TWAS
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Models
Genes
Traits
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Traits
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Blood Platelet Count
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chr9:71,961,923-73,722,464
Best TWAS P=2.26e-28 · Best GWAS P=6.76e-29 conditioned to 4.28e-06
72M
72.2M
72.4M
72.6M
72.8M
73M
73.2M
73.4M
73.6M
73.8M
0
5
10
15
20
25
30
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
KLF9
0.01
0.01
blup
37
0.01
0.01790
-9.6
11.0
2.3e-28
0.73
0.01
0.90
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
KLF9
0.04
0.01
blup
37
0.02
0.00989
9.0
10.9
8.3e-28
0.56
0.02
0.86
FALSE
1
GTEx
Brain Cerebellum
MAMDC2
0.25
0.05
enet
5
0.09
0.00109
7.2
7.4
1.8e-13
0.56
0.07
0.20
FALSE
2
METSIM
Adipose
KLF9
0.05
0.00
bslmm
509
0.02
0.00098
9.1
5.7
1.6e-08
0.09
0.30
0.02
FALSE