TWAS hub - NAP1L4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1280	0.0410	1.8e-04	0.020	NA	0.019	NA	0.033	8.2e-03	NA	9.2e-03	NA	9.8e-04
2	GTEx	Adipose Visceral Omentum	0.1280	0.0500	4.6e-03	0.012	NA	0.030	NA	0.017	7.2e-02	NA	1.0e-02	NA	4.5e-02
3	GTEx	Esophagus Mucosa	0.1670	0.0430	1.4e-06	0.104	NA	0.136	NA	0.122	1.8e-07	NA	2.4e-09	NA	1.6e-08
4	GTEx	Muscle Skeletal	0.0900	0.0364	2.6e-03	0.000	NA	-0.002	NA	-0.002	3.4e-01	NA	7.0e-01	NA	6.2e-01
5	GTEx	Nerve Tibial	0.1597	0.0496	3.4e-04	0.017	NA	0.087	NA	0.084	2.0e-02	NA	9.8e-07	NA	1.4e-06
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1680	0.0550	4.1e-04	0.004	NA	0.019	NA	0.015	1.8e-01	NA	3.0e-02	NA	4.9e-02
7	GTEx	Skin Sun Exposed Lower leg	0.1270	0.0370	1.2e-04	0.046	NA	0.026	NA	0.030	1.0e-04	NA	2.7e-03	NA	1.4e-03
8	GTEx	Testis	0.2370	0.0640	8.4e-06	0.122	NA	0.114	NA	0.129	4.5e-06	NA	1.0e-05	NA	2.4e-06
9	METSIM	Adipose	0.0932	0.0233	5.0e-08	0.092	0.046	0.079	0.075	0.084	1.1e-13	1.5e-07	8.0e-12	2.7e-11	1.4e-12
10	ROSMAP	Brain Pre-frontal Cortex	0.0698	0.0251	2.2e-03	0.008	0.018	0.023	0.016	0.012	2.7e-02	1.7e-03	4.7e-04	3.3e-03	1.0e-02
11	YFS	Blood	0.0638	0.0146	5.2e-09	0.031	0.024	0.030	0.028	0.027	2.3e-10	1.6e-08	4.5e-10	9.6e-10	3.5e-09
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0811	0.0287	7.1e-08	0.034	0.065	0.060	NA	0.025	9.7e-05	7.8e-08	2.3e-07	NA	6.9e-04
13	TCGA	Stomach Adenocarcinoma	0.0850	0.0410	2.1e-03	0.007	0.031	0.004	NA	0.001	9.1e-02	2.5e-03	1.6e-01	NA	2.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Type 2 Diabetes (T2D) (2012)	7.5	8.7	14.2	3.2	2.9	3.8	-3.4	3.3	3.3	3.4	3.3	2.8	2.3	2.1	2.3	1.0
Diverticular disease/diverticulitis (self-reported)	4.5	5.4	10.8	3.1	2.2	2.6	-1.4	2.7	1.8	3.1	3.1	3.3	0.6	1.3	2.0	0.5
Ever taken oral contraceptive pill	4.2	4.7	10.4	-2.5	-1.1	-1.8	2.0	-2.9	0.3	-3.1	-3.2	-2.9	-1.5	-1.4	-2.2	-0.6
Emphysema/chronic bronchitis	3.7	4.2	8.8	2.0	2.5	2.4	-1.3	2.1	1.9	2.5	3.0	2.8	0.6	0.2	1.9	0.5
HDL Cholesterol	3.2	5.3	9.0	-2.8	-1.4	-2.3	2.8	-3.0	-1.3	-2.9	-2.9	-2.3	-0.6	-2.4	-2.6	-0.6
Illnesses of siblings: Diabetes	3.1	3.8	6.8	2.2	1.9	2.1	-0.4	2.5	1.8	2.0	1.9	1.7	1.8	1.6	2.6	2.1
Relative age voice broke	2.9	4.4	7.6	2.4	2.6	2.0	1.2	2.6	0.9	2.4	2.5	2.8	2.0	-1.5	1.7	1.4
Ever had prostate specific antigen (PSA) test	2.8	3.3	6.8	-1.9	-2.2	-2.2	0.7	-2.4	-0.7	-1.9	-2.0	-1.8	-2.6	0.2	-1.8	-1.2
Primary Biliary Cirrhosis	2.7	3.9	9.6	-1.4	-2.5	-1.5	0.0	-2.4	-1.4	-2.0	-1.3	-1.8	-3.1	-0.7	-2.6	-2.4
Pain all over the body in last month	2.7	2.9	4.9	1.8	2.2	2.1	-0.0	2.0	1.7	1.5	1.8	1.8	1.8	-0.3	1.8	1.6
Arm fat percentage (right)	2.6	10.2	18.1	-3.2	-3.8	-4.2	1.7	-4.2	-1.2	-4.0	-4.0	-3.6	-3.5	-1.1	-2.9	-1.5
Breast cancer (self-reported)	2.6	3.1	6.6	2.0	1.5	2.3	-2.5	1.1	0.6	2.2	2.6	2.4	-0.4	-0.1	0.7	-1.6
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	9.1	-1.5	-3.0	-1.5	-0.1	-2.9	-2.5	-1.8	-1.8	-1.6	-2.5	-1.4	-2.0	-1.5
Worry too long after embarrassment	2.5	4.3	9.8	-2.8	-1.0	-2.0	3.1	-2.1	-3.0	-2.1	-2.4	-1.9	-0.5	-1.2	-1.7	0.4
Arm fat percentage (left)	2.5	9.9	17.3	-3.2	-3.7	-4.1	1.4	-4.2	-1.3	-4.0	-3.9	-3.6	-3.5	-1.2	-2.8	-1.4
Hip circumference	2.3	10.0	21.9	-2.6	-4.2	-3.9	0.9	-4.5	-0.5	-3.5	-3.3	-2.9	-4.7	-2.0	-2.8	-2.2
Alzheimer’s Disease (in father)	2.2	2.4	4.9	1.4	0.4	1.9	-1.1	1.2	2.2	1.7	1.6	1.5	0.7	1.8	2.2	1.2
HbA1C	2.2	2.4	5.2	2.0	1.9	2.3	-2.0	1.4	0.7	1.8	1.9	1.9	0.3	0.4	1.5	-0.1
Blood White Count	2.2	16.1	36.0	5.0	2.7	5.0	-4.4	4.4	2.5	5.3	6.0	5.2	1.1	1.1	3.5	0.7
Fractured/broken bones in last 5 years	2.2	2.8	8.4	-1.8	-2.9	-0.7	-0.1	-1.9	-2.1	-1.3	-1.4	-1.4	-1.9	-0.7	-1.8	-1.9
Allergy or Eczema	2.1	5.5	12.9	2.0	2.5	2.8	-2.8	1.9	2.1	2.5	2.1	2.0	1.0	3.6	3.0	1.1
Severe depression (siblings)	2.1	2.4	4.7	1.8	1.2	1.3	0.4	1.5	1.9	1.5	1.4	1.4	2.2	1.2	1.6	1.9
Serious illness, injury or assault to yourself	2.1	2.5	7.7	1.7	1.6	0.8	1.8	1.8	0.9	1.2	1.0	1.3	2.8	-1.0	1.3	2.3
Shortness of breath walking on level ground	2.1	2.6	5.0	-1.5	-1.3	-1.5	0.1	-2.2	-0.3	-1.9	-1.5	-1.6	-2.1	-1.5	-2.1	-1.5
Maternal smoking around birth	2.0	2.9	6.1	-2.5	-1.1	-2.3	1.4	-1.7	-2.1	-2.2	-2.3	-2.2	-0.4	0.2	-0.8	0.5
Headache pain in last month	2.0	3.4	6.5	-2.0	-2.4	-2.5	2.5	-0.6	-2.2	-2.1	-1.7	-2.1	-0.0	-1.5	-1.3	0.4
Chronic bronchitis/emphysema (mother)	2.0	2.3	6.0	-1.0	-2.5	-1.9	1.2	-2.0	-0.5	-1.3	-1.2	-0.7	-1.3	-1.5	-2.2	-1.3
Medication: Allopurinol	2.0	2.6	7.8	-2.1	-1.6	-1.7	2.8	-1.6	-0.4	-2.0	-2.2	-1.4	-0.2	-0.3	-1.5	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	6.2	-0.1	-1.5	-1.1	-0.9	-1.4	1.1	-1.3	-0.9	-0.8	-2.2	-0.9	-2.5	-2.5
Medication: Gliclazide	1.9	2.1	4.6	1.6	1.3	1.5	-1.2	2.1	1.5	1.7	1.5	1.1	1.8	1.2	1.2	0.7
Wears glasses or contact lenses	1.9	2.2	10.2	1.9	1.7	1.6	-1.6	0.8	3.2	1.0	1.5	1.3	0.0	0.4	0.7	-0.5
BMI	1.8	10.6	17.5	-3.4	-3.4	-4.2	2.8	-4.0	-1.7	-3.9	-4.0	-3.6	-3.1	-2.5	-3.1	-1.4
Body mass index (BMI)	1.8	7.5	14.7	-2.5	-3.4	-3.8	1.3	-3.7	-1.5	-3.4	-3.4	-2.8	-3.2	-1.1	-2.1	-0.7
Depression (self-reported)	1.8	2.1	9.1	0.3	-1.2	-0.7	-0.5	-1.1	-0.5	-0.8	-0.6	-0.7	-1.7	-3.0	-1.9	-2.6
Heel T-Score	1.7	13.4	22.5	4.3	3.6	3.6	-0.9	4.7	2.0	4.6	4.5	4.3	3.7	1.9	4.1	2.9
Comparative body size at age 10	1.7	4.7	9.9	-1.5	-2.8	-3.1	1.5	-3.0	-0.8	-3.0	-3.1	-2.4	-1.7	-1.0	-1.6	0.3
Osteoarthritis (self-reported)	1.7	2.2	5.9	-1.1	-2.2	-1.2	-0.7	-2.1	-2.4	-0.9	-0.7	-0.5	-2.2	0.3	-1.2	-1.2
Arm fat mass (left)	1.7	6.8	13.8	-2.4	-3.2	-3.4	1.1	-3.7	-1.4	-3.0	-3.1	-2.6	-3.4	-1.6	-2.1	-1.1
Leg fat percentage (left)	1.7	6.1	13.0	-2.2	-2.8	-3.1	1.2	-3.6	0.1	-3.2	-2.9	-2.6	-3.1	-1.3	-2.1	-1.2
Arm fat mass (right)	1.6	6.8	13.8	-2.5	-3.1	-3.4	1.2	-3.7	-1.7	-2.9	-3.0	-2.5	-3.4	-1.4	-2.0	-1.1
Loud music exposure frequency	1.6	1.7	4.6	-1.9	-0.3	-1.3	1.7	-0.5	-2.1	-1.2	-1.5	-1.4	0.7	1.1	-0.1	1.3
Leg fat percentage (right)	1.6	5.9	12.2	-2.2	-2.7	-3.0	1.2	-3.5	-0.0	-3.1	-2.8	-2.6	-3.0	-1.5	-2.2	-1.3
Age started oral contraceptive pill	1.6	2.0	4.7	1.3	1.6	1.9	0.1	1.2	-0.1	2.2	1.7	2.0	1.2	0.4	1.6	1.2
Blood Eosinophil Count	1.5	11.9	57.0	0.6	-0.2	2.6	-7.5	-1.5	1.1	0.4	2.1	0.7	-5.6	-1.2	-2.3	-6.6
Diabetes (father)	1.5	1.8	3.8	1.7	1.7	1.8	-0.9	1.4	1.8	1.3	1.9	1.5	0.5	0.6	0.8	-0.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	5.2	-1.3	-1.2	-0.5	0.2	-1.8	-1.4	-1.3	-1.1	-1.2	-1.1	-2.3	-1.5	-1.3
Body fat percentage	1.5	6.1	12.3	-2.3	-3.0	-3.2	1.2	-3.5	-0.5	-3.0	-2.9	-2.7	-2.9	-1.2	-2.1	-1.1
Eye problems/disorders: None of the above	1.4	1.6	3.0	1.4	1.5	1.4	-0.7	1.7	0.8	1.4	1.5	1.2	1.7	-0.2	1.2	0.9
Neck or shoulder pain in last month	1.4	2.0	6.4	-1.3	-0.9	-1.4	2.5	-1.1	-0.0	-1.6	-1.9	-1.8	0.8	0.1	-0.1	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	6.1	2.1	2.0	2.3	-0.5	1.2	0.9	2.2	2.5	2.2	1.1	-0.7	1.8	1.3
Commuting to job workplace: Walk	1.4	1.5	5.3	1.1	0.2	0.0	1.0	1.7	-0.5	0.8	-0.3	0.6	2.1	0.5	1.6	2.3
Medication for cholesterol	1.4	2.1	7.4	-1.0	-1.5	-1.0	0.9	-0.8	-0.0	-1.1	-0.7	-0.7	-1.6	-2.7	-1.9	-2.3
Average weekly beer plus cider intake	1.4	2.0	3.5	-1.2	-1.9	-1.5	0.7	-1.8	-1.5	-1.8	-1.5	-1.5	-1.7	1.1	-1.0	-0.2
Irritability	1.4	2.4	5.5	-1.8	-1.4	-2.1	1.7	-1.0	-1.6	-1.8	-2.3	-2.2	-0.3	-0.3	-0.9	0.4
Bipolar Disorder (2018)	1.3	2.0	5.3	1.3	2.3	1.6	-0.6	1.5	1.9	1.4	1.5	1.4	1.2	0.7	1.3	0.9
Worry (Nagel 2018)	1.3	2.7	9.6	0.0	1.6	1.2	2.2	2.1	-1.8	1.1	0.5	1.0	3.1	-1.2	1.2	1.8
Ovarian Cancer	1.3	1.7	3.7	1.8	0.8	1.4	-1.9	0.8	0.2	1.2	1.9	1.8	-0.9	-1.2	0.2	-1.3
Pulse rate	1.3	2.2	6.4	2.3	0.8	1.6	-1.7	1.6	0.4	1.9	2.5	2.0	0.2	-0.2	0.7	-0.4
Happiness	1.3	1.5	6.7	-1.1	-0.9	-0.5	-0.2	-0.8	-0.7	-0.9	-0.3	-0.7	-1.3	-2.6	-1.7	-2.0
Birth weight	1.3	2.9	6.0	-1.6	-1.1	-2.2	0.1	-1.7	-0.4	-2.3	-2.1	-2.4	-2.0	-1.7	-1.6	-1.1
Angina (self-reported)	1.3	1.7	3.8	1.6	0.9	1.6	-0.4	1.5	1.5	1.8	1.9	1.6	0.5	1.0	0.9	0.4
Medication: Seretide 50 evohaler	1.3	1.5	4.0	1.0	2.0	1.6	-0.8	1.3	-0.4	1.4	1.8	1.3	0.9	1.1	0.9	0.3
Heart disease (mother)	1.3	1.5	3.4	-1.0	-0.1	-1.1	1.4	0.2	-0.3	-1.3	-1.4	-1.7	1.6	1.8	0.4	1.7
Leg fat mass (right)	1.3	5.0	10.9	-2.0	-2.6	-2.9	1.2	-3.3	-0.7	-2.7	-2.6	-2.2	-3.1	-1.2	-1.6	-0.8
Mother’s age at death	1.3	1.6	4.7	0.9	1.8	0.9	-0.1	2.1	2.2	1.0	0.9	0.8	1.0	0.9	1.2	0.6
Angina	1.2	1.5	3.1	1.4	0.9	1.6	-0.3	1.5	1.4	1.7	1.8	1.4	0.6	1.0	0.9	0.4
Diabetes (mother)	1.2	1.5	4.1	1.4	0.9	1.6	-1.0	1.5	2.0	1.0	1.4	0.9	0.6	0.8	1.3	0.8
Worrier / anxious feelings	1.2	2.3	8.1	0.1	1.6	0.7	2.9	1.5	-1.7	0.8	0.5	0.8	2.5	-1.6	0.7	1.7
Loneliness, isolation	1.2	1.6	3.4	-1.4	-1.5	-1.1	1.8	-1.1	-1.4	-1.5	-1.4	-1.1	-0.6	-1.4	-0.8	0.7
Pain experienced in last month	1.2	2.1	7.9	0.5	0.9	1.9	-2.8	-1.0	1.1	1.0	1.3	1.2	-1.8	0.2	-0.4	-2.1
Leg fat mass (left)	1.2	4.7	10.4	-1.9	-2.5	-2.9	1.3	-3.2	-0.7	-2.6	-2.6	-2.1	-2.9	-1.1	-1.4	-0.6
Depression (Nagel 2018)	1.1	1.6	3.7	-1.7	-0.8	-0.8	1.8	-1.1	-1.7	-1.3	-1.1	-1.3	-0.4	-1.9	-1.0	-0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.3	-1.6	-1.7	-1.1	0.7	-1.1	-0.4	-1.5	-1.6	-1.8	-1.2	-1.0	-0.6	-0.3
Trunk fat percentage	1.1	4.5	9.8	-2.1	-2.7	-2.9	0.9	-3.1	-0.7	-2.5	-2.5	-2.2	-2.5	-0.9	-1.6	-0.8
Qualifications: CSEs or equivalent	1.1	1.4	3.8	-0.8	-1.5	-1.3	0.1	-0.5	-0.6	-1.5	-1.3	-2.0	-0.7	-1.4	-1.3	-1.2
Medication: Ibuprofen	1.1	1.3	3.2	-1.8	-0.1	-0.5	0.6	-1.2	-1.7	-1.5	-1.5	-1.7	-0.8	0.5	0.1	0.3
Whole body fat mass	1.1	4.8	10.8	-2.0	-2.6	-2.9	1.0	-3.3	-1.0	-2.5	-2.6	-2.1	-2.9	-1.1	-1.4	-0.7
Leg pain on walking	1.1	1.3	3.2	-0.6	-1.4	-1.0	0.1	-0.6	-0.8	-0.9	-0.8	-1.1	-1.3	-1.8	-1.8	-1.5
Medication: Atorvastatin	1.1	1.4	7.1	-0.8	1.5	-0.1	2.7	0.5	0.5	-0.4	-0.6	-0.6	1.9	-0.7	0.2	1.7
Blood Platelet Count	1.0	11.2	30.8	-2.3	-3.3	-1.4	-3.9	-4.0	-1.2	-3.1	-1.4	-2.3	-5.5	-1.5	-4.1	-5.3
Hypothyroidism (self reported)	1.0	2.4	4.0	1.8	1.4	1.6	0.0	1.9	0.8	1.8	2.0	1.9	0.9	1.4	1.9	1.5
Respiratory disease	1.0	2.2	12.3	0.2	1.5	1.4	-1.9	0.7	1.9	0.9	0.9	0.3	-0.2	3.5	1.6	0.5
Relative age of first facial hair	1.0	2.0	3.9	1.5	2.0	1.4	0.1	1.9	1.4	1.7	1.9	1.7	1.1	-1.0	1.0	0.6
Ever had hysterectomy (womb removed)	1.0	1.1	4.4	-1.2	-1.3	-2.1	0.3	-0.6	0.0	-1.2	-0.9	-1.4	0.4	-0.1	-1.4	-0.2
Hayfever, allergic rhinitis or eczema	1.0	2.3	6.6	0.9	1.7	1.7	-1.8	1.0	0.3	1.6	1.2	1.2	1.1	2.6	2.1	1.1
Trunk fat mass	1.0	4.2	10.0	-1.9	-2.5	-2.7	0.7	-3.2	-1.2	-2.2	-2.3	-1.9	-2.8	-1.1	-1.3	-0.8
Waist circumference	1.0	3.7	8.9	-1.8	-2.5	-2.3	0.5	-2.8	-0.6	-2.2	-2.0	-1.7	-3.0	-1.3	-1.5	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	10.2	0.9	0.3	0.7	2.0	1.1	0.7	0.9	0.5	1.0	2.4	0.3	2.1	3.2
Financial difficulties in last 2 years	1.0	1.3	2.7	-1.1	-1.2	-1.2	1.0	-1.4	-1.6	-1.3	-1.3	-1.4	-0.9	-0.3	-0.9	-0.4
Neuroticism score	1.0	2.1	9.7	-1.4	-0.2	-0.5	3.1	0.1	-2.6	-0.6	-1.1	-0.7	1.4	-1.0	0.1	1.7
Illnesses of mother	1.0	1.2	5.2	0.3	0.9	0.6	-1.0	0.4	0.6	0.1	0.7	0.6	-1.2	-1.9	-1.3	-2.3
Exposure to tobacco smoke outside home	1.0	1.4	3.0	-0.5	-1.7	-0.6	-1.1	-1.2	1.0	-1.3	-0.7	-1.4	-1.6	0.7	-1.1	-1.3
Age at last live birth	1.0	1.4	4.1	1.1	0.9	2.0	-0.8	0.7	0.4	1.4	1.8	1.6	-0.1	-1.3	0.0	-1.2
Miserableness	1.0	1.7	6.2	-1.0	-1.2	-0.9	2.2	-0.8	-2.5	-1.1	-1.3	-1.0	0.7	-1.3	-0.3	1.1
Risk taking	1.0	1.5	4.9	-1.4	-1.1	-1.6	1.2	-1.6	-2.2	-1.1	-1.6	-1.1	-0.3	-0.2	-0.3	0.6
Neuroticism (Nagel 2018)	0.9	2.1	7.0	-1.4	0.2	-0.6	2.6	0.7	-2.6	-0.5	-1.2	-0.9	2.1	-1.0	0.2	1.5
Age at First Birth	0.9	1.3	3.1	0.7	-0.2	1.5	-1.4	-0.2	-0.6	1.6	1.8	1.7	-1.2	-0.2	-0.3	-1.3
Medication: Metformin	0.9	1.3	4.0	1.0	1.5	2.0	-1.3	0.8	1.4	1.1	1.3	0.8	0.5	1.0	0.4	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.3	-1.5	-1.2	-0.6	1.5	-1.1	-1.8	-0.8	-0.9	-0.8	-0.5	-1.5	-0.7	0.2
High blood pressure (mother)	0.9	1.3	4.6	-0.8	-1.0	-0.3	-0.1	-1.4	-1.4	-0.4	-0.8	-0.5	-0.9	2.1	1.1	1.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.5	-1.6	-0.4	-1.3	1.1	-0.7	-1.5	-1.2	-1.5	-1.2	-0.4	0.9	-0.3	0.5
Pulse rate, automated reading	0.9	3.0	5.4	1.9	1.9	2.3	-0.7	1.9	0.1	2.1	2.3	2.2	1.8	-0.5	1.6	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.9	-0.3	-1.4	-1.4	0.9	-1.1	1.2	-1.3	-0.9	-1.1	-1.0	-0.2	-1.0	-0.7
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.3	-0.6	-1.0	-0.4	-0.6	-1.6	-1.8	-0.5	0.2	-0.1	-1.2	-0.8	-1.3	-1.8
Unable to work because of sickness or disability	0.9	1.2	4.5	-0.4	-0.4	0.3	-0.9	-1.6	1.4	-1.1	-0.6	-0.9	-2.1	-0.8	-0.7	-1.2
Fasting Glucose	0.8	1.0	2.0	-1.1	-0.6	-0.8	-0.3	-1.4	0.7	-1.3	-1.0	-1.3	-0.9	-0.2	-1.4	-0.9
Supplements: Zinc	0.8	0.8	3.8	-0.6	-0.0	-0.6	2.0	-0.1	-0.1	-0.3	-0.9	-0.6	1.2	0.2	0.3	1.9
Medication: Co-codamol	0.8	1.0	2.4	0.5	1.2	1.1	-0.4	0.5	1.3	0.8	1.1	0.7	0.9	0.8	1.5	0.9
Fed-up feelings	0.8	1.5	6.2	-1.1	-1.1	-1.1	2.5	-0.7	-0.7	-1.0	-1.6	-1.1	0.5	-1.2	-0.2	1.3
Nervous feelings	0.8	1.5	4.0	-1.9	-0.8	-0.6	1.9	0.0	-2.0	-0.9	-1.0	-1.1	1.3	-1.2	-0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.8	-1.7	-1.6	-0.8	0.7	-1.0	-1.4	-1.3	-1.4	-1.7	-0.5	-0.6	-0.5	-0.3
Falls in the last year	0.8	1.1	3.9	-0.6	-0.1	-1.2	2.0	-1.1	0.0	-1.4	-1.4	-1.2	0.1	-0.4	-1.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.9	-1.7	-0.2	-0.7	0.8	-0.9	-1.5	-1.4	-1.3	-1.5	-0.8	0.2	0.1	0.2
Medication: Cholesterol lowering	0.8	1.2	4.9	-0.3	0.5	1.0	-0.4	-1.0	-0.8	-0.3	-0.0	-0.2	-1.4	-1.5	-1.8	-2.2
Peak expiratory flow (PEF)	0.8	1.9	6.2	1.3	0.8	0.5	-0.0	1.7	-0.4	1.3	0.9	1.3	2.1	1.1	1.9	2.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.7	-1.1	-1.0	-1.2	0.8	-1.1	-1.2	-1.2	-1.3	-1.1	-0.6	-0.0	-0.9	-0.3
High blood pressure (siblings)	0.8	1.2	3.9	-0.2	1.0	-0.2	1.7	0.7	-1.4	0.4	-0.0	0.5	1.6	1.1	1.0	2.0
Suffer from ‘nerves’	0.8	1.3	7.0	-0.5	0.2	0.2	2.6	0.4	-0.5	-0.4	-0.8	-0.5	1.2	-2.6	-0.1	0.4
Knee pain experienced in last month	0.8	1.2	2.9	-1.2	-1.7	-1.2	0.9	-1.1	-1.3	-1.4	-1.2	-1.4	-0.4	0.6	-0.8	0.0
Qualifications: nursing, teaching	0.8	1.3	4.0	-1.7	-0.0	-1.5	0.9	0.2	-0.8	-1.3	-2.0	-2.0	0.4	0.7	-0.1	0.4
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.6	-1.5	-0.7	0.2	-1.4	-0.7	-1.0	-1.3	-0.7	-1.1	0.4	-1.1	-0.5
Asthma (self-reported)	0.8	1.5	9.9	-0.9	0.2	-0.0	-1.1	-0.8	1.5	-0.8	-0.9	-1.6	-0.7	3.1	0.3	0.0
Illnesses of father: None of the above (group 1)	0.8	1.0	2.9	-0.6	-1.5	-0.9	-0.2	-1.2	-1.0	-0.9	-1.1	-0.8	-0.8	-1.7	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.2	-0.8	-1.0	-1.7	1.6	-0.4	-1.0	-1.4	-1.7	-1.4	0.5	-2.3	-0.6	0.7
Financial situation satisfaction	0.8	1.0	2.0	-1.0	-0.9	-0.4	0.2	-1.1	-0.5	-0.9	-0.8	-1.1	-1.2	-1.1	-1.4	-1.2
Eye problems/disorders: Glaucoma	0.8	1.0	2.2	-1.2	-0.7	-1.1	1.0	-1.1	-1.5	-0.9	-1.4	-0.8	0.1	0.8	0.3	0.8
Alcohol drinker status: Never	0.8	0.9	3.1	-0.0	0.7	0.4	1.5	1.0	0.6	0.9	0.8	0.5	1.8	-0.8	0.7	1.2
Number of operations (self-reported)	0.8	1.1	4.9	0.4	-1.1	-0.6	0.2	-1.2	1.1	-0.5	0.0	0.4	-1.7	-2.2	-1.1	-0.8
Cholesterol lowering medication	0.8	1.2	5.9	0.9	1.0	0.0	0.2	0.5	1.0	0.6	0.1	0.2	1.8	1.1	1.4	2.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	-1.3	-0.8	-1.2	1.2	-1.0	-1.3	-0.4	-0.7	-0.4	0.7	-0.8	-0.9	0.4
Prostate Cancer	0.7	1.0	4.4	1.1	-0.3	1.0	-2.1	-0.3	0.2	0.7	1.3	1.0	-1.2	-0.4	-0.1	-1.3
Coronary Artery Disease (CAD)	0.7	0.8	2.2	0.5	0.1	0.7	-0.7	0.5	-0.4	1.5	1.4	1.3	1.1	-1.2	0.2	0.2
Ulcerative Colitis	0.7	1.1	3.2	-0.5	-1.5	0.0	-1.0	-0.8	-0.5	-0.5	-0.2	0.2	-1.7	-1.8	-1.0	-1.4
Height	0.7	13.4	26.5	3.7	3.9	5.1	-2.5	3.1	-1.5	5.1	5.0	5.2	1.1	-0.1	4.5	1.6
Neuroticism	0.7	1.7	7.1	-0.6	-0.1	-0.3	2.5	0.7	-2.7	-0.0	-0.6	-0.1	1.7	-0.9	0.4	1.8
Hand grip strength (left)	0.7	1.8	5.4	-1.1	-1.4	-1.2	0.5	-1.9	-2.3	-0.7	-0.8	-0.3	-1.3	-1.9	-1.5	-0.9
Townsend deprivation index at recruitment	0.7	0.9	4.1	-0.6	-1.1	-0.1	-0.8	-1.2	0.0	-0.8	-1.2	-0.8	-2.0	0.5	-0.6	-1.0
Age when periods started (menarche)	0.7	1.7	12.0	0.7	0.7	1.2	-0.5	-0.5	-1.1	0.6	1.1	1.4	-0.1	-3.5	-1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	8.4	0.2	-0.3	-0.0	2.0	0.5	0.1	0.1	-0.1	0.1	2.0	0.8	1.7	2.9
Number of incorrect matches in round	0.7	1.2	5.4	-1.0	0.3	-0.5	2.3	-0.5	0.1	-0.4	-0.9	-0.5	1.2	0.8	0.6	2.1
Allergy	0.7	1.7	5.2	-0.9	-1.3	-1.2	2.3	-0.6	-1.0	-1.2	-1.0	-0.8	-0.0	-2.2	-1.7	-0.4
Diabetes (self-reported)	0.7	1.1	2.3	1.1	1.5	1.5	-0.6	1.1	1.1	1.1	1.2	0.9	1.0	0.8	0.7	0.4
Weight	0.7	3.5	9.4	-1.5	-2.3	-2.4	0.7	-3.0	-1.8	-1.7	-1.9	-1.2	-3.1	-1.4	-0.9	-0.4
Mouth/teeth dental problems: Dentures	0.7	1.2	6.0	0.2	-0.3	0.4	-2.4	-0.6	1.4	-0.1	0.3	0.1	-2.0	1.2	0.0	-1.3
Number of children fathered	0.7	0.8	2.9	-0.3	-0.4	-0.7	-0.6	-1.0	-0.2	-1.1	-0.4	-0.4	-1.4	-0.7	-1.3	-1.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	-0.9	-1.1	-1.3	-0.4	-0.9	-1.0	-1.3	-1.3	-1.1	-0.7	0.1	-0.1	0.4
Number of full sisters	0.7	0.8	5.5	0.1	1.6	0.4	0.1	0.1	2.3	-0.5	-0.3	-0.4	0.6	0.9	0.4	0.8
Chest pain or discomfort	0.7	1.0	2.8	1.0	0.3	1.5	-0.7	0.6	0.6	1.5	1.7	1.4	0.1	0.8	1.1	0.4
Family relationship satisfaction	0.7	0.8	4.4	0.1	-0.5	0.4	-1.3	-0.0	-1.0	0.5	0.7	0.7	-0.5	-2.1	-0.7	-1.1
Smoking status: Previous	0.7	1.0	7.8	1.0	0.6	0.2	0.6	-0.1	0.5	0.3	0.6	0.9	0.1	-2.8	-1.0	-0.9
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.3	0.1	-1.6	0.1	-1.1	-0.6	-0.6	0.2	0.7	0.4	-0.8	-1.4	-0.7	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.2	-0.7	-1.0	-1.0	0.2	-0.6	0.1	-1.0	-0.7	-0.8	-1.5	-0.3	-0.8	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-1.1	-1.6	-1.1	-0.0	-0.9	-0.9	-1.0	-1.3	-1.2	-0.6	0.4	-0.5	0.1
Illnesses of father: High blood pressure	0.7	0.9	6.1	-0.8	-1.1	-1.1	0.2	-0.7	-2.5	-0.8	-0.5	-0.5	-0.5	0.1	-0.7	-0.2
Heart disease (siblings)	0.7	0.9	6.2	0.3	0.3	0.7	-0.4	0.8	-0.0	0.4	0.4	0.3	0.8	2.5	1.2	1.4
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	0.9	1.6	1.4	0.4	1.0	0.1	1.6	1.7	1.9	1.0	0.2	1.4	1.1
Schizophrenia vs Biploar Disorder	0.6	0.8	4.3	-0.4	-2.1	-0.5	0.6	-0.8	-0.7	-0.3	-0.1	-0.2	-1.4	-1.1	-0.7	-0.4
Crohns Disease (2012)	0.6	0.9	2.8	-0.9	-1.6	-0.5	-0.7	-1.2	-1.1	-0.8	-0.5	-0.5	-1.7	0.4	-0.5	-1.0
Neuroticism (2016)	0.6	0.8	3.6	-0.5	-0.9	-0.4	1.9	-1.0	-1.1	-0.2	-0.7	-0.2	-0.2	-1.4	-0.7	0.5
Triglycerides	0.6	0.9	1.6	1.3	1.1	1.0	-0.9	0.9	1.0	1.0	1.0	1.0	0.7	1.0	0.6	0.8
Waist Hip Ratio (WHR)	0.6	2.7	9.5	0.6	2.4	3.1	-0.9	1.6	1.0	1.9	2.1	1.7	1.5	0.3	1.2	0.7
Lung FVC	0.6	3.0	8.7	-2.5	-0.0	-2.3	1.5	1.0	-0.3	-1.8	-2.7	-3.0	1.4	1.3	0.2	1.1
Sensitivity / hurt feelings	0.6	1.0	3.8	-1.3	-0.9	-1.2	0.9	-0.3	-1.9	-0.8	-1.2	-1.1	0.4	-0.1	-0.2	0.8
Impedance of leg (left)	0.6	2.8	6.6	1.3	2.2	2.2	0.2	1.7	2.6	1.7	2.2	1.6	2.1	-0.0	0.6	0.3
Illnesses of siblings	0.6	0.9	3.7	-0.6	-1.1	-0.8	-0.3	-0.7	-0.2	-0.8	-0.6	-0.9	-0.6	-1.9	-1.2	-1.4
Asthma	0.6	1.3	7.7	-0.9	0.4	-0.1	-1.2	-0.7	1.3	-0.8	-0.9	-1.5	-0.8	2.8	0.2	-0.1
Lung cancer (father)	0.6	0.7	2.3	-0.1	-1.4	-1.2	-0.7	-1.0	-1.5	-1.0	-0.9	-0.5	-0.3	0.2	-0.2	0.1
Pulse wave Arterial Stiffness index	0.6	0.6	1.9	0.4	-1.4	-1.2	0.2	-0.4	-0.7	-0.5	0.0	0.1	-0.7	-0.9	-1.3	-1.0
Exposure to tobacco smoke at home	0.6	0.7	3.8	0.1	-0.5	0.5	-1.9	0.1	0.1	-0.3	0.1	-0.1	-1.4	-0.7	-0.5	-1.5
Tense / ‘highly strung’	0.6	1.0	4.4	-0.5	0.4	0.7	1.6	1.1	-0.4	0.4	-0.2	0.1	2.1	-0.7	0.8	1.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	-1.2	-0.5	-0.2	1.5	-1.0	-1.2	-0.6	-0.9	-0.6	-0.4	0.5	-0.2	0.7
Number of full brothers	0.6	0.7	4.0	0.6	0.3	0.9	-1.1	0.4	2.0	0.5	0.5	0.2	-0.9	1.0	0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.0	-0.2	0.4	0.0	-1.0	0.7	1.4	-0.1	0.2	-0.2	-0.6	-1.1	-0.6	-1.7
Diabetes diagnosed by doctor	0.6	1.0	2.6	0.9	1.6	1.4	-0.5	1.0	0.5	0.9	1.1	0.8	1.1	1.0	0.8	0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.7	-0.0	1.3	0.1	0.6	1.2	-1.3	0.5	0.1	0.2	1.9	-0.4	0.7	1.2
Medication: Aspirin	0.6	0.8	2.9	0.2	-0.1	0.4	-0.3	-1.7	1.0	-0.1	0.1	0.5	-1.4	-1.1	-1.6	-0.8
Guilty feelings	0.6	1.0	5.2	-0.6	0.1	-0.5	2.3	0.2	-0.9	-0.1	-0.5	-0.1	1.6	-0.6	-0.0	1.6
Medication: Blood pressure	0.6	1.1	5.1	-0.5	0.3	-0.8	0.3	-0.2	-1.0	-0.4	-0.7	-0.5	0.9	2.3	1.0	2.0
Commuting to job workplace: Cycle	0.6	0.7	5.3	-0.8	-0.3	-1.2	0.4	0.1	-2.3	-0.6	-0.8	-0.2	-0.0	-0.7	-0.2	-0.1
Depressed Affect (Nagel 2018)	0.5	1.1	5.0	-0.6	-0.4	-0.6	2.2	-0.1	-1.6	-0.7	-1.1	-0.8	0.9	-0.6	0.4	1.6
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.6	-0.8	-1.8	-1.6	-0.1	-1.6	-1.9	-1.0	-1.0	-0.5	-1.1	-0.2	-0.8	-0.4
Breast Cancer	0.5	1.3	4.8	-0.9	0.4	-1.2	2.2	0.1	1.4	-1.4	-1.3	-1.5	1.1	0.1	-0.3	0.8
LDL Cholesterol	0.5	0.7	2.3	-0.4	0.1	-0.0	-1.1	-0.9	0.3	-1.2	-1.1	-0.8	-1.5	0.9	-0.5	-0.6
Cardiovascular Disease	0.5	1.8	5.4	-1.4	-0.3	-0.9	0.2	-2.3	-1.9	-1.7	-1.8	-1.5	-1.2	-0.5	-1.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.6	1.1	0.5	0.3	-0.4	1.3	-1.3	0.9	0.9	0.8	0.7	-0.9	0.1	-0.6
Medication for hormone replacement therapy	0.5	0.6	1.2	0.7	0.4	0.8	0.0	0.9	-0.3	0.9	1.0	0.9	0.9	0.4	0.8	1.1
Impedance of leg (right)	0.5	2.6	5.8	1.3	2.0	2.4	-0.1	1.6	2.4	1.7	2.3	1.5	1.7	-0.5	0.4	-0.3
Heart attack	0.5	0.6	1.7	0.5	0.6	1.0	-0.5	0.6	0.2	0.8	1.3	0.7	-0.1	-1.3	-0.6	-1.1
Medication: Ramipril	0.5	0.6	2.1	0.6	0.0	0.7	-1.4	0.4	-1.0	0.2	0.8	0.5	-0.8	-0.6	-0.4	-1.3
Father’s age at death	0.5	0.7	1.9	0.6	1.1	1.1	-0.2	0.7	-0.2	0.7	0.7	0.6	1.1	0.9	1.4	0.9
Hair/balding pattern: Pattern 3	0.5	0.8	2.4	-0.3	-1.2	-0.3	-0.0	-1.2	-0.4	-0.5	-0.2	-0.3	-0.7	-1.5	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.5	0.3	1.0	0.4	1.1	1.8	-1.0	1.0	0.3	0.5	1.8	-0.0	2.1	2.4
Gout (self-reported)	0.5	0.6	1.5	-0.8	-0.3	-0.3	1.1	-1.0	0.9	-1.0	-1.0	-0.4	-1.2	0.7	-0.6	0.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.9	-0.7	-1.2	-0.9	-0.3	-1.7	-0.6	-0.9	-0.7	-1.0	-1.5	0.3	-1.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.4	0.1	0.1	1.0	0.3	-0.3	-0.8	0.4	0.6	0.7	-0.8	-1.8	0.1	-0.8
Age at first live birth	0.5	0.8	2.0	0.5	0.9	1.2	0.3	1.4	-0.5	1.2	1.0	1.1	1.4	-0.6	0.3	0.1
Pulse wave peak to peak time	0.5	0.6	1.9	-0.3	1.3	1.2	-0.2	0.3	0.3	0.6	0.1	0.1	0.7	0.8	1.4	1.0
Medication: Aspirin	0.5	0.7	2.1	-0.0	-0.1	0.6	-0.6	-1.4	0.7	-0.1	0.1	0.5	-1.5	-0.8	-1.4	-1.0
Illnesses of father: Heart disease	0.5	0.7	3.2	0.1	0.5	-0.0	0.6	0.8	-0.4	0.4	-0.0	-0.0	1.8	0.7	0.9	1.7
Mood swings	0.5	0.9	3.4	-0.4	-0.7	-0.4	1.1	0.2	-0.6	-0.3	-0.9	-0.6	0.2	1.8	1.3	1.8
Friendships satisfaction	0.5	0.6	1.4	0.9	-1.2	0.7	-0.9	0.6	0.5	1.1	0.9	0.9	-0.0	0.1	0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	-1.1	-0.3	-0.9	0.8	-1.0	-0.2	-1.1	-0.6	-1.3	-0.6	-0.6	-0.3	-0.2
Osteoporosis (self-reported)	0.5	0.6	1.6	0.6	0.6	1.3	0.6	0.4	0.6	0.9	1.0	1.1	0.1	-0.8	0.6	0.3
Commuting to job workplace: Public transport	0.5	0.6	1.7	-0.7	-0.3	-0.8	0.9	0.1	-0.9	-0.4	-0.2	-0.5	0.6	-1.1	-1.3	-0.7
Medication: Bendroflumethiazide	0.5	0.8	3.6	0.5	0.7	0.3	-0.0	0.1	0.6	0.5	0.0	0.3	0.5	1.9	1.4	1.8
Ever smoked	0.5	0.8	2.9	-0.1	-0.3	0.2	-1.0	-1.1	0.3	-0.4	0.2	0.1	-1.7	-1.4	-1.0	-1.5
Myopia	0.5	0.7	2.0	0.2	1.4	-0.1	-0.2	1.4	1.2	0.4	0.2	-0.1	1.3	1.4	0.5	0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	-1.1	-0.9	-0.7	0.9	-0.5	-0.1	-0.2	-0.5	-0.4	0.8	0.5	0.4	1.2
Mean Putamen Volume	0.4	0.4	1.0	-0.1	0.8	0.9	-0.2	0.2	0.2	0.8	1.0	0.8	-0.4	-1.0	-0.3	-0.8
Lupus	0.4	0.6	1.6	-1.3	-0.6	-0.5	-0.3	-0.7	-1.0	-1.0	-0.8	-0.8	-1.0	-0.1	-0.6	-0.8
Lung FEV1/FVC ratio	0.4	1.9	7.6	0.7	0.5	0.2	2.5	1.4	-0.2	0.8	0.1	0.7	1.9	-0.3	1.9	2.8
Chronotype (morning person)	0.4	0.9	3.0	0.8	0.5	1.2	-1.0	-0.0	1.7	0.6	1.1	0.4	-0.8	-0.2	-0.5	-1.4
Leg fat-free mass (left)	0.4	2.1	6.7	-0.9	-2.0	-1.5	-0.1	-2.0	-2.6	-0.6	-1.2	-0.5	-2.5	-0.9	0.1	-0.1
Average weekly fortified wine intake	0.4	0.4	1.8	0.8	0.3	0.3	-0.5	0.9	1.4	0.4	0.3	0.0	0.6	1.0	0.1	0.2
Taking other prescription medications	0.4	0.7	3.4	0.3	-0.3	0.2	-1.7	-0.4	0.7	0.1	0.5	0.2	-1.8	0.9	0.3	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	-0.3	-0.0	-0.5	0.1	-0.3	0.8	-1.0	-0.9	-1.5	-0.1	0.2	-0.5	-0.3
Stomach or abdominal pain in last month	0.4	0.5	1.6	-0.1	-0.3	-0.7	0.1	1.0	-0.3	-0.2	-0.6	-0.6	1.0	0.8	0.9	1.3
Supplements: Glucosamine	0.4	0.5	3.8	-0.3	0.5	-0.1	-0.1	0.8	0.5	0.1	-0.2	-0.3	0.1	2.0	0.9	0.5
Leg predicted mass (left)	0.4	2.2	6.8	-1.0	-2.0	-1.5	-0.0	-2.0	-2.6	-0.7	-1.2	-0.5	-2.5	-1.0	0.0	-0.2
Past tobacco smoking	0.4	0.7	5.8	-0.4	-0.3	-0.1	0.1	0.6	-0.4	0.1	-0.3	-0.5	0.7	2.4	1.0	1.1
Alcohol usually taken with meals	0.4	0.7	2.8	0.0	-0.2	-0.6	-0.1	-0.3	0.7	-0.1	-0.3	-0.2	-0.6	-1.7	-1.5	-1.6
Had other major operations	0.4	0.5	2.0	1.0	-0.7	0.2	-0.7	-0.2	0.8	-0.1	0.6	0.7	-1.0	-1.4	-0.3	-0.5
Mouth/teeth dental problems	0.4	0.6	1.7	0.9	0.6	1.3	-0.4	0.4	0.5	0.9	1.0	0.8	0.7	-1.0	-0.2	-0.7
Medication: Simvastatin	0.4	0.6	2.2	0.5	0.5	0.3	-0.4	-0.9	0.4	-0.4	-0.1	-0.2	-0.9	-1.5	-1.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.4	0.2	0.3	-0.2	0.8	0.8	1.6	0.3	-0.3	-0.3	0.7	0.2	0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.0	-0.3	0.8	0.1	1.6	1.1	-1.2	0.6	-0.0	0.1	1.5	-0.7	1.4	2.0
Standing height	0.4	3.8	10.3	1.7	1.9	2.6	-1.2	1.1	-1.1	3.2	2.8	3.1	0.1	-0.8	2.3	0.5
Length of working week for main job	0.4	0.4	3.6	0.4	0.1	0.6	-0.2	-0.2	1.9	0.1	0.1	0.1	-1.2	0.3	0.2	-0.3
Pulse wave reflection index	0.4	0.5	1.0	-0.7	-0.8	-1.0	0.9	-0.6	-0.6	-0.8	-1.0	-0.5	-0.4	0.7	-0.2	0.0
Glaucoma (self-reported)	0.4	0.4	2.7	-0.5	-0.3	-0.7	0.3	-0.5	-1.6	-0.3	-0.7	-0.5	-0.3	0.8	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.4	1.5	0.0	0.9	-0.6	1.0	0.4	0.9	1.6	1.1	-0.7	1.1	0.6	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.5	-0.6	-0.2	1.2	0.1	-0.8	0.1	-0.3	-0.2	1.2	-1.2	0.5	1.1
Health satisfaction	0.4	0.6	1.6	0.0	-0.9	-0.5	1.0	-0.9	-1.1	-0.2	-0.2	0.1	-0.1	-1.2	-0.4	1.1
Overall health rating	0.4	0.8	6.2	0.5	-0.7	-0.7	1.2	-0.5	-0.5	0.1	0.1	0.4	0.6	0.2	0.8	2.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.2	0.3	0.1	0.6	-1.0	-0.8	0.3	0.2	0.4	0.4	-0.4	1.5	0.5	0.5
Hypertension (Self-reported)	0.4	1.0	3.7	-0.7	-0.3	-0.7	-0.0	-1.9	-1.8	-0.9	-1.0	-0.6	-1.5	0.5	0.1	0.6
Average weekly red wine intake	0.4	0.5	2.2	-0.1	-0.8	-0.7	0.5	-0.5	-0.2	-0.5	-0.9	-0.2	-0.6	-1.5	-1.0	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	2.3	-0.1	1.1	-0.1	0.9	0.1	1.1	-0.0	0.0	-0.4	0.6	1.5	0.6	1.3
Back pain experienced in last month	0.4	0.6	3.4	-0.4	0.8	-0.2	1.8	0.7	-0.4	0.1	-0.2	-0.2	0.8	0.3	0.7	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	0.6	0.2	0.2	-0.0	1.0	0.3	0.7	1.0	0.8	0.5	-1.2	0.5	-0.0
Ever depressed for a whole week	0.4	0.5	2.8	-0.3	-0.2	-0.3	1.4	-0.6	-0.1	-0.6	-0.7	-0.5	0.0	-1.7	-0.4	0.3
Supplements: Calcium	0.4	0.5	2.2	-0.9	0.1	-0.4	0.4	-0.1	-0.7	-0.6	-0.9	-0.8	0.2	1.5	0.2	0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.3	0.6	0.9	-0.5	0.4	0.1	0.7	1.1	0.6	0.0	-1.1	-0.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-0.0	-0.2	-0.9	0.2	-1.0	-0.3	-0.6	-0.5	-0.2	-0.6	-1.2	-1.1	-0.5
Alcohol drinker status: Previous	0.4	0.4	1.9	0.8	0.4	0.2	0.7	-0.2	0.3	0.6	0.4	0.6	1.0	0.3	0.3	1.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.1	-0.4	-1.0	-0.7	-0.4	-0.7	-2.0	-0.3	-0.4	0.2	-1.2	-0.7	-0.7	-1.0
Schizophrenia (2018)	0.3	0.6	1.6	0.1	0.3	0.7	1.0	-0.1	-1.2	0.9	1.0	1.3	0.4	0.0	0.7	0.8
Crohns Disease (2017)	0.3	0.7	3.1	-0.7	-0.8	-0.4	-0.4	-0.7	-1.8	-0.3	-0.4	-0.7	-1.3	0.9	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.3	0.8	2.6	-0.8	-0.9	-0.4	-1.3	-0.7	-1.6	-0.4	-0.3	-0.5	-1.5	0.2	-0.6	-0.9
Ulcerative Colitis (UC)	0.3	0.6	2.6	-0.5	-0.7	0.1	-1.6	-0.4	-0.3	-0.0	0.1	0.0	-1.2	-0.7	-0.7	-1.2
Blood Red Count	0.3	2.5	9.3	0.7	2.0	2.2	-3.0	1.3	1.4	1.6	2.1	1.1	-0.4	0.8	0.5	-1.2
Smoking Status	0.3	0.6	1.3	-0.7	-0.3	-0.3	-0.0	-1.2	0.9	-0.9	-0.7	-0.9	-0.9	-0.7	-1.1	-0.7
Number of treatments/medications taken	0.3	0.6	2.0	-0.8	0.0	-0.2	-0.4	-1.1	-0.9	-0.8	-0.6	-0.8	-1.4	1.0	-0.2	-0.2
Average weekly spirits intake	0.3	0.4	2.8	-0.4	-0.2	0.1	-0.2	-0.7	1.7	-0.4	-0.3	-0.3	-0.8	0.9	0.0	-0.3
Current tobacco smoking	0.3	0.5	2.6	-1.0	0.0	0.2	-0.6	-0.2	0.4	-0.4	-0.5	-0.8	-0.1	1.6	0.8	0.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.7	0.6	0.2	0.1	0.5	0.7	-0.7	0.7	1.3	1.0	0.0	-0.4	0.1	0.2
High blood pressure	0.3	0.8	2.8	-0.5	-0.3	-0.5	-0.1	-1.7	-1.4	-0.9	-1.0	-0.6	-1.4	0.4	0.0	0.5
Medication: Levothyroxine sodium	0.3	0.5	1.3	0.9	0.2	0.6	-0.5	1.1	-0.1	0.7	1.0	0.6	-0.6	1.2	0.6	-0.2
Forced vital capacity (FVC)	0.3	1.1	3.0	0.1	1.2	0.5	0.8	1.5	-1.0	0.9	0.2	0.4	1.2	-0.2	1.7	1.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	0.4	0.5	1.1	-1.2	0.1	-0.5	0.6	0.5	0.5	0.4	0.2	0.6	-0.1
Alcohol intake versus 10 years previously	0.3	0.5	2.1	0.6	-1.5	-0.2	-1.0	-0.4	0.4	-0.0	-0.2	0.1	-1.2	1.0	0.1	-0.2
Number of live births	0.3	0.4	1.0	-0.3	-0.4	-0.2	-0.8	-0.7	-0.1	-0.6	-0.1	-0.2	-0.9	-0.6	-0.9	-1.0
Medication: Lansoprazole	0.3	0.3	2.9	-0.5	-0.3	0.3	0.4	0.1	-0.5	0.0	-0.1	-0.0	-0.5	-1.7	0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.4	-0.2	-0.1	-0.2	1.5	0.2	-0.6	-0.2	-0.4	-0.5	0.6	-1.3	0.3	0.5
Birth weight of first child	0.3	0.5	1.1	0.1	0.2	0.2	-1.0	-0.2	-1.1	0.8	0.6	1.0	-0.8	0.4	0.9	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-1.2	0.6	-0.3	0.3	-0.3	-0.7	-1.0	-1.1	-1.2	0.1	0.0	-0.7	-0.6
Medication: Amlodipine	0.3	0.4	1.5	0.2	0.7	0.8	0.1	0.1	-1.2	0.3	-0.0	0.4	0.0	0.1	1.0	1.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.8	1.3	0.3	0.3	-0.8	1.0	0.5	1.1	0.9	1.1	0.5	0.0	0.3	0.0
Medication: Blood pressure	0.3	0.5	0.9	0.8	0.8	0.9	-0.6	-0.1	-0.2	0.7	0.4	1.0	-0.2	0.7	0.9	0.8
Leg fat-free mass (right)	0.3	1.9	6.6	-0.9	-1.9	-1.5	-0.1	-1.8	-2.6	-0.5	-1.2	-0.4	-2.3	-0.6	0.3	0.2
Smoking status: Current	0.3	0.4	1.6	-0.8	0.2	0.3	-0.5	0.1	0.3	-0.3	-0.3	-0.6	0.0	1.3	1.1	0.9
Leg predicted mass (right)	0.3	1.8	6.5	-0.8	-1.9	-1.5	-0.1	-1.8	-2.5	-0.5	-1.1	-0.4	-2.3	-0.6	0.3	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	2.8	-0.4	-0.4	-0.3	-1.0	-1.2	0.1	-0.6	-0.2	-0.2	-1.7	0.9	-0.6	-0.4
Hearing aid user	0.3	0.4	0.7	-0.4	0.4	-0.1	-0.8	-0.2	0.8	-0.8	-0.4	-0.9	-0.1	0.8	-0.6	-0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.2	0.2	0.5	-1.2	-0.2	0.5	0.4	0.4	0.3	-1.0	1.2	0.1	-0.9
High cholesterol (Self-reported)	0.3	0.6	1.7	0.3	1.3	0.3	0.9	-0.8	-0.3	-0.1	-0.2	-0.2	1.3	-1.1	-0.2	1.0
Medication: Paracetamol	0.3	0.5	1.5	-0.9	-0.6	-0.1	0.5	-0.1	-0.3	-0.5	-0.8	-1.1	0.3	1.2	0.7	1.0
Medication: Lisinopril	0.3	0.5	2.1	0.5	0.4	0.8	-0.5	-0.7	0.8	0.4	0.4	0.7	-1.4	0.5	0.5	-0.1
Basal metabolic rate	0.3	1.7	6.6	-0.5	-1.6	-1.1	-0.1	-2.0	-2.2	-0.3	-0.7	0.0	-2.6	-1.2	0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.2	-0.1	0.5	0.7	-0.4	0.0	0.4	0.2	0.4	0.5	-0.5	1.1	0.9	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	3.4	-0.2	0.0	-0.3	0.2	0.0	-0.2	-0.4	-0.1	-0.4	0.6	-1.9	-0.8	-0.2
Major Depression (MDD)	0.2	0.2	2.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.6	1.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.6	-0.3	0.0	-0.8	-0.6	-0.1	-0.7	-0.7	-0.7	-0.4	0.4	-0.3	-0.3
Schizophrenia (2014)	0.2	0.5	1.4	0.8	-0.2	1.1	0.5	-0.4	0.1	0.6	1.2	1.1	-0.6	-0.6	0.3	-0.0
Systolic Blood Pressure	0.2	0.8	5.9	-0.5	0.5	0.7	-0.8	0.3	0.3	0.0	0.0	-0.1	0.3	2.4	1.2	1.4
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.7	0.1	1.0	0.7	-0.4	0.2	0.9	0.1	0.3	-0.3	0.1	1.3	0.0	-0.2
Hair Pigment	0.2	5.1	10.4	-3.1	-1.0	-1.5	0.3	-3.2	-2.7	-3.0	-2.9	-2.4	-1.2	-1.6	-2.4	-1.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	0.0	-0.6	-0.2	-0.6	-0.8	0.9	-0.5	-0.4	-0.3	-1.2	0.3	-0.0	-0.4
Systolic blood pressure, automated reading	0.2	0.5	2.9	-0.3	-0.0	0.3	-0.5	-0.3	0.1	0.0	0.3	0.3	-0.2	1.7	1.2	1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.7	0.2	-0.3	0.5	-0.6	-0.4	-0.6	-0.6	-0.5	-0.6	0.3	-0.5	0.1
Pack years adult smoking proportion	0.2	0.3	1.0	-1.0	-0.5	-0.5	-0.2	0.0	-0.5	-0.6	-0.6	-0.8	0.1	0.4	-0.1	-0.0
Hand grip strength (right)	0.2	0.6	3.3	-0.1	-0.4	-0.5	0.6	-0.9	-1.8	0.1	-0.2	0.4	-0.6	-1.5	-0.5	0.0
Multivitamins +/- minerals	0.2	0.2	1.3	0.8	-0.6	0.3	-1.1	0.6	0.2	0.3	0.3	0.3	-0.1	0.2	0.3	-0.1
Had menopause	0.2	0.2	0.5	0.0	0.4	0.5	-0.1	-0.0	-0.7	0.1	0.2	0.7	-0.7	-0.1	0.0	-0.7
Qualifications: None of the above	0.2	0.4	1.0	0.8	-0.8	0.4	-0.7	0.0	0.6	0.7	1.0	0.9	-0.7	-0.1	0.2	-0.3
Fluid intelligence score	0.2	0.4	2.3	-0.7	-0.3	-0.9	-0.2	-0.4	-1.5	-0.4	-0.7	-0.3	0.1	-0.2	-0.3	-0.2
Trunk fat-free mass	0.2	1.1	4.5	0.4	-0.7	0.0	-0.6	-1.2	-2.0	0.8	0.4	1.1	-2.1	-1.1	0.6	-0.2
Time employed in main current job	0.2	0.2	0.8	-0.2	0.4	0.6	-0.8	0.2	-0.2	0.2	0.1	-0.1	-0.5	-0.1	0.3	-0.9
Noisy workplace	0.2	0.2	0.8	0.8	0.1	-0.2	-0.2	-0.3	0.4	0.2	0.7	0.5	-0.4	-0.9	-0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.1	-0.7	0.7	0.2	0.2	0.6	-0.5	-0.2	-0.6	-0.1	1.4	0.3	-0.5	-0.1
Prospective memory result	0.2	0.3	1.6	0.7	-0.6	-0.2	-0.2	0.0	1.3	-0.2	0.2	0.1	-0.1	-1.0	-0.2	-0.0
Trunk predicted mass	0.2	1.1	4.9	0.4	-0.7	0.0	-0.6	-1.2	-1.9	0.7	0.4	1.1	-2.2	-1.2	0.5	-0.4
Breastfed as a baby	0.2	0.2	0.5	0.7	-0.7	0.2	-0.6	-0.4	0.2	-0.1	-0.0	0.5	-0.5	-0.4	-0.2	-0.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.3	-0.4	0.6	0.0	1.3	0.3	-1.5	0.5	0.3	0.0	0.2	1.1	0.7	0.5
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.3	-0.1	-0.9	0.5	-0.8	-0.0	-0.3	-0.4	0.1	-0.2	-0.9	-0.7	0.1
Medication: Paracetamol	0.2	0.4	0.9	-0.6	-0.6	-0.1	0.1	0.0	-0.6	-0.4	-0.7	-0.9	0.4	1.0	0.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.3	-0.8	-0.6	0.2	0.7	0.9	-0.0	-0.0	-0.2	0.7	0.7	0.5	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.4	-0.4	1.2	0.3	1.0	0.9	-0.9	0.6	0.2	0.0	0.8	-0.6	1.0	1.1
Arm fat-free mass (right)	0.2	0.8	2.5	0.6	-0.4	-0.0	-0.2	-0.8	-1.6	0.9	0.3	1.1	-1.4	-0.8	1.1	0.7
Qualifications: College or University degree	0.2	0.6	3.4	0.2	0.9	0.6	0.7	1.1	-0.7	0.6	-0.2	0.4	1.8	-0.2	0.3	0.8
Migraine (self-reported)	0.2	0.3	1.0	-0.0	1.0	-0.2	0.1	1.0	0.6	-0.1	0.4	0.0	0.9	-0.2	-0.2	-0.1
Medication: Omeprazole	0.2	0.3	1.5	-0.3	0.6	0.3	-0.3	-0.2	0.7	-0.2	0.0	0.1	-0.6	1.2	0.6	0.3
Mean time to correctly identify matches	0.2	0.3	2.1	-0.3	0.2	-0.3	-0.1	0.4	0.1	-0.3	-0.4	-0.7	0.0	1.5	0.7	0.6
Arm predicted mass (right)	0.2	0.8	2.4	0.7	-0.5	0.1	-0.4	-0.8	-1.6	0.9	0.5	1.1	-1.4	-0.7	1.0	0.5
Had major operations	0.2	0.2	0.8	-0.6	-0.2	-0.2	0.1	-0.4	0.0	-0.3	-0.3	-0.0	-0.9	-0.2	-0.6	-0.9
Whole body fat-free mass	0.2	1.3	5.6	-0.1	-1.4	-0.7	-0.3	-1.6	-2.2	0.2	-0.3	0.4	-2.4	-1.0	0.4	-0.1
Ever had bowel cancer screening	0.2	0.3	1.4	-0.0	-1.2	-0.5	-0.3	-0.2	0.2	-0.7	-0.6	-0.3	-0.3	0.9	0.4	0.2
Whole body water mass	0.2	1.4	5.5	-0.2	-1.4	-0.8	-0.3	-1.6	-2.3	0.1	-0.4	0.3	-2.4	-1.1	0.3	-0.1
Arm fat-free mass (left)	0.2	1.1	5.0	-0.0	-1.3	-0.6	0.0	-1.7	-1.6	0.2	-0.2	0.6	-2.2	-1.3	0.2	-0.1
Impedance of whole body	0.2	0.8	2.2	0.2	1.1	1.3	0.0	1.0	1.5	0.8	1.2	0.5	1.3	-0.4	-0.3	-0.7
Arm predicted mass (left)	0.2	1.1	4.3	0.0	-1.3	-0.7	0.2	-1.6	-1.8	0.2	-0.2	0.6	-2.1	-1.4	0.2	0.0
Reaction Time	0.1	0.2	0.9	-0.9	0.1	-0.3	0.3	0.1	0.1	-0.4	-0.3	-0.8	-0.1	0.3	0.1	0.3
Rheumatoid Arthritis	0.1	0.2	1.0	-0.4	0.1	0.3	0.2	-1.0	-0.6	-0.3	-0.0	0.2	-0.3	-0.4	-0.0	0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.9	-0.1	0.1	0.3	-0.3	0.4	-0.1	-0.4	-0.2	-0.2	0.9	0.2	0.3	0.7
Vitamin and mineral supplements	0.1	0.1	0.8	-0.4	0.9	0.2	0.6	-0.4	0.2	-0.1	0.2	0.1	-0.1	0.2	0.1	0.2
Medication: Atenolol	0.1	0.1	0.4	0.3	0.4	0.4	-0.5	0.4	-0.1	0.1	0.1	-0.1	-0.1	-0.2	-0.2	-0.7
Sitting height	0.1	1.1	3.4	0.2	0.3	0.7	0.2	-0.2	-1.9	1.3	0.9	1.7	-0.5	-0.8	1.5	1.0
Chronic bronchitis/emphysema (father)	0.1	0.2	0.8	-0.7	-0.2	-0.1	0.1	-0.4	-0.1	-0.4	-0.1	-0.4	-0.1	0.3	-0.9	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	1.4	0.3	0.5	0.6	-1.2	0.1	0.5	-0.1	0.2	-0.0	-0.0	0.2	0.4	-0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.8	-0.3	0.4	0.0	-0.0	-0.1	0.9	-0.5	-0.4	-0.5	0.2	0.3	0.1	0.6
Impedance of arm (right)	0.1	0.3	0.8	-0.9	0.1	0.2	0.1	0.1	0.7	-0.2	0.1	-0.5	0.5	-0.0	-0.8	-0.9
Impedance of arm (left)	0.1	0.3	1.1	-1.1	-0.1	0.1	-0.3	-0.0	0.4	-0.4	-0.1	-0.7	0.4	0.1	-1.0	-1.0
Alcohol intake frequency.	0.1	0.3	0.8	0.4	0.4	0.3	0.3	0.6	-0.4	0.7	0.7	0.6	0.9	0.0	0.5	0.6
Comparative height size at age 10	0.1	0.6	4.5	-0.4	-0.5	-0.2	0.3	-0.8	-2.1	0.4	0.1	0.4	-1.0	-0.1	0.9	0.2
Supplements: Vitamin C	0.1	0.1	0.4	-0.3	-0.5	-0.2	-0.2	-0.3	0.2	-0.2	-0.5	-0.4	0.3	0.7	-0.5	-0.1
Mineral and other dietary supplements	0.1	0.2	1.5	0.0	0.1	-0.0	0.1	0.4	-0.0	-0.1	0.2	0.0	0.9	-1.2	-0.3	0.0
Average weekly champagne plus white wine intake	0.1	0.1	0.6	-0.8	-0.1	0.0	-0.0	-0.6	-0.1	-0.3	-0.3	-0.4	-0.4	0.2	-0.4	-0.0
Diastolic blood pressure, automated reading	0.1	0.3	1.2	-0.5	0.6	-0.1	0.3	-1.1	-0.6	-0.3	-0.1	0.2	0.3	0.1	0.3	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.2	0.1	-0.9	-0.4	0.2	1.1	0.3	0.3	0.3	0.1	0.9	-0.4	-0.4	-0.6
Pack years of smoking	0.1	0.2	0.5	-0.6	-0.6	-0.3	-0.7	-0.0	-0.1	-0.4	-0.3	-0.5	-0.2	0.4	-0.2	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.5
Tanning	0.0	0.5	4.3	-0.1	0.9	-0.4	0.5	0.1	2.1	-0.3	-0.3	-0.3	0.2	0.2	-0.1	0.4

Hub : Genes

NAP1L4

Models

Trait associations