Best TWAS P=4.2e-10 · Best GWAS P=4.41e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 5.8 | -6.2 | 4.2e-10 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -4.2 | -5.5 | 4.1e-08 | -0.83 | 0.02 | 0.97 | FALSE |
| 3 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 6.2 | 6.0 | 1.6e-09 | 0.97 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 6.6 | -6.2 | 7.8e-10 | -0.95 | 0.01 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 6.6 | -6.2 | 6.2e-10 | -0.93 | 0.01 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 6.0 | -6.2 | 4.2e-10 | -0.98 | 0.03 | 0.89 | TRUE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -4.3 | 5.8 | 7.0e-09 | 0.75 | 0.02 | 0.76 | FALSE |