TWAS hub - FOXD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.134	0.0410	6.3e-07	0.043	0.032	0.046	0.038	0.050	4.8e-06	8.1e-05	2.8e-06	1.6e-05	9.9e-07
2	ROSMAP	Brain Pre-frontal Cortex	0.243	0.0486	2.7e-13	0.047	0.134	0.110	0.130	0.104	1.1e-06	7.9e-17	6.3e-14	2.4e-16	2.9e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of live births	8.6	12.2	14.0	-3.2	-3.7
Blood Platelet Count	5.4	62.7	93.3	5.7	9.7
Unable to work because of sickness or disability	4.5	5.9	6.3	-2.3	-2.5
Illness, injury, bereavement, stress in last 2 years	4.4	5.3	7.4	1.8	2.7
Coronary Artery Disease (CAD)	4.3	5.2	6.8	-2.6	-1.9
Hearing difficulty/problems: Yes	4.0	6.1	6.4	-2.5	-2.4
Exposure to tobacco smoke outside home	3.6	4.8	5.2	-2.1	-2.3
Relative age voice broke	3.5	5.4	5.8	-2.2	-2.4
Chronic bronchitis/emphysema (father)	3.4	4.0	4.6	1.8	2.1
Loud music exposure frequency	3.4	3.7	5.4	-2.3	-1.4
Serious illness, injury or assault to yourself	3.2	3.9	4.6	-2.1	-1.8
Noisy workplace	3.2	3.9	4.1	-2.0	-2.0
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	5.5	-1.3	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.5	5.0	-2.2	-1.4
Neuroticism (2016)	2.9	4.2	6.3	2.5	1.5
Type 2 Diabetes (T2D) (2012)	2.9	3.3	5.5	-2.4	-1.0
Number of children fathered	2.9	3.3	3.3	1.8	1.8
Nervous feelings	2.8	5.1	7.9	2.8	1.5
Myopia	2.8	4.0	7.0	2.6	1.0
Hair/balding pattern: Pattern 4	2.6	6.4	6.5	2.5	2.5
Irritable Bowel Disease (IBD)	2.4	5.8	6.1	-2.4	-2.5
Father’s age at death	2.4	3.2	3.5	-1.9	-1.7
Pulse wave peak to peak time	2.4	2.8	4.0	2.0	1.3
Pulse wave Arterial Stiffness index	2.3	2.7	3.9	-2.0	-1.2
Glaucoma (self-reported)	2.3	2.8	3.9	2.0	1.3
Average weekly fortified wine intake	2.2	2.6	4.9	-2.2	-0.4
Exposure to tobacco smoke at home	2.2	2.4	3.7	1.9	1.1
Pulse wave reflection index	2.2	2.7	3.2	-1.8	-1.5
Suffer from ‘nerves’	2.1	3.3	4.6	2.1	1.4
Eye problems/disorders: Glaucoma	2.1	2.5	4.2	2.0	0.9
Hair Pigment	2.0	56.0	58.4	-7.3	-7.6
Breastfed as a baby	2.0	2.5	4.2	-0.8	-2.0
Crohns Disease (2017)	1.9	4.3	4.9	-2.2	-1.9
Prostate Cancer	1.9	2.7	2.7	-1.6	-1.7
Systolic Blood Pressure	1.9	9.5	11.8	-3.4	-2.7
High blood pressure (siblings)	1.9	2.7	3.3	1.5	1.8
Neck or shoulder pain in last month	1.9	2.6	3.0	1.7	1.5
Medication: Aspirin	1.9	2.5	3.5	-1.9	-1.2
Age started oral contraceptive pill	1.9	2.3	4.2	-0.6	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.8	1.0	1.9
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	2.6	-1.4	-1.6
Hearing aid user	1.8	2.0	3.0	-1.0	-1.7
Primary Biliary Cirrhosis	1.7	2.4	3.7	-1.9	-1.1
Medication: Atorvastatin	1.7	2.0	4.1	0.1	2.0
High blood pressure (mother)	1.6	2.3	2.9	1.7	1.3
Falls in the last year	1.6	2.2	3.6	-0.9	-1.9
Illnesses of siblings: Diabetes	1.6	2.0	2.0	-1.4	-1.4
Supplements: Calcium	1.6	1.7	1.9	-1.2	-1.4
Ulcerative Colitis (UC)	1.5	2.8	4.2	-1.2	-2.1
Fasting Glucose	1.5	1.8	2.0	1.2	1.4
Relative age of first facial hair	1.5	3.2	5.2	-1.0	-2.3
Medication: Bendroflumethiazide	1.5	2.3	2.5	-1.6	-1.4
Ovarian Cancer	1.4	1.9	3.0	-1.7	-0.9
HbA1C	1.4	1.5	2.5	1.6	0.7
Townsend deprivation index at recruitment	1.4	2.0	2.6	1.2	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.0	1.7	0.8
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.0	1.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.4	-0.9	-1.6
Reaction Time	1.3	2.6	3.4	1.9	1.3
Sensitivity / hurt feelings	1.3	2.2	2.9	1.7	1.2
Angina	1.3	1.7	2.2	-1.5	-1.1
Angina (self-reported)	1.3	1.8	2.3	-1.5	-1.1
Medication: Seretide 50 evohaler	1.3	1.5	2.9	0.2	-1.7
Commuting to job workplace: Car/motor vehicle	1.3	1.4	1.5	-1.2	-1.2
Medication: Aspirin	1.3	1.7	2.3	-1.5	-1.1
Ever taken oral contraceptive pill	1.3	1.4	1.7	1.3	1.1
Basal cell carcinoma (self-reported)	1.3	1.5	1.8	1.3	1.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.4	1.6	0.9
Alzheimer’s Disease (in father)	1.2	1.4	2.7	1.6	-0.2
Systolic blood pressure, automated reading	1.2	3.5	4.3	-1.7	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.0	1.4	1.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.3	1.5	0.7
Medication for cholesterol	1.2	1.9	2.3	1.5	1.2
Commuting to job workplace: Cycle	1.2	1.5	1.6	1.2	1.2
Ulcerative Colitis	1.1	1.6	1.7	-1.2	-1.3
Depression (self-reported)	1.1	1.3	2.3	1.5	0.6
Age at first live birth	1.1	1.9	3.2	0.8	1.8
Financial situation satisfaction	1.1	1.4	1.5	-1.2	-1.1
Blood Red Count	1.0	9.6	10.1	-3.0	-3.2
Heel T-Score	1.0	8.3	8.9	2.8	3.0
Neuroticism score	1.0	2.0	3.6	1.9	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.2	-1.1	-1.0
Medication: Cholesterol lowering	1.0	1.6	3.1	-0.3	1.8
Peak expiratory flow (PEF)	1.0	2.2	2.6	1.6	1.3
Medication: Omeprazole	1.0	1.1	1.9	0.6	1.4
Supplements: Vitamin C	1.0	1.2	1.8	0.7	1.3
Knee pain experienced in last month	1.0	1.5	2.3	0.9	1.5
Medication: Blood pressure	1.0	1.9	2.4	-1.5	-1.2
Pain experienced in last month	1.0	1.6	3.0	-0.5	-1.7
Alcohol usually taken with meals	0.9	1.5	2.9	0.3	-1.7
Medication: Ramipril	0.9	1.1	2.2	0.1	1.5
Medication: Simvastatin	0.9	1.4	2.3	-1.5	-0.7
Prospective memory result	0.9	1.1	1.4	-1.2	-0.8
Ever had bowel cancer screening	0.9	1.0	1.9	-1.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.8	-0.2	1.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.9	-1.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.4	-0.1	-1.6
Medication: Paracetamol	0.9	1.4	1.8	1.3	1.0
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.2	2.1	0.8
Neuroticism (Nagel 2018)	0.8	1.8	2.8	1.7	0.9
Worry (Nagel 2018)	0.8	1.8	2.9	1.7	0.8
Cardiovascular Disease	0.8	2.5	5.0	-2.2	-0.2
Medication: Co-codamol	0.8	1.0	1.7	-0.5	-1.3
Illnesses of siblings	0.8	1.1	1.3	-1.0	-1.1
Medication: Paracetamol	0.8	1.4	1.8	1.4	0.9
Comparative body size at age 10	0.8	2.3	3.1	1.2	1.8
Medication: Ibuprofen	0.8	0.9	1.6	1.3	0.5
Alcohol drinker status: Never	0.8	1.0	1.1	-1.0	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	0.3	1.4
Neuroticism	0.7	1.6	2.4	1.6	0.9
Current tobacco smoking	0.7	1.1	2.1	0.3	1.5
Maternal smoking around birth	0.7	1.0	1.7	-0.5	-1.3
Pain all over the body in last month	0.7	0.7	1.0	-1.0	-0.7
Time employed in main current job	0.7	0.8	0.9	-1.0	-0.8
Worrier / anxious feelings	0.7	1.4	2.3	1.5	0.6
Blood clot in the leg (DVT)	0.7	0.9	1.5	1.2	0.5
Medication: Amlodipine	0.7	0.9	1.2	-0.8	-1.1
Breast cancer (self-reported)	0.7	0.8	1.6	0.1	1.3
Asthma (self-reported)	0.7	1.3	1.6	-1.0	-1.3
Smoking status: Current	0.7	1.2	2.2	0.3	1.5
Wears glasses or contact lenses	0.7	0.8	1.6	1.3	-0.1
Irritability	0.7	1.2	2.3	-0.3	-1.5
Diastolic blood pressure, automated reading	0.7	2.0	3.0	-1.0	-1.7
Crohns Disease (2012)	0.6	1.0	1.5	-1.2	-0.7
HDL Cholesterol	0.6	0.9	1.7	1.3	0.5
Lupus	0.6	1.0	1.7	-0.4	1.3
Rheumatoid Arthritis	0.6	0.8	1.1	-1.0	-0.8
Supplements: Zinc	0.6	0.7	0.8	0.7	0.9
Medication: Metformin	0.6	0.8	1.2	-0.6	1.1
Age when periods started (menarche)	0.6	1.5	2.4	-0.7	-1.5
High blood pressure	0.6	1.7	3.1	-1.7	-0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	1.1	0.5
Mean time to correctly identify matches	0.6	1.1	1.6	1.3	0.7
Guilty feelings	0.6	0.9	0.9	1.0	-0.9
Mother’s age at death	0.6	0.8	1.5	1.2	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-0.5	-1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.3	-0.1	-1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	-1.0	-0.4
Qualifications: CSEs or equivalent	0.5	0.7	0.8	-0.8	-0.9
Medication: Atenolol	0.5	0.6	1.2	-0.3	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.4	-0.4	-1.2
Had menopause	0.5	0.7	1.0	1.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.4	1.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	1.6	1.3	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	1.2	0.3
Headache pain in last month	0.5	0.8	1.5	0.4	1.2
Forced vital capacity (FVC), Best measure	0.5	1.7	2.4	1.6	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	0.9	-0.9	-1.0
Chest pain or discomfort	0.5	0.7	0.7	0.8	0.8
Family relationship satisfaction	0.5	0.7	1.3	1.1	0.3
Hypertension (Self-reported)	0.5	1.5	2.7	-1.6	-0.6
Illnesses of father: Heart disease	0.5	0.6	0.7	-0.8	-0.8
Medication: Gliclazide	0.5	0.6	1.1	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.1	1.0	1.0
Major Depression (MDD)	0.4	0.5	0.8	-0.9	-0.5
Age at First Birth	0.4	0.5	1.0	0.1	1.0
Mean Putamen Volume	0.4	0.4	0.7	-0.4	0.8
Hypothyroidism (self reported)	0.4	0.9	1.6	-0.3	-1.3
Average weekly spirits intake	0.4	0.5	0.9	-0.5	-0.9
Pack years adult smoking proportion	0.4	0.6	0.7	0.7	0.8
Hair/balding pattern: Pattern 2	0.4	0.4	0.9	0.9	0.1
Heart attack	0.4	0.6	0.8	-0.9	-0.6
Trunk fat-free mass	0.4	2.1	4.2	0.1	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.2	1.1	0.0
Asthma	0.4	0.8	1.0	-0.8	-1.0
Medication: Lansoprazole	0.4	0.5	0.7	-0.5	-0.9
Impedance of arm (left)	0.4	1.7	3.0	0.6	-1.7
Tense / ‘highly strung’	0.4	0.6	0.9	0.5	1.0
Worry too long after embarrassment	0.4	0.7	1.4	1.2	0.2
Health satisfaction	0.4	0.5	0.9	-0.2	-0.9
Number of full sisters	0.4	0.5	0.7	-0.8	-0.5
Leg pain on walking	0.4	0.5	0.6	-0.6	-0.8
Whole body fat-free mass	0.4	2.0	4.0	0.0	2.0
Average weekly red wine intake	0.4	0.5	0.8	-0.5	-0.9
Mood swings	0.4	0.7	0.9	0.9	0.7
Loneliness, isolation	0.4	0.6	1.1	-1.1	-0.1
Medication: Lisinopril	0.4	0.5	1.0	-1.0	-0.2
Illnesses of father: High blood pressure	0.4	0.5	0.8	-0.5	-0.9
Fractured/broken bones in last 5 years	0.4	0.5	0.6	-0.7	-0.8
Cholesterol lowering medication	0.4	0.5	0.7	-0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	-0.9	-0.5
Depressed Affect (Nagel 2018)	0.3	0.6	0.8	0.9	0.6
Depression (Nagel 2018)	0.3	0.5	0.9	0.3	1.0
Waist Hip Ratio (WHR)	0.3	1.6	1.9	-1.1	-1.4
Smoking Status	0.3	0.8	1.5	0.3	1.2
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	-0.1	-0.8
Diabetes (mother)	0.3	0.4	0.8	-0.1	0.9
Impedance of leg (right)	0.3	1.3	2.5	-0.1	-1.6
Leg fat-free mass (left)	0.3	1.3	2.7	-0.0	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.7	0.7	0.9
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.3	0.9
Leg predicted mass (left)	0.3	1.5	3.0	0.0	1.7
Number of incorrect matches in round	0.3	0.4	0.5	0.6	0.7
Weight	0.3	1.3	2.6	-0.1	1.6
Impedance of arm (right)	0.3	1.5	2.0	1.0	-1.4
Alcohol intake versus 10 years previously	0.3	0.5	0.7	0.8	0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.1	0.9
Trunk predicted mass	0.3	2.0	4.0	0.0	2.0
Length of working week for main job	0.3	0.4	0.7	0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.2	-0.8
Arm predicted mass (right)	0.3	1.4	1.7	-1.0	1.3
Smoking status: Previous	0.3	0.4	0.4	0.6	0.7
Leg fat-free mass (right)	0.3	1.6	3.2	0.0	1.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	0.9	0.1
Whole body water mass	0.3	1.8	3.6	-0.0	1.9
Leg predicted mass (right)	0.3	1.4	2.8	-0.1	1.7
Basal metabolic rate	0.3	1.7	3.5	-0.0	1.9
Arm fat-free mass (left)	0.3	1.6	3.0	-0.4	1.7
Number of operations (self-reported)	0.3	0.5	0.6	0.7	0.7
Pack years of smoking	0.3	0.4	0.5	0.7	0.6
Impedance of whole body	0.3	1.4	2.7	0.3	-1.7
Leg fat mass (left)	0.3	1.1	2.2	-0.2	1.5
Arm predicted mass (left)	0.3	1.3	2.3	-0.6	1.5
Bipolar Disorder (2018)	0.2	0.2	0.4	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	-0.1	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	-0.4	-0.5
LDL Cholesterol	0.2	0.3	0.6	0.2	0.8
Schizophrenia (2014)	0.2	0.4	0.8	0.9	-0.2
Triglycerides	0.2	0.3	0.5	0.3	0.7
Blood Eosinophil Count	0.2	1.4	2.1	-1.4	-0.8
Allergy or Eczema	0.2	0.5	1.0	0.3	1.0
Respiratory disease	0.2	0.3	0.6	-0.3	-0.8
Number of treatments/medications taken	0.2	0.4	0.8	-0.9	-0.3
Severe depression (siblings)	0.2	0.3	0.4	0.6	0.4
Fed-up feelings	0.2	0.3	0.7	0.8	0.2
Multivitamins +/- minerals	0.2	0.2	0.4	0.6	0.1
Supplements: Glucosamine	0.2	0.3	0.6	0.2	0.8
Body mass index (BMI)	0.2	0.8	1.4	-0.3	1.2
Impedance of leg (left)	0.2	0.8	1.6	-0.2	-1.3
Past tobacco smoking	0.2	0.3	0.5	-0.4	-0.7
Had other major operations	0.2	0.3	0.5	-0.7	0.2
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.3	-0.7
Arm fat percentage (right)	0.2	0.9	1.3	0.7	1.1
Hip circumference	0.2	0.8	1.6	0.1	1.3
Illnesses of mother	0.2	0.2	0.3	-0.5	-0.3
Leg fat percentage (right)	0.2	0.6	1.1	-0.2	1.0
Arm fat-free mass (right)	0.2	1.2	1.6	-0.9	1.3
Number of full brothers	0.2	0.2	0.5	-0.1	0.7
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	-0.3
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.7	-0.0
Heart disease (mother)	0.2	0.2	0.5	0.7	-0.1
Leg fat mass (right)	0.2	0.8	1.4	-0.3	1.2
Pulse rate, automated reading	0.2	0.7	1.2	0.5	1.1
Overall health rating	0.2	0.5	0.5	0.7	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	-0.8	0.4
Diabetes diagnosed by doctor	0.2	0.4	0.5	-0.4	0.7
Qualifications: nursing, teaching	0.2	0.3	0.3	-0.6	0.6
Back pain experienced in last month	0.2	0.3	0.5	0.4	0.7
Mineral and other dietary supplements	0.2	0.3	0.5	0.2	0.7
Arm fat mass (left)	0.2	0.7	1.3	0.0	1.1
Average weekly champagne plus white wine intake	0.2	0.2	0.4	-0.0	-0.7
Leg fat percentage (left)	0.2	0.9	1.8	-0.2	1.3
Risk taking	0.2	0.3	0.6	-0.8	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.6	-0.3
Schizophrenia (2018)	0.1	0.3	0.5	0.2	-0.7
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	0.0
Blood White Count	0.1	1.1	1.5	-1.2	0.8
BMI	0.1	0.5	1.0	-0.1	1.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.4	0.6
Lung FEV1/FVC ratio	0.1	0.4	0.7	-0.4	0.8
Lung FVC	0.1	0.4	0.7	0.9	0.3
Chronotype (morning person)	0.1	0.2	0.3	-0.3	-0.5
Tanning	0.1	0.7	1.3	-0.4	-1.1
Hand grip strength (left)	0.1	0.3	0.6	0.3	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	-0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.3	0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	0.2
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	0.1
Diabetes (father)	0.1	0.1	0.3	0.0	-0.5
Hand grip strength (right)	0.1	0.2	0.3	-0.5	0.2
Taking other prescription medications	0.1	0.1	0.3	-0.5	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	-0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.2	-0.4
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.1	-0.6
Sitting height	0.1	0.5	0.8	-0.9	0.5
Trunk fat mass	0.1	0.4	0.8	0.1	0.9
Waist circumference	0.1	0.3	0.4	-0.5	0.6
Forced vital capacity (FVC)	0.1	0.5	1.0	1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.5	0.2
Qualifications: None of the above	0.1	0.3	0.3	0.5	0.6
Mouth/teeth dental problems	0.1	0.1	0.1	0.1	0.4
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.9	1.0	0.2
Pulse rate	0.1	0.1	0.2	-0.5	-0.2
Lung cancer (father)	0.1	0.2	0.3	0.1	0.6
Arm fat mass (right)	0.1	0.6	1.2	0.2	1.1
Standing height	0.1	0.7	1.3	0.4	1.1
Birth weight of first child	0.1	0.2	0.3	0.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.6	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.1	-0.7
Body fat percentage	0.1	0.3	0.6	0.1	0.8
Wheeze or whistling in the chest in last year	0.1	0.3	0.3	-0.6	-0.5
Qualifications: College or University degree	0.1	0.2	0.3	0.5	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.0
Medication: Blood pressure	0.1	0.2	0.5	-0.7	-0.0
Migraine (self-reported)	0.1	0.1	0.1	0.3	0.4
Whole body fat mass	0.1	0.6	1.2	0.1	1.1
Comparative height size at age 10	0.1	0.5	0.5	0.7	0.7
Arm fat percentage (left)	0.1	0.4	0.8	0.3	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	0.0	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.1	-0.3	-0.3
Friendships satisfaction	0.1	0.2	0.3	0.6	-0.0
Commuting to job workplace: Walk	0.1	0.1	0.3	0.5	-0.1
Eye problems/disorders: Cataract	0.1	0.1	0.1	-0.1	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.5	0.0
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.2	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.4	0.1
Miserableness	0.1	0.1	0.2	-0.1	-0.5
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.6	0.1
High cholesterol (Self-reported)	0.1	0.3	0.4	-0.3	0.6
Average weekly beer plus cider intake	0.1	0.1	0.2	0.3	0.4
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	-0.0
Heart disease (siblings)	0.1	0.1	0.2	-0.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.2	0.2
Breast Cancer	0.0	0.1	0.2	-0.4	0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.1
Height	0.0	0.1	0.2	-0.5	0.1
Trunk fat percentage	0.0	0.1	0.1	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.1	0.3
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.4	-0.2
Allergy	0.0	0.0	0.0	0.1	0.0
Fluid intelligence score	0.0	0.1	0.1	0.3	-0.2
Happiness	0.0	0.0	0.0	0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.4	0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	-0.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.2	-0.2
Gout (self-reported)	0.0	0.0	0.0	-0.2	-0.2
Birth weight	0.0	0.1	0.2	-0.4	0.0
Medication: Allopurinol	0.0	0.0	0.0	-0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.3	0.0
Alcohol intake frequency.	0.0	0.1	0.1	0.1	0.4
Had major operations	0.0	0.0	0.1	-0.3	0.0
Age at last live birth	0.0	0.0	0.0	-0.1	0.2
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.1	0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.1	-0.1
Ever smoked	0.0	0.0	0.1	0.0	0.3
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	0.2	0.0
Alcohol drinker status: Previous	0.0	0.0	0.0	0.2	0.0

Hub : Genes

FOXD4

Models

Trait associations