Best TWAS P=6.8e-34 · Best GWAS P=9.85e-58 conditioned to 1.53e-29
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FOXD4 | 0.13 | 0.04 | lasso | 6 | 0.05 | 9.9e-07 | 0.037 | 5.7 | 1.4e-08 | -0.31 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Artery Coronary | CBWD1 | 0.35 | 0.12 | enet | 12 | 0.17 | 2.7e-06 | -14.442 | 10.9 | 1.1e-27 | -0.65 | 0.32 | 0.44 | FALSE |
| 3 | GTEx | Brain Cortex | DOCK8 | 0.22 | 0.05 | lasso | 5 | 0.04 | 3.2e-02 | 2.921 | 8.8 | 8.9e-19 | -0.49 | 0.15 | 0.16 | FALSE |
| 4 | GTEx | Brain Hippocampus | CBWD1 | 0.23 | 0.04 | enet | 21 | 0.01 | 1.5e-01 | 3.332 | 5.5 | 3.4e-08 | -0.57 | 0.11 | 0.38 | FALSE |
| 5 | GTEx | Liver | CBWD1 | 0.30 | 0.00 | lasso | 4 | 0.04 | 3.4e-02 | 2.986 | 7.9 | 2.3e-15 | -0.53 | 0.14 | 0.07 | FALSE |
| 6 | GTEx | Pancreas | DOCK8 | 0.39 | 0.24 | lasso | 7 | 0.26 | 1.5e-11 | -8.802 | -9.8 | 1.9e-22 | 0.44 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Stomach | XXyac-YRM2039.2 | 0.18 | 0.01 | enet | 24 | 0.05 | 1.6e-03 | -8.563 | 12.1 | 6.8e-34 | -0.39 | 0.04 | 0.60 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | FOXD4 | 0.24 | 0.05 | blup | 371 | 0.13 | 7.9e-17 | 0.037 | 9.7 | 4.7e-22 | -0.28 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C9orf66 | 0.05 | 0.04 | lasso | 4 | 0.04 | 1.0e-05 | 3.601 | -5.7 | 1.4e-08 | 0.35 | 0.02 | 0.97 | FALSE |