Best TWAS P=8.2e-10 · Best GWAS P=4.18e-09 conditioned to 0.383
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | RP11-165J3.6 | 0.26 | 0.13 | lasso | 6 | 0.13 | 4.2e-07 | 4.7 | 5.5 | 3.9e-08 | 0.70 | 0.23 | 0.76 | FALSE |
2 | GTEx | Artery Aorta | RP11-165J3.6 | 0.23 | 0.22 | enet | 10 | 0.22 | 2.3e-12 | 5.8 | 5.7 | 9.6e-09 | 0.86 | 0.02 | 0.98 | FALSE |
3 | GTEx | Artery Tibial | RP11-165J3.6 | 0.22 | 0.20 | lasso | 2 | 0.19 | 4.9e-15 | 5.8 | 5.7 | 1.2e-08 | 0.85 | 0.01 | 0.99 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | RP11-165J3.6 | 0.47 | 0.33 | lasso | 7 | 0.31 | 1.0e-09 | 5.8 | 5.4 | 7.5e-08 | 0.83 | 0.01 | 0.99 | FALSE |
5 | GTEx | Brain Cerebellum | RP11-165J3.6 | 0.44 | 0.31 | lasso | 7 | 0.28 | 5.0e-09 | 5.8 | 5.4 | 5.9e-08 | 0.86 | 0.01 | 0.99 | FALSE |
6 | GTEx | Brain Frontal Cortex BA9 | RP11-165J3.6 | 0.41 | 0.14 | lasso | 6 | 0.20 | 6.1e-06 | 5.8 | 5.7 | 1.2e-08 | 0.84 | 0.01 | 0.99 | FALSE |
7 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-165J3.6 | 0.31 | 0.11 | lasso | 6 | 0.16 | 5.4e-05 | 5.8 | 5.7 | 1.4e-08 | 0.79 | 0.01 | 0.93 | FALSE |
8 | GTEx | Breast Mammary Tissue | RP11-165J3.6 | 0.28 | 0.11 | enet | 24 | 0.13 | 2.7e-07 | 5.5 | 5.5 | 4.9e-08 | 0.85 | 0.02 | 0.98 | FALSE |
9 | GTEx | Breast Mammary Tissue (Female) | RP11-165J3.6 | 0.21 | 0.02 | lasso | 3 | 0.00 | 2.3e-01 | 5.5 | 5.7 | 1.4e-08 | 0.88 | 0.03 | 0.68 | FALSE |
10 | GTEx | Colon Sigmoid | RP11-165J3.6 | 0.31 | 0.12 | enet | 17 | 0.16 | 1.8e-06 | 5.7 | 5.2 | 1.5e-07 | 0.83 | 0.01 | 0.98 | FALSE |
11 | GTEx | Colon Transverse | RP11-165J3.6 | 0.37 | 0.20 | lasso | 4 | 0.18 | 3.6e-09 | 5.8 | 6.1 | 8.2e-10 | 0.89 | 0.01 | 0.99 | TRUE |
12 | GTEx | Esophagus Gastroesophageal Junction | RP11-165J3.6 | 0.34 | 0.26 | lasso | 8 | 0.27 | 3.0e-10 | 5.8 | 5.9 | 4.8e-09 | 0.88 | 0.01 | 0.99 | FALSE |
13 | GTEx | Heart Atrial Appendage | RP11-165J3.6 | 0.38 | 0.21 | lasso | 7 | 0.25 | 8.7e-12 | 5.5 | 5.9 | 3.6e-09 | 0.94 | 0.01 | 0.99 | FALSE |
14 | GTEx | Heart Left Ventricle | RP11-165J3.6 | 0.13 | 0.06 | lasso | 5 | 0.05 | 1.9e-03 | 5.8 | 5.3 | 1.2e-07 | 0.82 | 0.02 | 0.96 | FALSE |
15 | GTEx | Lung | RP11-165J3.6 | 0.25 | 0.16 | lasso | 7 | 0.17 | 4.1e-13 | 5.8 | 5.9 | 3.1e-09 | 0.89 | 0.01 | 0.99 | FALSE |
16 | GTEx | Pituitary | RP11-165J3.6 | 0.49 | 0.22 | lasso | 8 | 0.29 | 6.9e-08 | 5.5 | 5.5 | 3.7e-08 | 0.94 | 0.01 | 0.99 | FALSE |
17 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-165J3.6 | 0.27 | 0.14 | lasso | 7 | 0.19 | 1.4e-10 | 5.8 | 5.9 | 3.9e-09 | 0.94 | 0.01 | 0.99 | FALSE |
18 | GTEx | Skin Sun Exposed Lower leg | RP11-165J3.6 | 0.32 | 0.27 | lasso | 5 | 0.35 | 6.8e-30 | 5.5 | 5.9 | 4.7e-09 | 0.96 | 0.01 | 0.99 | FALSE |
19 | GTEx | Thyroid | RP11-165J3.6 | 0.35 | 0.27 | lasso | 3 | 0.29 | 1.2e-22 | 5.8 | 5.8 | 5.2e-09 | 0.86 | 0.01 | 0.99 | FALSE |