Best TWAS P=2.37e-08 · Best GWAS P=3.23e-07 conditioned to 0.793
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | SMC2 | 0.20 | 0.24 | enet | 10 | 0.17 | 1.1e-05 | -5.0 | -5.2 | 2.2e-07 | 0.98 | 0.03 | 0.96 | FALSE |
| 2 | METSIM | Adipose | SMC2 | 0.05 | 0.05 | lasso | 10 | 0.04 | 5.4e-07 | -5.1 | -5.3 | 1.2e-07 | 0.96 | 0.02 | 0.98 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SMC2 | 0.11 | 0.13 | blup | 63 | 0.15 | 4.5e-17 | -5.0 | -5.2 | 1.8e-07 | 0.95 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SMC2 | 0.06 | 0.01 | blup | 63 | 0.02 | 2.0e-02 | -5.0 | 5.6 | 2.4e-08 | -0.89 | 0.02 | 0.93 | TRUE |