[Hub]/) : Traits : Blood Platelet Count : ← →

chr6:108,994,161-111,190,694

Best TWAS P=2.09e-20 · Best GWAS P=8.52e-38 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	GTEx	Cells Transformed fibroblasts	CD164	0.14	0.07	lasso	6	0.05	1.9e-04	10.404	9.3	2.1e-20	0.83	0.90	0.03	TRUE
11	GTEx	Artery Aorta	AK9	0.16	0.14	enet	32	0.14	3.7e-08	-7.117	-9.0	1.6e-19	-0.35	1.00	0.00	TRUE
4	GTEx	Adipose Subcutaneous	AK9	0.12	0.09	lasso	7	0.10	2.1e-08	6.431	-7.5	6.3e-14	-0.21	0.95	0.00	TRUE
62	GTEx	Spleen	RP11-425D10.10	0.17	0.04	enet	26	0.12	4.7e-04	6.333	7.1	1.1e-12	0.33	0.24	0.18	TRUE
10	GTEx	Artery Aorta	SMPD2	0.10	0.04	enet	11	0.03	1.5e-02	6.333	7.1	1.3e-12	0.13	0.67	0.04	TRUE
2	GTEx	Adipose Subcutaneous	FIG4	0.12	0.08	lasso	4	0.07	4.4e-06	-7.143	-7.1	1.5e-12	-0.32	0.96	0.00	TRUE
40	GTEx	Esophagus Mucosa	SMPD2	0.17	0.20	lasso	10	0.22	2.2e-14	6.550	6.6	4.9e-11	0.14	1.00	0.00	TRUE
106	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMPD2	0.10	0.04	lasso	2	0.07	1.2e-03	5.915	6.2	5.9e-10	0.26	0.02	0.59	TRUE
50	GTEx	Muscle Skeletal	WASF1	0.11	0.04	enet	22	0.05	7.8e-06	4.275	-5.4	6.0e-08	0.08	0.92	0.00	TRUE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AKD1	0.07	0.06	blup	116	0.06	4.2e-07	6.348	-5.1	3.0e-07	-0.06	0.56	0.44	TRUE
76	ROSMAP	Brain Pre-frontal Cortex	CD164	0.07	0.01	enet	16	0.05	1.6e-07	6.012	-9.2	2.3e-20	-0.45	0.72	0.15	FALSE
3	GTEx	Adipose Subcutaneous	SMPD2	0.14	0.10	lasso	10	0.12	2.3e-10	5.832	9.2	3.3e-20	0.46	0.97	0.03	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	CD164	0.03	0.01	blup	49	0.01	2.1e-02	5.832	9.0	1.8e-19	0.44	0.08	0.15	FALSE
79	YFS	Blood	CD164	0.03	0.01	blup	382	0.02	1.9e-07	-7.326	9.0	3.4e-19	0.57	0.97	0.02	FALSE
86	The Cancer Genome Atlas	Esophageal Carcinoma	C6orf182	0.10	-0.01	blup	40	0.03	4.2e-02	10.172	8.8	2.1e-18	0.58	0.01	0.79	FALSE
21	GTEx	Brain Cortex	AK9	0.21	0.03	enet	29	0.16	3.2e-05	6.640	-8.3	6.9e-17	-0.32	0.57	0.08	FALSE
52	GTEx	Muscle Skeletal	AK9	0.08	0.02	lasso	6	0.03	4.3e-04	-7.353	-8.1	4.8e-16	-0.26	0.86	0.03	FALSE
74	NTR	Blood	CD164	0.01	0.00	bslmm	372	0.00	2.0e-02	-3.706	8.1	5.6e-16	0.58	0.08	0.62	FALSE
54	GTEx	Nerve Tibial	AK9	0.18	0.15	enet	26	0.18	1.5e-12	6.431	-8.1	7.6e-16	-0.23	1.00	0.00	FALSE
63	GTEx	Stomach	SMPD2	0.14	-0.01	lasso	5	-0.01	8.6e-01	5.303	8.0	1.0e-15	0.46	0.06	0.20	FALSE
14	GTEx	Artery Coronary	AK9	0.27	0.26	enet	18	0.28	5.2e-10	-7.354	-8.0	1.4e-15	-0.26	1.00	0.00	FALSE
51	GTEx	Muscle Skeletal	CD164	0.07	0.07	enet	15	0.06	3.7e-06	-7.326	-8.0	1.9e-15	-0.67	0.98	0.01	FALSE
60	GTEx	Skin Sun Exposed Lower leg	RP11-425D10.10	0.19	0.23	enet	18	0.23	3.4e-19	6.309	7.9	2.5e-15	0.24	1.00	0.00	FALSE
49	GTEx	Lung	RP11-425D10.10	0.10	0.08	enet	24	0.07	6.4e-06	6.632	7.8	4.9e-15	0.18	0.99	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CD164	0.11	0.07	blup	376	0.10	1.6e-12	5.915	-7.6	3.5e-14	-0.40	1.00	0.00	FALSE
44	GTEx	Esophagus Muscularis	AK9	0.41	0.22	enet	60	0.29	5.7e-18	6.309	-7.5	7.9e-14	-0.25	1.00	0.00	FALSE
72	METSIM	Adipose	AK9	0.05	0.03	lasso	6	0.02	1.0e-04	6.333	-7.5	8.2e-14	-0.19	0.97	0.00	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	AKD1	0.05	0.03	blup	122	0.04	1.3e-05	7.452	-7.4	1.1e-13	-0.22	0.06	0.94	FALSE
41	GTEx	Esophagus Mucosa	AK9	0.11	0.06	lasso	13	0.04	6.0e-04	6.640	-7.3	2.4e-13	-0.21	0.84	0.01	FALSE
32	GTEx	Cells Transformed fibroblasts	AK9	0.14	0.17	lasso	4	0.15	2.4e-11	-7.209	-7.2	4.2e-13	-0.32	1.00	0.00	FALSE
45	GTEx	Heart Atrial Appendage	RP11-425D10.10	0.12	0.11	lasso	5	0.07	4.0e-04	6.431	7.2	5.1e-13	0.19	0.71	0.02	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKD1	0.12	0.11	lasso	6	0.12	9.8e-14	6.640	-7.0	2.0e-12	-0.15	0.62	0.38	FALSE
87	The Cancer Genome Atlas	Esophageal Carcinoma	SMPD2	0.12	0.09	blup	41	0.07	2.6e-03	6.523	7.0	3.7e-12	0.14	0.05	0.60	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	ZBTB24	0.03	0.00	blup	389	0.00	7.3e-02	6.333	-6.9	4.0e-12	-0.20	0.32	0.02	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB24	0.04	0.05	lasso	4	0.04	7.8e-06	6.583	-6.9	5.3e-12	-0.12	0.01	0.99	FALSE
43	GTEx	Esophagus Muscularis	CD164	0.04	0.02	enet	6	0.01	1.0e-01	6.222	6.9	6.7e-12	0.12	0.26	0.03	FALSE
28	GTEx	Breast Mammary Tissue (Female)	RP11-425D10.10	0.14	0.04	lasso	10	0.02	6.5e-02	6.577	6.9	6.8e-12	0.16	0.06	0.07	FALSE
69	GTEx	Vagina	RP11-425D10.10	0.42	0.22	lasso	19	0.17	9.0e-05	6.431	6.8	1.2e-11	0.13	0.53	0.03	FALSE
84	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMPD2	0.07	0.08	blup	45	0.07	2.3e-04	5.754	6.8	1.4e-11	0.20	0.07	0.84	FALSE
109	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMPD2	0.07	0.07	blup	44	0.08	3.4e-06	6.583	6.7	2.3e-11	0.17	0.03	0.97	FALSE
71	GTEx	Whole Blood	RP11-425D10.10	0.04	0.03	enet	16	0.03	6.2e-04	6.141	6.7	2.6e-11	0.15	0.74	0.05	FALSE
93	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKD1	0.11	0.06	lasso	3	0.06	2.7e-04	6.632	-6.6	3.2e-11	-0.15	0.67	0.30	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-425D10.10	0.16	0.10	lasso	6	0.06	7.2e-04	6.431	6.6	3.4e-11	0.10	0.63	0.04	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	AK9	0.08	0.06	bslmm	456	0.06	5.3e-08	6.306	-6.6	4.3e-11	-0.22	1.00	0.00	FALSE
18	GTEx	Artery Tibial	AK9	0.13	0.12	enet	18	0.13	3.5e-10	6.309	-6.6	4.8e-11	-0.12	1.00	0.00	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	AK9	0.19	0.10	enet	25	0.13	1.7e-05	-7.342	-6.6	4.9e-11	-0.25	0.86	0.01	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMPD2	0.04	0.06	blup	45	0.06	8.9e-08	5.912	6.6	5.3e-11	0.20	0.46	0.54	FALSE
65	GTEx	Testis	ZBTB24	0.11	0.11	lasso	4	0.10	4.9e-05	6.431	-6.6	5.5e-11	-0.17	0.72	0.02	FALSE
42	GTEx	Esophagus Mucosa	RP11-425D10.10	0.09	0.13	lasso	5	0.12	1.1e-08	6.431	6.5	6.4e-11	0.11	1.00	0.00	FALSE
26	GTEx	Breast Mammary Tissue (Male)	AK9	0.10	0.03	lasso	3	-0.01	5.4e-01	6.333	-6.5	7.1e-11	-0.11	0.06	0.06	FALSE
58	GTEx	Skin Sun Exposed Lower leg	SMPD2	0.19	0.19	lasso	12	0.24	1.6e-19	6.622	6.5	7.9e-11	0.14	1.00	0.00	FALSE
17	GTEx	Artery Tibial	MICAL1	0.08	0.02	lasso	3	0.01	6.5e-02	6.549	6.5	8.3e-11	0.10	0.42	0.06	FALSE
33	GTEx	Colon Sigmoid	FIG4	0.17	0.11	lasso	9	0.03	3.7e-02	6.484	-6.5	9.8e-11	-0.10	0.25	0.04	FALSE
37	GTEx	Colon Transverse	RP11-425D10.10	0.12	0.13	enet	21	0.14	2.2e-07	6.567	6.5	1.0e-10	0.12	1.00	0.00	FALSE
61	GTEx	Small Intestine Terminal Ileum	RP11-425D10.10	0.16	0.07	lasso	9	0.06	1.5e-02	6.554	6.5	1.1e-10	0.19	0.11	0.06	FALSE
67	GTEx	Testis	MICAL1	0.28	0.02	enet	25	0.02	4.2e-02	2.649	6.4	1.2e-10	0.22	0.16	0.04	FALSE
25	GTEx	Breast Mammary Tissue	RP11-425D10.10	0.12	0.12	lasso	1	0.08	5.1e-05	6.431	6.4	1.3e-10	0.10	0.94	0.00	FALSE
27	GTEx	Breast Mammary Tissue (Female)	AK9	0.12	0.15	lasso	1	0.12	1.9e-04	6.431	-6.4	1.3e-10	-0.10	0.15	0.05	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	RP11-425D10.10	0.20	0.27	lasso	5	0.27	5.5e-15	6.309	6.4	1.5e-10	0.12	1.00	0.00	FALSE
19	GTEx	Brain Caudate basal ganglia	AK9	0.20	0.16	enet	16	0.17	1.1e-05	6.640	-6.4	1.8e-10	-0.19	0.69	0.02	FALSE
55	GTEx	Ovary	RP11-425D10.10	0.15	0.10	lasso	5	0.02	9.0e-02	6.431	6.4	1.9e-10	0.10	0.22	0.06	FALSE
22	GTEx	Brain Frontal Cortex BA9	AK9	0.50	0.02	enet	47	0.15	1.1e-04	6.431	-6.3	2.9e-10	-0.20	0.25	0.04	FALSE
20	GTEx	Brain Cerebellar Hemisphere	AK9	0.24	0.17	lasso	3	0.11	1.0e-03	6.431	-6.3	3.2e-10	-0.10	0.33	0.05	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FIG4	0.07	0.02	lasso	2	0.04	5.5e-05	-7.353	-6.2	4.3e-10	-0.20	0.00	0.98	FALSE
59	GTEx	Skin Sun Exposed Lower leg	AK9	0.14	0.12	lasso	3	0.14	1.9e-11	6.431	-6.2	4.5e-10	-0.08	1.00	0.00	FALSE
73	METSIM	Adipose	SMPD2	0.06	0.08	enet	14	0.08	2.0e-12	5.754	6.2	4.6e-10	0.20	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SMPD2	0.04	0.04	blup	43	0.05	3.9e-05	6.567	6.2	7.1e-10	0.10	0.07	0.88	FALSE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMPD2	0.05	0.07	lasso	4	0.06	9.6e-08	5.915	6.1	8.7e-10	0.23	0.45	0.55	FALSE
13	GTEx	Artery Coronary	SMPD2	0.11	0.09	lasso	4	0.07	1.9e-03	5.806	6.1	9.5e-10	0.24	0.36	0.04	FALSE
98	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PPIL6	0.07	0.03	blup	53	0.02	5.8e-02	5.827	-6.1	1.0e-09	-0.16	0.03	0.21	FALSE
46	GTEx	Heart Left Ventricle	AK9	0.17	0.04	enet	11	0.13	2.3e-07	6.651	-6.1	1.3e-09	0.02	0.94	0.00	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	SMPD2	0.11	0.06	lasso	6	0.06	4.1e-03	5.806	6.0	1.6e-09	0.25	0.36	0.04	FALSE
23	GTEx	Brain Nucleus accumbens basal ganglia	AK9	0.28	0.02	enet	22	0.09	1.8e-03	6.640	-6.0	1.9e-09	-0.18	0.23	0.09	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	SMPD2	0.17	0.14	lasso	4	0.14	2.3e-08	5.915	6.0	2.5e-09	0.24	0.61	0.38	FALSE
35	GTEx	Colon Transverse	SMPD2	0.19	0.25	lasso	5	0.24	1.1e-11	5.827	5.9	2.8e-09	0.20	1.00	0.00	FALSE
80	YFS	Blood	SMPD2	0.06	0.08	lasso	7	0.08	2.5e-24	5.832	5.9	2.9e-09	0.19	1.00	0.00	FALSE
53	GTEx	Nerve Tibial	SMPD2	0.12	0.08	lasso	4	0.08	3.6e-06	5.639	5.9	3.0e-09	0.24	0.96	0.00	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	MICAL1	0.08	0.11	lasso	4	0.12	1.8e-13	5.915	-5.9	3.7e-09	-0.23	0.97	0.03	FALSE
8	GTEx	Adrenal Gland	WASF1	0.22	-0.01	enet	20	0.03	2.2e-02	2.443	-5.9	3.9e-09	-0.10	0.06	0.43	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMPD2	0.04	0.07	lasso	4	0.07	8.8e-14	5.754	5.9	3.9e-09	0.19	0.81	0.19	FALSE
108	The Cancer Genome Atlas	Rectum Adenocarcinoma	SMPD2	0.13	0.08	lasso	2	0.06	1.5e-02	5.827	5.8	5.6e-09	0.18	0.01	0.49	FALSE
48	GTEx	Lung	SMPD2	0.10	0.12	lasso	2	0.10	7.5e-08	5.827	5.8	5.9e-09	0.18	1.00	0.00	FALSE
105	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMPD2	0.08	0.07	lasso	3	0.05	3.3e-03	5.827	5.8	6.0e-09	0.18	0.04	0.81	FALSE
6	GTEx	Adipose Visceral Omentum	AK9	0.10	0.02	enet	27	0.04	2.7e-03	6.141	-5.8	6.4e-09	-0.11	0.76	0.01	FALSE
15	GTEx	Artery Coronary	RP11-425D10.10	0.31	0.00	enet	20	0.01	1.3e-01	-1.830	5.8	6.4e-09	0.34	0.04	0.05	FALSE
94	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMPD2	0.12	0.15	enet	6	0.14	3.8e-08	5.754	5.8	6.8e-09	0.19	0.95	0.05	FALSE
110	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SMPD2	0.23	0.13	lasso	5	0.17	1.4e-06	6.309	5.8	6.8e-09	0.10	0.02	0.98	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMPD2	0.08	0.13	lasso	3	0.13	2.4e-13	5.754	5.8	7.7e-09	0.18	0.98	0.02	FALSE
16	GTEx	Artery Tibial	FIG4	0.18	0.01	enet	41	0.07	4.1e-06	0.096	-5.8	7.8e-09	-0.23	0.27	0.27	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	SMPD2	0.15	0.17	enet	14	0.18	9.4e-18	5.754	5.7	9.3e-09	0.21	0.98	0.02	FALSE
5	GTEx	Adipose Subcutaneous	RP11-425D10.10	0.10	0.08	enet	22	0.07	4.4e-06	6.431	5.7	9.8e-09	0.07	0.95	0.00	FALSE
64	GTEx	Stomach	RP11-425D10.10	0.25	0.10	lasso	6	0.09	3.0e-05	6.012	5.7	1.1e-08	0.16	0.90	0.00	FALSE
34	GTEx	Colon Sigmoid	RP11-425D10.10	0.13	0.00	enet	14	0.02	5.2e-02	6.640	5.7	1.2e-08	0.01	0.41	0.03	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	SMPD2	0.27	0.15	lasso	10	0.17	1.6e-09	6.431	5.7	1.2e-08	0.10	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AKD1	0.08	0.06	blup	114	0.05	4.7e-05	6.635	-5.7	1.4e-08	-0.10	0.28	0.71	FALSE
31	GTEx	Cells Transformed fibroblasts	SMPD2	0.20	0.13	lasso	9	0.15	3.1e-11	5.827	5.6	1.7e-08	0.12	1.00	0.00	FALSE
47	GTEx	Heart Left Ventricle	RP11-425D10.10	0.13	0.04	enet	34	0.03	9.2e-03	6.333	5.6	1.7e-08	0.01	0.37	0.03	FALSE
9	GTEx	Adrenal Gland	RP11-425D10.10	0.11	0.00	enet	11	0.02	4.9e-02	5.566	5.6	2.4e-08	0.23	0.15	0.33	FALSE
12	GTEx	Artery Aorta	RP11-425D10.10	0.12	0.06	lasso	4	0.09	1.4e-05	6.431	5.6	2.5e-08	-0.01	0.90	0.00	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKD1	0.11	0.08	lasso	5	0.10	5.8e-11	6.583	-5.5	3.2e-08	-0.04	0.15	0.85	FALSE
104	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SMPD2	0.06	0.05	lasso	3	0.06	9.2e-05	5.827	5.5	3.9e-08	0.22	0.47	0.33	FALSE
89	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMPD2	0.09	0.09	blup	42	0.10	2.1e-11	6.012	5.4	7.7e-08	0.20	0.88	0.12	FALSE
70	GTEx	Whole Blood	SMPD2	0.15	0.16	lasso	8	0.15	1.0e-13	5.827	5.3	9.8e-08	0.12	1.00	0.00	FALSE
68	GTEx	Thyroid	PPIL6	0.17	0.05	lasso	4	0.12	4.4e-09	6.551	-5.3	1.0e-07	0.01	0.98	0.00	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AKD1	0.04	0.03	blup	114	0.03	4.7e-03	6.648	-5.3	1.0e-07	-0.07	0.13	0.18	FALSE
36	GTEx	Colon Transverse	AK9	0.26	0.12	enet	46	0.12	2.6e-06	6.431	-5.3	1.4e-07	0.05	0.97	0.00	FALSE
101	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AKD1	0.06	0.07	lasso	4	0.05	2.8e-06	6.222	-5.2	1.5e-07	-0.02	0.72	0.27	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	SMPD2	0.12	0.10	lasso	5	0.09	1.3e-11	5.832	5.2	2.3e-07	0.20	1.00	0.00	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	SMPD2	0.06	0.09	enet	11	0.08	4.7e-10	5.754	5.2	2.3e-07	0.13	0.94	0.06	FALSE
24	GTEx	Breast Mammary Tissue	AK9	0.17	0.13	enet	19	0.13	4.0e-07	6.431	-5.2	2.5e-07	-0.02	0.99	0.00	FALSE
66	GTEx	Testis	SMPD2	0.28	0.18	lasso	7	0.17	7.6e-08	5.827	5.2	2.5e-07	0.13	0.98	0.01	FALSE
29	GTEx	Cells Transformed fibroblasts	WASF1	0.11	0.03	lasso	5	0.02	6.0e-03	4.217	-5.1	2.7e-07	0.09	0.60	0.03	FALSE