Best TWAS P=6.64e-18 · Best GWAS P=2.66e-28 conditioned to 1.02e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TRIM5 | 0.06 | 0.03 | enet | 25 | 0.05 | 3.1e-06 | -5.8 | 8.6 | 9.3e-18 | -0.22 | 0.64 | 0.13 | FALSE |
| 2 | GTEx | Esophagus Mucosa | TRIM5 | 0.19 | 0.04 | enet | 29 | 0.05 | 1.5e-04 | -7.4 | 8.0 | 1.1e-15 | -0.06 | 0.86 | 0.01 | TRUE |
| 3 | GTEx | Esophagus Muscularis | DCHS1 | 0.44 | 0.08 | lasso | 8 | 0.22 | 1.9e-13 | 4.6 | 6.0 | 2.0e-09 | -0.04 | 0.04 | 0.94 | TRUE |
| 4 | GTEx | Esophagus Muscularis | RP11-732A19.5 | 0.40 | 0.17 | lasso | 6 | 0.17 | 1.7e-10 | 4.6 | 5.9 | 3.6e-09 | -0.03 | 0.04 | 0.93 | FALSE |
| 5 | GTEx | Muscle Skeletal | TRIM5 | 0.13 | 0.07 | enet | 3 | 0.05 | 1.4e-05 | -5.8 | 5.8 | 7.9e-09 | -0.25 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-732A19.8 | 0.12 | 0.10 | lasso | 5 | 0.08 | 1.7e-06 | 4.7 | 5.5 | 4.1e-08 | -0.02 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Nerve Tibial | RP11-732A19.2 | 0.35 | 0.18 | lasso | 6 | 0.19 | 1.6e-13 | 4.7 | 5.3 | 1.0e-07 | -0.01 | 0.02 | 0.97 | FALSE |
| 8 | METSIM | Adipose | ILK | 0.09 | 0.06 | lasso | 3 | 0.05 | 1.5e-08 | 4.9 | 5.2 | 1.5e-07 | -0.04 | 0.01 | 0.98 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | DCHS1 | 0.24 | 0.18 | lasso | 5 | 0.21 | 1.2e-26 | 4.6 | 5.4 | 6.1e-08 | 0.01 | 0.03 | 0.94 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | UBQLNL | 0.09 | 0.00 | blup | 839 | 0.02 | 9.8e-04 | 4.4 | 6.5 | 1.1e-10 | -0.18 | 0.17 | 0.05 | TRUE |
| 11 | YFS | Blood | TRIM5 | 0.02 | 0.01 | enet | 24 | 0.02 | 6.7e-07 | -3.0 | 7.4 | 1.9e-13 | 0.05 | 0.99 | 0.00 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRIM5 | 0.06 | 0.04 | lasso | 4 | 0.04 | 2.0e-08 | -7.4 | 7.3 | 2.5e-13 | 0.02 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | TRIM5 | 0.20 | 0.00 | enet | 30 | 0.08 | 1.0e-04 | -1.7 | 7.6 | 3.6e-14 | -0.15 | 0.04 | 0.04 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | TRIM5 | 0.14 | 0.03 | lasso | 6 | 0.07 | 9.1e-05 | -6.9 | 6.7 | 1.7e-11 | 0.01 | 0.30 | 0.06 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TRIM5 | 0.11 | 0.10 | lasso | 1 | 0.09 | 1.7e-10 | -7.4 | 7.4 | 1.3e-13 | 0.02 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TRIM5 | 0.07 | 0.06 | lasso | 4 | 0.05 | 1.1e-06 | -7.4 | 7.4 | 1.2e-13 | 0.02 | 0.98 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TRIM5 | 0.08 | 0.07 | enet | 4 | 0.06 | 1.2e-07 | 10.1 | 8.6 | 6.6e-18 | -0.26 | 0.95 | 0.03 | TRUE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM5 | 0.08 | 0.05 | lasso | 2 | 0.05 | 5.6e-07 | -7.4 | 7.4 | 1.4e-13 | 0.05 | 0.97 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM6 | 0.04 | 0.01 | blup | 113 | 0.01 | 6.3e-03 | -6.8 | 7.0 | 2.2e-12 | -0.31 | 0.04 | 0.42 | FALSE |
| 20 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | OR52N2 | 0.12 | 0.06 | lasso | 3 | 0.07 | 6.1e-04 | 6.3 | -6.9 | 6.4e-12 | -0.03 | 0.06 | 0.24 | TRUE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | DCHS1 | 0.10 | 0.04 | lasso | 5 | 0.07 | 1.3e-07 | 4.6 | 5.3 | 9.5e-08 | 0.03 | 0.03 | 0.86 | FALSE |