Best TWAS P=1.7e-20 · Best GWAS P=8.24e-18 conditioned to 0.00254
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ACPL2 | 0.13 | 0.12 | lasso | 4 | 0.15 | 1.3e-08 | 7.1 | 5.4 | 5.6e-08 | 0.21 | 0.18 | 0.81 | FALSE |
| 2 | GTEx | Skin Sun Exposed Lower leg | ACPL2 | 0.13 | 0.05 | enet | 7 | 0.05 | 3.1e-05 | 7.4 | 8.8 | 1.3e-18 | 0.88 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Spleen | ACPL2 | 0.29 | 0.16 | lasso | 1 | 0.18 | 1.8e-05 | 7.3 | 7.3 | 2.9e-13 | 0.48 | 0.04 | 0.89 | FALSE |
| 4 | GTEx | Testis | ACPL2 | 0.21 | 0.16 | lasso | 7 | 0.16 | 1.4e-07 | 7.2 | -8.5 | 1.7e-17 | -0.68 | 0.21 | 0.70 | FALSE |
| 5 | GTEx | Thyroid | ACPL2 | 0.25 | 0.12 | lasso | 5 | 0.19 | 3.5e-14 | 6.5 | 6.3 | 3.5e-10 | 0.36 | 1.00 | 0.00 | FALSE |
| 6 | NTR | Blood | ACPL2 | 0.07 | 0.07 | lasso | 6 | 0.08 | 7.9e-24 | 7.3 | 8.8 | 1.8e-18 | 0.68 | 0.51 | 0.49 | FALSE |
| 7 | YFS | Blood | ACPL2 | 0.19 | 0.24 | lasso | 8 | 0.29 | 2.2e-96 | 6.8 | 9.3 | 1.7e-20 | 0.69 | 0.90 | 0.10 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ACPL2 | 0.03 | 0.02 | blup | 87 | 0.02 | 7.1e-04 | 6.2 | -8.0 | 9.6e-16 | -0.82 | 0.01 | 0.90 | FALSE |