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chr3:135,273,949-137,368,142

Best TWAS P=2.39e-13 · Best GWAS P=3.89e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NCK1	0.04	0.02	blup	66	0.01	1.0e-02	-7.2	-7.3	2.4e-13	0.95	0.03	0.91	TRUE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCK1	0.01	0.00	blup	66	0.01	1.6e-02	-5.9	7.3	3.7e-13	-0.92	0.03	0.58	FALSE
9	GTEx	Brain Hippocampus	RP11-731C17.2	0.19	0.06	enet	24	0.11	1.8e-03	-6.7	7.2	4.4e-13	-0.84	0.05	0.84	FALSE
12	GTEx	Colon Transverse	RP11-85F14.5	0.07	0.06	lasso	4	0.04	6.3e-03	-7.1	7.2	5.4e-13	-1.00	0.03	0.94	FALSE
2	GTEx	Adipose Subcutaneous	RP11-85F14.5	0.07	0.08	lasso	13	0.07	3.3e-06	-7.2	7.1	9.1e-13	-1.00	0.03	0.97	FALSE
13	GTEx	Esophagus Mucosa	SLC35G2	0.13	0.10	lasso	10	0.09	1.3e-06	-7.1	-7.1	9.5e-13	1.00	0.03	0.97	FALSE
22	GTEx	Testis	SLC35G2	0.17	0.19	lasso	10	0.18	1.5e-08	-7.2	-7.1	1.6e-12	0.96	0.03	0.97	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	RP11-85F14.5	0.23	0.14	lasso	19	0.12	8.4e-05	-7.2	7.0	1.8e-12	-0.99	0.03	0.96	FALSE
16	GTEx	Lung	RP11-85F14.5	0.07	0.05	lasso	19	0.05	8.8e-05	-5.8	7.0	1.8e-12	-0.89	0.04	0.96	FALSE
7	GTEx	Brain Cerebellum	RP11-85F14.5	0.13	0.10	lasso	7	0.07	4.1e-03	-7.1	7.0	2.1e-12	-0.98	0.04	0.94	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP11-731C17.2	0.16	0.02	enet	24	0.09	3.0e-03	-4.9	7.0	2.5e-12	-0.78	0.05	0.76	FALSE
20	GTEx	Stomach	RP11-85F14.5	0.17	0.11	lasso	5	0.08	9.4e-05	-7.1	7.0	2.6e-12	-0.93	0.03	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-85F14.5	0.09	0.07	lasso	3	0.04	2.4e-03	-7.2	6.9	4.1e-12	-0.99	0.03	0.96	FALSE
15	GTEx	Esophagus Muscularis	RP11-85F14.5	0.13	0.09	lasso	4	0.06	8.9e-05	-7.2	6.6	3.2e-11	-0.96	0.03	0.97	FALSE
19	GTEx	Skin Sun Exposed Lower leg	RP11-85F14.5	0.04	0.01	enet	9	0.03	2.8e-03	-7.2	6.5	5.9e-11	-0.93	0.03	0.93	FALSE
8	GTEx	Brain Cortex	RP11-731C17.2	0.11	0.08	lasso	3	0.09	1.6e-03	-6.5	6.5	6.3e-11	-0.95	0.04	0.85	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NCK1	0.05	0.00	blup	357	0.01	1.2e-02	-7.0	6.5	6.9e-11	-0.92	0.03	0.96	FALSE
17	GTEx	Muscle Skeletal	RP11-731C17.2	0.15	0.12	lasso	16	0.12	3.8e-12	-7.1	6.4	1.2e-10	-0.94	0.03	0.97	FALSE
18	GTEx	Pancreas	RP11-731C17.2	0.09	0.03	lasso	2	0.02	6.0e-02	-6.5	-6.4	2.0e-10	0.89	0.04	0.88	FALSE
26	GTEx	Thyroid	RP11-731C17.2	0.06	0.03	enet	6	0.02	1.5e-02	5.5	-6.3	2.8e-10	0.84	0.04	0.90	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL20RB	0.03	0.01	blup	67	0.02	6.3e-05	-7.2	6.3	2.8e-10	-0.87	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PCCB	0.07	0.06	blup	53	0.06	2.1e-04	4.4	6.1	1.3e-09	-0.56	0.16	0.43	FALSE
24	GTEx	Testis	RP11-731C17.2	0.10	0.03	enet	22	0.00	2.5e-01	-7.0	-6.0	1.4e-09	0.81	0.03	0.73	FALSE
27	METSIM	Adipose	PCCB	0.07	0.06	lasso	12	0.06	4.1e-09	5.1	5.9	3.1e-09	-0.54	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM22	0.03	0.01	enet	9	0.01	4.0e-03	-5.8	5.9	3.7e-09	-0.75	0.11	0.26	FALSE
14	GTEx	Esophagus Mucosa	RP11-85F14.5	0.13	0.10	lasso	3	0.11	5.1e-08	-5.8	5.8	5.2e-09	-0.78	0.39	0.61	FALSE
4	GTEx	Adrenal Gland	PCCB	0.17	0.09	lasso	6	0.10	2.1e-04	4.6	5.8	5.8e-09	-0.64	0.24	0.51	FALSE
11	GTEx	Cells Transformed fibroblasts	RP11-85F14.5	0.10	0.08	enet	38	0.09	3.9e-07	-7.3	5.8	5.8e-09	-0.84	0.03	0.97	FALSE
29	YFS	Blood	NCK1	0.01	0.02	enet	4	0.02	2.2e-06	-5.8	5.8	5.8e-09	-0.78	0.58	0.41	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PCCB	0.13	0.02	blup	53	0.02	4.4e-02	1.3	5.8	9.0e-09	-0.63	0.02	0.22	FALSE
25	GTEx	Thyroid	PCCB	0.10	0.09	lasso	6	0.09	1.3e-07	4.9	5.7	1.2e-08	-0.51	0.99	0.00	FALSE
5	GTEx	Artery Tibial	PCCB	0.05	0.02	lasso	5	0.02	1.7e-02	4.8	5.6	1.7e-08	-0.54	0.62	0.20	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	PCCB	0.10	0.07	lasso	4	0.10	4.2e-13	4.6	5.6	1.9e-08	-0.51	1.00	0.00	FALSE
23	GTEx	Testis	RP11-85F14.5	0.12	0.03	enet	28	0.02	3.8e-02	-7.0	5.5	3.2e-08	-0.80	0.03	0.94	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PCCB	0.05	0.03	blup	53	0.03	1.2e-03	4.6	5.4	6.7e-08	-0.50	0.14	0.25	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PCCB	0.12	0.07	enet	3	0.06	1.0e-04	4.9	5.3	9.5e-08	-0.48	0.21	0.49	FALSE
21	GTEx	Testis	PCCB	0.26	0.22	lasso	10	0.22	4.7e-10	4.6	5.3	1.5e-07	-0.46	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	PCCB	0.06	0.05	lasso	2	0.03	1.2e-04	4.6	5.2	2.1e-07	-0.46	0.39	0.49	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	PCCB	0.06	0.03	enet	8	0.03	2.3e-04	4.3	5.2	2.2e-07	-0.43	0.33	0.47	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	PCCB	0.05	0.02	enet	12	0.04	4.0e-09	4.4	5.2	2.3e-07	-0.50	0.58	0.40	FALSE