Best TWAS P=2.05e-09 · Best GWAS P=3.84e-11 conditioned to 2.22e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC22A18 | 0.09 | 0.05 | lasso | 5 | 0.09 | 8.8e-11 | 5.7 | 5.7 | 1.2e-08 | -0.01 | 0.59 | 0.41 | FALSE |
| 2 | METSIM | Adipose | SLC22A18 | 0.34 | 0.20 | enet | 36 | 0.23 | 3.0e-33 | -3.5 | 5.6 | 1.7e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | NAP1L4 | 0.07 | 0.01 | enet | 13 | 0.02 | 4.7e-04 | 6.2 | -5.5 | 2.9e-08 | -0.03 | 0.04 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC22A18AS | 0.28 | 0.15 | enet | 23 | 0.20 | 1.3e-22 | 5.7 | 5.6 | 2.3e-08 | -0.01 | 0.10 | 0.90 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC22A18AS | 0.08 | 0.09 | lasso | 2 | 0.08 | 1.7e-05 | 5.7 | 5.7 | 1.1e-08 | 0.01 | 0.07 | 0.65 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC22A18AS | 0.09 | 0.03 | blup | 60 | 0.06 | 2.3e-07 | 4.4 | 5.4 | 8.3e-08 | 0.03 | 0.56 | 0.41 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | NAP1L4 | 0.09 | 0.01 | blup | 80 | 0.03 | 2.5e-03 | 6.3 | -5.3 | 1.2e-07 | -0.04 | 0.01 | 0.80 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC22A18AS | 0.34 | 0.10 | blup | 60 | 0.15 | 3.2e-14 | 5.7 | 6.0 | 2.1e-09 | 0.01 | 0.10 | 0.90 | TRUE |