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chr7:75,059,331-76,390,970

Best TWAS P=1.22e-13 · Best GWAS P=7.78e-13 conditioned to 0.00837

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	YFS	Blood	POR	0.15	0.12	enet	19	0.17	2.8e-53	5.2	7.4	1.2e-13	0.72	0.96	0.04	TRUE
1	GTEx	Adrenal Gland	TMEM120A	0.11	-0.01	lasso	6	0.00	5.0e-01	6.4	-7.0	3.0e-12	-0.69	0.06	0.59	FALSE
17	YFS	Blood	MDH2	0.01	0.00	enet	4	0.01	3.1e-03	7.2	-6.8	7.3e-12	-0.99	0.00	0.99	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	MDH2	0.03	0.04	lasso	4	0.04	2.2e-05	6.7	-6.7	2.5e-11	-0.88	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MDH2	0.11	0.10	lasso	1	0.09	1.6e-03	6.7	-6.7	2.5e-11	-0.89	0.00	0.70	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	MDH2	0.02	0.03	lasso	2	0.03	8.4e-04	6.7	-6.7	2.7e-11	-0.89	0.00	0.91	FALSE
5	GTEx	Esophagus Muscularis	HIP1	0.07	0.03	lasso	3	0.00	6.6e-01	6.5	6.6	4.5e-11	0.79	0.07	0.67	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MDH2	0.03	0.03	enet	5	0.02	9.7e-04	6.7	-6.5	9.9e-11	-0.87	0.00	0.96	FALSE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	MDH2	0.03	0.04	lasso	3	0.04	2.8e-03	6.3	-6.3	3.6e-10	-0.80	0.01	0.70	FALSE
8	GTEx	Nerve Tibial	MDH2	0.05	0.00	lasso	4	0.00	5.8e-01	5.4	-6.2	5.0e-10	-0.74	0.04	0.74	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	AC005077.14	0.04	0.04	lasso	7	0.04	6.9e-06	6.4	6.2	7.1e-10	0.81	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MDH2	0.09	0.00	blup	14	0.00	3.4e-01	6.7	-6.2	7.6e-10	-0.80	0.00	0.38	FALSE
4	GTEx	Esophagus Gastroesophageal Junction	POR	0.26	0.17	lasso	4	0.13	1.9e-05	5.3	6.1	9.4e-10	0.75	0.03	0.96	FALSE
10	GTEx	Skin Sun Exposed Lower leg	POR	0.06	0.02	lasso	3	0.02	4.8e-03	5.3	6.1	1.0e-09	0.65	0.02	0.93	FALSE
11	GTEx	Testis	MDH2	0.14	0.07	lasso	3	0.05	3.6e-03	5.3	-6.1	1.3e-09	-0.75	0.02	0.91	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	POR	0.13	0.02	lasso	3	0.09	4.1e-11	2.0	6.0	2.2e-09	0.38	0.04	0.95	FALSE
3	GTEx	Cells Transformed fibroblasts	MDH2	0.20	0.11	lasso	5	0.14	1.7e-10	5.4	-5.8	9.1e-09	-0.79	0.23	0.77	FALSE
2	GTEx	Artery Aorta	POR	0.09	0.09	lasso	4	0.05	1.3e-03	5.2	5.5	3.7e-08	0.71	0.04	0.94	FALSE
7	GTEx	Muscle Skeletal	MDH2	0.21	0.05	enet	29	0.08	4.5e-08	5.4	-5.5	5.1e-08	-0.72	0.37	0.62	FALSE
13	GTEx	Thyroid	TMEM120A	0.08	0.01	enet	12	0.02	1.3e-02	5.4	5.3	1.1e-07	0.49	0.12	0.13	FALSE
6	GTEx	Esophagus Muscularis	POR	0.15	0.10	lasso	5	0.08	2.5e-05	5.2	5.2	1.9e-07	0.68	0.14	0.86	FALSE
9	GTEx	Pancreas	POR	0.20	0.07	lasso	4	0.03	1.4e-02	5.4	5.2	2.5e-07	0.61	0.06	0.42	FALSE
12	GTEx	Thyroid	POR	0.07	0.00	enet	15	0.01	2.5e-02	5.4	5.2	2.6e-07	0.42	0.06	0.28	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TMEM120A	0.05	0.01	bslmm	102	0.02	1.4e-03	6.7	-5.1	2.7e-07	-0.64	0.01	0.98	FALSE