Best TWAS P=1.44e-21 · Best GWAS P=1.42e-19 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | -9.0 | -9.1 | 7.6e-20 | 0.90 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | -9.0 | -9.0 | 3.2e-19 | 0.98 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | NSUN5 | 0.07 | 0.03 | enet | 11 | 0.04 | 4.0e-03 | -8.5 | -6.2 | 4.5e-10 | 0.69 | 0.01 | 0.84 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | -8.8 | -9.3 | 9.0e-21 | 0.90 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Heart Left Ventricle | MLXIPL | 0.14 | 0.00 | enet | 24 | 0.01 | 1.3e-01 | -2.4 | -6.0 | 2.0e-09 | 0.57 | 0.06 | 0.67 | FALSE |
| 6 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | -9.0 | -7.6 | 3.9e-14 | 0.65 | 0.01 | 0.98 | TRUE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | -8.8 | -8.4 | 4.0e-17 | 0.93 | 0.01 | 0.98 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | -8.7 | -9.2 | 4.8e-20 | 0.94 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | -8.1 | 9.5 | 1.4e-21 | -0.69 | 0.02 | 0.60 | TRUE |
| 10 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | -5.2 | -7.6 | 2.4e-14 | 0.63 | 0.02 | 0.64 | FALSE |
| 11 | GTEx | Testis | VPS37D | 0.15 | 0.01 | lasso | 5 | 0.03 | 2.7e-02 | 5.4 | 5.7 | 1.6e-08 | -0.24 | 0.13 | 0.05 | TRUE |
| 12 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | -9.0 | -9.3 | 1.3e-20 | 0.91 | 0.01 | 0.99 | FALSE |
| 13 | METSIM | Adipose | ABHD11 | 0.08 | 0.08 | enet | 22 | 0.09 | 2.5e-13 | 4.9 | -5.8 | 5.9e-09 | -0.02 | 1.00 | 0.00 | TRUE |
| 14 | METSIM | Adipose | BCL7B | 0.10 | 0.02 | enet | 20 | 0.05 | 1.2e-07 | -9.0 | -5.9 | 3.6e-09 | 0.72 | 0.01 | 0.99 | TRUE |
| 15 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | -8.5 | -9.0 | 1.9e-19 | 0.83 | 0.03 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | STX1A | 0.03 | 0.02 | lasso | 1 | 0.01 | 2.9e-02 | 5.5 | 5.5 | 3.1e-08 | -0.21 | 0.00 | 0.79 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | -8.5 | -8.1 | 5.9e-16 | 0.74 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | -8.5 | -8.5 | 2.5e-17 | 0.74 | 0.00 | 0.91 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | -8.5 | -7.3 | 3.1e-13 | 0.68 | 0.00 | 0.98 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | BCL7B | 0.05 | 0.01 | blup | 5 | 0.03 | 1.3e-03 | -8.5 | 7.2 | 6.1e-13 | -0.44 | 0.00 | 0.63 | FALSE |