TWAS
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About
Usage
Models
Genes
Traits
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Traits
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Blood Platelet Count
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chr8:56,002,516-57,623,583
Best TWAS P=6.89e-14 · Best GWAS P=1.74e-22 conditioned to 3.28e-06
56M
56.2M
56.4M
56.6M
56.8M
57M
57.2M
57.4M
57.6M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Spleen
LYN
0.25
0.00
enet
29
0.02
1.1e-01
3.6
-7.5
6.9e-14
0.51
0.07
0.19
TRUE
1
GTEx
Brain Cerebellar Hemisphere
LYN
0.45
0.01
enet
31
0.15
9.9e-05
-2.8
-6.7
2.9e-11
0.43
0.06
0.28
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
TMEM68
0.10
0.09
lasso
3
0.09
2.4e-10
6.2
6.6
4.3e-11
-0.42
0.79
0.21
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
TGS1
0.04
0.00
enet
19
0.02
3.7e-03
-8.5
6.7
2.5e-11
-0.47
0.06
0.51
FALSE
5
The Cancer Genome Atlas
Ovarian Serous Cystadenocarcinoma
TMEM68
0.09
0.06
lasso
3
0.06
5.7e-05
4.9
6.0
2.2e-09
-0.48
0.41
0.37
FALSE