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chr11:4,838,968-7,371,849

Best TWAS P=6.64e-18 · Best GWAS P=2.66e-28 conditioned to 1.02e-16

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM5	0.08	0.07	enet	4	0.06	1.2e-07	10.1	8.6	6.6e-18	-0.26	0.95	0.03	TRUE
2	GTEx	Esophagus Mucosa	TRIM5	0.19	0.04	enet	29	0.05	1.5e-04	-7.4	8.0	1.1e-15	-0.06	0.86	0.01	TRUE
11	YFS	Blood	TRIM5	0.02	0.01	enet	24	0.02	6.7e-07	-3.0	7.4	1.9e-13	0.05	0.99	0.00	TRUE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	OR52N2	0.12	0.06	lasso	3	0.07	6.1e-04	6.3	-6.9	6.4e-12	-0.03	0.06	0.24	TRUE
10	ROSMAP	Brain Pre-frontal Cortex	UBQLNL	0.09	0.00	blup	839	0.02	9.8e-04	4.4	6.5	1.1e-10	-0.18	0.17	0.05	TRUE
3	GTEx	Esophagus Muscularis	DCHS1	0.44	0.08	lasso	8	0.22	1.9e-13	4.6	6.0	2.0e-09	-0.04	0.04	0.94	TRUE
1	CommonMind	Brain Pre-frontal Cortex	TRIM5	0.06	0.03	enet	25	0.05	3.1e-06	-5.8	8.6	9.3e-18	-0.22	0.64	0.13	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM5	0.20	0.00	enet	30	0.08	1.0e-04	-1.7	7.6	3.6e-14	-0.15	0.04	0.04	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM5	0.07	0.06	lasso	4	0.05	1.1e-06	-7.4	7.4	1.2e-13	0.02	0.98	0.00	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TRIM5	0.11	0.10	lasso	1	0.09	1.7e-10	-7.4	7.4	1.3e-13	0.02	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM5	0.08	0.05	lasso	2	0.05	5.6e-07	-7.4	7.4	1.4e-13	0.05	0.97	0.00	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM5	0.06	0.04	lasso	4	0.04	2.0e-08	-7.4	7.3	2.5e-13	0.02	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM6	0.04	0.01	blup	113	0.01	6.3e-03	-6.8	7.0	2.2e-12	-0.31	0.04	0.42	FALSE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM5	0.14	0.03	lasso	6	0.07	9.1e-05	-6.9	6.7	1.7e-11	0.01	0.30	0.06	FALSE
4	GTEx	Esophagus Muscularis	RP11-732A19.5	0.40	0.17	lasso	6	0.17	1.7e-10	4.6	5.9	3.6e-09	-0.03	0.04	0.93	FALSE
5	GTEx	Muscle Skeletal	TRIM5	0.13	0.07	enet	3	0.05	1.4e-05	-5.8	5.8	7.9e-09	-0.25	1.00	0.00	FALSE
6	GTEx	Nerve Tibial	RP11-732A19.8	0.12	0.10	lasso	5	0.08	1.7e-06	4.7	5.5	4.1e-08	-0.02	0.01	0.98	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	DCHS1	0.24	0.18	lasso	5	0.21	1.2e-26	4.6	5.4	6.1e-08	0.01	0.03	0.94	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	DCHS1	0.10	0.04	lasso	5	0.07	1.3e-07	4.6	5.3	9.5e-08	0.03	0.03	0.86	FALSE
7	GTEx	Nerve Tibial	RP11-732A19.2	0.35	0.18	lasso	6	0.19	1.6e-13	4.7	5.3	1.0e-07	-0.01	0.02	0.97	FALSE
8	METSIM	Adipose	ILK	0.09	0.06	lasso	3	0.05	1.5e-08	4.9	5.2	1.5e-07	-0.04	0.01	0.98	FALSE