Best TWAS P=1.19e-07 · Best GWAS P=1.98e-07 conditioned to 0.274
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | IRAK1BP1 | 0.11 | 0.15 | lasso | 4 | 0.16 | 1.4e-12 | -4.8 | -5.1 | 2.9e-07 | -0.80 | 0.04 | 0.95 | FALSE |
2 | GTEx | Brain Hypothalamus | IRAK1BP1 | 0.21 | 0.16 | enet | 28 | 0.18 | 4.4e-05 | 5.2 | -5.2 | 2.1e-07 | -0.89 | 0.04 | 0.93 | FALSE |
3 | GTEx | Breast Mammary Tissue (Male) | IRAK1BP1 | 0.10 | 0.00 | enet | 2 | 0.00 | 3.9e-01 | 5.2 | -5.2 | 2.2e-07 | -1.00 | 0.04 | 0.46 | FALSE |
4 | GTEx | Colon Transverse | IRAK1BP1 | 0.11 | 0.18 | lasso | 2 | 0.16 | 4.0e-08 | 5.1 | -5.1 | 2.7e-07 | -0.91 | 0.02 | 0.98 | FALSE |
5 | GTEx | Esophagus Muscularis | IRAK1BP1 | 0.17 | 0.22 | lasso | 4 | 0.22 | 1.6e-13 | -4.9 | -5.1 | 2.7e-07 | -0.79 | 0.04 | 0.95 | FALSE |
6 | GTEx | Nerve Tibial | IRAK1BP1 | 0.12 | 0.16 | lasso | 6 | 0.14 | 8.8e-10 | 5.1 | -5.3 | 1.2e-07 | -0.89 | 0.03 | 0.96 | TRUE |
7 | GTEx | Skin Sun Exposed Lower leg | IRAK1BP1 | 0.17 | 0.18 | lasso | 4 | 0.18 | 2.0e-14 | 5.1 | -5.2 | 2.3e-07 | -0.91 | 0.02 | 0.98 | FALSE |
8 | METSIM | Adipose | IRAK1BP1 | 0.15 | 0.17 | lasso | 6 | 0.16 | 1.1e-23 | 5.1 | -5.2 | 2.3e-07 | -0.94 | 0.02 | 0.98 | FALSE |
9 | YFS | Blood | PHIP | 0.05 | 0.07 | lasso | 5 | 0.08 | 1.8e-24 | 5.1 | -5.2 | 1.6e-07 | -0.96 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | IRAK1BP1 | 0.03 | 0.03 | lasso | 4 | 0.02 | 1.2e-03 | 5.1 | -5.2 | 2.5e-07 | -0.90 | 0.02 | 0.80 | FALSE |
11 | The Cancer Genome Atlas | Thyroid Carcinoma | PHIP | 0.11 | 0.08 | blup | 75 | 0.07 | 2.6e-07 | -5.0 | -5.2 | 2.7e-07 | -0.70 | 0.03 | 0.97 | FALSE |