Best TWAS P=8.65e-19 · Best GWAS P=1.92e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C9orf43 | 0.06 | 0.05 | lasso | 3 | 0.05 | 9.0e-05 | 5.2 | -6.4 | 2.0e-10 | -0.87 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C9orf43 | 0.12 | 0.08 | lasso | 10 | 0.06 | 3.0e-04 | 8.3 | -8.3 | 9.1e-17 | -1.00 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Adrenal Gland | C9orf43 | 0.16 | 0.06 | enet | 19 | 0.03 | 3.7e-02 | 8.2 | -6.5 | 1.1e-10 | -0.84 | 0.04 | 0.88 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | C9orf43 | 0.20 | 0.21 | lasso | 2 | 0.18 | 2.4e-06 | 8.3 | -8.3 | 7.6e-17 | -0.98 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | C9orf43 | 0.13 | 0.09 | enet | 31 | 0.11 | 1.6e-08 | 8.3 | -7.2 | 5.7e-13 | -0.84 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Esophagus Mucosa | DFNB31 | 0.18 | 0.09 | lasso | 4 | 0.05 | 2.5e-04 | 5.3 | 5.3 | 1.4e-07 | 0.02 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Esophagus Mucosa | C9orf43 | 0.13 | 0.13 | lasso | 4 | 0.12 | 1.4e-08 | 8.3 | -8.3 | 7.9e-17 | -0.98 | 0.04 | 0.96 | FALSE |
| 8 | GTEx | Pancreas | DFNB31 | 0.22 | 0.17 | lasso | 6 | 0.13 | 5.4e-06 | 5.2 | 5.1 | 3.0e-07 | 0.03 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Stomach | C9orf43 | 0.11 | 0.01 | enet | 13 | 0.03 | 1.3e-02 | 8.3 | -6.5 | 6.9e-11 | -0.84 | 0.04 | 0.93 | FALSE |
| 10 | GTEx | Testis | C9orf43 | 0.52 | 0.59 | enet | 31 | 0.65 | 3.4e-37 | 8.3 | -8.4 | 3.2e-17 | -0.93 | 0.05 | 0.95 | FALSE |
| 11 | METSIM | Adipose | C9orf43 | 0.05 | 0.05 | lasso | 1 | 0.03 | 5.8e-06 | 8.4 | -8.4 | 3.1e-17 | -0.99 | 0.04 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C9orf43 | 0.10 | 0.12 | lasso | 1 | 0.12 | 2.0e-10 | 8.2 | -8.2 | 2.3e-16 | -0.95 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C9orf43 | 0.08 | 0.10 | lasso | 3 | 0.10 | 2.5e-20 | 8.3 | -8.1 | 5.4e-16 | -1.00 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C9orf43 | 0.10 | 0.06 | lasso | 6 | 0.06 | 1.0e-03 | 8.2 | -7.4 | 1.6e-13 | -0.88 | 0.00 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | C9orf43 | 0.19 | 0.17 | enet | 9 | 0.16 | 1.2e-09 | 8.3 | -8.8 | 8.7e-19 | -0.97 | 0.00 | 1.00 | TRUE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C9orf43 | 0.12 | 0.13 | lasso | 2 | 0.13 | 5.2e-14 | 8.3 | -8.3 | 9.2e-17 | -1.00 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C9orf43 | 0.09 | 0.10 | lasso | 2 | 0.09 | 5.9e-10 | 8.2 | -8.3 | 8.6e-17 | -0.97 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C9orf43 | 0.13 | 0.08 | blup | 57 | 0.07 | 4.9e-05 | 8.3 | -8.1 | 5.7e-16 | -0.86 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C9orf43 | 0.07 | 0.05 | lasso | 5 | 0.05 | 5.8e-06 | 8.3 | -8.2 | 1.7e-16 | -0.99 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | C9orf43 | 0.12 | 0.16 | enet | 5 | 0.16 | 6.9e-18 | 8.3 | -8.2 | 3.3e-16 | -0.99 | 0.00 | 1.00 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf43 | 0.21 | 0.19 | blup | 58 | 0.19 | 7.5e-21 | 8.2 | -7.1 | 1.4e-12 | -0.92 | 0.00 | 1.00 | FALSE |
| 22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C9orf43 | 0.11 | 0.08 | lasso | 5 | 0.06 | 3.8e-05 | 8.2 | -8.2 | 1.9e-16 | -0.95 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C9orf43 | 0.26 | 0.26 | lasso | 4 | 0.23 | 1.0e-09 | 8.2 | -8.0 | 8.9e-16 | -0.95 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf43 | 0.18 | 0.24 | enet | 6 | 0.24 | 4.3e-25 | 8.2 | -8.1 | 4.9e-16 | -0.99 | 0.00 | 1.00 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RGS3 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.5e-04 | 6.5 | -6.5 | 8.7e-11 | -0.86 | 0.08 | 0.75 | FALSE |
| 26 | The Cancer Genome Atlas | Rectum Adenocarcinoma | C9orf43 | 0.49 | 0.17 | enet | 6 | 0.14 | 4.7e-04 | 8.2 | -8.2 | 2.7e-16 | -0.99 | 0.00 | 0.92 | FALSE |
| 27 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf43 | 0.11 | 0.10 | lasso | 5 | 0.09 | 4.9e-06 | 8.3 | -8.3 | 8.8e-17 | -0.98 | 0.00 | 0.99 | FALSE |
| 28 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C9orf43 | 0.30 | 0.17 | lasso | 4 | 0.16 | 4.9e-05 | 5.1 | -5.9 | 3.0e-09 | -0.84 | 0.01 | 0.96 | FALSE |
| 29 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C9orf43 | 0.11 | 0.06 | lasso | 5 | 0.05 | 1.7e-04 | 8.2 | -7.5 | 7.6e-14 | -0.94 | 0.00 | 1.00 | FALSE |
| 30 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf43 | 0.13 | 0.15 | enet | 6 | 0.13 | 2.3e-05 | 8.2 | -8.1 | 7.7e-16 | -0.97 | 0.00 | 0.98 | FALSE |
| 31 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf43 | 0.13 | 0.11 | blup | 57 | 0.16 | 3.7e-15 | 5.1 | -6.8 | 1.3e-11 | -0.87 | 0.02 | 0.98 | FALSE |