Best TWAS P=1.22e-13 · Best GWAS P=7.78e-13 conditioned to 0.00837
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | TMEM120A | 0.11 | -0.01 | lasso | 6 | 0.00 | 5.0e-01 | 6.4 | -7.0 | 3.0e-12 | -0.69 | 0.06 | 0.59 | FALSE |
| 2 | GTEx | Artery Aorta | POR | 0.09 | 0.09 | lasso | 4 | 0.05 | 1.3e-03 | 5.2 | 5.5 | 3.7e-08 | 0.71 | 0.04 | 0.94 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | MDH2 | 0.20 | 0.11 | lasso | 5 | 0.14 | 1.7e-10 | 5.4 | -5.8 | 9.1e-09 | -0.79 | 0.23 | 0.77 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | POR | 0.26 | 0.17 | lasso | 4 | 0.13 | 1.9e-05 | 5.3 | 6.1 | 9.4e-10 | 0.75 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Esophagus Muscularis | HIP1 | 0.07 | 0.03 | lasso | 3 | 0.00 | 6.6e-01 | 6.5 | 6.6 | 4.5e-11 | 0.79 | 0.07 | 0.67 | FALSE |
| 6 | GTEx | Esophagus Muscularis | POR | 0.15 | 0.10 | lasso | 5 | 0.08 | 2.5e-05 | 5.2 | 5.2 | 1.9e-07 | 0.68 | 0.14 | 0.86 | FALSE |
| 7 | GTEx | Muscle Skeletal | MDH2 | 0.21 | 0.05 | enet | 29 | 0.08 | 4.5e-08 | 5.4 | -5.5 | 5.1e-08 | -0.72 | 0.37 | 0.62 | FALSE |
| 8 | GTEx | Nerve Tibial | MDH2 | 0.05 | 0.00 | lasso | 4 | 0.00 | 5.8e-01 | 5.4 | -6.2 | 5.0e-10 | -0.74 | 0.04 | 0.74 | FALSE |
| 9 | GTEx | Pancreas | POR | 0.20 | 0.07 | lasso | 4 | 0.03 | 1.4e-02 | 5.4 | 5.2 | 2.5e-07 | 0.61 | 0.06 | 0.42 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | POR | 0.06 | 0.02 | lasso | 3 | 0.02 | 4.8e-03 | 5.3 | 6.1 | 1.0e-09 | 0.65 | 0.02 | 0.93 | FALSE |
| 11 | GTEx | Testis | MDH2 | 0.14 | 0.07 | lasso | 3 | 0.05 | 3.6e-03 | 5.3 | -6.1 | 1.3e-09 | -0.75 | 0.02 | 0.91 | FALSE |
| 12 | GTEx | Thyroid | POR | 0.07 | 0.00 | enet | 15 | 0.01 | 2.5e-02 | 5.4 | 5.2 | 2.6e-07 | 0.42 | 0.06 | 0.28 | FALSE |
| 13 | GTEx | Thyroid | TMEM120A | 0.08 | 0.01 | enet | 12 | 0.02 | 1.3e-02 | 5.4 | 5.3 | 1.1e-07 | 0.49 | 0.12 | 0.13 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | POR | 0.13 | 0.02 | lasso | 3 | 0.09 | 4.1e-11 | 2.0 | 6.0 | 2.2e-09 | 0.38 | 0.04 | 0.95 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | TMEM120A | 0.05 | 0.01 | bslmm | 102 | 0.02 | 1.4e-03 | 6.7 | -5.1 | 2.7e-07 | -0.64 | 0.01 | 0.98 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | AC005077.14 | 0.04 | 0.04 | lasso | 7 | 0.04 | 6.9e-06 | 6.4 | 6.2 | 7.1e-10 | 0.81 | 0.01 | 0.99 | FALSE |
| 17 | YFS | Blood | MDH2 | 0.01 | 0.00 | enet | 4 | 0.01 | 3.1e-03 | 7.2 | -6.8 | 7.3e-12 | -0.99 | 0.00 | 0.99 | FALSE |
| 18 | YFS | Blood | POR | 0.15 | 0.12 | enet | 19 | 0.17 | 2.8e-53 | 5.2 | 7.4 | 1.2e-13 | 0.72 | 0.96 | 0.04 | TRUE |
| 19 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MDH2 | 0.09 | 0.00 | blup | 14 | 0.00 | 3.4e-01 | 6.7 | -6.2 | 7.6e-10 | -0.80 | 0.00 | 0.38 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MDH2 | 0.03 | 0.03 | enet | 5 | 0.02 | 9.7e-04 | 6.7 | -6.5 | 9.9e-11 | -0.87 | 0.00 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | MDH2 | 0.03 | 0.04 | lasso | 4 | 0.04 | 2.2e-05 | 6.7 | -6.7 | 2.5e-11 | -0.88 | 0.01 | 0.99 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MDH2 | 0.02 | 0.03 | lasso | 2 | 0.03 | 8.4e-04 | 6.7 | -6.7 | 2.7e-11 | -0.89 | 0.00 | 0.91 | FALSE |
| 23 | The Cancer Genome Atlas | Soft Tissue Sarcoma | MDH2 | 0.03 | 0.04 | lasso | 3 | 0.04 | 2.8e-03 | 6.3 | -6.3 | 3.6e-10 | -0.80 | 0.01 | 0.70 | FALSE |
| 24 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | MDH2 | 0.11 | 0.10 | lasso | 1 | 0.09 | 1.6e-03 | 6.7 | -6.7 | 2.5e-11 | -0.89 | 0.00 | 0.70 | FALSE |