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chr9:115,476,640-117,966,294

Best TWAS P=8.65e-19 · Best GWAS P=1.92e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	The Cancer Genome Atlas	Colon Adenocarcinoma	C9orf43	0.19	0.17	enet	9	0.16	1.2e-09	8.3	-8.8	8.7e-19	-0.97	0.00	1.00	TRUE
6	GTEx	Esophagus Mucosa	DFNB31	0.18	0.09	lasso	4	0.05	2.5e-04	5.3	5.3	1.4e-07	0.02	0.01	0.99	TRUE
11	METSIM	Adipose	C9orf43	0.05	0.05	lasso	1	0.03	5.8e-06	8.4	-8.4	3.1e-17	-0.99	0.04	0.96	FALSE
10	GTEx	Testis	C9orf43	0.52	0.59	enet	31	0.65	3.4e-37	8.3	-8.4	3.2e-17	-0.93	0.05	0.95	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	C9orf43	0.20	0.21	lasso	2	0.18	2.4e-06	8.3	-8.3	7.6e-17	-0.98	0.03	0.96	FALSE
7	GTEx	Esophagus Mucosa	C9orf43	0.13	0.13	lasso	4	0.12	1.4e-08	8.3	-8.3	7.9e-17	-0.98	0.04	0.96	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C9orf43	0.09	0.10	lasso	2	0.09	5.9e-10	8.2	-8.3	8.6e-17	-0.97	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Soft Tissue Sarcoma	C9orf43	0.11	0.10	lasso	5	0.09	4.9e-06	8.3	-8.3	8.8e-17	-0.98	0.00	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	C9orf43	0.12	0.08	lasso	10	0.06	3.0e-04	8.3	-8.3	9.1e-17	-1.00	0.03	0.96	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C9orf43	0.12	0.13	lasso	2	0.13	5.2e-14	8.3	-8.3	9.2e-17	-1.00	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	C9orf43	0.07	0.05	lasso	5	0.05	5.8e-06	8.3	-8.2	1.7e-16	-0.99	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C9orf43	0.11	0.08	lasso	5	0.06	3.8e-05	8.2	-8.2	1.9e-16	-0.95	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C9orf43	0.10	0.12	lasso	1	0.12	2.0e-10	8.2	-8.2	2.3e-16	-0.95	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Rectum Adenocarcinoma	C9orf43	0.49	0.17	enet	6	0.14	4.7e-04	8.2	-8.2	2.7e-16	-0.99	0.00	0.92	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	C9orf43	0.12	0.16	enet	5	0.16	6.9e-18	8.3	-8.2	3.3e-16	-0.99	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	C9orf43	0.18	0.24	enet	6	0.24	4.3e-25	8.2	-8.1	4.9e-16	-0.99	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	C9orf43	0.08	0.10	lasso	3	0.10	2.5e-20	8.3	-8.1	5.4e-16	-1.00	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C9orf43	0.13	0.08	blup	57	0.07	4.9e-05	8.3	-8.1	5.7e-16	-0.86	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C9orf43	0.13	0.15	enet	6	0.13	2.3e-05	8.2	-8.1	7.7e-16	-0.97	0.00	0.98	FALSE
23	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C9orf43	0.26	0.26	lasso	4	0.23	1.0e-09	8.2	-8.0	8.9e-16	-0.95	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	C9orf43	0.11	0.06	lasso	5	0.05	1.7e-04	8.2	-7.5	7.6e-14	-0.94	0.00	1.00	FALSE
14	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C9orf43	0.10	0.06	lasso	6	0.06	1.0e-03	8.2	-7.4	1.6e-13	-0.88	0.00	0.98	FALSE
5	GTEx	Cells Transformed fibroblasts	C9orf43	0.13	0.09	enet	31	0.11	1.6e-08	8.3	-7.2	5.7e-13	-0.84	0.04	0.96	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C9orf43	0.21	0.19	blup	58	0.19	7.5e-21	8.2	-7.1	1.4e-12	-0.92	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	C9orf43	0.13	0.11	blup	57	0.16	3.7e-15	5.1	-6.8	1.3e-11	-0.87	0.02	0.98	FALSE
9	GTEx	Stomach	C9orf43	0.11	0.01	enet	13	0.03	1.3e-02	8.3	-6.5	6.9e-11	-0.84	0.04	0.93	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS3	0.04	0.04	lasso	2	0.03	2.5e-04	6.5	-6.5	8.7e-11	-0.86	0.08	0.75	FALSE
3	GTEx	Adrenal Gland	C9orf43	0.16	0.06	enet	19	0.03	3.7e-02	8.2	-6.5	1.1e-10	-0.84	0.04	0.88	FALSE
1	GTEx	Adipose Subcutaneous	C9orf43	0.06	0.05	lasso	3	0.05	9.0e-05	5.2	-6.4	2.0e-10	-0.87	0.04	0.95	FALSE
28	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C9orf43	0.30	0.17	lasso	4	0.16	4.9e-05	5.1	-5.9	3.0e-09	-0.84	0.01	0.96	FALSE
8	GTEx	Pancreas	DFNB31	0.22	0.17	lasso	6	0.13	5.4e-06	5.2	5.1	3.0e-07	0.03	0.01	0.98	FALSE