Best TWAS P=6.89e-14 · Best GWAS P=1.74e-22 conditioned to 3.28e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | LYN | 0.45 | 0.01 | enet | 31 | 0.15 | 9.9e-05 | -2.8 | -6.7 | 2.9e-11 | 0.43 | 0.06 | 0.28 | TRUE |
| 2 | GTEx | Spleen | LYN | 0.25 | 0.00 | enet | 29 | 0.02 | 1.1e-01 | 3.6 | -7.5 | 6.9e-14 | 0.51 | 0.07 | 0.19 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | TGS1 | 0.04 | 0.00 | enet | 19 | 0.02 | 3.7e-03 | -8.5 | 6.7 | 2.5e-11 | -0.47 | 0.06 | 0.51 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM68 | 0.10 | 0.09 | lasso | 3 | 0.09 | 2.4e-10 | 6.2 | 6.6 | 4.3e-11 | -0.42 | 0.79 | 0.21 | TRUE |
| 5 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TMEM68 | 0.09 | 0.06 | lasso | 3 | 0.06 | 5.7e-05 | 4.9 | 6.0 | 2.2e-09 | -0.48 | 0.41 | 0.37 | FALSE |