Best TWAS P=6.98e-31 · Best GWAS P=1.36e-76 conditioned to 2.21e-70
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | GTEx | Whole Blood | CDKN2B | 0.09 | 0.03 | lasso | 6 | 0.02 | 1.4e-02 | -11.66 | 11.6 | 7.0e-31 | 0.01 | 0.52 | 0.05 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | MTAP | 0.07 | 0.04 | lasso | 5 | 0.02 | 2.1e-03 | 0.51 | 5.4 | 7.8e-08 | -0.04 | 0.04 | 0.08 | TRUE |
| 1 | GTEx | Adipose Subcutaneous | MTAP | 0.12 | 0.07 | enet | 22 | 0.10 | 7.2e-09 | 0.27 | -5.2 | 1.7e-07 | 0.17 | 1.00 | 0.00 | TRUE |
| 6 | YFS | Blood | CDKN2B | 0.07 | 0.05 | bslmm | 427 | 0.05 | 5.8e-17 | -11.66 | 11.3 | 1.6e-29 | 0.04 | 1.00 | 0.00 | FALSE |
| 4 | NTR | Blood | CDKN2B | 0.02 | 0.00 | enet | 9 | 0.01 | 2.7e-03 | -11.66 | 8.4 | 5.1e-17 | 0.00 | 0.33 | 0.05 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CDKN2A | 0.10 | 0.02 | lasso | 5 | 0.03 | 1.6e-04 | 8.32 | -7.5 | 4.5e-14 | 0.00 | 0.63 | 0.01 | FALSE |
| 2 | GTEx | Prostate | RP11-70L8.4 | 0.28 | -0.01 | enet | 44 | -0.01 | 4.7e-01 | 0.89 | -5.2 | 2.1e-07 | 0.12 | 0.07 | 0.06 | FALSE |