	-0.0	-0.7	-0.0	2.6	1.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.7	-0.2	1.3	-1.2	-1.1	0.4	0.1	0.2	-0.1	-2.2	-0.5
Loud music exposure frequency	0.8	0.9	4.0	-0.5	1.0	-0.8	-0.4	0.4	-2.0	1.0	-1.2	0.2	-0.0
Number of full brothers	0.8	1.0	4.2	0.6	0.4	0.6	0.3	-1.2	1.6	0.0	2.0	0.6	-0.3
Shortness of breath walking on level ground	0.8	0.9	3.7	-1.2	-0.7	-0.2	-0.3	-1.5	-0.9	-1.9	-0.2	0.8	-0.2
Medication: Ibuprofen	0.8	1.0	3.2	-1.8	0.1	-1.1	-1.4	0.6	-0.7	-0.5	-1.3	-0.3	-0.7
Average weekly red wine intake	0.8	1.2	3.6	0.3	0.6	-0.9	-0.6	1.9	0.3	1.7	-0.2	-1.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	3.3	-0.4	0.4	0.3	0.8	-1.8	1.1	-1.4	0.6	0.9	1.1
Back pain experienced in last month	0.8	1.2	3.8	0.9	-1.2	1.5	1.9	1.5	0.8	0.6	0.4	-0.5	0.5
Breast cancer (self-reported)	0.8	1.0	2.1	-1.3	1.1	-1.1	-1.2	0.2	-0.5	-0.7	-1.2	0.2	-1.5
Ever taken oral contraceptive pill	0.8	0.9	2.7	-1.4	0.7	-1.1	-1.2	-0.1	-0.1	0.6	-0.6	1.6	-0.3
Unable to work because of sickness or disability	0.8	1.0	2.2	-1.5	0.3	-1.2	-1.0	-0.8	-1.2	0.7	-0.8	1.0	-0.9
Commuting to job workplace: Cycle	0.8	1.0	3.0	-1.4	0.6	-0.5	0.0	-0.7	-0.8	-1.7	-1.4	0.9	0.5
Alcohol drinker status: Previous	0.8	1.0	4.8	-0.3	-0.2	0.3	0.4	-2.2	-0.7	-1.7	0.0	0.4	-1.0
Prostate Cancer	0.7	1.0	2.3	-1.5	0.4	-1.2	-1.1	1.1	-1.3	0.9	-1.0	-0.4	0.4
Lupus	0.7	1.1	3.0	-0.6	-0.8	-0.3	-0.3	-1.6	-1.1	-1.7	-0.2	-0.7	1.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.6	-0.8	0.9	-0.8	-0.4	-0.0	-1.9	-0.4	-1.2	0.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.4	-0.1	0.3	-1.0	-1.3	-1.3	0.4	-0.8	0.7	-0.0	-1.8
Medication for hormone replacement therapy	0.7	0.7	4.7	0.1	-0.0	0.2	0.0	-1.4	0.4	-0.6	0.5	2.2	-0.0
Medication: Co-codamol	0.7	0.8	2.0	-1.4	0.5	-0.6	-0.9	1.1	-0.5	1.2	-0.9	0.2	-0.7
Pack years adult smoking proportion	0.7	1.1	2.1	1.4	-1.1	1.3	1.2	0.2	1.1	-0.6	1.1	-1.4	-0.0
Leg fat-free mass (left)	0.7	3.8	10.3	-3.2	0.5	-0.7	-0.4	-1.1	-2.2	-2.1	-2.5	3.2	-0.1
Age when periods started (menarche)	0.7	1.6	4.2	2.0	-0.5	0.8	0.4	0.3	1.9	0.4	1.9	-1.9	0.1
Leg predicted mass (left)	0.7	3.8	10.6	-3.2	0.4	-0.7	-0.4	-1.1	-2.2	-2.1	-2.5	3.3	-0.1
Diabetes (self-reported)	0.7	1.1	5.5	-0.3	0.2	-0.9	-0.0	-0.1	-2.0	0.3	-0.7	-2.3	-0.1
Noisy workplace	0.7	0.9	3.6	-0.0	-1.0	0.8	0.7	-1.0	-0.9	-0.8	0.7	1.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.1	1.4	-0.8	1.4	1.1	-1.4	1.3	-1.8	1.3	0.9	1.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	5.9	1.4	-0.6	0.1	-0.2	2.4	0.7	2.0	0.4	-0.8	-0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.8	0.6	-0.0	1.0	1.1	1.7	0.3	1.2	0.6	-0.9	-0.1
Medication: Seretide 50 evohaler	0.7	0.8	4.1	-1.0	-0.7	0.2	0.3	-0.7	0.0	-0.7	-0.6	2.0	-1.1
Heart disease (mother)	0.7	0.8	2.3	1.5	-1.3	0.6	0.4	0.2	0.7	-0.1	1.1	-1.3	0.4
Supplements: Vitamin C	0.7	0.8	4.6	0.9	0.4	0.3	0.3	1.5	0.4	2.1	-0.2	-0.2	-0.0
Illnesses of father: Heart disease	0.7	1.0	1.7	-1.3	1.0	-1.2	-1.3	0.6	-0.0	0.9	-0.8	1.2	-0.8
Leg fat-free mass (right)	0.7	4.0	11.7	-3.2	0.3	-0.6	-0.3	-1.3	-2.1	-2.2	-2.5	3.4	-0.2
Medication: Aspirin	0.7	0.9	2.0	-0.4	0.2	-1.2	-0.9	0.9	-1.3	1.1	-0.9	-1.4	-0.3
Whole body water mass	0.7	3.9	13.0	-3.0	-0.1	-0.2	-0.0	-1.4	-1.7	-2.6	-2.2	3.6	-0.0
Leg predicted mass (right)	0.7	3.8	11.3	-3.1	0.3	-0.6	-0.3	-1.2	-2.1	-2.2	-2.5	3.4	-0.2
Mother’s age at death	0.7	0.9	2.5	1.3	-0.7	0.4	0.7	-0.1	1.0	-0.0	1.1	-1.6	1.0
Basal metabolic rate	0.7	4.1	14.6	-3.1	-0.1	-0.3	-0.0	-1.3	-2.0	-2.3	-2.5	3.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	3.0	1.0	-0.6	0.6	-0.1	-1.4	0.5	-0.4	1.7	0.5	-1.0
Depression (Nagel 2018)	0.6	0.8	5.1	-0.0	-0.1	-0.3	0.1	-2.3	0.3	-1.5	0.8	0.2	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	4.1	-0.8	1.0	-0.6	-0.4	1.0	-0.5	0.3	-0.7	-2.0	-0.2
Reaction Time	0.6	1.1	4.3	0.8	0.3	-0.2	0.3	1.2	-0.6	2.1	-0.1	-1.4	1.6
Hypothyroidism (self reported)	0.6	1.5	6.5	1.3	0.1	-0.3	-0.6	2.5	0.4	2.1	0.3	-1.0	-0.6
Relative age of first facial hair	0.6	1.2	2.2	1.1	0.4	-0.3	-1.1	1.5	1.4	1.2	0.8	-0.8	-1.4
Had other major operations	0.6	0.8	2.9	-0.7	0.4	-0.8	-1.3	0.5	-0.9	-0.5	-0.7	0.4	-1.7
Forced vital capacity (FVC)	0.6	2.2	5.5	1.6	-1.0	2.2	2.4	0.0	1.7	-0.4	1.3	1.6	1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	1.5	-0.6	1.1	0.8	-0.5	0.4	-0.5	1.7	0.2	-0.3
Trunk fat-free mass	0.6	3.2	13.0	-2.3	-0.6	0.4	0.5	-1.5	-1.0	-2.7	-1.6	3.6	0.3
Happiness	0.6	0.7	3.2	0.8	1.0	-0.5	-0.7	0.6	0.6	-0.0	0.9	-1.8	-0.0
Illnesses of mother	0.6	0.8	1.9	-0.5	0.7	-1.1	-1.0	1.0	-0.6	1.4	-0.8	-0.4	0.7
Trunk predicted mass	0.6	3.2	12.9	-2.3	-0.6	0.3	0.5	-1.4	-1.1	-2.6	-1.6	3.6	0.2
Tense / ‘highly strung’	0.6	1.0	3.3	0.5	1.0	-0.6	-0.5	1.5	0.3	1.3	0.0	-1.8	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.1	-0.8	1.2	-1.4	-1.3	-0.3	1.5	-0.7	0.5	-0.9	-0.4
Headache pain in last month	0.6	1.1	2.2	-1.1	0.7	-0.5	-0.1	-1.5	-1.1	-1.3	-1.0	1.5	0.9
Arm fat-free mass (right)	0.6	3.2	10.2	-2.3	-0.7	0.1	0.4	-1.5	-1.4	-3.0	-1.8	3.2	0.1
Eye problems/disorders: None of the above	0.6	0.6	4.2	0.5	-0.3	0.6	0.1	0.2	0.8	0.4	0.7	2.1	0.2
Medication for pain relief, constipation, heartburn	0.6	1.1	2.4	1.0	0.0	1.3	0.9	-0.3	1.6	0.4	1.3	0.8	1.5
Mean time to correctly identify matches	0.6	1.1	3.4	1.1	-0.7	0.2	0.4	0.9	0.0	1.7	0.8	-1.8	1.2
Arm predicted mass (right)	0.6	3.1	10.4	-2.4	-0.5	-0.0	0.3	-1.2	-1.4	-2.8	-2.0	3.2	-0.1
Whole body fat-free mass	0.6	3.6	13.7	-2.7	-0.3	0.0	0.2	-1.5	-1.5	-2.6	-2.0	3.7	0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	5.2	0.2	0.0	-0.0	0.0	-0.9	0.6	-0.3	0.2	2.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.8	-1.1	0.3	-0.9	-1.0	-0.2	-0.4	0.3	-0.8	1.0	-1.3
Miserableness	0.6	1.1	3.9	-1.5	2.0	-1.2	-1.2	-0.4	1.0	-0.2	-0.5	-0.1	0.4
Hearing aid user	0.6	0.7	2.7	-0.9	-0.5	0.1	0.4	-0.3	-1.1	0.7	-0.6	1.6	1.1
Alcohol drinker status: Never	0.6	0.8	2.0	1.4	-0.9	1.2	0.8	0.6	0.8	0.2	0.8	0.9	-0.5
Arm fat-free mass (left)	0.6	3.1	11.0	-2.7	-0.2	-0.3	-0.2	-1.0	-1.4	-2.1	-2.0	3.3	-0.4
Number of operations (self-reported)	0.6	0.8	2.7	0.4	-0.5	-0.1	-0.8	-0.1	1.2	-1.0	1.0	-0.9	-1.7
Arm predicted mass (left)	0.6	3.0	10.2	-2.8	-0.3	-0.3	-0.2	-1.0	-1.5	-2.1	-2.1	3.2	-0.2
Schizophrenia (2014)	0.5	1.1	3.1	0.2	0.1	-0.3	-0.5	-1.5	1.8	-1.5	1.1	-1.3	-0.3
Smoking Status	0.5	1.2	2.7	-1.6	1.1	-1.1	-1.2	-0.4	-1.5	0.7	-0.9	1.1	-1.1
Lung FEV1/FVC ratio	0.5	2.7	8.3	-1.0	-0.3	0.2	0.8	-2.9	-2.7	-1.1	-1.3	1.4	2.2
Diabetes (father)	0.5	0.6	3.1	0.0	-0.9	0.6	0.7	0.3	-0.4	0.9	-0.1	1.8	-0.7
Supplements: Glucosamine	0.5	0.7	1.5	0.4	0.4	-0.6	-0.8	0.9	1.1	1.0	0.6	-1.2	-0.6
Medication: Levothyroxine sodium	0.5	0.8	2.3	1.0	-0.8	0.1	0.1	1.5	0.4	1.4	0.2	-1.2	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	-0.5	1.2	-0.3	-0.4	0.0	-0.7	-0.0	-0.8	-1.0	-1.4
Nervous feelings	0.5	1.0	3.1	1.0	-0.4	0.6	1.2	-0.6	1.7	0.1	1.2	-0.9	1.0
Had menopause	0.5	0.6	1.9	0.6	-0.6	-0.3	-0.3	-0.6	0.5	-1.0	0.6	-1.4	-1.3
Allergy	0.5	1.1	5.5	-0.0	0.2	-0.6	-0.3	2.0	0.5	2.3	-0.2	-0.8	0.5
Illnesses of siblings	0.5	0.7	2.6	0.7	-0.9	0.9	1.1	-0.7	0.1	-1.0	0.1	0.2	1.6
Worrier / anxious feelings	0.5	1.0	2.4	1.4	-0.2	1.0	1.4	-0.4	0.5	-0.2	0.8	-1.5	1.6
Prospective memory result	0.5	0.6	1.6	0.2	0.3	0.8	1.0	-0.6	0.7	-0.8	0.5	1.1	1.3
Blood clot in the leg (DVT)	0.5	0.7	2.7	1.0	-0.4	0.6	-0.1	-1.2	0.4	-0.3	1.6	0.3	-1.0
Medication: Paracetamol	0.5	0.9	3.6	0.6	-1.9	1.0	1.0	-0.6	0.4	-1.4	0.6	0.4	-0.2
Pulse wave peak to peak time	0.5	0.5	1.5	1.2	-0.7	0.9	0.9	-0.1	0.1	0.1	0.7	-0.0	1.2
Health satisfaction	0.5	0.7	5.0	-0.1	0.5	-0.7	-0.6	0.4	-0.2	-0.5	-0.2	-2.2	0.2
Leg pain on walking	0.5	0.6	1.7	-1.3	0.6	-0.8	-0.4	0.5	-1.0	0.1	-1.0	-0.7	-0.4
Medication: Aspirin	0.5	0.6	2.1	-0.3	0.0	-1.1	-0.8	0.3	-1.4	0.5	-0.8	-1.0	-0.2
Medication for cholesterol	0.5	0.8	2.1	0.7	-1.3	1.2	1.4	0.1	0.8	-0.4	0.2	0.0	1.2
Fractured/broken bones in last 5 years	0.5	0.6	1.6	-1.3	1.0	-0.9	-1.2	0.6	0.1	0.2	-0.3	-0.3	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	4.0	0.4	-0.8	0.1	-0.1	-0.3	-0.5	-1.0	0.3	0.5	-2.0
Bipolar Disorder or Schizophrenia	0.4	0.9	5.3	0.0	-0.4	-0.2	-0.6	-2.3	0.7	-1.4	0.5	0.4	-0.3
Neuroticism (Nagel 2018)	0.4	1.0	3.7	-0.8	1.9	-1.5	-1.4	-0.5	0.4	-0.2	-0.5	-0.8	-0.0
Alzheimer’s Disease (in father)	0.4	0.4	1.9	0.4	-0.8	0.8	0.8	0.0	0.4	-0.0	0.1	1.4	0.7
Age at First Birth	0.4	0.5	2.3	-0.1	1.5	-0.6	-0.6	0.5	0.4	0.3	0.1	0.5	-1.2
LDL Cholesterol	0.4	0.7	3.4	0.4	0.2	-0.2	-0.3	1.9	-0.2	1.7	-0.4	0.2	0.1
Rheumatoid Arthritis	0.4	0.6	2.3	0.9	-1.5	0.8	0.8	-0.8	-0.3	-0.5	0.4	-0.0	0.7
Ulcerative Colitis	0.4	0.5	2.7	0.2	-0.2	-0.0	0.2	-1.6	-0.1	-1.0	0.2	0.2	1.2
Respiratory disease	0.4	0.9	3.3	-1.8	-0.2	-0.6	-0.5	-0.5	-1.3	-1.2	-1.4	0.3	0.3
Chronotype (morning person)	0.4	0.9	3.0	-0.2	-0.4	0.6	0.5	1.2	-1.1	1.7	-1.3	0.3	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.3	-0.1	0.4	-0.2	-0.1	-1.3	0.4	-1.0	0.7	-0.0	1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	-0.2	0.7	-0.6	-0.5	-0.3	-1.3	0.0	-0.3	-0.6	-1.2
Vitamin and mineral supplements	0.4	0.5	1.5	-1.2	-0.2	-0.6	-0.3	0.8	-1.1	0.4	-1.1	0.3	0.0
Current tobacco smoking	0.4	0.6	2.0	-0.8	0.6	-0.9	-0.7	0.2	-0.6	1.0	-0.4	0.8	-1.4
Fed-up feelings	0.4	0.8	2.6	0.0	-0.2	0.9	1.1	-0.7	0.7	-0.2	0.3	1.5	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	0.6	-0.1	0.2	0.7	-0.8	1.1	-0.6	1.2	0.9	0.1
High blood pressure (mother)	0.4	0.6	2.1	0.3	-0.5	0.8	0.7	-1.1	-0.2	-1.4	0.3	0.6	-0.8
Past tobacco smoking	0.4	0.7	2.8	1.0	-0.7	0.7	0.6	0.2	1.7	-0.5	1.0	-0.4	0.5
Alcohol intake versus 10 years previously	0.4	0.5	2.4	-0.8	-0.5	-0.0	-0.1	-0.6	-0.6	-1.6	-0.6	0.6	-0.8
Father’s age at death	0.4	0.5	1.6	0.6	-1.3	0.5	0.3	-0.9	0.7	-0.1	0.5	-0.6	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.3	-0.1	-0.1	0.3	0.4	-1.5	0.7	-1.1	0.9	0.7	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.5	-0.5	-0.1	-0.3	-0.5	-1.6	-0.6	-1.4	0.2	-0.0	-0.6
Number of live births	0.4	0.6	2.7	0.0	-1.4	0.7	0.5	-0.1	0.6	-0.5	0.5	1.6	0.2
Pulse rate	0.4	0.6	2.3	-0.7	-0.1	-0.2	-0.1	-0.2	1.0	-0.5	0.3	1.4	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.1	-0.3	0.9	-0.5	-0.3	-0.1	-0.4	-0.6	-0.3	-1.4	1.1
Asthma	0.4	0.9	2.4	-1.5	-0.4	-0.1	-0.1	-1.2	-1.0	-1.2	-0.9	1.0	0.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.2	-1.1	0.6	-0.8	-0.7	0.0	0.0	-0.1	-0.6	0.1	-1.1
Glaucoma (self-reported)	0.4	0.4	1.4	0.5	0.6	-0.3	0.2	0.3	0.9	0.3	0.7	-0.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	0.9	-0.4	-0.1	-0.1	0.9	1.4	0.3	1.1	-0.6	-0.2
Alcohol intake frequency.	0.4	0.9	1.9	-1.4	-0.1	0.1	0.1	-0.2	-1.3	-1.2	-1.1	0.6	-1.4
Number of full sisters	0.4	0.5	1.7	-1.3	0.2	-0.7	-1.0	-0.8	0.2	-1.0	-0.3	0.4	-0.1
Knee pain experienced in last month	0.4	0.7	1.9	-1.2	-0.2	-0.5	-0.7	0.3	-1.4	0.4	-1.0	-1.1	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	2.1	-0.6	0.1	-0.5	-0.0	1.4	-1.2	0.3	-0.8	-0.9	-0.4
Mineral and other dietary supplements	0.4	0.6	2.3	-1.2	-0.2	-0.1	0.1	-0.6	-1.5	-0.5	-0.9	0.5	0.7
Asthma (self-reported)	0.4	0.8	1.9	-1.4	-0.5	0.1	0.2	-1.2	-0.8	-1.3	-0.8	1.0	0.6
Smoking status: Current	0.4	0.7	1.5	-0.9	0.7	-1.0	-0.7	0.0	-0.7	1.1	-0.5	0.8	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.4	1.0	-0.4	1.3	1.6	-0.6	-0.2	-0.5	0.2	1.3	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.2	0.5	0.3	0.8	1.5	0.3	-0.2	-0.8	0.0	-0.8	-0.0
Eye problems/disorders: Glaucoma	0.4	0.4	1.3	-0.1	0.2	-0.7	-0.2	-0.2	0.8	0.4	0.6	-1.1	1.1
Medication: Paracetamol	0.4	0.7	1.9	0.1	-1.3	0.7	1.1	-0.8	0.2	-1.4	0.4	-0.3	0.6
Ever smoked	0.4	0.7	3.3	-0.9	0.1	-0.3	-0.3	-0.5	-1.8	0.5	-0.9	0.7	-0.7
Risk taking	0.4	0.5	3.5	-0.2	-0.5	0.0	-0.0	0.9	-0.6	1.9	-0.2	0.1	0.5
Heart disease (siblings)	0.4	0.5	2.8	-0.2	0.6	-0.0	-0.5	-0.5	-0.1	-0.9	0.2	0.3	-1.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.1	1.4	-1.1	0.7	0.9	1.1	-0.4	0.7	1.0	-1.2	-0.0
Schizophrenia (2018)	0.3	0.7	2.8	0.6	-0.3	0.0	-0.3	-0.9	1.7	-0.6	1.2	-1.1	0.1
Breast Cancer	0.3	0.6	1.8	0.6	0.2	-0.1	-0.8	0.2	0.9	1.1	0.7	1.0	-1.4
Ovarian Cancer	0.3	0.3	1.0	0.6	-0.6	0.3	0.6	0.3	-0.3	0.7	0.2	-0.7	1.0
Neuroticism (2016)	0.3	0.5	1.4	0.3	1.0	-0.0	-0.1	-0.9	1.2	-0.8	0.3	-0.5	0.9
Height	0.3	5.8	11.4	2.9	-2.9	3.4	3.1	-1.2	1.3	-2.2	2.4	2.2	1.1
Waist Hip Ratio (WHR)	0.3	1.3	3.6	1.6	-1.0	0.3	-0.4	1.0	1.7	0.6	1.9	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.1	-0.2	0.3	-0.7	-0.0	-0.3	-1.4	-0.0	-0.8	-1.1	0.7
Sensitivity / hurt feelings	0.3	0.5	1.8	-0.1	0.9	0.0	0.1	1.4	0.3	1.2	-0.6	-0.5	0.8
Ever had hysterectomy (womb removed)	0.3	0.3	1.7	-0.6	0.0	-0.4	-0.5	-0.7	0.4	-0.4	0.1	1.3	0.2
Sitting height	0.3	2.0	4.9	0.4	-1.2	1.5	1.8	-1.0	1.5	-2.2	0.7	1.9	0.6
Alcohol usually taken with meals	0.3	0.5	2.2	0.8	-0.3	0.5	0.1	1.5	-0.2	0.9	0.0	-0.7	0.5
Hearing difficulty/problems with background noise	0.3	0.4	1.0	-0.8	1.0	-0.8	-0.6	-0.8	-0.0	-0.7	-0.0	0.2	0.4
Time employed in main current job	0.3	0.3	1.1	-0.4	-0.1	-0.0	0.2	-1.0	-0.7	-0.6	0.2	-1.0	-0.2
Depression (self-reported)	0.3	0.4	1.4	0.2	-0.4	0.0	0.4	-0.9	0.2	-0.7	0.3	-1.2	0.9
Birth weight	0.3	0.7	2.7	0.2	0.7	-0.0	-0.1	0.8	1.4	-0.6	0.7	-1.6	-0.2
Migraine (self-reported)	0.3	0.4	1.9	-0.0	-0.2	0.6	0.2	-0.9	-0.3	-1.4	0.4	0.8	0.5
Pulse rate, automated reading	0.3	0.9	2.4	0.3	-1.2	0.7	1.1	-0.6	0.8	-0.6	1.0	1.6	0.9
Financial situation satisfaction	0.3	0.3	1.0	-0.5	-0.0	-0.5	-0.4	-0.7	0.2	-0.8	-0.3	-0.7	-1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.3	-0.6	-0.3	0.1	0.3	-0.9	0.3	-0.7	0.1	-1.2	0.2
Cholesterol lowering medication	0.3	0.4	1.8	-0.2	0.6	-0.6	-1.0	-0.0	-0.3	0.6	0.4	-0.2	-1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	-0.7	0.0	0.2	0.6	-0.6	-0.7	-1.2	-0.3	0.5	0.5
Worry (Nagel 2018)	0.2	0.4	2.4	0.6	-0.7	0.0	0.4	-0.4	0.6	-0.1	0.5	-1.6	0.5
Heel T-Score	0.2	1.5	6.6	-0.7	1.3	-1.2	-1.0	0.7	-1.1	2.6	-1.3	-0.6	0.2
Lung FVC	0.2	1.2	3.2	1.0	-1.2	1.8	1.6	0.6	1.6	-0.5	1.1	0.3	-0.4
Neuroticism	0.2	0.5	1.4	-0.3	1.0	-0.7	-0.5	-0.9	0.6	-0.1	0.0	-1.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	-0.2	0.6	0.2	0.3	0.6	-0.2	-0.2	0.5	-0.8	-0.6
Hand grip strength (right)	0.2	0.6	2.3	0.1	-0.3	0.4	0.9	0.9	-0.8	0.1	-0.9	0.6	1.5
Stomach or abdominal pain in last month	0.2	0.3	0.6	0.1	0.1	0.1	0.5	-0.7	-0.7	-0.7	0.1	0.7	0.6
Heart attack	0.2	0.3	0.9	-0.8	0.2	0.1	0.4	-0.5	-0.8	-0.9	-0.4	0.6	0.1
Length of working week for main job	0.2	0.2	1.0	-0.2	0.4	0.2	0.6	-0.3	-0.1	-0.7	-0.4	1.0	-0.4
Breastfed as a baby	0.2	0.2	0.8	-0.0	-0.8	0.0	0.0	-0.4	0.1	-0.9	0.4	-0.4	0.1
High blood pressure (siblings)	0.2	0.2	1.4	0.2	-0.7	0.1	-0.1	0.1	-0.1	0.4	0.4	-0.1	-1.2
Qualifications: College or University degree	0.2	0.8	1.9	0.9	-0.2	0.6	0.5	-1.2	0.7	-0.6	0.8	1.4	1.1
Smoking status: Previous	0.2	0.4	1.9	-0.6	0.6	-0.3	-0.3	-0.3	-1.4	-0.1	-0.8	-0.0	-0.4
Loneliness, isolation	0.2	0.3	1.5	-0.0	1.2	-0.7	-0.1	-0.2	0.2	0.0	0.3	-1.1	0.3
Osteoarthritis (self-reported)	0.2	0.3	1.3	-0.3	-1.1	0.3	0.3	-0.7	0.3	-0.2	0.3	-0.5	0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.9	0.3	0.2	-0.1	0.0	0.9	0.8	0.5	0.6	-0.6
Wears glasses or contact lenses	0.2	0.2	0.8	0.0	-0.1	0.5	0.9	0.5	-0.3	-0.1	-0.0	-0.3	-0.5
Pain experienced in last month	0.2	0.4	1.7	0.4	0.3	0.2	-0.7	-0.2	0.8	-0.3	0.8	1.3	-0.4
HDL Cholesterol	0.1	0.1	0.7	0.3	-0.5	0.1	0.2	0.3	0.3	0.3	0.0	0.2	-0.8
Triglycerides	0.1	0.2	0.8	0.3	-0.5	0.5	0.1	-0.0	0.1	-0.5	0.3	0.7	-0.9
Blood Eosinophil Count	0.1	0.6	2.2	-0.8	-0.3	-0.3	-0.1	-0.6	-1.2	-1.5	-0.5	-0.1	0.9
Blood Platelet Count	0.1	1.2	3.4	-0.8	1.4	-1.8	-1.0	0.3	-1.7	0.9	-1.0	-0.6	-0.6
Tanning	0.1	0.9	4.7	-0.2	-0.1	0.0	0.1	2.2	0.1	1.4	-0.6	-0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.9	-0.2	-0.3	0.1	0.1	-0.9	0.1	-0.3	-0.3	0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.0	0.3	0.0	0.3	0.3	0.1	0.6	-0.6	0.6	-0.6
Financial difficulties in last 2 years	0.1	0.1	0.4	0.3	0.2	0.2	0.1	0.6	0.0	0.4	0.1	0.6	-0.5
Fluid intelligence score	0.1	0.3	1.0	0.1	-0.5	0.1	-0.2	-1.0	-0.5	-0.9	0.5	0.3	-0.0
Neuroticism score	0.1	0.3	1.3	-0.6	1.1	-0.6	-0.4	-0.4	0.5	-0.1	-0.3	-0.2	0.4
Falls in the last year	0.1	0.2	0.5	0.1	-0.5	0.5	0.4	-0.2	-0.3	-0.4	-0.1	0.3	-0.7
Pulse wave reflection index	0.1	0.1	0.6	-0.0	0.6	-0.0	-0.2	-0.1	-0.1	0.2	-0.2	-0.4	0.7
Comparative height size at age 10	0.1	0.7	1.6	0.7	-1.0	0.8	0.9	0.6	0.5	0.9	0.2	1.2	1.1
Suffer from ‘nerves’	0.1	0.2	0.9	0.2	-0.2	-0.0	0.1	-0.0	1.0	0.1	0.4	-0.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.6	0.6	0.2	0.2	0.4	-0.2	0.1	-0.6	0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	1.0	-0.0	-0.1	-0.3	-0.2	-0.6	0.6	-1.0	0.0	-0.2	0.4
Medication: Atorvastatin	0.1	0.2	0.8	-0.3	-0.1	-0.6	-0.9	-0.1	0.3	0.0	0.4	0.1	0.1
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.3	0.6	-0.6	-0.7	0.0	-0.1	0.1	-0.3	0.1	-0.4
Hair Pigment	0.0	0.2	0.6	0.6	-0.1	-0.3	-0.3	-0.3	-0.2	0.7	0.4	-0.6	0.3

Hub : Genes

KAT2B

Models

Trait associations