Best TWAS P=5.07e-14 · Best GWAS P=1.34e-14 conditioned to 0.0445
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | HAUS6 | 0.14 | 0.13 | lasso | 4 | 0.12 | 2.3e-10 | 5.8 | -6.8 | 1.3e-11 | -0.90 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Visceral Omentum | HAUS6 | 0.15 | 0.02 | lasso | 5 | 0.05 | 1.4e-03 | 7.5 | -6.9 | 6.4e-12 | -0.78 | 0.02 | 0.90 | FALSE |
3 | GTEx | Artery Aorta | HAUS6 | 0.14 | 0.05 | lasso | 5 | 0.07 | 8.7e-05 | 5.8 | -6.0 | 1.7e-09 | -0.83 | 0.02 | 0.97 | FALSE |
4 | GTEx | Artery Tibial | HAUS6 | 0.14 | 0.14 | lasso | 1 | 0.14 | 3.7e-11 | 5.8 | -5.8 | 6.4e-09 | -0.83 | 0.65 | 0.35 | FALSE |
5 | GTEx | Breast Mammary Tissue | HAUS6 | 0.12 | 0.06 | lasso | 2 | 0.05 | 1.7e-03 | 7.3 | -6.9 | 5.2e-12 | -0.94 | 0.02 | 0.97 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | HAUS6 | 0.28 | 0.17 | lasso | 8 | 0.20 | 1.4e-14 | 7.6 | -7.5 | 5.1e-14 | -0.92 | 0.01 | 0.99 | TRUE |
7 | GTEx | Nerve Tibial | HAUS6 | 0.14 | 0.04 | enet | 22 | 0.08 | 1.9e-06 | 4.1 | -5.5 | 4.9e-08 | -0.76 | 0.05 | 0.95 | FALSE |
8 | GTEx | Thyroid | HAUS6 | 0.12 | 0.05 | lasso | 3 | 0.02 | 5.3e-03 | 5.8 | -6.3 | 2.3e-10 | -0.88 | 0.01 | 0.98 | FALSE |
9 | METSIM | Adipose | HAUS6 | 0.06 | 0.04 | bslmm | 666 | 0.03 | 4.9e-06 | 7.5 | -7.2 | 8.8e-13 | -0.87 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HAUS6 | 0.04 | 0.03 | blup | 87 | 0.05 | 4.1e-10 | 7.5 | -7.2 | 4.8e-13 | -0.88 | 0.02 | 0.98 | FALSE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | HAUS6 | 0.05 | 0.04 | lasso | 2 | 0.03 | 5.1e-03 | -6.4 | -6.9 | 6.3e-12 | -0.74 | 0.05 | 0.71 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HAUS6 | 0.04 | 0.06 | lasso | 2 | 0.05 | 9.1e-07 | 5.8 | -5.8 | 6.1e-09 | -0.83 | 0.12 | 0.88 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | HAUS6 | 0.09 | 0.04 | lasso | 5 | 0.07 | 1.2e-04 | 4.0 | -7.0 | 1.8e-12 | -0.80 | 0.05 | 0.89 | FALSE |
14 | The Cancer Genome Atlas | Lung Adenocarcinoma | HAUS6 | 0.06 | 0.04 | blup | 87 | 0.04 | 6.9e-06 | 7.3 | -6.1 | 1.2e-09 | -0.88 | 0.02 | 0.98 | FALSE |
15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAM154A | 0.06 | 0.00 | blup | 174 | 0.01 | 1.3e-01 | 7.3 | -6.4 | 1.7e-10 | -0.87 | 0.02 | 0.92 | FALSE |
16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HAUS6 | 0.07 | 0.00 | enet | 7 | 0.04 | 1.3e-03 | 1.4 | -5.6 | 1.8e-08 | -0.60 | 0.03 | 0.84 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HAUS6 | 0.12 | 0.09 | blup | 87 | 0.10 | 1.4e-10 | 5.8 | -6.1 | 8.9e-10 | -0.81 | 0.02 | 0.98 | FALSE |
18 | The Cancer Genome Atlas | Thyroid Carcinoma | HAUS6 | 0.07 | 0.11 | blup | 87 | 0.11 | 6.8e-11 | 5.8 | -6.7 | 1.9e-11 | -0.89 | 0.06 | 0.94 | FALSE |