TWAS hub - VPS37D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.116	0.044	0.0010	0.095	NA	0.065	NA	0.083	3.7e-08	NA	4.7e-06	NA	2.7e-07
2	GTEx	Testis	0.145	0.065	0.0041	0.007	NA	0.006	NA	0.025	1.4e-01	NA	1.6e-01	NA	2.7e-02
3	TCGA	Liver Hepatocellular Carcinoma	0.182	0.089	0.0009	0.050	0.047	0.061	NA	0.033	2.2e-03	0.003	7.9e-04	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Triglycerides	6.2	10.2	16.3	-3.8	4.0	0.0
Eye problems/disorders: Glaucoma	5.7	6.8	12.1	-3.5	1.9	2.1
Hearing difficulty/problems with background noise	5.2	8.4	18.3	0.8	-4.3	-2.5
Hearing difficulty/problems: Yes	4.9	7.5	16.2	1.6	-4.0	-1.9
Mean time to correctly identify matches	4.5	8.6	13.2	-0.2	-3.6	-3.5
Bilateral oophorectomy (both ovaries removed)	4.4	5.0	6.0	2.3	-2.0	-2.4
Heart attack	4.3	5.5	10.8	-0.9	-2.2	-3.3
Chest pain or discomfort	4.3	6.2	9.0	2.1	-3.0	-2.3
Heart attack/myocardial infarction (self-reported)	3.8	4.9	9.7	-1.0	-2.0	-3.1
Ever unenthusiastic/disinterested for a whole week	3.7	4.5	8.5	0.4	-2.2	-2.9
Myopia	3.6	5.2	8.2	-1.0	2.9	2.5
Reaction Time	3.4	6.5	9.9	0.1	-3.1	-3.1
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.3	10.2	3.2	-1.4	-1.9
Glaucoma (self-reported)	3.1	3.7	6.6	-2.6	1.2	1.7
Health satisfaction	3.1	4.0	4.5	2.1	-1.9	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	7.5	2.7	-1.5	-0.8
Supplements: Vitamin C	2.8	3.3	4.4	-1.2	-2.0	-2.1
Illnesses of father: None of the above (group 1)	2.7	3.3	7.3	2.7	1.5	0.7
Waist Hip Ratio (WHR)	2.6	11.9	21.0	-4.6	-0.1	-3.8
Supplements: Zinc	2.6	2.8	7.2	-2.7	-1.1	-0.4
Medication for pain relief, constipation, heartburn	2.6	4.5	8.7	0.0	2.2	3.0
Trunk fat-free mass	2.5	14.3	38.7	-0.4	-6.2	-2.0
Trunk predicted mass	2.5	14.2	38.7	-0.3	-6.2	-2.0
Emphysema/chronic bronchitis	2.4	2.7	2.9	1.6	-1.6	-1.7
Neuroticism (2016)	2.3	3.3	5.3	2.3	2.0	0.7
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	5.6	-0.4	-2.4	-1.2
Supplements: Calcium	2.3	2.5	3.5	-1.9	-1.3	-1.5
Medication for hormone replacement therapy	2.2	2.4	2.9	1.7	-1.6	-1.3
Arm predicted mass (right)	2.2	11.3	31.4	-0.9	-5.6	-1.3
Nervous feelings	2.1	3.9	6.4	1.4	1.8	2.5
Qualifications: College or University degree	2.1	6.6	7.1	-2.7	2.6	2.4
Supplements: Glucosamine	2.0	2.6	6.0	-2.5	1.3	0.3
Pulse rate	2.0	3.3	8.3	-0.8	2.9	1.0
Arm fat-free mass (right)	2.0	10.2	28.8	-0.8	-5.4	-1.1
Pulse wave peak to peak time	2.0	2.3	5.1	2.3	-0.7	-1.2
Comparative height size at age 10	2.0	11.3	23.8	2.1	-4.9	-2.4
Mineral and other dietary supplements	2.0	2.8	7.3	2.7	-0.9	0.4
Arm fat-free mass (left)	2.0	9.9	27.7	-0.5	-5.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	5.1	0.4	-2.3	-1.5
Arm predicted mass (left)	2.0	9.9	27.9	-0.5	-5.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	5.4	2.3	-1.0	-1.2
Breastfed as a baby	1.9	2.4	3.8	-1.3	2.0	1.2
Birth weight of first child	1.9	3.4	10.0	3.2	-0.1	0.5
Number of children fathered	1.9	2.1	2.9	-1.0	-1.7	-1.6
Whole body water mass	1.9	10.7	30.1	-0.7	-5.5	-1.3
Supplements: Fish oil (including cod liver oil)	1.9	2.4	4.7	-2.2	1.6	0.0
Number of treatments/medications taken	1.8	3.3	6.6	-0.8	-1.6	-2.6
Whole body fat-free mass	1.8	10.6	29.6	-0.7	-5.4	-1.3
Hair/balding pattern: Pattern 2	1.7	2.1	5.1	-0.4	-1.1	-2.3
Pulse wave Arterial Stiffness index	1.7	2.0	4.5	-2.1	0.4	1.1
Medication: Amlodipine	1.7	2.4	6.8	-2.6	-0.5	-0.1
Smoking status: Previous	1.7	2.6	5.0	0.9	-2.2	-1.4
Commuting to job workplace: Public transport	1.7	2.1	3.0	1.1	1.7	1.4
Illnesses of father: High blood pressure	1.7	2.1	2.5	-1.4	1.3	1.6
Number of operations (self-reported)	1.7	2.6	4.6	0.2	-2.1	-1.7
Serious illness, injury or assault to yourself	1.6	2.0	3.1	-1.0	-1.8	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.6	7.2	2.7	-0.2	-0.7
Alcohol intake versus 10 years previously	1.6	2.4	6.6	0.6	2.6	0.5
Worry too long after embarrassment	1.6	2.6	4.1	2.0	-1.4	-1.4
Long-standing illness, disability or infirmity	1.6	2.4	3.1	1.1	-1.8	-1.7
Risk taking	1.6	2.4	3.3	-1.6	1.8	1.1
Smoking Status	1.5	3.7	5.5	1.5	-2.4	-1.8
Lung cancer (father)	1.5	1.7	4.5	2.1	0.2	0.8
Impedance of arm (left)	1.5	7.2	19.8	1.1	4.4	0.7
Loud music exposure frequency	1.5	1.6	2.2	1.5	1.3	0.9
Blood clot in the leg (DVT)	1.5	1.9	4.0	0.1	-2.0	-1.3
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.8	-1.1	1.3	1.7
Pulse rate, automated reading	1.5	4.7	10.3	-1.6	3.2	1.2
Illnesses of father: Heart disease	1.5	2.0	5.9	-2.4	0.3	0.3
Average weekly champagne plus white wine intake	1.5	2.0	4.1	0.6	1.2	2.0
Basal metabolic rate	1.5	8.5	23.9	-0.7	-4.9	-1.0
Worry (Nagel 2018)	1.4	3.1	4.3	2.1	1.6	1.5
Diabetes (mother)	1.4	1.8	3.1	-1.3	-1.8	-0.8
Number of incorrect matches in round	1.4	2.3	3.7	1.4	1.9	1.2
Past tobacco smoking	1.4	2.5	4.8	-0.9	2.2	1.3
Birth weight	1.4	3.1	7.7	2.8	-0.1	1.3
Wheeze or whistling in the chest in last year	1.4	2.5	6.9	2.6	-0.7	0.5
Medication: Omeprazole	1.4	1.7	3.2	0.4	-1.4	-1.8
Number of full sisters	1.4	1.7	2.3	-1.4	-1.0	-1.5
Miserableness	1.4	2.4	4.1	-1.4	2.0	1.0
Diastolic blood pressure, automated reading	1.4	4.2	8.6	-1.6	2.9	1.3
Commuting to job workplace: Cycle	1.4	1.6	3.9	0.9	-2.0	-0.4
Ever had hysterectomy (womb removed)	1.3	1.4	2.5	0.4	-1.3	-1.6
Multivitamins +/- minerals	1.3	1.6	2.5	-1.0	-1.2	-1.6
Prospective memory result	1.3	1.6	2.4	0.3	-1.5	-1.6
Overall health rating	1.3	2.7	7.9	2.8	-0.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	-0.5	-1.5	-1.3
Breast cancer (self-reported)	1.3	1.5	3.8	1.9	-0.7	-0.5
Heart disease (siblings)	1.3	1.6	3.6	-1.9	0.8	0.7
Blood Platelet Count	1.2	13.9	31.9	-2.4	5.7	1.9
Relative age of first facial hair	1.2	2.6	5.1	-0.6	2.3	1.5
Severe depression (siblings)	1.2	1.3	2.0	1.3	0.5	1.4
Sitting height	1.2	8.4	24.0	-0.5	-4.9	-0.9
Impedance of arm (right)	1.2	5.5	14.5	1.4	3.8	0.0
Hair/balding pattern: Pattern 3	1.2	1.8	2.7	0.7	1.7	1.5
Medication: Cholesterol lowering	1.2	1.9	4.5	0.4	-1.0	-2.1
Standing height	1.2	12.3	29.8	-0.5	-5.5	-2.6
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	2.8	-1.7	1.5	1.5
High blood pressure (siblings)	1.2	1.7	2.4	-1.2	1.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.8	1.7	0.3	1.1
Alcohol drinker status: Never	1.2	1.4	1.9	1.4	-0.8	-1.3
Height	1.1	21.5	52.3	1.1	-7.2	-3.3
Lung FEV1/FVC ratio	1.1	5.4	6.6	-2.2	-2.6	-2.2
Qualifications: None of the above	1.1	2.4	2.9	1.7	-1.6	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	5.3	-1.6	-2.3	-1.7
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.4	1.1	0.9	1.9
Gout (self-reported)	1.1	1.5	3.6	0.1	1.9	-0.9
Medication: Allopurinol	1.1	1.5	4.4	-0.1	2.1	-0.3
Number of self-reported non-cancer illnesses	1.1	1.9	3.4	-1.9	-1.0	-1.2
Medication: Bendroflumethiazide	1.1	1.6	2.9	-0.0	1.4	1.7
Unable to work because of sickness or disability	1.1	1.5	2.9	1.7	-1.0	-0.7
Impedance of whole body	1.1	5.7	16.4	0.9	4.1	0.1
Leg fat-free mass (left)	1.0	5.5	15.8	-0.8	-4.0	-0.4
Leg predicted mass (left)	1.0	5.5	15.8	-0.7	-4.0	-0.4
Mouth/teeth dental problems: Dentures	1.0	1.6	4.3	-0.1	-2.1	-0.8
Qualifications: nursing, teaching	1.0	1.6	2.7	-1.6	1.2	0.7
Leg predicted mass (right)	1.0	5.2	14.7	-0.9	-3.8	-0.2
Mother’s age at death	1.0	1.2	3.3	-1.8	-0.0	-0.6
Medication: Blood pressure	1.0	1.8	2.9	-1.7	1.4	0.8
Ever depressed for a whole week	1.0	1.3	1.8	-0.3	-1.3	-1.4
Depression (Nagel 2018)	0.9	1.3	3.2	1.8	-0.7	-0.5
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.9	1.2	-1.4	0.1
Medication: Co-codamol	0.9	1.0	1.8	1.3	-0.5	-1.0
Falls in the last year	0.9	1.2	1.3	1.1	1.1	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.3	-1.0	0.1	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.4	1.9	-0.1	0.8
Pulse wave reflection index	0.9	1.1	1.7	-1.3	-1.2	-0.4
Medication: Seretide 50 evohaler	0.9	1.0	2.8	1.7	-0.2	0.4
Alcohol intake frequency.	0.9	2.0	4.9	-0.6	0.9	-2.2
Family relationship satisfaction	0.9	1.1	1.3	-1.0	-1.1	-1.1
Medication: Aspirin	0.9	1.2	1.9	-1.4	-0.6	-1.2
Leg fat-free mass (right)	0.9	4.9	13.8	-0.9	-3.7	-0.1
Average weekly beer plus cider intake	0.9	1.3	2.0	0.7	-1.4	-1.2
Schizophrenia vs Biploar Disorder	0.8	1.0	3.0	1.7	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.8	-0.8	0.8	2.2
Respiratory disease	0.8	1.7	4.7	2.2	0.0	0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.4	1.6	-0.6	-0.7
Average weekly fortified wine intake	0.8	0.9	2.5	-1.6	-0.0	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	2.9	1.5	0.7	1.7
Medication: Ramipril	0.8	1.0	1.4	0.5	-1.2	-1.2
Worrier / anxious feelings	0.8	1.5	4.1	2.0	-0.5	-0.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.6	1.2	-0.4	-1.0
Forced vital capacity (FVC), Best measure	0.8	3.1	6.8	-0.6	-2.6	-1.5
Medication: Ibuprofen	0.8	1.0	2.3	-0.7	-0.2	-1.5
Suffer from ‘nerves’	0.8	1.2	3.3	1.8	-0.1	0.5
Eye problems/disorders: Cataract	0.8	0.9	1.3	-1.0	-1.1	-0.5
Guilty feelings	0.8	1.3	1.7	1.3	-0.7	-1.3
LDL Cholesterol	0.7	1.1	1.8	-1.4	1.2	0.0
Heel T-Score	0.7	5.4	8.8	3.0	0.9	2.6
Systolic Blood Pressure	0.7	3.3	4.6	-2.1	2.0	1.1
Hypothyroidism (self reported)	0.7	1.6	3.2	-1.8	0.9	0.8
Diabetes (father)	0.7	0.9	1.9	-0.1	-1.4	-0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	-0.8	0.4	1.3
Had other major operations	0.7	0.9	1.8	-0.7	-1.4	-0.6
Pain all over the body in last month	0.7	0.8	2.2	-1.5	0.2	-0.4
Illnesses of siblings	0.7	0.9	1.4	1.0	-0.8	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.4	-1.0	-2.1	-1.3
Shortness of breath walking on level ground	0.7	0.8	2.3	1.5	-0.2	-0.1
Eye problems/disorders: None of the above	0.7	0.8	2.0	1.4	0.6	0.2
Medication: Blood pressure	0.7	1.3	2.0	-1.4	-0.6	-1.2
Angina (self-reported)	0.7	0.9	1.2	0.6	-1.1	-1.0
Migraine (self-reported)	0.7	0.9	1.5	1.0	1.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	-1.6	-0.1	0.1
Knee pain experienced in last month	0.7	1.1	2.6	-1.6	-0.7	-0.2
Illnesses of siblings: Diabetes	0.7	0.9	2.2	-0.6	-1.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	1.9	-0.9	-1.2	-1.4
Loneliness, isolation	0.7	1.0	2.8	-1.7	0.0	-0.5
Back pain experienced in last month	0.7	1.0	2.5	1.6	-0.7	-0.0
Medication: Aspirin	0.7	0.9	1.0	-1.0	-0.8	-1.0
Wears glasses or contact lenses	0.7	0.8	1.2	0.2	-1.1	-1.0
Medication: Atorvastatin	0.7	0.8	1.2	-1.1	1.0	-0.5
Crohns Disease (2017)	0.6	1.2	3.5	0.1	1.9	0.5
Blood White Count	0.6	4.2	9.9	-1.5	3.1	-0.5
Cardiovascular Disease	0.6	2.0	4.0	-2.0	1.2	-0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-1.2	-0.4	-0.8
Angina	0.6	0.8	1.2	0.4	-1.0	-1.1
Vitamin and mineral supplements	0.6	0.8	1.0	1.0	0.7	1.0
Maternal smoking around birth	0.6	0.8	2.3	1.5	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.4	1.9	-0.5	0.7
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.2	0.3	-0.9
Stomach or abdominal pain in last month	0.6	0.7	1.9	1.4	-0.1	-0.6
Medication: Atenolol	0.6	0.8	1.5	-0.6	-0.8	-1.2
Alcohol usually taken with meals	0.6	1.0	1.9	-0.9	1.4	0.6
Medication: Simvastatin	0.6	0.9	1.5	-1.2	-0.4	-1.0
Weight	0.6	3.0	8.8	-0.5	-3.0	0.1
Hip circumference	0.6	2.7	3.8	1.5	-1.4	1.9
Happiness	0.6	0.7	1.5	0.5	1.2	0.5
Illnesses of mother	0.6	0.8	2.1	1.5	-0.3	0.2
Comparative body size at age 10	0.6	1.6	4.0	-2.0	0.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	1.2	0.7	0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.9	1.4	0.0	0.9
Hearing aid user	0.6	0.7	0.8	-0.9	-0.7	-0.9
High cholesterol (Self-reported)	0.6	1.1	1.7	-1.3	0.6	-1.1
Irritability	0.6	1.1	3.2	1.8	0.1	-0.2
Age started oral contraceptive pill	0.6	0.7	1.5	-0.4	0.7	1.2
Neuroticism (Nagel 2018)	0.5	1.3	2.1	1.5	1.2	0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	1.0	0.6	0.6
HbA1C	0.5	0.5	1.0	0.7	-0.0	1.0
Blood Red Count	0.5	4.5	12.4	-3.5	-0.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.0	-0.9	-1.0	0.9
Father’s age at death	0.5	0.7	1.4	-0.5	0.5	1.2
Leg pain on walking	0.5	0.6	1.0	0.9	-0.3	-1.0
Arm fat percentage (left)	0.5	2.1	3.4	0.3	1.7	1.8
Ever taken oral contraceptive pill	0.5	0.5	1.0	-1.0	0.2	0.7
Ever smoked	0.5	0.9	1.5	0.6	-1.2	-0.9
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.8	1.7	0.7	1.0
Basal cell carcinoma (self-reported)	0.5	0.5	1.2	1.1	-0.5	-0.5
Bipolar Disorder or Schizophrenia	0.4	1.1	1.8	-1.3	-0.6	-1.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	-0.1	1.5	0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.2	-0.1	1.1	0.4
Prostate Cancer	0.4	0.5	1.3	-1.1	0.5	-0.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.7	-0.1	-1.3	0.0
Allergy or Eczema	0.4	1.0	2.3	1.5	-0.8	0.4
Neuroticism	0.4	1.0	2.1	1.4	0.8	0.4
Chronotype (morning person)	0.4	1.0	1.5	-1.2	1.0	0.7
Average weekly spirits intake	0.4	0.5	1.2	0.2	-1.1	-0.5
Sensitivity / hurt feelings	0.4	0.7	1.7	-1.3	-0.2	-0.5
Impedance of leg (right)	0.4	2.0	4.4	0.6	2.1	-1.1
Current tobacco smoking	0.4	0.7	1.9	0.1	-1.4	-0.3
Relative age voice broke	0.4	0.7	0.9	-0.6	0.9	0.9
Taking other prescription medications	0.4	0.7	0.9	-0.8	-0.9	-0.7
Age when periods started (menarche)	0.4	0.9	2.6	-1.6	0.2	-0.2
Medication: Levothyroxine sodium	0.4	0.8	1.0	-1.0	1.0	0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	1.0	-0.6	-0.2
High blood pressure (mother)	0.4	0.5	1.5	-0.4	0.0	-1.2
Impedance of leg (left)	0.4	2.2	5.8	0.3	2.4	-0.8
Forced vital capacity (FVC)	0.4	1.7	3.9	-0.0	-2.0	-1.1
Diabetes (self-reported)	0.4	0.6	0.8	-0.9	-0.9	0.4
Arm fat percentage (right)	0.4	1.6	2.4	0.5	1.4	1.6
Asthma	0.4	0.8	2.1	0.5	0.3	1.5
Medication: Lansoprazole	0.4	0.5	1.1	1.1	-0.3	0.3
Exposure to tobacco smoke at home	0.4	0.4	0.9	-0.0	0.9	0.7
Tense / ‘highly strung’	0.4	0.6	1.1	1.1	0.9	0.2
Peak expiratory flow (PEF)	0.4	0.9	1.7	-0.5	-1.3	-0.9
Number of full brothers	0.4	0.5	0.8	-0.9	0.7	0.5
Ever had bowel cancer screening	0.4	0.4	1.2	-1.1	-0.1	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-0.5	1.1	0.5
Cholesterol lowering medication	0.4	0.6	1.3	-1.1	-0.1	-0.8
Bipolar Disorder (2018)	0.3	0.5	1.1	-1.1	-0.6	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.9	-0.7	-0.4	1.4
Schizophrenia (2018)	0.3	0.5	0.8	-0.9	-0.4	-0.8
Irritable Bowel Disease (IBD)	0.3	0.6	1.9	-0.2	1.4	0.1
Mean Putamen Volume	0.3	0.3	0.7	0.4	0.3	0.8
Lupus	0.3	0.4	0.7	0.8	0.7	-0.1
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.1	0.8	-0.7
BMI	0.3	1.5	4.1	0.0	-2.0	0.6
Hand grip strength (left)	0.3	0.7	1.7	0.6	-1.3	-0.0
Systolic blood pressure, automated reading	0.3	0.8	1.9	-1.4	0.5	0.2
Pack years adult smoking proportion	0.3	0.4	0.8	0.9	0.6	-0.1
High blood pressure	0.3	0.8	2.2	-1.5	0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.0	1.0	0.3	1.0
Waist circumference	0.3	1.1	2.5	-0.8	-1.6	-0.3
Allergy	0.3	0.6	1.2	-1.1	0.5	-0.7
Fluid intelligence score	0.3	0.6	1.5	0.4	0.5	1.2
Depression (self-reported)	0.3	0.3	0.4	0.6	-0.5	-0.5
Hair/balding pattern: Pattern 4	0.3	0.7	1.2	-0.1	-1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	0.7	-0.8	0.8	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.5	0.9	-0.2
Headache pain in last month	0.3	0.6	0.7	0.8	0.8	-0.6
Age at last live birth	0.3	0.5	0.7	0.8	-0.8	-0.4
Hypertension (Self-reported)	0.3	0.9	2.2	-1.5	0.6	0.3
Mood swings	0.3	0.6	0.9	1.0	0.8	-0.5
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.7	-1.0	0.2
Friendships satisfaction	0.3	0.3	0.6	0.8	0.6	0.1
Commuting to job workplace: Walk	0.3	0.3	0.3	0.5	0.5	0.5
Asthma (self-reported)	0.3	0.6	1.3	0.7	-0.1	1.2
Osteoporosis (self-reported)	0.3	0.4	0.6	-0.1	-0.8	-0.7
Smoking status: Current	0.3	0.5	1.2	0.2	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	-1.2	-0.7	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	-0.1	0.3	-1.1
Medication: Lisinopril	0.3	0.4	0.8	-0.3	0.9	0.6
Alcohol drinker status: Previous	0.3	0.3	1.0	1.0	-0.2	0.2
Pack years of smoking	0.3	0.4	0.7	0.9	0.6	-0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	0.8	0.2	0.2
Crohns Disease (2012)	0.2	0.4	0.6	-0.8	0.7	0.0
Fasting Glucose	0.2	0.3	0.5	0.7	-0.2	0.4
HDL Cholesterol	0.2	0.4	1.1	-0.2	-1.0	0.0
Rheumatoid Arthritis	0.2	0.3	0.5	-0.7	-0.4	-0.5
Hair Pigment	0.2	5.0	11.0	0.9	3.3	1.8
Medication: Metformin	0.2	0.2	0.4	0.6	-0.3	0.5
Trunk fat percentage	0.2	1.0	1.7	-0.2	1.1	1.3
Hand grip strength (right)	0.2	0.5	1.5	0.4	-1.2	0.1
Body mass index (BMI)	0.2	0.7	1.4	-0.4	-0.7	1.2
Had menopause	0.2	0.3	0.5	-0.1	-0.7	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.6	0.5	-0.8	0.0
Mouth/teeth dental problems	0.2	0.3	0.7	-0.5	0.3	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.3	-0.4	-0.7
Neuroticism score	0.2	0.4	1.0	1.0	0.4	0.0
Number of live births	0.2	0.3	0.6	-0.2	-0.5	0.8
Noisy workplace	0.2	0.3	0.5	0.4	0.7	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.2	-1.1	0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.5	-0.3	0.4
Medication: Paracetamol	0.2	0.3	0.7	-0.6	-0.2	-0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	0.5	0.1
Body fat percentage	0.2	0.9	1.8	-0.2	1.0	1.3
Neck or shoulder pain in last month	0.2	0.4	0.6	0.8	0.2	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	0.0	-0.7	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.6	-0.7	-0.3
Medication: Gliclazide	0.2	0.2	0.3	0.4	-0.6	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.6	0.2	0.4
Medication: Paracetamol	0.2	0.4	0.5	-0.7	-0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.0	-0.5	-0.6
Ulcerative Colitis (UC)	0.1	0.3	0.5	-0.7	0.6	-0.0
Major Depression (MDD)	0.1	0.1	0.2	0.5	0.1	0.0
Breast Cancer	0.1	0.3	0.5	-0.7	0.7	0.1
Ovarian Cancer	0.1	0.1	0.1	0.2	-0.4	-0.2
Age at First Birth	0.1	0.2	0.3	0.1	-0.6	-0.4
Ulcerative Colitis	0.1	0.1	0.2	-0.5	0.0	-0.1
Blood Eosinophil Count	0.1	1.0	2.0	0.9	-1.4	0.4
Lung FVC	0.1	0.6	1.3	0.7	0.3	1.1
Tanning	0.1	1.1	2.8	0.1	-0.8	1.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.5	-0.3	0.1
Fed-up feelings	0.1	0.2	0.2	0.4	0.4	-0.5
Trunk fat mass	0.1	0.3	0.5	-0.3	-0.6	0.7
Arm fat mass (right)	0.1	0.4	0.7	-0.1	-0.8	0.7
Length of working week for main job	0.1	0.1	0.4	0.6	-0.1	0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.2	-0.3	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.6	-0.2	-0.0
Whole body fat mass	0.1	0.4	0.6	-0.0	-0.8	0.8
Leg fat mass (right)	0.1	0.6	1.4	-0.3	-1.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.0	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	0.5	0.2
Average weekly red wine intake	0.1	0.2	0.3	-0.6	-0.4	0.1
Medication for cholesterol	0.1	0.2	0.3	0.5	0.1	0.6
Arm fat mass (left)	0.1	0.4	1.1	-0.1	-0.5	1.0
Financial situation satisfaction	0.1	0.2	0.4	-0.2	-0.6	-0.2
Leg fat percentage (left)	0.1	0.5	1.1	-0.2	0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.0	-0.3	-0.4
Leg fat mass (left)	0.1	0.6	1.0	-0.4	-1.0	0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.2	-0.2	0.0	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Townsend deprivation index at recruitment	0.0	0.1	0.1	0.3	-0.2	0.1
Time employed in main current job	0.0	0.0	0.1	-0.2	-0.3	-0.2
Leg fat percentage (right)	0.0	0.2	0.4	0.0	0.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.2	0.4	-0.0	0.1
Age at first live birth	0.0	0.1	0.1	-0.2	-0.3	-0.3
Heart disease (mother)	0.0	0.0	0.0	0.2	-0.2	0.0
Had major operations	0.0	0.1	0.1	-0.1	0.1	0.4
Osteoarthritis (self-reported)	0.0	0.0	0.0	0.0	0.1	-0.1
Pain experienced in last month	0.0	0.0	0.1	0.3	0.1	-0.2

Hub : Genes

VPS37D

Models

Trait associations