Hub : Genes

NAP1L4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1280	0.0410	1.8e-04	0.020	NA	0.019	NA	0.033	8.2e-03	NA	9.2e-03	NA	9.8e-04
2	GTEx	Adipose Visceral Omentum	0.1280	0.0500	4.6e-03	0.012	NA	0.030	NA	0.017	7.2e-02	NA	1.0e-02	NA	4.5e-02
3	GTEx	Esophagus Mucosa	0.1670	0.0430	1.4e-06	0.104	NA	0.136	NA	0.122	1.8e-07	NA	2.4e-09	NA	1.6e-08
4	GTEx	Muscle Skeletal	0.0900	0.0364	2.6e-03	0.000	NA	-0.002	NA	-0.002	3.4e-01	NA	7.0e-01	NA	6.2e-01
5	GTEx	Nerve Tibial	0.1597	0.0496	3.4e-04	0.017	NA	0.087	NA	0.084	2.0e-02	NA	9.8e-07	NA	1.4e-06
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1680	0.0550	4.1e-04	0.004	NA	0.019	NA	0.015	1.8e-01	NA	3.0e-02	NA	4.9e-02
7	GTEx	Skin Sun Exposed Lower leg	0.1270	0.0370	1.2e-04	0.046	NA	0.026	NA	0.030	1.0e-04	NA	2.7e-03	NA	1.4e-03
8	GTEx	Testis	0.2370	0.0640	8.4e-06	0.122	NA	0.114	NA	0.129	4.5e-06	NA	1.0e-05	NA	2.4e-06
9	METSIM	Adipose	0.0932	0.0233	5.0e-08	0.092	0.046	0.079	0.075	0.084	1.1e-13	1.5e-07	8.0e-12	2.7e-11	1.4e-12
10	ROSMAP	Brain Pre-frontal Cortex	0.0698	0.0251	2.2e-03	0.008	0.018	0.023	0.016	0.012	2.7e-02	1.7e-03	4.7e-04	3.3e-03	1.0e-02
11	YFS	Blood	0.0638	0.0146	5.2e-09	0.031	0.024	0.030	0.028	0.027	2.3e-10	1.6e-08	4.5e-10	9.6e-10	3.5e-09
12	TCGA	Kidney Renal Clear Cell Carcinoma	0.0811	0.0287	7.1e-08	0.034	0.065	0.060	NA	0.025	9.7e-05	7.8e-08	2.3e-07	NA	6.9e-04
13	TCGA	Stomach Adenocarcinoma	0.0850	0.0410	2.1e-03	0.007	0.031	0.004	NA	0.001	9.1e-02	2.5e-03	1.6e-01	NA	2.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.3	2.0	5.3	1.3	2.3	1.6	-0.6	1.5	1.9	1.4	1.5	1.4	1.2	0.7	1.3	0.9
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	0.9	1.6	1.4	0.4	1.0	0.1	1.6	1.7	1.9	1.0	0.2	1.4	1.1
Depressed Affect (Nagel 2018)	0.5	1.1	5.0	-0.6	-0.4	-0.6	2.2	-0.1	-1.6	-0.7	-1.1	-0.8	0.9	-0.6	0.4	1.6
Depression (Nagel 2018)	1.1	1.6	3.7	-1.7	-0.8	-0.8	1.8	-1.1	-1.7	-1.3	-1.1	-1.3	-0.4	-1.9	-1.0	-0.3
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.1	-0.4	-1.0	-0.7	-0.4	-0.7	-2.0	-0.3	-0.4	0.2	-1.2	-0.7	-0.7	-1.0
Neuroticism (Nagel 2018)	0.9	2.1	7.0	-1.4	0.2	-0.6	2.6	0.7	-2.6	-0.5	-1.2	-0.9	2.1	-1.0	0.2	1.5
Schizophrenia (2018)	0.3	0.6	1.6	0.1	0.3	0.7	1.0	-0.1	-1.2	0.9	1.0	1.3	0.4	0.0	0.7	0.8
Schizophrenia vs Biploar Disorder	0.6	0.8	4.3	-0.4	-2.1	-0.5	0.6	-0.8	-0.7	-0.3	-0.1	-0.2	-1.4	-1.1	-0.7	-0.4
Worry (Nagel 2018)	1.3	2.7	9.6	0.0	1.6	1.2	2.2	2.1	-1.8	1.1	0.5	1.0	3.1	-1.2	1.2	1.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	-1.3	-0.8	-1.2	1.2	-1.0	-1.3	-0.4	-0.7	-0.4	0.7	-0.8	-0.9	0.4
Alzheimer’s Disease (in father)	2.2	2.4	4.9	1.4	0.4	1.9	-1.1	1.2	2.2	1.7	1.6	1.5	0.7	1.8	2.2	1.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	-1.1	-0.9	-0.7	0.9	-0.5	-0.1	-0.2	-0.5	-0.4	0.8	0.5	0.4	1.2
Crohns Disease (2017)	0.3	0.7	3.1	-0.7	-0.8	-0.4	-0.4	-0.7	-1.8	-0.3	-0.4	-0.7	-1.3	0.9	-0.2	-0.2
Irritable Bowel Disease (IBD)	0.3	0.8	2.6	-0.8	-0.9	-0.4	-1.3	-0.7	-1.6	-0.4	-0.3	-0.5	-1.5	0.2	-0.6	-0.9
Ulcerative Colitis (UC)	0.3	0.6	2.6	-0.5	-0.7	0.1	-1.6	-0.4	-0.3	-0.0	0.1	0.0	-1.2	-0.7	-0.7	-1.2
Major Depression (MDD)	0.2	0.2	2.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.6	1.7
Reaction Time	0.1	0.2	0.9	-0.9	0.1	-0.3	0.3	0.1	0.1	-0.4	-0.3	-0.8	-0.1	0.3	0.1	0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.6	-0.8	-1.8	-1.6	-0.1	-1.6	-1.9	-1.0	-1.0	-0.5	-1.1	-0.2	-0.8	-0.4
Breast Cancer	0.5	1.3	4.8	-0.9	0.4	-1.2	2.2	0.1	1.4	-1.4	-1.3	-1.5	1.1	0.1	-0.3	0.8
Ovarian Cancer	1.3	1.7	3.7	1.8	0.8	1.4	-1.9	0.8	0.2	1.2	1.9	1.8	-0.9	-1.2	0.2	-1.3
Prostate Cancer	0.7	1.0	4.4	1.1	-0.3	1.0	-2.1	-0.3	0.2	0.7	1.3	1.0	-1.2	-0.4	-0.1	-1.3
Age at First Birth	0.9	1.3	3.1	0.7	-0.2	1.5	-1.4	-0.2	-0.6	1.6	1.8	1.7	-1.2	-0.2	-0.3	-1.3
Bipolar Disorder (2011)	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.6	-0.3	0.0	-0.8	-0.6	-0.1	-0.7	-0.7	-0.7	-0.4	0.4	-0.3	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	2.2	0.5	0.1	0.7	-0.7	0.5	-0.4	1.5	1.4	1.3	1.1	-1.2	0.2	0.2
Crohns Disease (2012)	0.6	0.9	2.8	-0.9	-1.6	-0.5	-0.7	-1.2	-1.1	-0.8	-0.5	-0.5	-1.7	0.4	-0.5	-1.0
Mean Putamen Volume	0.4	0.4	1.0	-0.1	0.8	0.9	-0.2	0.2	0.2	0.8	1.0	0.8	-0.4	-1.0	-0.3	-0.8
Fasting Glucose	0.8	1.0	2.0	-1.1	-0.6	-0.8	-0.3	-1.4	0.7	-1.3	-1.0	-1.3	-0.9	-0.2	-1.4	-0.9
HbA1C	2.2	2.4	5.2	2.0	1.9	2.3	-2.0	1.4	0.7	1.8	1.9	1.9	0.3	0.4	1.5	-0.1
HDL Cholesterol	3.2	5.3	9.0	-2.8	-1.4	-2.3	2.8	-3.0	-1.3	-2.9	-2.9	-2.3	-0.6	-2.4	-2.6	-0.6
LDL Cholesterol	0.5	0.7	2.3	-0.4	0.1	-0.0	-1.1	-0.9	0.3	-1.2	-1.1	-0.8	-1.5	0.9	-0.5	-0.6
Lupus	0.4	0.6	1.6	-1.3	-0.6	-0.5	-0.3	-0.7	-1.0	-1.0	-0.8	-0.8	-1.0	-0.1	-0.6	-0.8
Neuroticism (2016)	0.6	0.8	3.6	-0.5	-0.9	-0.4	1.9	-1.0	-1.1	-0.2	-0.7	-0.2	-0.2	-1.4	-0.7	0.5
Primary Biliary Cirrhosis	2.7	3.9	9.6	-1.4	-2.5	-1.5	0.0	-2.4	-1.4	-2.0	-1.3	-1.8	-3.1	-0.7	-2.6	-2.4
Rheumatoid Arthritis	0.1	0.2	1.0	-0.4	0.1	0.3	0.2	-1.0	-0.6	-0.3	-0.0	0.2	-0.3	-0.4	-0.0	0.3
Schizophrenia (2014)	0.2	0.5	1.4	0.8	-0.2	1.1	0.5	-0.4	0.1	0.6	1.2	1.1	-0.6	-0.6	0.3	-0.0
Triglycerides	0.6	0.9	1.6	1.3	1.1	1.0	-0.9	0.9	1.0	1.0	1.0	1.0	0.7	1.0	0.6	0.8
Type 2 Diabetes (T2D) (2012)	7.5	8.7	14.2	3.2	2.9	3.8	-3.4	3.3	3.3	3.4	3.3	2.8	2.3	2.1	2.3	1.0
Ulcerative Colitis	0.7	1.1	3.2	-0.5	-1.5	0.0	-1.0	-0.8	-0.5	-0.5	-0.2	0.2	-1.7	-1.8	-1.0	-1.4
Blood Eosinophil Count	1.5	11.9	57.0	0.6	-0.2	2.6	-7.5	-1.5	1.1	0.4	2.1	0.7	-5.6	-1.2	-2.3	-6.6
Blood Platelet Count	1.0	11.2	30.8	-2.3	-3.3	-1.4	-3.9	-4.0	-1.2	-3.1	-1.4	-2.3	-5.5	-1.5	-4.1	-5.3
Blood Red Count	0.3	2.5	9.3	0.7	2.0	2.2	-3.0	1.3	1.4	1.6	2.1	1.1	-0.4	0.8	0.5	-1.2
Blood White Count	2.2	16.1	36.0	5.0	2.7	5.0	-4.4	4.4	2.5	5.3	6.0	5.2	1.1	1.1	3.5	0.7
Heel T-Score	1.7	13.4	22.5	4.3	3.6	3.6	-0.9	4.7	2.0	4.6	4.5	4.3	3.7	1.9	4.1	2.9
BMI	1.8	10.6	17.5	-3.4	-3.4	-4.2	2.8	-4.0	-1.7	-3.9	-4.0	-3.6	-3.1	-2.5	-3.1	-1.4
Height	0.7	13.4	26.5	3.7	3.9	5.1	-2.5	3.1	-1.5	5.1	5.0	5.2	1.1	-0.1	4.5	1.6
Waist Hip Ratio (WHR)	0.6	2.7	9.5	0.6	2.4	3.1	-0.9	1.6	1.0	1.9	2.1	1.7	1.5	0.3	1.2	0.7
Systolic Blood Pressure	0.2	0.8	5.9	-0.5	0.5	0.7	-0.8	0.3	0.3	0.0	0.0	-0.1	0.3	2.4	1.2	1.4
Smoking Status	0.3	0.6	1.3	-0.7	-0.3	-0.3	-0.0	-1.2	0.9	-0.9	-0.7	-0.9	-0.9	-0.7	-1.1	-0.7
Allergy or Eczema	2.1	5.5	12.9	2.0	2.5	2.8	-2.8	1.9	2.1	2.5	2.1	2.0	1.0	3.6	3.0	1.1
Cardiovascular Disease	0.5	1.8	5.4	-1.4	-0.3	-0.9	0.2	-2.3	-1.9	-1.7	-1.8	-1.5	-1.2	-0.5	-1.0	-0.1
Hypothyroidism (self reported)	1.0	2.4	4.0	1.8	1.4	1.6	0.0	1.9	0.8	1.8	2.0	1.9	0.9	1.4	1.9	1.5
Respiratory disease	1.0	2.2	12.3	0.2	1.5	1.4	-1.9	0.7	1.9	0.9	0.9	0.3	-0.2	3.5	1.6	0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.7	0.1	1.0	0.7	-0.4	0.2	0.9	0.1	0.3	-0.3	0.1	1.3	0.0	-0.2
Lung FEV1/FVC ratio	0.4	1.9	7.6	0.7	0.5	0.2	2.5	1.4	-0.2	0.8	0.1	0.7	1.9	-0.3	1.9	2.8
Lung FVC	0.6	3.0	8.7	-2.5	-0.0	-2.3	1.5	1.0	-0.3	-1.8	-2.7	-3.0	1.4	1.3	0.2	1.1
Neuroticism	0.7	1.7	7.1	-0.6	-0.1	-0.3	2.5	0.7	-2.7	-0.0	-0.6	-0.1	1.7	-0.9	0.4	1.8
Chronotype (morning person)	0.4	0.9	3.0	0.8	0.5	1.2	-1.0	-0.0	1.7	0.6	1.1	0.4	-0.8	-0.2	-0.5	-1.4
Hair Pigment	0.2	5.1	10.4	-3.1	-1.0	-1.5	0.3	-3.2	-2.7	-3.0	-2.9	-2.4	-1.2	-1.6	-2.4	-1.4
Tanning	0.0	0.5	4.3	-0.1	0.9	-0.4	0.5	0.1	2.1	-0.3	-0.3	-0.3	0.2	0.2	-0.1	0.4
Hand grip strength (left)	0.7	1.8	5.4	-1.1	-1.4	-1.2	0.5	-1.9	-2.3	-0.7	-0.8	-0.3	-1.3	-1.9	-1.5	-0.9
Number of treatments/medications taken	0.3	0.6	2.0	-0.8	0.0	-0.2	-0.4	-1.1	-0.9	-0.8	-0.6	-0.8	-1.4	1.0	-0.2	-0.2
Average weekly spirits intake	0.3	0.4	2.8	-0.4	-0.2	0.1	-0.2	-0.7	1.7	-0.4	-0.3	-0.3	-0.8	0.9	0.0	-0.3
Sensitivity / hurt feelings	0.6	1.0	3.8	-1.3	-0.9	-1.2	0.9	-0.3	-1.9	-0.8	-1.2	-1.1	0.4	-0.1	-0.2	0.8
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.3	-1.6	-1.7	-1.1	0.7	-1.1	-0.4	-1.5	-1.6	-1.8	-1.2	-1.0	-0.6	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.9	-0.1	0.1	0.3	-0.3	0.4	-0.1	-0.4	-0.2	-0.2	0.9	0.2	0.3	0.7
Relative age of first facial hair	1.0	2.0	3.9	1.5	2.0	1.4	0.1	1.9	1.4	1.7	1.9	1.7	1.1	-1.0	1.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	0.0	-0.6	-0.2	-0.6	-0.8	0.9	-0.5	-0.4	-0.3	-1.2	0.3	-0.0	-0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.6	1.1	0.5	0.3	-0.4	1.3	-1.3	0.9	0.9	0.8	0.7	-0.9	0.1	-0.6
Ever had hysterectomy (womb removed)	1.0	1.1	4.4	-1.2	-1.3	-2.1	0.3	-0.6	0.0	-1.2	-0.9	-1.4	0.4	-0.1	-1.4	-0.2
Systolic blood pressure, automated reading	0.2	0.5	2.9	-0.3	-0.0	0.3	-0.5	-0.3	0.1	0.0	0.3	0.3	-0.2	1.7	1.2	1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.7	0.2	-0.3	0.5	-0.6	-0.4	-0.6	-0.6	-0.5	-0.6	0.3	-0.5	0.1
Angina	1.2	1.5	3.1	1.4	0.9	1.6	-0.3	1.5	1.4	1.7	1.8	1.4	0.6	1.0	0.9	0.4
Medication for hormone replacement therapy	0.5	0.6	1.2	0.7	0.4	0.8	0.0	0.9	-0.3	0.9	1.0	0.9	0.9	0.4	0.8	1.1
Vitamin and mineral supplements	0.1	0.1	0.8	-0.4	0.9	0.2	0.6	-0.4	0.2	-0.1	0.2	0.1	-0.1	0.2	0.1	0.2
Supplements: Zinc	0.8	0.8	3.8	-0.6	-0.0	-0.6	2.0	-0.1	-0.1	-0.3	-0.9	-0.6	1.2	0.2	0.3	1.9
Medication: Co-codamol	0.8	1.0	2.4	0.5	1.2	1.1	-0.4	0.5	1.3	0.8	1.1	0.7	0.9	0.8	1.5	0.9
Medication: Metformin	0.9	1.3	4.0	1.0	1.5	2.0	-1.3	0.8	1.4	1.1	1.3	0.8	0.5	1.0	0.4	-0.3
Diabetes (father)	1.5	1.8	3.8	1.7	1.7	1.8	-0.9	1.4	1.8	1.3	1.9	1.5	0.5	0.6	0.8	-0.1
Diabetes (mother)	1.2	1.5	4.1	1.4	0.9	1.6	-1.0	1.5	2.0	1.0	1.4	0.9	0.6	0.8	1.3	0.8
Severe depression (siblings)	2.1	2.4	4.7	1.8	1.2	1.3	0.4	1.5	1.9	1.5	1.4	1.4	2.2	1.2	1.6	1.9
Pack years adult smoking proportion	0.2	0.3	1.0	-1.0	-0.5	-0.5	-0.2	0.0	-0.5	-0.6	-0.6	-0.8	0.1	0.4	-0.1	-0.0
Impedance of leg (right)	0.5	2.6	5.8	1.3	2.0	2.4	-0.1	1.6	2.4	1.7	2.3	1.5	1.7	-0.5	0.4	-0.3
Leg fat-free mass (left)	0.4	2.1	6.7	-0.9	-2.0	-1.5	-0.1	-2.0	-2.6	-0.6	-1.2	-0.5	-2.5	-0.9	0.1	-0.1
Trunk fat percentage	1.1	4.5	9.8	-2.1	-2.7	-2.9	0.9	-3.1	-0.7	-2.5	-2.5	-2.2	-2.5	-0.9	-1.6	-0.8
Hand grip strength (right)	0.2	0.6	3.3	-0.1	-0.4	-0.5	0.6	-0.9	-1.8	0.1	-0.2	0.4	-0.6	-1.5	-0.5	0.0
Townsend deprivation index at recruitment	0.7	0.9	4.1	-0.6	-1.1	-0.1	-0.8	-1.2	0.0	-0.8	-1.2	-0.8	-2.0	0.5	-0.6	-1.0
Current tobacco smoking	0.3	0.5	2.6	-1.0	0.0	0.2	-0.6	-0.2	0.4	-0.4	-0.5	-0.8	-0.1	1.6	0.8	0.7
Average weekly fortified wine intake	0.4	0.4	1.8	0.8	0.3	0.3	-0.5	0.9	1.4	0.4	0.3	0.0	0.6	1.0	0.1	0.2
Maternal smoking around birth	2.0	2.9	6.1	-2.5	-1.1	-2.3	1.4	-1.7	-2.1	-2.2	-2.3	-2.2	-0.4	0.2	-0.8	0.5
Fed-up feelings	0.8	1.5	6.2	-1.1	-1.1	-1.1	2.5	-0.7	-0.7	-1.0	-1.6	-1.1	0.5	-1.2	-0.2	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.3	-1.5	-1.2	-0.6	1.5	-1.1	-1.8	-0.8	-0.9	-0.8	-0.5	-1.5	-0.7	0.2
Relative age voice broke	2.9	4.4	7.6	2.4	2.6	2.0	1.2	2.6	0.9	2.4	2.5	2.8	2.0	-1.5	1.7	1.4
Taking other prescription medications	0.4	0.7	3.4	0.3	-0.3	0.2	-1.7	-0.4	0.7	0.1	0.5	0.2	-1.8	0.9	0.3	-0.8
Age when periods started (menarche)	0.7	1.7	12.0	0.7	0.7	1.2	-0.5	-0.5	-1.1	0.6	1.1	1.4	-0.1	-3.5	-1.0	-1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.7	0.6	0.2	0.1	0.5	0.7	-0.7	0.7	1.3	1.0	0.0	-0.4	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	8.4	0.2	-0.3	-0.0	2.0	0.5	0.1	0.1	-0.1	0.1	2.0	0.8	1.7	2.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	-0.3	-0.0	-0.5	0.1	-0.3	0.8	-1.0	-0.9	-1.5	-0.1	0.2	-0.5	-0.3
Qualifications: CSEs or equivalent	1.1	1.4	3.8	-0.8	-1.5	-1.3	0.1	-0.5	-0.6	-1.5	-1.3	-2.0	-0.7	-1.4	-1.3	-1.2
Serious illness, injury or assault to yourself	2.1	2.5	7.7	1.7	1.6	0.8	1.8	1.8	0.9	1.2	1.0	1.3	2.8	-1.0	1.3	2.3
High blood pressure	0.3	0.8	2.8	-0.5	-0.3	-0.5	-0.1	-1.7	-1.4	-0.9	-1.0	-0.6	-1.4	0.4	0.0	0.5
Hayfever, allergic rhinitis or eczema	1.0	2.3	6.6	0.9	1.7	1.7	-1.8	1.0	0.3	1.6	1.2	1.2	1.1	2.6	2.1	1.1
Multivitamins +/- minerals	0.2	0.2	1.3	0.8	-0.6	0.3	-1.1	0.6	0.2	0.3	0.3	0.3	-0.1	0.2	0.3	-0.1
Stomach or abdominal pain in last month	0.4	0.5	1.6	-0.1	-0.3	-0.7	0.1	1.0	-0.3	-0.2	-0.6	-0.6	1.0	0.8	0.9	1.3
Supplements: Glucosamine	0.4	0.5	3.8	-0.3	0.5	-0.1	-0.1	0.8	0.5	0.1	-0.2	-0.3	0.1	2.0	0.9	0.5
Diverticular disease/diverticulitis (self-reported)	4.5	5.4	10.8	3.1	2.2	2.6	-1.4	2.7	1.8	3.1	3.1	3.3	0.6	1.3	2.0	0.5
Medication: Atenolol	0.1	0.1	0.4	0.3	0.4	0.4	-0.5	0.4	-0.1	0.1	0.1	-0.1	-0.1	-0.2	-0.2	-0.7
Medication: Levothyroxine sodium	0.3	0.5	1.3	0.9	0.2	0.6	-0.5	1.1	-0.1	0.7	1.0	0.6	-0.6	1.2	0.6	-0.2
Sitting height	0.1	1.1	3.4	0.2	0.3	0.7	0.2	-0.2	-1.9	1.3	0.9	1.7	-0.5	-0.8	1.5	1.0
Chronic bronchitis/emphysema (father)	0.1	0.2	0.8	-0.7	-0.2	-0.1	0.1	-0.4	-0.1	-0.4	-0.1	-0.4	-0.1	0.3	-0.9	-0.4
High blood pressure (mother)	0.9	1.3	4.6	-0.8	-1.0	-0.3	-0.1	-1.4	-1.4	-0.4	-0.8	-0.5	-0.9	2.1	1.1	1.8
Body mass index (BMI)	1.8	7.5	14.7	-2.5	-3.4	-3.8	1.3	-3.7	-1.5	-3.4	-3.4	-2.8	-3.2	-1.1	-2.1	-0.7
Impedance of leg (left)	0.6	2.8	6.6	1.3	2.2	2.2	0.2	1.7	2.6	1.7	2.2	1.6	2.1	-0.0	0.6	0.3
Leg predicted mass (left)	0.4	2.2	6.8	-1.0	-2.0	-1.5	-0.0	-2.0	-2.6	-0.7	-1.2	-0.5	-2.5	-1.0	0.0	-0.2
Trunk fat mass	1.0	4.2	10.0	-1.9	-2.5	-2.7	0.7	-3.2	-1.2	-2.2	-2.3	-1.9	-2.8	-1.1	-1.3	-0.8
Waist circumference	1.0	3.7	8.9	-1.8	-2.5	-2.3	0.5	-2.8	-0.6	-2.2	-2.0	-1.7	-3.0	-1.3	-1.5	-0.9
Number of incorrect matches in round	0.7	1.2	5.4	-1.0	0.3	-0.5	2.3	-0.5	0.1	-0.4	-0.9	-0.5	1.2	0.8	0.6	2.1
Past tobacco smoking	0.4	0.7	5.8	-0.4	-0.3	-0.1	0.1	0.6	-0.4	0.1	-0.3	-0.5	0.7	2.4	1.0	1.1
Alcohol usually taken with meals	0.4	0.7	2.8	0.0	-0.2	-0.6	-0.1	-0.3	0.7	-0.1	-0.3	-0.2	-0.6	-1.7	-1.5	-1.6
Nervous feelings	0.8	1.5	4.0	-1.9	-0.8	-0.6	1.9	0.0	-2.0	-0.9	-1.0	-1.1	1.3	-1.2	-0.8	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.8	-1.7	-1.6	-0.8	0.7	-1.0	-1.4	-1.3	-1.4	-1.7	-0.5	-0.6	-0.5	-0.3
Hearing difficulty/problems with background noise	0.1	0.2	1.4	0.3	0.5	0.6	-1.2	0.1	0.5	-0.1	0.2	-0.0	-0.0	0.2	0.4	-0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.8	-0.3	0.4	0.0	-0.0	-0.1	0.9	-0.5	-0.4	-0.5	0.2	0.3	0.1	0.6
Had menopause	0.2	0.2	0.5	0.0	0.4	0.5	-0.1	-0.0	-0.7	0.1	0.2	0.7	-0.7	-0.1	0.0	-0.7
Had other major operations	0.4	0.5	2.0	1.0	-0.7	0.2	-0.7	-0.2	0.8	-0.1	0.6	0.7	-1.0	-1.4	-0.3	-0.5
Forced vital capacity (FVC)	0.3	1.1	3.0	0.1	1.2	0.5	0.8	1.5	-1.0	0.9	0.2	0.4	1.2	-0.2	1.7	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	10.2	0.9	0.3	0.7	2.0	1.1	0.7	0.9	0.5	1.0	2.4	0.3	2.1	3.2
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	5.2	-1.3	-1.2	-0.5	0.2	-1.8	-1.4	-1.3	-1.1	-1.2	-1.1	-2.3	-1.5	-1.3
Qualifications: None of the above	0.2	0.4	1.0	0.8	-0.8	0.4	-0.7	0.0	0.6	0.7	1.0	0.9	-0.7	-0.1	0.2	-0.3
Financial difficulties in last 2 years	1.0	1.3	2.7	-1.1	-1.2	-1.2	1.0	-1.4	-1.6	-1.3	-1.3	-1.4	-0.9	-0.3	-0.9	-0.4
Mouth/teeth dental problems	0.4	0.6	1.7	0.9	0.6	1.3	-0.4	0.4	0.5	0.9	1.0	0.8	0.7	-1.0	-0.2	-0.7
Heart attack	0.5	0.6	1.7	0.5	0.6	1.0	-0.5	0.6	0.2	0.8	1.3	0.7	-0.1	-1.3	-0.6	-1.1
Allergy	0.7	1.7	5.2	-0.9	-1.3	-1.2	2.3	-0.6	-1.0	-1.2	-1.0	-0.8	-0.0	-2.2	-1.7	-0.4
Pain all over the body in last month	2.7	2.9	4.9	1.8	2.2	2.1	-0.0	2.0	1.7	1.5	1.8	1.8	1.8	-0.3	1.8	1.6
Diabetes (self-reported)	0.7	1.1	2.3	1.1	1.5	1.5	-0.6	1.1	1.1	1.1	1.2	0.9	1.0	0.8	0.7	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	0.4	0.5	1.1	-1.2	0.1	-0.5	0.6	0.5	0.5	0.4	0.2	0.6	-0.1
Medication: Ramipril	0.5	0.6	2.1	0.6	0.0	0.7	-1.4	0.4	-1.0	0.2	0.8	0.5	-0.8	-0.6	-0.4	-1.3
Medication: Simvastatin	0.4	0.6	2.2	0.5	0.5	0.3	-0.4	-0.9	0.4	-0.4	-0.1	-0.2	-0.9	-1.5	-1.1	-1.3
Fluid intelligence score	0.2	0.4	2.3	-0.7	-0.3	-0.9	-0.2	-0.4	-1.5	-0.4	-0.7	-0.3	0.1	-0.2	-0.3	-0.2
Illnesses of siblings	0.6	0.9	3.7	-0.6	-1.1	-0.8	-0.3	-0.7	-0.2	-0.8	-0.6	-0.9	-0.6	-1.9	-1.2	-1.4
Neuroticism score	1.0	2.1	9.7	-1.4	-0.2	-0.5	3.1	0.1	-2.6	-0.6	-1.1	-0.7	1.4	-1.0	0.1	1.7
Weight	0.7	3.5	9.4	-1.5	-2.3	-2.4	0.7	-3.0	-1.8	-1.7	-1.9	-1.2	-3.1	-1.4	-0.9	-0.4
Impedance of arm (right)	0.1	0.3	0.8	-0.9	0.1	0.2	0.1	0.1	0.7	-0.2	0.1	-0.5	0.5	-0.0	-0.8	-0.9
Arm fat percentage (right)	2.6	10.2	18.1	-3.2	-3.8	-4.2	1.7	-4.2	-1.2	-4.0	-4.0	-3.6	-3.5	-1.1	-2.9	-1.5
Trunk fat-free mass	0.2	1.1	4.5	0.4	-0.7	0.0	-0.6	-1.2	-2.0	0.8	0.4	1.1	-2.1	-1.1	0.6	-0.2
Hip circumference	2.3	10.0	21.9	-2.6	-4.2	-3.9	0.9	-4.5	-0.5	-3.5	-3.3	-2.9	-4.7	-2.0	-2.8	-2.2
Time employed in main current job	0.2	0.2	0.8	-0.2	0.4	0.6	-0.8	0.2	-0.2	0.2	0.1	-0.1	-0.5	-0.1	0.3	-0.9
Alcohol intake versus 10 years previously	0.3	0.5	2.1	0.6	-1.5	-0.2	-1.0	-0.4	0.4	-0.0	-0.2	0.1	-1.2	1.0	0.1	-0.2
Father’s age at death	0.5	0.7	1.9	0.6	1.1	1.1	-0.2	0.7	-0.2	0.7	0.7	0.6	1.1	0.9	1.4	0.9
Worrier / anxious feelings	1.2	2.3	8.1	0.1	1.6	0.7	2.9	1.5	-1.7	0.8	0.5	0.8	2.5	-1.6	0.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	9.1	-1.5	-3.0	-1.5	-0.1	-2.9	-2.5	-1.8	-1.8	-1.6	-2.5	-1.4	-2.0	-1.5
Falls in the last year	0.8	1.1	3.9	-0.6	-0.1	-1.2	2.0	-1.1	0.0	-1.4	-1.4	-1.2	0.1	-0.4	-1.0	0.4
Hair/balding pattern: Pattern 3	0.5	0.8	2.4	-0.3	-1.2	-0.3	-0.0	-1.2	-0.4	-0.5	-0.2	-0.3	-0.7	-1.5	-1.5	-1.3
Number of live births	0.3	0.4	1.0	-0.3	-0.4	-0.2	-0.8	-0.7	-0.1	-0.6	-0.1	-0.2	-0.9	-0.6	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.5	0.3	1.0	0.4	1.1	1.8	-1.0	1.0	0.3	0.5	1.8	-0.0	2.1	2.4
Pulse rate	1.3	2.2	6.4	2.3	0.8	1.6	-1.7	1.6	0.4	1.9	2.5	2.0	0.2	-0.2	0.7	-0.4
Happiness	1.3	1.5	6.7	-1.1	-0.9	-0.5	-0.2	-0.8	-0.7	-0.9	-0.3	-0.7	-1.3	-2.6	-1.7	-2.0
Noisy workplace	0.2	0.2	0.8	0.8	0.1	-0.2	-0.2	-0.3	0.4	0.2	0.7	0.5	-0.4	-0.9	-0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.1	-0.7	0.7	0.2	0.2	0.6	-0.5	-0.2	-0.6	-0.1	1.4	0.3	-0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.4	0.2	0.3	-0.2	0.8	0.8	1.6	0.3	-0.3	-0.3	0.7	0.2	0.2	0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	6.0	0.2	-0.3	0.4	-2.4	-0.6	1.4	-0.1	0.3	0.1	-2.0	1.2	0.0	-1.3
Asthma	0.6	1.3	7.7	-0.9	0.4	-0.1	-1.2	-0.7	1.3	-0.8	-0.9	-1.5	-0.8	2.8	0.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.9	-1.7	-0.2	-0.7	0.8	-0.9	-1.5	-1.4	-1.3	-1.5	-0.8	0.2	0.1	0.2
Medication: Cholesterol lowering	0.8	1.2	4.9	-0.3	0.5	1.0	-0.4	-1.0	-0.8	-0.3	-0.0	-0.2	-1.4	-1.5	-1.8	-2.2
Depression (self-reported)	1.8	2.1	9.1	0.3	-1.2	-0.7	-0.5	-1.1	-0.5	-0.8	-0.6	-0.7	-1.7	-3.0	-1.9	-2.6
Medication: Lansoprazole	0.3	0.3	2.9	-0.5	-0.3	0.3	0.4	0.1	-0.5	0.0	-0.1	-0.0	-0.5	-1.7	0.4	-0.6
Prospective memory result	0.2	0.3	1.6	0.7	-0.6	-0.2	-0.2	0.0	1.3	-0.2	0.2	0.1	-0.1	-1.0	-0.2	-0.0
Lung cancer (father)	0.6	0.7	2.3	-0.1	-1.4	-1.2	-0.7	-1.0	-1.5	-1.0	-0.9	-0.5	-0.3	0.2	-0.2	0.1
Illnesses of mother	1.0	1.2	5.2	0.3	0.9	0.6	-1.0	0.4	0.6	0.1	0.7	0.6	-1.2	-1.9	-1.3	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.0	-0.3	0.8	0.1	1.6	1.1	-1.2	0.6	-0.0	0.1	1.5	-0.7	1.4	2.0
Pulse wave Arterial Stiffness index	0.6	0.6	1.9	0.4	-1.4	-1.2	0.2	-0.4	-0.7	-0.5	0.0	0.1	-0.7	-0.9	-1.3	-1.0
Impedance of arm (left)	0.1	0.3	1.1	-1.1	-0.1	0.1	-0.3	-0.0	0.4	-0.4	-0.1	-0.7	0.4	0.1	-1.0	-1.0
Arm fat mass (right)	1.6	6.8	13.8	-2.5	-3.1	-3.4	1.2	-3.7	-1.7	-2.9	-3.0	-2.5	-3.4	-1.4	-2.0	-1.1
Trunk predicted mass	0.2	1.1	4.9	0.4	-0.7	0.0	-0.6	-1.2	-1.9	0.7	0.4	1.1	-2.2	-1.2	0.5	-0.4
Standing height	0.4	3.8	10.3	1.7	1.9	2.6	-1.2	1.1	-1.1	3.2	2.8	3.1	0.1	-0.8	2.3	0.5
Length of working week for main job	0.4	0.4	3.6	0.4	0.1	0.6	-0.2	-0.2	1.9	0.1	0.1	0.1	-1.2	0.3	0.2	-0.3
Exposure to tobacco smoke at home	0.6	0.7	3.8	0.1	-0.5	0.5	-1.9	0.1	0.1	-0.3	0.1	-0.1	-1.4	-0.7	-0.5	-1.5
Breastfed as a baby	0.2	0.2	0.5	0.7	-0.7	0.2	-0.6	-0.4	0.2	-0.1	-0.0	0.5	-0.5	-0.4	-0.2	-0.5
Tense / ‘highly strung’	0.6	1.0	4.4	-0.5	0.4	0.7	1.6	1.1	-0.4	0.4	-0.2	0.1	2.1	-0.7	0.8	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.4	-0.2	-0.1	-0.2	1.5	0.2	-0.6	-0.2	-0.4	-0.5	0.6	-1.3	0.3	0.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.3	-0.4	0.6	0.0	1.3	0.3	-1.5	0.5	0.3	0.0	0.2	1.1	0.7	0.5
Birth weight of first child	0.3	0.5	1.1	0.1	0.2	0.2	-1.0	-0.2	-1.1	0.8	0.6	1.0	-0.8	0.4	0.9	-0.0
Peak expiratory flow (PEF)	0.8	1.9	6.2	1.3	0.8	0.5	-0.0	1.7	-0.4	1.3	0.9	1.3	2.1	1.1	1.9	2.5
Pulse wave reflection index	0.4	0.5	1.0	-0.7	-0.8	-1.0	0.9	-0.6	-0.6	-0.8	-1.0	-0.5	-0.4	0.7	-0.2	0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.2	-1.2	-0.5	-0.2	1.5	-1.0	-1.2	-0.6	-0.9	-0.6	-0.4	0.5	-0.2	0.7
Loud music exposure frequency	1.6	1.7	4.6	-1.9	-0.3	-1.3	1.7	-0.5	-2.1	-1.2	-1.5	-1.4	0.7	1.1	-0.1	1.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-1.2	0.6	-0.3	0.3	-0.3	-0.7	-1.0	-1.1	-1.2	0.1	0.0	-0.7	-0.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.5	-1.6	-0.4	-1.3	1.1	-0.7	-1.5	-1.2	-1.5	-1.2	-0.4	0.9	-0.3	0.5
Blood clot in the leg (DVT)	0.2	0.2	0.8	0.3	-0.1	-0.9	0.5	-0.8	-0.0	-0.3	-0.4	0.1	-0.2	-0.9	-0.7	0.1
Medication: Paracetamol	0.2	0.4	0.9	-0.6	-0.6	-0.1	0.1	0.0	-0.6	-0.4	-0.7	-0.9	0.4	1.0	0.7	0.8
Headache pain in last month	2.0	3.4	6.5	-2.0	-2.4	-2.5	2.5	-0.6	-2.2	-2.1	-1.7	-2.1	-0.0	-1.5	-1.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.3	-0.8	-0.6	0.2	0.7	0.9	-0.0	-0.0	-0.2	0.7	0.7	0.5	0.6
Glaucoma (self-reported)	0.4	0.4	2.7	-0.5	-0.3	-0.7	0.3	-0.5	-1.6	-0.3	-0.7	-0.5	-0.3	0.8	0.5	0.4
Gout (self-reported)	0.5	0.6	1.5	-0.8	-0.3	-0.3	1.1	-1.0	0.9	-1.0	-1.0	-0.4	-1.2	0.7	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.4	1.5	0.0	0.9	-0.6	1.0	0.4	0.9	1.6	1.1	-0.7	1.1	0.6	0.0
Medication: Amlodipine	0.3	0.4	1.5	0.2	0.7	0.8	0.1	0.1	-1.2	0.3	-0.0	0.4	0.0	0.1	1.0	1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.7	-1.1	-1.0	-1.2	0.8	-1.1	-1.2	-1.2	-1.3	-1.1	-0.6	-0.0	-0.9	-0.3
Birth weight	1.3	2.9	6.0	-1.6	-1.1	-2.2	0.1	-1.7	-0.4	-2.3	-2.1	-2.4	-2.0	-1.7	-1.6	-1.1
Chronic bronchitis/emphysema (mother)	2.0	2.3	6.0	-1.0	-2.5	-1.9	1.2	-2.0	-0.5	-1.3	-1.2	-0.7	-1.3	-1.5	-2.2	-1.3
High blood pressure (siblings)	0.8	1.2	3.9	-0.2	1.0	-0.2	1.7	0.7	-1.4	0.4	-0.0	0.5	1.6	1.1	1.0	2.0
Forced vital capacity (FVC), Best measure	0.2	0.6	1.4	-0.4	1.2	0.3	1.0	0.9	-0.9	0.6	0.2	0.0	0.8	-0.6	1.0	1.1
Body fat percentage	1.5	6.1	12.3	-2.3	-3.0	-3.2	1.2	-3.5	-0.5	-3.0	-2.9	-2.7	-2.9	-1.2	-2.1	-1.1
Leg fat percentage (right)	1.6	5.9	12.2	-2.2	-2.7	-3.0	1.2	-3.5	-0.0	-3.1	-2.8	-2.6	-3.0	-1.5	-2.2	-1.3
Arm fat-free mass (right)	0.2	0.8	2.5	0.6	-0.4	-0.0	-0.2	-0.8	-1.6	0.9	0.3	1.1	-1.4	-0.8	1.1	0.7
Exposure to tobacco smoke outside home	1.0	1.4	3.0	-0.5	-1.7	-0.6	-1.1	-1.2	1.0	-1.3	-0.7	-1.4	-1.6	0.7	-1.1	-1.3
Comparative body size at age 10	1.7	4.7	9.9	-1.5	-2.8	-3.1	1.5	-3.0	-0.8	-3.0	-3.1	-2.4	-1.7	-1.0	-1.6	0.3
Number of full brothers	0.6	0.7	4.0	0.6	0.3	0.9	-1.1	0.4	2.0	0.5	0.5	0.2	-0.9	1.0	0.1	-0.8
Worry too long after embarrassment	2.5	4.3	9.8	-2.8	-1.0	-2.0	3.1	-2.1	-3.0	-2.1	-2.4	-1.9	-0.5	-1.2	-1.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.5	-0.6	-0.2	1.2	0.1	-0.8	0.1	-0.3	-0.2	1.2	-1.2	0.5	1.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.9	-0.7	-1.2	-0.9	-0.3	-1.7	-0.6	-0.9	-0.7	-1.0	-1.5	0.3	-1.0	-0.6
Number of children fathered	0.7	0.8	2.9	-0.3	-0.4	-0.7	-0.6	-1.0	-0.2	-1.1	-0.4	-0.4	-1.4	-0.7	-1.3	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.4	0.1	0.1	1.0	0.3	-0.3	-0.8	0.4	0.6	0.7	-0.8	-1.8	0.1	-0.8
Age at first live birth	0.5	0.8	2.0	0.5	0.9	1.2	0.3	1.4	-0.5	1.2	1.0	1.1	1.4	-0.6	0.3	0.1
Pulse wave peak to peak time	0.5	0.6	1.9	-0.3	1.3	1.2	-0.2	0.3	0.3	0.6	0.1	0.1	0.7	0.8	1.4	1.0
Health satisfaction	0.4	0.6	1.6	0.0	-0.9	-0.5	1.0	-0.9	-1.1	-0.2	-0.2	0.1	-0.1	-1.2	-0.4	1.1
Shortness of breath walking on level ground	2.1	2.6	5.0	-1.5	-1.3	-1.5	0.1	-2.2	-0.3	-1.9	-1.5	-1.6	-2.1	-1.5	-2.1	-1.5
Qualifications: College or University degree	0.2	0.6	3.4	0.2	0.9	0.6	0.7	1.1	-0.7	0.6	-0.2	0.4	1.8	-0.2	0.3	0.8
Eye problems/disorders: None of the above	1.4	1.6	3.0	1.4	1.5	1.4	-0.7	1.7	0.8	1.4	1.5	1.2	1.7	-0.2	1.2	0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	-0.9	-1.1	-1.3	-0.4	-0.9	-1.0	-1.3	-1.3	-1.1	-0.7	0.1	-0.1	0.4
Emphysema/chronic bronchitis	3.7	4.2	8.8	2.0	2.5	2.4	-1.3	2.1	1.9	2.5	3.0	2.8	0.6	0.2	1.9	0.5
Medication for pain relief, constipation, heartburn	0.3	0.6	1.8	1.3	0.3	0.3	-0.8	1.0	0.5	1.1	0.9	1.1	0.5	0.0	0.3	0.0
Neck or shoulder pain in last month	1.4	2.0	6.4	-1.3	-0.9	-1.4	2.5	-1.1	-0.0	-1.6	-1.9	-1.8	0.8	0.1	-0.1	1.9
Medication: Blood pressure	0.3	0.5	0.9	0.8	0.8	0.9	-0.6	-0.1	-0.2	0.7	0.4	1.0	-0.2	0.7	0.9	0.8
Angina (self-reported)	1.3	1.7	3.8	1.6	0.9	1.6	-0.4	1.5	1.5	1.8	1.9	1.6	0.5	1.0	0.9	0.4
Migraine (self-reported)	0.2	0.3	1.0	-0.0	1.0	-0.2	0.1	1.0	0.6	-0.1	0.4	0.0	0.9	-0.2	-0.2	-0.1
Medication: Ibuprofen	1.1	1.3	3.2	-1.8	-0.1	-0.5	0.6	-1.2	-1.7	-1.5	-1.5	-1.7	-0.8	0.5	0.1	0.3
Medication: Allopurinol	2.0	2.6	7.8	-2.1	-1.6	-1.7	2.8	-1.6	-0.4	-2.0	-2.2	-1.4	-0.2	-0.3	-1.5	0.9
Medication: Omeprazole	0.2	0.3	1.5	-0.3	0.6	0.3	-0.3	-0.2	0.7	-0.2	0.0	0.1	-0.6	1.2	0.6	0.3
Medication: Seretide 50 evohaler	1.3	1.5	4.0	1.0	2.0	1.6	-0.8	1.3	-0.4	1.4	1.8	1.3	0.9	1.1	0.9	0.3
Mean time to correctly identify matches	0.2	0.3	2.1	-0.3	0.2	-0.3	-0.1	0.4	0.1	-0.3	-0.4	-0.7	0.0	1.5	0.7	0.6
Heart disease (mother)	1.3	1.5	3.4	-1.0	-0.1	-1.1	1.4	0.2	-0.3	-1.3	-1.4	-1.7	1.6	1.8	0.4	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	6.2	-0.1	-1.5	-1.1	-0.9	-1.4	1.1	-1.3	-0.9	-0.8	-2.2	-0.9	-2.5	-2.5
Whole body fat mass	1.1	4.8	10.8	-2.0	-2.6	-2.9	1.0	-3.3	-1.0	-2.5	-2.6	-2.1	-2.9	-1.1	-1.4	-0.7
Leg fat mass (right)	1.3	5.0	10.9	-2.0	-2.6	-2.9	1.2	-3.3	-0.7	-2.7	-2.6	-2.2	-3.1	-1.2	-1.6	-0.8
Arm predicted mass (right)	0.2	0.8	2.4	0.7	-0.5	0.1	-0.4	-0.8	-1.6	0.9	0.5	1.1	-1.4	-0.7	1.0	0.5
Pulse rate, automated reading	0.9	3.0	5.4	1.9	1.9	2.3	-0.7	1.9	0.1	2.1	2.3	2.2	1.8	-0.5	1.6	1.2
Alcohol intake frequency.	0.1	0.3	0.8	0.4	0.4	0.3	0.3	0.6	-0.4	0.7	0.7	0.6	0.9	0.0	0.5	0.6
Comparative height size at age 10	0.1	0.6	4.5	-0.4	-0.5	-0.2	0.3	-0.8	-2.1	0.4	0.1	0.4	-1.0	-0.1	0.9	0.2
Number of full sisters	0.7	0.8	5.5	0.1	1.6	0.4	0.1	0.1	2.3	-0.5	-0.3	-0.4	0.6	0.9	0.4	0.8
Suffer from ‘nerves’	0.8	1.3	7.0	-0.5	0.2	0.2	2.6	0.4	-0.5	-0.4	-0.8	-0.5	1.2	-2.6	-0.1	0.4
Overall health rating	0.4	0.8	6.2	0.5	-0.7	-0.7	1.2	-0.5	-0.5	0.1	0.1	0.4	0.6	0.2	0.8	2.5
Chest pain or discomfort	0.7	1.0	2.8	1.0	0.3	1.5	-0.7	0.6	0.6	1.5	1.7	1.4	0.1	0.8	1.1	0.4
Had major operations	0.2	0.2	0.8	-0.6	-0.2	-0.2	0.1	-0.4	0.0	-0.3	-0.3	-0.0	-0.9	-0.2	-0.6	-0.9
Age at last live birth	1.0	1.4	4.1	1.1	0.9	2.0	-0.8	0.7	0.4	1.4	1.8	1.6	-0.1	-1.3	0.0	-1.2
Family relationship satisfaction	0.7	0.8	4.4	0.1	-0.5	0.4	-1.3	-0.0	-1.0	0.5	0.7	0.7	-0.5	-2.1	-0.7	-1.1
Leg pain on walking	1.1	1.3	3.2	-0.6	-1.4	-1.0	0.1	-0.6	-0.8	-0.9	-0.8	-1.1	-1.3	-1.8	-1.8	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.9	-0.3	-1.4	-1.4	0.9	-1.1	1.2	-1.3	-0.9	-1.1	-1.0	-0.2	-1.0	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.2	0.3	0.1	0.6	-1.0	-0.8	0.3	0.2	0.4	0.4	-0.4	1.5	0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	3.3	-0.6	-1.0	-0.4	-0.6	-1.6	-1.8	-0.5	0.2	-0.1	-1.2	-0.8	-1.3	-1.8
Medication: Aspirin	0.5	0.7	2.1	-0.0	-0.1	0.6	-0.6	-1.4	0.7	-0.1	0.1	0.5	-1.5	-0.8	-1.4	-1.0
Supplements: Vitamin C	0.1	0.1	0.4	-0.3	-0.5	-0.2	-0.2	-0.3	0.2	-0.2	-0.5	-0.4	0.3	0.7	-0.5	-0.1
Knee pain experienced in last month	0.8	1.2	2.9	-1.2	-1.7	-1.2	0.9	-1.1	-1.3	-1.4	-1.2	-1.4	-0.4	0.6	-0.8	0.0
Hypertension (Self-reported)	0.4	1.0	3.7	-0.7	-0.3	-0.7	-0.0	-1.9	-1.8	-0.9	-1.0	-0.6	-1.5	0.5	0.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.0	-0.2	0.4	0.0	-1.0	0.7	1.4	-0.1	0.2	-0.2	-0.6	-1.1	-0.6	-1.7
Illnesses of father: Heart disease	0.5	0.7	3.2	0.1	0.5	-0.0	0.6	0.8	-0.4	0.4	-0.0	-0.0	1.8	0.7	0.9	1.7
Illnesses of siblings: Diabetes	3.1	3.8	6.8	2.2	1.9	2.1	-0.4	2.5	1.8	2.0	1.9	1.7	1.8	1.6	2.6	2.1
Smoking status: Previous	0.7	1.0	7.8	1.0	0.6	0.2	0.6	-0.1	0.5	0.3	0.6	0.9	0.1	-2.8	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	6.1	2.1	2.0	2.3	-0.5	1.2	0.9	2.2	2.5	2.2	1.1	-0.7	1.8	1.3
Whole body fat-free mass	0.2	1.3	5.6	-0.1	-1.4	-0.7	-0.3	-1.6	-2.2	0.2	-0.3	0.4	-2.4	-1.0	0.4	-0.1
Leg fat-free mass (right)	0.3	1.9	6.6	-0.9	-1.9	-1.5	-0.1	-1.8	-2.6	-0.5	-1.2	-0.4	-2.3	-0.6	0.3	0.2
Arm fat percentage (left)	2.5	9.9	17.3	-3.2	-3.7	-4.1	1.4	-4.2	-1.3	-4.0	-3.9	-3.6	-3.5	-1.2	-2.8	-1.4
Average weekly red wine intake	0.4	0.5	2.2	-0.1	-0.8	-0.7	0.5	-0.5	-0.2	-0.5	-0.9	-0.2	-0.6	-1.5	-1.0	-0.7
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.3	0.1	-1.6	0.1	-1.1	-0.6	-0.6	0.2	0.7	0.4	-0.8	-1.4	-0.7	-1.8
Mood swings	0.5	0.9	3.4	-0.4	-0.7	-0.4	1.1	0.2	-0.6	-0.3	-0.9	-0.6	0.2	1.8	1.3	1.8
Loneliness, isolation	1.2	1.6	3.4	-1.4	-1.5	-1.1	1.8	-1.1	-1.4	-1.5	-1.4	-1.1	-0.6	-1.4	-0.8	0.7
Long-standing illness, disability or infirmity	0.4	0.6	2.3	-0.1	1.1	-0.1	0.9	0.1	1.1	-0.0	0.0	-0.4	0.6	1.5	0.6	1.3
Ever had bowel cancer screening	0.2	0.3	1.4	-0.0	-1.2	-0.5	-0.3	-0.2	0.2	-0.7	-0.6	-0.3	-0.3	0.9	0.4	0.2
Diabetes diagnosed by doctor	0.6	1.0	2.6	0.9	1.6	1.4	-0.5	1.0	0.5	0.9	1.1	0.8	1.1	1.0	0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.2	-0.7	-1.0	-1.0	0.2	-0.6	0.1	-1.0	-0.7	-0.8	-1.5	-0.3	-0.8	-1.1
Friendships satisfaction	0.5	0.6	1.4	0.9	-1.2	0.7	-0.9	0.6	0.5	1.1	0.9	0.9	-0.0	0.1	0.7	0.6
Qualifications: nursing, teaching	0.8	1.3	4.0	-1.7	-0.0	-1.5	0.9	0.2	-0.8	-1.3	-2.0	-2.0	0.4	0.7	-0.1	0.4
Commuting to job workplace: Walk	1.4	1.5	5.3	1.1	0.2	0.0	1.0	1.7	-0.5	0.8	-0.3	0.6	2.1	0.5	1.6	2.3
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.6	-1.5	-0.7	0.2	-1.4	-0.7	-1.0	-1.3	-0.7	-1.1	0.4	-1.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.7	-0.0	1.3	0.1	0.6	1.2	-1.3	0.5	0.1	0.2	1.9	-0.4	0.7	1.2
Medication for cholesterol	1.4	2.1	7.4	-1.0	-1.5	-1.0	0.9	-0.8	-0.0	-1.1	-0.7	-0.7	-1.6	-2.7	-1.9	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	-1.1	-0.3	-0.9	0.8	-1.0	-0.2	-1.1	-0.6	-1.3	-0.6	-0.6	-0.3	-0.2
Back pain experienced in last month	0.4	0.6	3.4	-0.4	0.8	-0.2	1.8	0.7	-0.4	0.1	-0.2	-0.2	0.8	0.3	0.7	0.9
Mineral and other dietary supplements	0.1	0.2	1.5	0.0	0.1	-0.0	0.1	0.4	-0.0	-0.1	0.2	0.0	0.9	-1.2	-0.3	0.0
Breast cancer (self-reported)	2.6	3.1	6.6	2.0	1.5	2.3	-2.5	1.1	0.6	2.2	2.6	2.4	-0.4	-0.1	0.7	-1.6
Asthma (self-reported)	0.8	1.5	9.9	-0.9	0.2	-0.0	-1.1	-0.8	1.5	-0.8	-0.9	-1.6	-0.7	3.1	0.3	0.0
Osteoporosis (self-reported)	0.5	0.6	1.6	0.6	0.6	1.3	0.6	0.4	0.6	0.9	1.0	1.1	0.1	-0.8	0.6	0.3
Osteoarthritis (self-reported)	1.7	2.2	5.9	-1.1	-2.2	-1.2	-0.7	-2.1	-2.4	-0.9	-0.7	-0.5	-2.2	0.3	-1.2	-1.2
Medication: Aspirin	0.6	0.8	2.9	0.2	-0.1	0.4	-0.3	-1.7	1.0	-0.1	0.1	0.5	-1.4	-1.1	-1.6	-0.8
Medication: Gliclazide	1.9	2.1	4.6	1.6	1.3	1.5	-1.2	2.1	1.5	1.7	1.5	1.1	1.8	1.2	1.2	0.7
Illnesses of father: None of the above (group 1)	0.8	1.0	2.9	-0.6	-1.5	-0.9	-0.2	-1.2	-1.0	-0.9	-1.1	-0.8	-0.8	-1.7	-0.4	-0.4
Smoking status: Current	0.3	0.4	1.6	-0.8	0.2	0.3	-0.5	0.1	0.3	-0.3	-0.3	-0.6	0.0	1.3	1.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.2	-0.8	-1.0	-1.7	1.6	-0.4	-1.0	-1.4	-1.7	-1.4	0.5	-2.3	-0.6	0.7
Whole body water mass	0.2	1.4	5.5	-0.2	-1.4	-0.8	-0.3	-1.6	-2.3	0.1	-0.4	0.3	-2.4	-1.1	0.3	-0.1
Leg predicted mass (right)	0.3	1.8	6.5	-0.8	-1.9	-1.5	-0.1	-1.8	-2.5	-0.5	-1.1	-0.4	-2.3	-0.6	0.3	0.1
Arm fat mass (left)	1.7	6.8	13.8	-2.4	-3.2	-3.4	1.1	-3.7	-1.4	-3.0	-3.1	-2.6	-3.4	-1.6	-2.1	-1.1
Number of self-reported non-cancer illnesses	0.3	0.6	2.8	-0.4	-0.4	-0.3	-1.0	-1.2	0.1	-0.6	-0.2	-0.2	-1.7	0.9	-0.6	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.6	-0.8	-0.1	0.0	-0.0	-0.6	-0.1	-0.3	-0.3	-0.4	-0.4	0.2	-0.4	-0.0
Miserableness	1.0	1.7	6.2	-1.0	-1.2	-0.9	2.2	-0.8	-2.5	-1.1	-1.3	-1.0	0.7	-1.3	-0.3	1.1
Guilty feelings	0.6	1.0	5.2	-0.6	0.1	-0.5	2.3	0.2	-0.9	-0.1	-0.5	-0.1	1.6	-0.6	-0.0	1.6
Wears glasses or contact lenses	1.9	2.2	10.2	1.9	1.7	1.6	-1.6	0.8	3.2	1.0	1.5	1.3	0.0	0.4	0.7	-0.5
Ever taken oral contraceptive pill	4.2	4.7	10.4	-2.5	-1.1	-1.8	2.0	-2.9	0.3	-3.1	-3.2	-2.9	-1.5	-1.4	-2.2	-0.6
Hearing aid user	0.3	0.4	0.7	-0.4	0.4	-0.1	-0.8	-0.2	0.8	-0.8	-0.4	-0.9	-0.1	0.8	-0.6	-0.6
Mother’s age at death	1.3	1.6	4.7	0.9	1.8	0.9	-0.1	2.1	2.2	1.0	0.9	0.8	1.0	0.9	1.2	0.6
Financial situation satisfaction	0.8	1.0	2.0	-1.0	-0.9	-0.4	0.2	-1.1	-0.5	-0.9	-0.8	-1.1	-1.2	-1.1	-1.4	-1.2
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	0.6	0.2	0.2	-0.0	1.0	0.3	0.7	1.0	0.8	0.5	-1.2	0.5	-0.0
Commuting to job workplace: Public transport	0.5	0.6	1.7	-0.7	-0.3	-0.8	0.9	0.1	-0.9	-0.4	-0.2	-0.5	0.6	-1.1	-1.3	-0.7
Eye problems/disorders: Glaucoma	0.8	1.0	2.2	-1.2	-0.7	-1.1	1.0	-1.1	-1.5	-0.9	-1.4	-0.8	0.1	0.8	0.3	0.8
Medication: Blood pressure	0.6	1.1	5.1	-0.5	0.3	-0.8	0.3	-0.2	-1.0	-0.4	-0.7	-0.5	0.9	2.3	1.0	2.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-1.1	-1.6	-1.1	-0.0	-0.9	-0.9	-1.0	-1.3	-1.2	-0.6	0.4	-0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.2	0.2	0.5	-1.2	-0.2	0.5	0.4	0.4	0.3	-1.0	1.2	0.1	-0.9
High cholesterol (Self-reported)	0.3	0.6	1.7	0.3	1.3	0.3	0.9	-0.8	-0.3	-0.1	-0.2	-0.2	1.3	-1.1	-0.2	1.0
Medication: Bendroflumethiazide	0.5	0.8	3.6	0.5	0.7	0.3	-0.0	0.1	0.6	0.5	0.0	0.3	0.5	1.9	1.4	1.8
Medication: Paracetamol	0.3	0.5	1.5	-0.9	-0.6	-0.1	0.5	-0.1	-0.3	-0.5	-0.8	-1.1	0.3	1.2	0.7	1.0
Medication: Lisinopril	0.3	0.5	2.1	0.5	0.4	0.8	-0.5	-0.7	0.8	0.4	0.4	0.7	-1.4	0.5	0.5	-0.1
Medication: Atorvastatin	1.1	1.4	7.1	-0.8	1.5	-0.1	2.7	0.5	0.5	-0.4	-0.6	-0.6	1.9	-0.7	0.2	1.7
Illnesses of father: High blood pressure	0.7	0.9	6.1	-0.8	-1.1	-1.1	0.2	-0.7	-2.5	-0.8	-0.5	-0.5	-0.5	0.1	-0.7	-0.2
Alcohol drinker status: Never	0.8	0.9	3.1	-0.0	0.7	0.4	1.5	1.0	0.6	0.9	0.8	0.5	1.8	-0.8	0.7	1.2
Ever smoked	0.5	0.8	2.9	-0.1	-0.3	0.2	-1.0	-1.1	0.3	-0.4	0.2	0.1	-1.7	-1.4	-1.0	-1.5
Basal metabolic rate	0.3	1.7	6.6	-0.5	-1.6	-1.1	-0.1	-2.0	-2.2	-0.3	-0.7	0.0	-2.6	-1.2	0.1	-0.2
Leg fat percentage (left)	1.7	6.1	13.0	-2.2	-2.8	-3.1	1.2	-3.6	0.1	-3.2	-2.9	-2.6	-3.1	-1.3	-2.1	-1.2
Arm fat-free mass (left)	0.2	1.1	5.0	-0.0	-1.3	-0.6	0.0	-1.7	-1.6	0.2	-0.2	0.6	-2.2	-1.3	0.2	-0.1
Number of operations (self-reported)	0.8	1.1	4.9	0.4	-1.1	-0.6	0.2	-1.2	1.1	-0.5	0.0	0.4	-1.7	-2.2	-1.1	-0.8
Average weekly beer plus cider intake	1.4	2.0	3.5	-1.2	-1.9	-1.5	0.7	-1.8	-1.5	-1.8	-1.5	-1.5	-1.7	1.1	-1.0	-0.2
Irritability	1.4	2.4	5.5	-1.8	-1.4	-2.1	1.7	-1.0	-1.6	-1.8	-2.3	-2.2	-0.3	-0.3	-0.9	0.4
Risk taking	1.0	1.5	4.9	-1.4	-1.1	-1.6	1.2	-1.6	-2.2	-1.1	-1.6	-1.1	-0.3	-0.2	-0.3	0.6
Ever had prostate specific antigen (PSA) test	2.8	3.3	6.8	-1.9	-2.2	-2.2	0.7	-2.4	-0.7	-1.9	-2.0	-1.8	-2.6	0.2	-1.8	-1.2
Fractured/broken bones in last 5 years	2.2	2.8	8.4	-1.8	-2.9	-0.7	-0.1	-1.9	-2.1	-1.3	-1.4	-1.4	-1.9	-0.7	-1.8	-1.9
Age started oral contraceptive pill	1.6	2.0	4.7	1.3	1.6	1.9	0.1	1.2	-0.1	2.2	1.7	2.0	1.2	0.4	1.6	1.2
Diastolic blood pressure, automated reading	0.1	0.3	1.2	-0.5	0.6	-0.1	0.3	-1.1	-0.6	-0.3	-0.1	0.2	0.3	0.1	0.3	1.0
Ever depressed for a whole week	0.4	0.5	2.8	-0.3	-0.2	-0.3	1.4	-0.6	-0.1	-0.6	-0.7	-0.5	0.0	-1.7	-0.4	0.3
Unable to work because of sickness or disability	0.9	1.2	4.5	-0.4	-0.4	0.3	-0.9	-1.6	1.4	-1.1	-0.6	-0.9	-2.1	-0.8	-0.7	-1.2
Commuting to job workplace: Cycle	0.6	0.7	5.3	-0.8	-0.3	-1.2	0.4	0.1	-2.3	-0.6	-0.8	-0.2	-0.0	-0.7	-0.2	-0.1
Myopia	0.5	0.7	2.0	0.2	1.4	-0.1	-0.2	1.4	1.2	0.4	0.2	-0.1	1.3	1.4	0.5	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.2	0.1	-0.9	-0.4	0.2	1.1	0.3	0.3	0.3	0.1	0.9	-0.4	-0.4	-0.6
Cholesterol lowering medication	0.8	1.2	5.9	0.9	1.0	0.0	0.2	0.5	1.0	0.6	0.1	0.2	1.8	1.1	1.4	2.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.2	-0.1	0.5	0.7	-0.4	0.0	0.4	0.2	0.4	0.5	-0.5	1.1	0.9	0.5
Pain experienced in last month	1.2	2.1	7.9	0.5	0.9	1.9	-2.8	-1.0	1.1	1.0	1.3	1.2	-1.8	0.2	-0.4	-2.1
Supplements: Calcium	0.4	0.5	2.2	-0.9	0.1	-0.4	0.4	-0.1	-0.7	-0.6	-0.9	-0.8	0.2	1.5	0.2	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	3.4	-0.2	0.0	-0.3	0.2	0.0	-0.2	-0.4	-0.1	-0.4	0.6	-1.9	-0.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	0.3	0.6	0.9	-0.5	0.4	0.1	0.7	1.1	0.6	0.0	-1.1	-0.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	-0.0	-0.2	-0.9	0.2	-1.0	-0.3	-0.6	-0.5	-0.2	-0.6	-1.2	-1.1	-0.5
Heart disease (siblings)	0.7	0.9	6.2	0.3	0.3	0.7	-0.4	0.8	-0.0	0.4	0.4	0.3	0.8	2.5	1.2	1.4
Alcohol drinker status: Previous	0.4	0.4	1.9	0.8	0.4	0.2	0.7	-0.2	0.3	0.6	0.4	0.6	1.0	0.3	0.3	1.4
Pack years of smoking	0.1	0.2	0.5	-0.6	-0.6	-0.3	-0.7	-0.0	-0.1	-0.4	-0.3	-0.5	-0.2	0.4	-0.2	-0.6
Impedance of whole body	0.2	0.8	2.2	0.2	1.1	1.3	0.0	1.0	1.5	0.8	1.2	0.5	1.3	-0.4	-0.3	-0.7
Leg fat mass (left)	1.2	4.7	10.4	-1.9	-2.5	-2.9	1.3	-3.2	-0.7	-2.6	-2.6	-2.1	-2.9	-1.1	-1.4	-0.6
Arm predicted mass (left)	0.2	1.1	4.3	0.0	-1.3	-0.7	0.2	-1.6	-1.8	0.2	-0.2	0.6	-2.1	-1.4	0.2	0.0